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Abstrak :
ABSTRAK Usnea dasypoga Rohl, adalah tumbuhan yang dikumpulkan dari Taman Nasional Botani Seblat, Gunung Kerinci, Propinsi Jambi, Sumatra. Dari ekstraks aseton yang berasal dari talus Usnea dasypoga Rohl, berhasil di isolasi (+) - asam usnat dalam bentuk kristal berwarna kuning. Dari ekstraks petroleum eter berhasil juga diisolasi (+)- asam usnat dan suatu senyawa baru yang berupa kristal putih, dimana strukturnya ditetapkan berdasarkan data spektra inframerah,1H-NMR, 13C-NMR, FAB-MS dan spektra NMR dua dimensi, COSY, HMBC dan HMQC. Dari data spektroskopi diketahui bahwa senyawa baru tersebut adalah ester siklis dalam bentuk lakton dengan rumus molekul C30H54O9. Senyawa baru ini untuk sementara disebut sebagai LAKTON TRIMER. Sifat anti bakteri (+)- asam usnat sudah diketahui dengan baik, sedangkan senyawa baru yang berhasil diisolasi ini diketahui tidak mempunyai aktivitas biologi terhadap E. coli dan S. aureus.

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ABSTRACT Usnea dasypoga Rohl is herb that was collected from the Seblat-National Botanical Garden, Mount Kerinci, Sumatra. From the acetone extract of the Usnea dasypoga Rohl. has been isolated (+)- usnic acid as a yellow crystal. From the petroleum ether extract has also been isolated (+)- usnic acid and a new compound as white crystal. Its structure was established by 'H-NMR, 13C-NMR and its related 2D-spectrum, infra red and FAB-MS. From its spectral data are known that the new compound is timer cyclic ester (C3oHuO9). The biological activities of usnic acid is well known, but unfortunately the new isolated compound has no biological activities against E. coil and S. aureus.

Abstrak :
Tujuan: (1) mengetahui perubahan komposisi cairan tubuh dalam 24 jam pasca bedah pintas koroner dengan pintas jantung paru (BPK+PJP); (2) mengetahui besarya katabolisme protein dalam 24 jam pasca PBK+PJP; (3) mengetahui hubungan antara perubahan cairan infra sal (OS) dengan katabolisme protein.
Tempat: Unit Terapi Intensif Rumah Sakit Jantung Harapan Kita
Metodologi: Setelah mendapat persetujuan etik dari komite etik penelitian medis NCC, Harapan Kita Hospital, diperoleh 20 pasien laki-laki dengan BPK terencana. Volume cairan tubuh diukur dengan multiple frequency bioelecirical impedance (Dietosystem, Italy) pada frekuensi 1, 50, dan 100 kHz dengan menggunakan formula Guricci. Impedans diukur, 1 kali pra bedah dan 3 kali pasca bedah setiap 8 jam. Perubahan komposisi cairan tubuh dinilai dengan uji-t untuk 2 kelompok berpasangan. Nitrogen urea urin (NUU), kreatinin urin dan imbang nitrogen digunakan sebagai indikator katabolisme protein dengan menampung urin 8 jam pada interval yang sama dengan pe ukuran MFBIA Imbang nitrogen diperoleh dengan menghitung asupan dan NUU 24 jam pasta bedah. Hubungan antara perubahan cairan infra sel (CIS) dengan indikator katabolisme dihitung dengan uji korelasi Spearman Rank
Hasil: Nilai ZI00 adalah 479 5l, indeks impedans 57,3 cm2/Q, dan volume cairan tubuh total (CM') 33,1 L terdiri dari 44,0% cairan ekstra sel (CES) dan 56,0% CIS. Pra bedah pasien termasuk euvolemia. Intra bedah terjadi imbang cairan +1744 (826-4312) mL. Delapan jam pertama terjadi peningkatan bermakna dari cairan tubuh. Dalam 24 jam pasca BPK+PJP terjadi peningkatan CTT 16,0%; CES 20,7%, dan CIS 13,0%. Peningkatan cairan masih dalam nilai euvolemia. Tidak terdapat hubungan bermakna antara perubahan volume cairan tubuh yang diukur dengan MFBIA dan imbang cairan. Median asupan selama 24 jam pasca bedah adalah 926 (127-1903) kkal dan 28 (0-69) g protein. Secara statistik terjadi peningkatan bermakna dari NUU pada 8 jam ketiga pasca BPK+PIP. Tidak terdapat perbedaan bermakna antara kreatinin urin pra bedah dan pasca bedah. Median imbang nitrogen -8{(-12,7) - (-1,6)} g. Terdapat korelasi negatif antara peningkatan volume CIS dan NUU (r - 0,57; p = 0,01).
Kesimpulan Penelitian ini menunjukkan kompartemen cairan tubuh meningkat dalam 24 jam pasca BPK+PJP. Katabolisme protein ringan terjadi dalam 24 jam pasca BPK+PTP. Terdapat korelasi negatif antara peningkatan volume CIS dengan NUU, namun diperlukan penelitian lebih lanjut untuk menjelaskan hubungan ini, terutama pada pasien BPK+PJP".

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The Correlation Between Intra Cellular Water And Protein Catabolism After Coronary Artery Bypass Grafting: Using Multiple Frequency Bioelectrical Impedance
Objective: (1) to investigate the changes of body water compartment within 24 hours after elective coronary artery bypass grafting (CABG) surgery with extracorporeal circulation; (2) to observe protein catabolism within 24 hours after elective CABG with extracorporeal circulation, and (3) to correlate between the changes of intra cellular water (ICW) with protein catabolism indicators.
Location: Intensive Care Unit, Harapan Kita National Cardiac Center, Jakarta.
Subjects and Methods: Twenty male patients with coronary artery disease were recruited for the study. Impedance was measured at 1, 50, 100 kHz using multiple frequency bioelectrical impedance (Dietosystem, Italy) four times: at baseline, at the 1°, 2 and 3 8 hours after surgery. The volume of body water compartment was calculated using Guricci's formula. Urinary urea nitrogen (UUN) and urinary creatinine were assessed using 8-hour urine collection within 24-hour period. Nitrogen balance was calculated by subtracting nitrogen intake with urinary nitrogen. The correlation between the changes of ICW and protein catabolism indicators was tested with Spearman Rank Correlation.
Results: At the baseline, mean values of Ziw impedance and impedance index were 479 S~ and 57.3 cm21n, respectively. Mean total body water (TBW) was 33.1 ± 3.1 L or 48.8% of body weight, consist of 44.0% ECW and 56.0% ICW. This composition was classified as euvolemic. Median intra-operative fluid balance was 1744 (826-3412) mL. Significant increased in TBW, ECW, and ICW was observed at the 1' 8 hours. At the 3'a 8 hours after surgery, TRW, ECW, and ICW increased by 16.3%, 20.7%, and 12.8%, respectively, but the values were within desirable ranges. There was no correlation between TBW changes measured by MFBIA and calculated fluid balance. During 24 hours after surgery, median total energy intake was 926 (127-1903) kcal and protein intake was 28 (0-69) g. UUN increased significantly at the 3'd 8 hours after surgery. No significant difference in urinary creatinine was observed between before and after surgery. Nitrogen balance was -8 ((-12,7)-(-1.6)) g, and there was a negative correlation between ICW changes and NL-U (r = - 0.57; p = 0.01).

Conclusions: The current study indicates that changes of body water compartment occur during 24 hours after CABG, ICW increases within 24 hours after CABG. Mild protein catabolism occurs within 24 hours after CABG. ICW changes have negative correlation with NULL However further comprehensive study is needed to explain this association, especially in CABG patients.

Abstrak :
Latar Belakang: Skizofrenia merupakan masalah gangguan mental berat yang menyebabkan penderitaan di dunia. Di Indonesia, prevalensi gangguan mental berat sebesar  1,7  per  mil. Di Jakarta, untuk populasi di atas usia 15 tahun, 2,03% di antaranya menunjukkan gejala positif gangguan psikosis. Skizofrenia membutuhkan perawatan jangka panjang, menyebabkan produktivitas menurun atau hilang, beban sosial dan keuangan sangat besar, serta biaya perawatan tinggi. Ketersediaan Pusat Kesehatan Masyarakat dikaitkan dengan menurunnya angka morbiditas pada orang dengan skizofrenia. Tatalaksana segera akan memperbaiki keluaran pada pasien skizofrenia. oleh karena itu penting untuk diketahui pengetahuan dokter di Puskesmas mengenai tatalaksana skizofrenia. Metode: Studi ini merupakan studi deskriptif analitik yang menggunakan desain potong lintang, dilakukan di Puskesmas Provinsi DKI Jakarta. Subjek penelitian adalah dokter umum yang melakukan pelayanan kesehatan jiwa di Puskesmas Propinsi DKI Jakarta. Total 32 subjek diikutsertakan dalam studi, mengisi kuesioner Pengetahuan Dokter Puskesmas Mengenai Antipsikotika. Pola peresepan dikumpulkan dengan melihat peresepan bulan Juli-Desember 2017. Hasil: Pengetahuan dokter mengenai antipsikotika lebih banyak kurang baik (59,4%). Sumber pengetahuan terbanyak adalah dari pendidikan fakultas kedokteran (93%).  Pola peresepan yang lebih banyak dijumpai adalah tidak tepat (96,9%) dan  politerapi (59,7%). Penelitian ini juga mendapatkan tidak ada hubungan bermakna antara pengetahuan dokter mengenai antipsikotika dengan pola peresepan antipsikotika dalam tatalaksana skizofrenia (p>0,05). Kesimpulan: Dokter Puskesmas di DKI propinsi Jakarta banyak meresepkan antipsikotika, misalnya kombinasi haloperidol dan klorpromazin, bersamaan dengan antikolinergik. Hal ini tidak berhubungan dengan pengetahuan mengenai antipsikotika. ......Background: Schizophrenia is a severe mental disorder that cause severe burden in the world. The prevalene of severe mental disorder in Indonesia is 1,7‰. In Jakarta, the prevalence of positive psychotic symptoms for people above 15 years old is 2,03%. People with schizophrenia have low productivity and require a life long treatment which cause high social and economical burden. The availibility of primary public health is associated with decreased schizophrenia’s morbidity rate. Early treatment will influence the outcome of schizophrenia, hence it is important to obtain the knowledge of primary care physicians about the management of schizophrenia. Method: This is a descriptive analytic study with a cross sectional design. The study was conducted in Primary Public Health Care in Jakarta. Subjects are doctors who provide mental health services in the selected primary public health. Thirty two subjects were recruited in the study. They were asked to take the questionnaire that could measure the knowledge of the primary care physicians regarding antipsychotics. Prescription patterns were obtained by looking at the prescription data from July to December 2017. Results:  This research shows that about 59,4% physicians have low knowledge about antipsychotics. The physican’s knowledge was mostly obtained from studying at medical faculty (93%). Majority of prescription pattern are inexact (96,9%) and polytherapy (59,7%). This study also shows that there is no correlation between physican’s knowledge about antipsychotics and prescription pattern for schizophrenia management. Conclusion: The physicians of primary health care in DKI Jakarta often prescribed antipsychotics, such as combination of haloperidol and chlorpromazine, with addition of anticholinergics. This is not related to their knowledge about antipsychotics.

Abstrak :
ABSTRAK Dewasa awal memiliki tugas perkembangan mandiri dengan memiliki pekerjaan dan berkomitmen dalam sebuah hubungan. Fase dewasa awal sedang dialami oleh sarjana baru. Untuk menyelesaikan tugas-tugas perkembangan tersebut dibutuhkan efikasi diri. Keberadaan efikasi diri merupakan salah satu faktor yang memengaruhi mekanisme koping. Tujuan penelitian ini mengetahui hubungan antara tingkat efikasi diri dengan kedua jenis mekanisme koping pada sarjana baru yang berstatus lajang. Penelitian ini menggunakan desain cross sectional dengan total sampel 107 orang. Hasil analisis dalam penelitian ini. Pertama, terdapat hubungan yang signifikan antara tingkat efikasi diri dengan problem focused coping (p value=0,002), dan tidak ada hubungan yang signifikan antara tingkat efikasi diri dengan emotional focused coping (p value=0,266). Hasil penelitian ini merekomendasikan kepada tenaga kesehatan untuk melakukan promosi kesehatan terkait cara-cara meningkatkan efikasi diri dan pilihan-pilihan penggunaan mekanisme koping yang adaptif.

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ABSTRACT Young Adults have development tasks by having work and commitment in a relationship. The early adult phase is being experienced by new graduates of the bachelor degrees. To complete development tasks required self-efficacy. The existence of self-efficacy is one of the factors that influence coping mechanisms. This research was conducted on the relationship between the levels of self-efficacy with the two types of coping mechanisms in new graduates with single status. This study uses a cross-sectional design with sample of 107 people. The results of the analysis in this study here is a significant relationship between the level of self-efficacy and problem-focused coping (p-value = 0.002), and there is no significant relationship between the level of self-efficacy with emotion-focused coping (p-value = 0.266). The results of this study recommend that health workers carry out health promotion related to ways to improve self-efficacy and choices for using adaptive coping mechanisms.

Abstrak :
IFToMM conferences have a history of success due to the various advances achieved in the field of rotor dynamics over the past three decades. These meetings have since become a leading global event, bringing together specialists from industry and academia to promote the exchange of knowledge, ideas, and information on the latest developments in the dynamics of rotating machinery. The scope of the conference is broad, including e.g. active components and vibration control, balancing, bearings, condition monitoring, dynamic analysis and stability, wind turbines and generators, electromechanical interactions in rotor dynamics and turbochargers. The proceedings are divided into four volumes. This first volume covers the following main topics: Active Components and Vibration Control; Balancing; Bearings: Fluid Film Bearings, Magnetic Bearings, Rolling Bearings and Seals; and Blades, Bladed Systems and Impellers.

Abstrak :
This book offers recommendations on the milling processes for the carbon fiber reinforced plastic CFRP/Al2024. Due to the anisotropic and non-homogeneous structure of CFRP and the ductile nature of aluminum, the machining of this material is very challenging and causes various types of damage, such as matrix cracking and thermal alterations, fiber pullout and fuzzing during drilling and trimming, which affect the quality of machined surface. The book studies and models the machined surface quality of CFRP/Al2024 using a two-level full factorial design experiment. It describes the processes of trimming using down milling, and statistically and graphically analyzes the influence and interaction of cutting parameters. Lastly, the book presents the optimization of the cutting parameters in order to create a surface texture quality of CFRP/Al2024 to less than 1 µm.

Abstrak :
IFToMM conferences have a history of success due to the various advances achieved in the field of rotor dynamics over the past three decades. These meetings have since become a leading global event, bringing together specialists from industry and academia to promote the exchange of knowledge, ideas, and information on the latest developments in the dynamics of rotating machinery. The scope of the conference is broad, including e.g. active components and vibration control, balancing, bearings, condition monitoring, dynamic analysis and stability, wind turbines and generators, electromechanical interactions in rotor dynamics and turbochargers. The proceedings are divided into four volumes. This second volume covers the following main topics: condition monitoring, fault diagnostics and prognostics; modal testing and identification; parametric and self-excitation in rotor dynamics; uncertainties, reliability and life predictions of rotating machinery; and torsional vibrations and geared systems dynamics.