Penggunaan telenursing memiliki potensi dalam menjembatani kesenjangan antara perawat dan pasien, sehingga memungkinkan pertukaran informasi dilakukan lebih cepat daripada melalui tatap muka. Tulisan ini bertujuan untuk menunjukkan implikasi telenursing melalui SMS pada klinik MTBS Puskesmas Pancoran Mas terhadap frekuensi kunjungan ulang pasien serta respon yang diberikan oleh partisipan. Penelitian ini menggunakan metode eksperimental melalui pengamatan dan pendekatan cross sectional static group comparison pada dua kelompok yang masing-masing terdiri atas 25 peserta diperlakukan secara berbeda. Hasil menunjukkan bahwa melalui uji Fisher exact ditemukan tidak ada perbedaan antara jarak tempuh ke pusat kesehatan dengan kunjungan ulang. Juga tidak ada hubungan antara telenursing dengan frekuensi jumlah kunjungan ulang kedua kelompok. Meskipun demikian, 64% partisipan intervensi merespon pesan, yang berarti membuka kemungkinan untuk proses pendidikan kesehatan untuk dilakukan dari jarak jauh. Penelitian yang bersifat kualitatif di setting yang sama untuk meninjau ulang kepuasan pasien terhadap proses telenursing ini sangat direkomendasikan
The use of telenursing has revealed its potential benefits in bridging the gap between nurses and the patients. Thus, enabling information exchange process could be done faster than conventional face-to-face visits. This paper aims to show implications of telenursing method on a community health center pediatric clinic in Pancoran Mas Depok, Indonesia, towards its patient?s behavior to revisit as well as responses given by the patients. This research includes a set of experiment-base static group comparison method. Two groups, each consisted of 25 participants were treated differently at the same time. Using Fisher Exact technique, analysis revealed that there was no difference between distance from house to the health center and no difference between both groups in terms of repeated visits? frequency. However, it turned out that 64% participants responded the messages, opening up the possibility for health education to be undergone from distance. It is further recommended to measure patient?s satisfaction during the telenursing process in qualitative fashion
"Rubus fraxinifolius dan R. rosifolius merupakan tanaman Rubus yang dapat ditemukan di daerah pegunungan Indonesia. Kedua tanaman memiliki morfologi buah yang mirip yaitu berbentuk berry merah dan edible, serta mengandung senyawa golongan triterpenoid, polifenol dan flavonoid. Beberapa spesies Rubus dilaporkan memiliki aktivitas sebagai antiaging yaitu antielastase, antioksidan, dan antitirosinase. Penelitian ini bertujuan untuk menelaah aktivitas antiaging secara in vitro pada ekstrak dan isolat dari tanaman R. fraxinifolius dan R. rosifolius. Batang, buah, dan daun kedua tanaman diekstraksi menggunakan alat Soxhlet serta dilakukan skrining aktivitas anti elastase dan antioksidan. Selanjutnya terhadap ekstrak terpilih dilakukan pemisahan, fraksinasi dan isolasi senyawa. Isolat yang didapat diidentifikasi menggunakan spektrometri FTIR, 1H-NMR, 13C-NMR, DEPT, HSQC, HMQC, HMBC, dan LC-MS, serta diuji aktivitas antielastase, antitirosinase dan sitotoksisitas pada sel fibroblast secara in vitro. Hasil ekstraksi bertingkat menunjukkan bahwa ekstrak metanol daun R. fraxinifolius memiliki aktivitas antielastase dan antioksidan tertinggi dengan masing-masing IC50 57,45 dan 4,33 µg/ml. Terhadap fraksi metanol daun R. fraxinifolius (DFM) dilakukan pemisahan menggunakan kromatografi cair vakum dan diperoleh 11 fraksi. Uji antielastase fraksi menunjukkan fraksi paling aktif adalah DFM8. Selanjutnya dilakukan isolasi lebih lanjut terhadap DFM8 dan diperoleh 3 isolat. Hasil elusidasi struktur menunjukkan bahwa ketiga isolat merupakan suatu triterpen pentasiklik tipe ursan. Hasil telaah data pengujian DEPT, HMQC, HSQC, HMBC serta IR dan MS disimpulkan senyawa DFM 8a adalah asam 2,3-glikol, 19α-hidroksi-12-ursen-23,28-dioat (C32H48O7, BM 544); DFM8b asam 2,3-propanandiol, 19α-hidroksi-12-ursen-28-oat (C33H52O5, BM 528,38); dan DFM8c asam 2,3-glikol-19α-hidroksi-23,24-nor-12-ursen-28-oat (C30H46O5, BM 486,33). Ketiga senyawa hasil isolasi ini merupakan senyawa baru dan belum pernah ditemukan sebelumnya. Uji aktivitas antielastase senyawa DFM8a, DFM8b, dan DFM8c memiliki IC50 berturut-turut adalah 122,199; 98,22; dan 54,33 µg/ml, serta antitirosinase dengan IC50 207,8; 221,5; dan 335,9 µg/ml. Uji toksisitas menunjukkan bahwa ekstrak DFM, fraksi DFM8, dan isolat DFM8b tidak toksik terhadap sel fibroblas NIH/3T3.
Rubus fraxinifolius and R. rosifolius are Rubus genus, which can be found in the mountain of Indonesia. Both plants have similar fruit morphology: red and edible berries and contain triterpenoid, polyphenols, and flavonoids. Some species of Rubus are reported to have antiaging activity, antielastase, antioxidant, and antityrosinase. This study aims to examine the in vitro antiaging activity of extracts and isolated compounds from R. fraxinifolius and R. rosifolius. The stems, fruits, and leaves of both plants were extracted and screened for antielastase and antioxidant activity. Furthermore, the selected extracts were separated, fractionated, and isolated to yield isolates. The obtained isolates were identified using FTIR spectrometry, 1H-NMR, 13C-NMR, DEPT, HSQC, HMQC, HMBC, and LC-MS, and also were tested for antielastase, antityrosinase, and cytotoxicity activities in fibroblast cells. The continuous extraction results showed that the methanol extract of R. fraxinifolius leaves had the highest antielastase and antioxidant activity with IC50 57.45 ppm and 4.33 ppm, respectively. The methanol fraction of R. fraxinifolius (DFM) leaves were separated using vacuum liquid chromatography and obtained 11 fractions. The antielastase assay of fractions gave the most active fraction was DFM8. Then, further isolation of DFM8 was carried out, and three isolates were obtained. The structural elucidation showed that the three isolates were ursane-type of pentacyclic triterpenes. The results of DEPT, HMQC, HSQC, HMBC, IR and MS spectrometry test concluded that the compound DFM 8a was 2,3-glycol, 19α-hydroxy-12-ursen-23,28-dioic acid (C32H48O7, MW 544); DFM8b 2,3-propanandiol, 19α-hydroxy-12-ursen-28-oic acid (C33H52O5, MW 528.38); and DFM8c 2,3-glycol-19α-hydroxy-23,24-nor-urs-12-en-28-oic acid (C30H46O5, MW 486.33). All isolated compounds are new compounds and have never been found before. The IC50 of antielastase activity of DFM8a, DFM8b, and DFM8c were 122.199; 98.22; and 54.33 ppm, respectively, and the IC50 of antityrosinase activity were 207.8; 221.5; and 335.9 ppm, respectively. Toxicity tests showed that the DFM extract, the DFM8 fraction, and the DFM8b were not toxic to NIH/3T3 fibroblast cells.
"