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"Tujuan: Untuk melihat respon pemberian regimen kemoterapi paclitaxel, ifosfamide, dan cisplatin pada pasien dengan kanker penis. Metode Penelitian: Pasien SCC penis dengan pembesaran kelenjar getah bening di inguinal dan pelvik di RS. Haji Adam Malik dari tahun 2014 sampai 2016 diinklusikan. Kami menggunakan regimen kemoterapi TIP yaitu paclitaxel 175 mg/m2 pada hari 1, ifosfamide 1200 mg/m2 pada hari 1-3, dan cisplatin 25 mg/m2 pada hari 1-3 setiap 21-28 hari. Hasil Penelitian: Selama 2 tahun terdapat 17 pasien kanker penis dengan keterlibatan kelenjer getah bening yang mendapat regimen TIP dengan rata-rata umur pasien 44,18 11,13. Hanya 10 pasien yang menyelesaikan kemoterapi secara penuh. Dari 10 pasien, tidak ada yang menunjukkan komplit respon. Enam pasien menunjukkan parsial respon, 3 pasien stabil respon dan 1 pasien progresif. Kaplan-Meier overall survival rate OS adalah 6 bulan 95 CI: 4,4-7,6 bulan . Median waktu follow up adalah 7 bulan antara 1 sampai 11 bulan . Analisis subgrup, OS pasien yang memiliki respon lebih baik secara signifikan bila dibandingkan dengan yang tidak berespon log-rank test, p?0,004 . Kesimpulan: Kemoterapi TIP memberikan manfaat klinik pada pasien kanker penis dengan penyebaran kelenjer getah bening. ......Aim This study was conducted to evaluate the response of penile cancer patients who were in TIP Paclitaxel, Ifosfamide, Cisplatin regimen. Method We included all medical records of penile squamous cell carcinoma patients associated with nodal involvement who acquired TIP regimen in Adam Malik Hospital between 2014 and 2016. We administered 175 mg m2 of Paclitaxel on day 1, 1200 mg m2 of Ifosfamide on day 1 3, and 25 mg m2 of Cisplatin on day 1 3 every 21 28 days. Results We extracted data from 17 patients of penile cancer with nodal involvement who acquired TIP regimen with mean age of 44.18 11.13 years old from our medical records. Only 10 patients completed 4 cycles of the regimen. There was no complete respond noted. Six patients were noted as partial respond and 1 patient was noted as progressive disease. The Kaplan Meier curve shows an overall 6 months 95 CI 4.4 7.6 months of survival with median of follow up time was 7 1 11 months. In subgroup analysis, we found that the responder group have significantly better overall survival than the non responder group log rank test, p 0.004 . Conclusion TIP regimen gives significant clinical benefit in penile cancer with nodal involvement. "

"Textbook of penile cancer reports accurately on recent developments in the management of penile cancer, whilst also covering the fundamentals of the disease, to provide a comprehensive, stand-alone and up-to-date volume on the subject. The surgical management of penile cancer is shifting towards increasingly refined methods, as it is believed that a proportion of patients undergo overtreatment for the disease. Where traditionally the management of penile cancer has involved partial or total penectomy combined with radical inguinal lymphadenectomy, over the last few years the treatment involves conservative penile reconstructive surgery such that sexual function and phallic length is preserved. Furthermore, the increasing utilization of sentinel lymph node biopsy rather than radical inguinal lymphadenectomy prevents the unnecessary removal of lymph nodes in patients where lymph node metastases has not occurred. There is also likely to be a change in the role of chemotherapy and radiotherapy for advanced disease.Textbook of penile cancer covers the epidemiology, molecular biology, radiological imaging, as well as the latest surgical advances in the treatment of this disease. "

"Salah satu program spesialistik keperawatan medikal bedah adalah keperawatan onkologi. Keperawatan onkologi merupakan suatu area spesialisasi keperawatan yang mempelajari penyakit akibat tumor atau keganasan. Program spesialis keperawatan onkologi bertujuan untuk meningkatkan pemberian asuhan keperawatan pada kasus paliatif dan kasus kanker yang bersifat komplek dan komprehensif yang hanya dapat diberikan oleh perawat spesialis onkologi. Tujuan Karya Ilmiah Akhir ini melaporkan pencapaian target kompetensi spesialis keperawatan onkologi yang telah dilakukan. Target kompetensi pertama yaitu analisis pendekatan Teori Keperawatan Virginia Henderson pada pasien kanker penis. Selanjutnya target kompetensi kedua yaitu penerapan instrumen Oral Assessment Guide OAG sebagai format pengkajian mukositis akibat kemoterapi, dan target kompetensi ketiga yaitu program inovasi berupa penerapan intervensi oral cryoterapi sebagai tindakan mandiri perawat dalam mencegah dan mengatasi mukositis. Kesimpulan: Model teori keperawatan Virginia Henderson efektif di terapkan sebagai acuan dalam memberikan asuhan keperawatan pada pasien dengan masalah onkologi atau paliatif. Selain itu, instrumen Oral Assessment Guide OAG terbukti efektif dan efisien sebagai deteksi awal mukositis dan untuk intervensi mandiri keperawatan, intervensi oral cryoterapi juga terbukti efektif dalam mencegah dan mengurangi mukositis pada pasien kanker yang menjalani kemoterapi sehingga mudah untuk diaplikasikan oleh perawat ruangan. ......One of the specialist courses of medical surgical nursing is oncology nursing. Oncology nursing is an area of ??nursing specialization that studies disease due to tumor or malignancy. The oncology nursing specialist program aims to improve the provision of nursing care in cases of palliative and complex cancer cases and comprehensive that can only be provided by the oncology specialist nurse. The aim of this Final Scientific Works reports on achieving the target of specialist competence of oncology nursing that has been done. The first target of competence is the analysis of the Virginia Henderson Nursing Theory approach in patients with penile cancer. Furthermore, the second target of competence is the application of Oral Assessment Guide OAG instrument as a mukositis assessment format due to chemotherapy, and the third competency target is innovation program in the form of oral cryotherapy intervention as the independent action of nurse in preventing and overcoming mukositis. Conclusion: Virginia Henderson 39;s model of nursing theory is effectively applied as a reference in providing nursing care in patients with oncology or palliative problems. In addition, the Oral Assessment Guide OAG instrument proved to be effective and efficient as early detection of mucositis and for self-care nursing intervention, oral intervention cryotherapy has also proven effective in preventing and reducing mucositis in cancer patients undergoing chemotherapy making it easy to apply by nurses."