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Abstrak :
Benzena dikenal sebagai salah satu senyawa karsinogen. IARC telah menggolongkan benzena sebagai senyawa karsinogenik golongan 1 yang menunjukkan paparan benzena sangat berbahaya bagi kesehatan manusia. Paparan dari aktivitas merokok dan emisi kendaraan bermotor pada polisi lalu lintas secara terus menerus akan mengakibatkan tingginya resiko paparan benzena sehingga perlu dilakukan kajian resiko paparan benzena terhadap polisi lalu lintas khususnya di wilayah Depok yang merupakan kota penyangga ibukota Jakarta. Asam s-fenilmerkapturat (SPMA) dalam urin merupakan metabolit spesifik terhadap paparan benzena sehingga representatif sebagai biomarker paparan benzena. Rata-rata konsentrasi SPMA pada polisi lalu lintas yang merokok, polisi lalu lintas yang tidak merokok, dan kontrol memberikan hasil 150,44 + 75,13 μg /g kreatinin, 70,44 + 64,21 μg /g kreatinin, dan 14,3 + 19,61 μg /g kreatinin. Hasil uji statistik menunjukkan bahwa faktor emisi kendaraan bermotor, lama bekerja serta merokok meningkatkan resiko paparan benzena polisi lalu lintas. ......Benzene has been known as one of the carcinogen agent. IARC had been categorized benzene as carcinogen compound in group 1 that indicates benzene exposure very harmful to human health. Exposure over and over from smoking activities and automobile emission to traffic policemen, will resulting a high risk benzene exposure, as a result, risk study of benzene exposure need to be done toward traffic policemen, specially in Depok area as Jakarta’s buffer zone. Sphenylmercapturic acid (SPMA) in urine is specific metabolite to benzene exposure, so it represents as biomarker benzene exposure. SPMA concentration average in smoking traffic policemen, nonsmoking traffic policemen and control respectively, give a result 150,44 + 75,13 μg /g creatinine, 70,44 + 64,21 μg /g creatinine, dan 14,3 + 19,61 μg /g creatinine. The statistical test result, show that automobile emission, working duration as traffic policemen, and smoking habit factor can increase traffic policemen benzene exposure risk.

Abstrak :
Industri sepatu merupakan salah satu industri informal yang semakin berkembang di Indonesia. Proses pembuatan sandal/sepatu menggunakan bahan kimia yaitu benzena pada proses pengeleman. Pajanan benzena akan mengakibatkan masalah pada sistem hematopoetik yang menyebabkan penurunan kadar hemoglobin. Penelitian ini bertujuan mengindentifikasi hubungan benzena di dalam tubuh melalui pengukuran biomarker SPhenylmercapturic Acid (S-PMA) terhadap kadar hemoglobin pekerja bengkel sandal/sepatu di Desa Sukajaya. Penelitian ini menggunakan studi cross-sectional yang dilaksanakan pada Maret-Mei 2018. Jumlah sampel sebanyak 73 pekerja dengan metode total sampling. Hasil analisis menunjukkan bahwa pekerja dengan umur >29 tahun berisiko 1,76 kali, memiliki riwayat infeksi berisiko 1,51 kali, IMT tidak normal berisiko 1,51 kali, masa kerja >5 tahun berisiko 1,01 kali, dan durasi >11 jam berisiko 1,04 kali memiliki kadar hemoglobin <14 g/dL. Hasil analisis juga menunjukkan bahwa pekerja dengan konsentrasi S-PMA tinggi (>1,53 µg/g kreatinin) berisiko 1,84 kali lebih besar memiliki kadar hemoglobin <14 g/dL dibandingkan pekerja dengan konsentrasi S-PMA rendah (< 1,53 µg/g kreatinin) setelah dikontrol variabel umur, kebiasaan olahraga, dan jenis pekerjaan. Perlu dilakukan pengendalian risiko di tempat kerja dengan membatasi jam kerja, pengaturan ruang kerja, dan menerapkan pelarangan merokok di ruang kerja. ...... The shoe industry is one of the growing informal industries in Indonesia. The process of making sandals/shoes used a chemical benzene in the process of sizing. Benzene exposure will caused problems in the hematopoetic system that caused a decrease in hemoglobin levels. This study aimed to identify benzene relationship in the body through measurement of S Phenylmercapturic Acid (S-PMA) biomarker on hemoglobin level of sandals/shoes workshop workers in Sukajaya Village. This study used crosssectional study conducted in March-May 2018. The number of sample was 73 workers with total sampling method. The results of the analysis showed that workers with age> 29 years were at risk 1.76 times, had a history of infection at risk 1.51 times, Body Mass Indices (BMI) was not normal at risk 1.51 times, working period > 5 years at risk 1.01 times, and working hours > 11 hours at risk of 1.04 times having hemoglobin <14 g/dL. The results also showed that workers with high S-PMA concentrations (> 1.53 μg / g creatinine) were 1.84 times more likely to have hemoglobin <14 g/dL than those who had low S-PMA concentrations (<1.53 μg/g creatinine) after controlled by age, exercise, and type of work variables. Risk control in the workplace is required by limiting of working hours, arranging working space, and applying smoking ban in the workplace.

Abstrak :
Keberadaan benzena dalam lem alas kaki ini membahayakan kesehatan para pekerjadi bengkel alas kaki karena sifatnya yang toksik dan karsinogenik. Dampak yangditimbulkan adalah terganggunya sumsum tulang yang merupakan tempat produksi seldarah merah; darah putih dan trombosit. Tujuan dari penelitian ini adalah menganalisishubungan pajanan benzena melalui pemeriksaan konsentrasi S-phenylmercapturic acid S-PMA di urin terhadap kadar trombosit pada pekerja bengkel alas. Desain daripenelitian adalah cross sectional pada pekerja pabrik alas kaki di Desa Sukajaya denganjumlah sampel 73 pekerja. Sampel yang diambil adalah urin dan darah dari pekerjauntuk mengetahui konsentrasi S-PMA dan kadar trombosit. Konsentrasi S-PMA diukurdengan alat LC-MS/MS dan trombosit dengan Automated Hematology Analyzer.Karakteristik individu dengan wawancara secara langsung. Hasil penelitianmenunjukkan nilai OR=2,28 antara konsentrasi S-PMA terhadap kadar trombosit.Variabel kebiasaan olahraga dengan OR=1,58 antara olahraga tidak rutin terhadaptrombosit dan konsumsi alkohol OR=1,78 antara yang mengkonsumsi terhadap kadartrombosit. Hasil uji regresi logistik multivariabel menunjukkan nilai OR=2,59 pekerjadengan konsentrasi S-PMA >0,67 g/g kreatinin terhadap kadar trombosit setelahdikontrol variabel umur dan konsumsi alkohol. ...... The existence of benzene in the glue of footwear is endangering the health of theworkers in the footwear workshop because of its toxic and carcinogenic nature. Theimpact is the disruption of the bone marrow which is where the production of red bloodcells; white blood and platelets. The purpose of this study was to analyze therelationship of benzene exposure through the examination of S phenylmercapturic acid S PMA concentration in urine on platelet levels in base workshop workers. The designof the study was cross sectional on footwear factory workers in Sukajaya Village with asample of 73 workers. Samples taken are urine and blood from workers to know theconcentration of S PMA and platelet levels. The concentration of S PMA was measuredby LC MS MS and platelets with Automated Hematology Analyzer. Individualcharacteristics with direct interview. The results showed the value of OR 2.28between S PMA concentration to platelet level. Variables of exercise habits with OR 1.58 between non routine exercise on platelets and alcohol consumption OR 1.78among those who consume to platelet levels. Multivariable logistic regression testresults showed OR 2.59 workers with S PMA concentration 0.67 g g creatinine on platelet count after controlled for age and alcohol consumption.