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Abstrak :
ABSTRAK
Odontocem® dan Biodentine®, berbahan dasar kalsium silikat. Tetapi terdapat kandungan lain yang mungkin memiliki efek pada viabiltas sel. Contohnya penambahan steroid dalam Odontocem®. Belum diketahui apakah penambahan steroid tersebut memiliki efek atau tidak terhadap viabilitas sel. Sel fibroblas yang diambil dari Telur Embrio Tertunas (TET), dipajan dengan Odontocem® dan Biodentine® dengan jumlah masing-masing kelompok sebesar 15 well. Kemudian viabilitas sel diukur selama 24 jam dan 72 jam. Hasil penelitian diuji dengan uji statistik Kruskal Wallis dengan uji post hoc Mann-Whitney. Berdasarkan hasil penelitian, didapatkan bahwa Odontocem® dan Biodentine® memiliki efek menurunkan viabiltas sel fibroblas pada pengukuran 24 jam dan 72 jam. Juga viabilitas sel fibroblas pada kelompok perlakuan Odontocem ® lebih tinggi daripada Biodentine® baik pada pengukuran 24 jam maupun 72 jam. ABSTRACT
Odontocem® and Biodentine®, both consist of calcium silicate. But there are other substances which may have an effect on cell viability. For example, addition of steroids in Odontocem®. It is not yet known whether these steroids have an effect or not on the cell viability. Fibroblasts taken from Chicken Embryo, added with Odontocem® and Biodentine® by each group of 15 wells. Then the cell viability was measured for 24 hours and 72 hours. The result were tested by Kruskal Wallis statistical test with post hoc test of Mann-Whitney. Based on this research, it was found that Odontocem® and Biodentine® have a lowering effect on the fibroblast cell viability for 24 hours and 72 hours. Thus, fibroblast cell viability the treatment group Odontocem ® is higher than both the measurement Biodentine® 24 hours or 72 hours.;Odontocem® and Biodentine®, both consist of calcium silicate. But there are other substances which may have an effect on cell viability. For example, addition of steroids in Odontocem®. It is not yet known whether these steroids have an effect or not on the cell viability. Fibroblasts taken from Chicken Embryo, added with Odontocem® and Biodentine® by each group of 15 wells. Then the cell viability was measured for 24 hours and 72 hours. The result were tested by Kruskal Wallis statistical test with post hoc test of Mann-Whitney. Based on this research, it was found that Odontocem® and Biodentine® have a lowering effect on the fibroblast cell viability for 24 hours and 72 hours. Thus, fibroblast cell viability the treatment group Odontocem ® is higher than both the measurement Biodentine® 24 hours or 72 hours.

Abstrak :
ABSTRAK
Latar Belakang: siler polidimetilsiloksan merupakan siler baru yang berpotensi menutup saluran akar lebih baik. Tujuan: membandingkan tingkat kerapatan pengisian di sepertiga apeks antara teknik kon tunggal (KT) dan downpackbackfill (DB) menggunakan siler polidimetilsiloksan. Metode: empat puluh gigi premolar bawah dibagi menjadi dua kelompok KT dan DB. Setelah pengisian saluran akar, sampel diinkubasi, dilapisi cat kuku, direndam dalam tinta India, lalu dibuat transparan dengan metode Robertson. Kebocoran di sepertiga apeks dievaluasi dengan mikroskop stereo. Hasil: skor kebocoran terendah (0-0,5 mm) dimiliki oleh kelompok KT dan skor kebocoran tertinggi (>1 mm) dimiliki oleh kelompok DB. Kesimpulan: teknik kon tunggal memberikan tingkat kerapatan yang lebih baik dibandingkan downpack-backfill, walaupun secara statistik perbedaan antar keduanya tidak signifikan. ABSTRACT
Background: polydimethylsiloxane sealer is a brand new sealer that potentially has a better sealing ability to the root canal. Aim: to compare the apical sealing ability in one third apex between single cone (SC) and downpack-backfill (DB) technique using polydimethylsiloxane sealer. Methods: fourty extracted human manibular premolars devided into two group, SC and DB. After obturated with polydimethylsiloxane sealer, samples were stored in incubator, coated with nail varnish, immersed in India ink, and then specimens were cleared using Robertson?s technique. The apical dye penetration was evaluated using a stereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SC group and the highest score(>1 mm) in DB group. Summary: single cone technique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques. ;Background: polydimethylsiloxane sealer is a brand new sealer that potentially has a better sealing ability to the root canal. Aim: to compare the apical sealing ability in one third apex between single cone (SC) and downpack-backfill (DB) technique using polydimethylsiloxane sealer. Methods: fourty extracted human manibular premolars devided into two group, SC and DB. After obturated with polydimethylsiloxane sealer, samples were stored in incubator, coated with nail varnish, immersed in India ink, and then specimens were cleared using Robertson?s technique. The apical dye penetration was evaluated using a stereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SC group and the highest score(>1 mm) in DB group. Summary: single cone technique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques. ;Background: polydimethylsiloxane sealer is a brand new sealer that potentially has a better sealing ability to the root canal. Aim: to compare the apical sealing ability in one third apex between single cone (SC) and downpack-backfill (DB) technique using polydimethylsiloxane sealer. Methods: fourty extracted human manibular premolars devided into two group, SC and DB. After obturated with polydimethylsiloxane sealer, samples were stored in incubator, coated with nail varnish, immersed in India ink, and then specimens were cleared using Robertson?s technique. The apical dye penetration was evaluated using a stereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SC group and the highest score(>1 mm) in DB group. Summary: single cone technique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques.

Abstrak :
ABSTRAK
Saat ini non-alcoholic fatty liver disease (NAFLD) merupakan penyebab terbanyak dari penyakit kronik hati pada anak dan dewasa. Penelitian terbaru memperlihatkan chemerin yang merupakan salah satu zat yang diproduksi oleh jaringan lemak memiliki andil penting pada NAFLD. Tujuan penelitian ini adalah membandingkan kadar chemerin dalam darah dibandingkan enzim transaminase dalam mendeteksi secara dini kerusakan sel hati karena non alcoholic fatty liver disease (NAFLD) pada anak dengan obesitas. Penelitian deskriptif potong lintang (n=57) dilakukan pada 2 buah sekolah di Jakarta pada anak usia 9-12 tahun dengan obesitas. Anak yang masuk kriteria penelitian dilakukan pemeriksaan ultrasonografi hati untuk mendeteksi perlemakan hati. Kedua kelompok tersebut sama sama dilakukan pemeriksan kadar enzim transaminase dan chemerin darah. Hasil dari penelitian ini di dapatkan nilai rerata chemerin pada anak yang menderita NAFLD sebesar 96,71 ng/ml sedangkan yang tidak menderita NAFLD sebesar 92,8 ng/ml dengan P= 0,463. Hal ini menunjukkan nilai rerata anak dengan NAFLD dibandingkan dengan anak tanpa NAFLD tidak terdapat perbedaan bermakna. Pada penelitian ini didapatkan pula bahwa pemeriksaan chemerin darah memiliki nilai AUC 0,52 dimana nilainya lebih rendah dibandingkan nilai AUC pemeriksaan SGOT dan SGPT yakni 0,81 dan 0,90. Hasil ini menunjukkan bahwa kadar chemerin darah tidak dapat menjadi prediktor yang lebih baik untuk mendeteksi perlemakan hati dibandingkan pemeriksaan kadar SGOT dan SGPT pada penelitian ini. Manfaat chemerin sebagai prediktor kelainan hati pada anak dengan obesitas perlu diteliti lebih lanjut. ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated.;Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated.;Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated.

Abstrak :
ABSTRAK
Latar Belakang: Preparasi saluran akar oval memiliki tantangan tersendiri karena bentuknya yang ireguler sehingga file tidak dapat berkontak dengan seluruh dinding. Penelitian ini bertujuan untuk membandingkan luas dinding saluran akar oval yang tidak terpreparasi dengan gerakan sirkumferensial filing. Metode: Tiga puluh dua gigi premolar mandibula diisi tinta cina kemudian dipreparasi menjadi dua kelompok: Mtwo® dan ProTaper Next®. Luas sisa tinta cina dianalisis dengan Adobe Photoshop CS6 dan ImageJ. Hasil: Tidak terdapat perbedaan bermakna antara kedua kelompok, namun ProTaper Next® meninggalkan area lebih sedikit dibandingkan Mtwo®. Kesimpulan: Mtwo® dan ProTaper Next® tetap meninggalkan area yang tidak terpreparasi pada saluran akar oval.ABSTRACT
Background: Mechanical preparation of oval root canal has its own challenge due to the irregular shape leaving some area uninstrumented. This study compared uninstrumented area of oval root canal with circumferential filing using two different files. Methods: Thirty-two mandibular premolars were dyed with china ink and divided into two groups, Mtwo® and ProTaper Next®. The uninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ. Results: There were no significant difference between two files, thou ProTaper Next® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® and ProTaper Next® left uninstrumented areas in oval root canal.;Background: Mechanical preparation of oval root canal has its own challenge due to the irregular shape leaving some area uninstrumented. This study compared uninstrumented area of oval root canal with circumferential filing using two different files. Methods: Thirty-two mandibular premolars were dyed with china ink and divided into two groups, Mtwo® and ProTaper Next®. The uninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ. Results: There were no significant difference between two files, thou ProTaper Next® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® and ProTaper Next® left uninstrumented areas in oval root canal.;Background: Mechanical preparation of oval root canal has its own challenge due to the irregular shape leaving some area uninstrumented. This study compared uninstrumented area of oval root canal with circumferential filing using two different files. Methods: Thirty-two mandibular premolars were dyed with china ink and divided into two groups, Mtwo® and ProTaper Next®. The uninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ. Results: There were no significant difference between two files, thou ProTaper Next® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® and ProTaper Next® left uninstrumented areas in oval root canal.;Background: Mechanical preparation of oval root canal has its own challenge due to the irregular shape leaving some area uninstrumented. This study compared uninstrumented area of oval root canal with circumferential filing using two different files. Methods: Thirty-two mandibular premolars were dyed with china ink and divided into two groups, Mtwo® and ProTaper Next®. The uninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ. Results: There were no significant difference between two files, thou ProTaper Next® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® and ProTaper Next® left uninstrumented areas in oval root canal.