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Abstrak :
ABSTRAK
Latar belakang Tingginya angka komplikasi morbiditas pasien-pasien yang menjalani prosedur mandibulektomi pada pasien-pasien dengan tumor mandi.bula telah banyak dilaporkan di jurnal-jurnal internasional. Komplikasi tersebut menyebabkan interfensi bedah, bertambahnya lama rawat dan disabilitas. Komplikasi tersebut meliputi infeksi, ekspose plate, rembesan luka, hematorna yang luas, operasi, nyeri, hilangnya sensorik daerah tersebut, jaringan parut yang buruk.

Metode Pengambilan sampel dilakukan dengan menelusuri data rekam medik pasien yang menjalani operasi mandibulektomi di divisi bedah onkologi tahun 2011. Didapat 10 pasien dengan tumor mandibulla yang menjalani mandibulektomi dan rekontruksi dengan bone graft.

Hasil Dari 10 pasien yang karni dapat, 4 pasien pria dan sisanya wanita. (6 pasien). Satu pasien dengan tumor ganas. Empat pasien menjalani prosedur hemi-mandibulektomi dan sisanya menjalani operasi sub-total mandibulektomi (6 pasien). Sehubungan dengan komplikasi pada tempat resipien diantarnya empat pasien mengalami infeksi pasca operasi, dari empat pasien tersebut tiga pasien didapat adanya fistel dan exposed plate dan satu pasien menajalani pengangkatan plate. Dua pasien mengeluhkan. gangguan gerak mulut dan keloid. Tidak ditemukan komplikasi tempat donor diantaranya tidak adanya keluhan dalam berjalan, nyeri pasca operasi maupun keloid. Lama pemakaian naso-gastric tube sebagai sarana intake antara 5 sampai 60 hari dengan rerata 31 hari.

Kesimpulan Prosedur mandibulektomi khususnya pada tumor mandibular membutuhkan perhatian yang sangat serius dan perencanaan yang matang, hal tersebut berhubungan dengan tingginya morbiditas.;

Abstrak :
ABSTRAK
Penelitian ini bertujuan untuk mempeiajari konsumsi glukosa. aktivitas spesifik LDH dan pola isozim LDH pada kondisi hipoksia sistemik kronik. Penelitian dilakukan terhadap hati tikus yang diinduksi hipoksia sistemik kronik 1, 3. 7 dan 14 hari. Konsumsi glukosa diukur dengan metode enzimatik Trlnder. Aktivitas spesiflk LDH diukur dengan metode German Society of Clinical Chemistry (DGKC). Poia isozim LDH dianaJisis dengan eJektroforesis Titan Gel. Hasil peneHtian menunjukkan bahwa konsumsi g!ukosa pada hipoksia sistemik kronik cenderung rneningkat walaupun tidak. berbeda dengan kontrol. Aktivitas spesIfik LDH ditemukan paling tinggi pada hipoksia 3 hari sedangkan pola elektroforesis isozim LDH menunjukkan perbeda.an pada hari ke-3 dan ke-7 hipoksia dengan kontroL Tidak terdapat hubungan antara konsumsi glukosa dengan aktivitas spesifik LDH.

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ABSTRACT
The aim of this study was to observe glucose consumption, specific activity of LDH and electrophoretic LDH isoenzyme patterns on systemic chronic hypoxia. The study was carried out with Jiver tissue of rats exposed to systemic hypoxia for 3, 7 and 14 days. Glucose consumption was measured by Trinder method. The specific activity ofLDH was performed using Gcnnan Society of Clinical Chemistry (DGKC) method, while LDH isoenzyme patterns were analyzed using Titcm Gel electrophoresis, Results indicated that glucose consumption showed tendencies to increase compared to control group, although the difference were not sigr.itlcant. The specific activity of LDH was highest on day 3 of the hypoxic group. Electrophoretic patterns of LDH isoenzyme showed differences on day 3 and day 7 of hypoxia with controL It is concluded that glucose consumption is not related to specific activity of LDH.

Abstrak :
This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion. As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general.

Abstrak :
This is a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body. The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, "Drug transporters : molecular characterization and role in drug disposition": provides a comprehensive overview of drug transporters; and, includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy.It describes transporter-mediated drug disposition, a newly emerging field in drug therapy. It gives a comprehensive summary of drug transport across biological membranes in the liver, brain, kidney, and intestine.

Abstrak :
Based on the 38th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Ascona, Switzerland in July 2010, this volume covers all aspects of oxygen transport from air to the cells, organs and organisms, instrumentation and methods to sense oxygen and clinical evidence.