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"Infeksi STH (Soil transmitted helminth) masih merupakan masalah kesehatan di Indonesia dan dapat ditemukan bersamaan dengan Kurang Vitamin A (KVA). Infeksi STH dapat menyebabkan gangguan penyerapan nutrisi termasuk vitamin A. Belum diketahui pengaruh pengobatan cacingan terhadap status vitamin A anak SD. Penelitian pre-eksperimental dilakukan pada anak SD kelas 3-5 di salah satu SDN di Jakarta Utara. Sampel tinja dan darah diambil sebelum dan tiga minggu sesudah pengobatan (albendazol 400mg tiga hari berturut-turut). Pemeriksaan FLOTAC dilakukan untuk infeksi STH dan High Performance Liquid Chromatography untuk retinol. Prevalensi STH didapatkan sebesar 61,9%. Dari 99 anak, prevalensi KVA kategori ringan (<1,05 μmol/l) ditemukan pada 17,2% anak dan sedang (<0,70 μmol/l) pada 2% anak. Status infeksi STH tidak berhubungan signifikan dengan konsentrasi retinol baseline. Anak laki-laki memiliki konsentrasi retinol baseline lebih rendah dibandingkan anak perempuan (p=0,045). Terjadi kenaikan konsentrasi retinol mendekati bermakna (p=0,05) setelah pengobatan, pada anak terinfeksi STH dan tidak terinfeksi. Konsentrasi retinol baseline memiliki hubungan terbalik dengan perubahan konsentrasi retinol (􀀁= -0,340, p=0,002). Dapat disimpulkan bahwa infeksi STH tidak mempengaruhi konsentrasi retinol baseline atau perubahan konsentrasi retinol setelah pengobatan. Jenis kelamin berperan sebagai salah satu faktor yang mempengaruhi konsentrasi retinol baseline. Selisih konsentrasi retinol setelah pengobatan dapat diprediksi oleh konsentrasi retinol baseline.

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Soil Transmitted Helminthes (STH) infection is still a health problem in Indonesia and often found together with Vitamin A Deficiency (VAD). STH infection can impair absorption of nutrients including vitamin A. The effect of deworming on the vitamin A status of primary school children is unknown. Pre-experimental study was carried on children of grade 3-5 at one of primary schools in North Jakarta. Stool and blood samples were taken before and three weeks after treatment (albendazole 400 mg for three consecutive days). FLOTAC examination was used to determine STH infections and High Performance Liquid Chromatography for serum retinol. The prevalence of STH was 61.9%. Of 99 children, 2% had moderate deficiency (<0,7 μmol/l) and 17,2% had mild (<1,05 μmol/l) deficiency of vitamin A. STH infection was not significantly associated with serum retinol concentration at baseline. Boys had lower serum retinol concentration compared to girls (p = 0.045). After treatment serum retinol concentrations was increased with marginal significance (p = 0.05), occurring in those infected with STH or not. Serum retinol concentration at baseline had an inverse association with the change in serum retinol concentration after treatment (ß = -0.340, p = 0.002). To conclude, STH infection had no effect on serum retinol concentration before treatment as well as the change in serum retinol concentration after treatment. Gender was one of the factors that influenced the serum retinol concentrations at baseline. Serum retinol concentration at baseline can be used as a predictor for the magnitude of change in serum retinol concentration after treatment."

"Preeklampsia merupakan gangguan kehamilan yang mengancam kesehatan ibu dan bayi Penelitian ini merupakan studi potong melintang yang bertujuan untuk mengetahui perbedaan kadar vitamin E dan MDA pada 48 subyek preeklampsia dan non preeklampsia di RS Tarakan Jakarta Penilaian mencakup wawancara sosio demografi riwayat obstetri asupan vitamin E dengan FFQ semikuantitatif LILA kadar vitamin E dan MDA serum Kategori usia usia kehamilan dan kadar MDA lebih tinggi pada preeklampsia Edukasi untuk perempuan usia reproduktif tentang pentingnya asupan makanan vitamin E yang cukup diperlukan untuk mencapai keberhasilan kehamilan.

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Preeclampsia is a disorder of pregnancy that deteriorate mother and baby rsquo s health This study was a cross sectional study aiming to investigate differences in the levels of vitamin E and MDA of 48 subjects with preeclampsia and non preeclampsia in Tarakan Hospital Jakarta Assessment included interviews of socio demographic obstetric history vitamin E intake with semiquantitative FFQ MUAC serum vitamin E and MDA concentrations Categories of age gestational age and MDA levels were higher among preeclamptics Education for reproductive age women about the importance of sufficient intake of vitamin E foods is necessary to achieve successful pregnancy."

"ABSTRAKToddler period, especially the first two years of life is considered as golden age for children because of their rapid growth and development. Therefore, the occurrence of nutritional disorders in the period can be permanent and irreversible. This study tried to assess correlation between early initiation of breastfeeding and vitamin A with nutritional status. The total of samples analyzed in this study was 1,592 toddlers aged 6-59 months that were drawn from 2015 Indonesia Nutritional Status Monitoring Survey in Bengkulu. Data including age, sex, early initiation of breastfeeding, birth length, birth weight, vitamin A supplementation were collected by using questionnaire. Weight and height of children were obtained through anthropometric measurements. More than half of the toddlers (54.6%) did not get early initiation of breastfeeding. Based on multivariate analysis results, most dominant variables related to weight/age, height/age and weight/height indicators were early initiation of breastfeeding and Vitamin A supplementation. Toddlers who did not get early initiation of breastfeeding are at risk of 1.555 times stunting compared to toddlers who got early initiation of breastfeeding. The most dominant variable related to height/age is vitamin A supplementation. Children who do not get vitamin A supplementation are at risk of stunting 2.402 times compared to children who get vitamin A supplementation."

"ABSTRAKBanyak studiBanyak studi epidemiologi, klinis dan in vitro terakhir menunjukkan hubungan antara vitaminD dengan tuberkulosis (TB) paru. Kadar 25-hidroksivitamin D (25(OH)D) yang rendahberhubungan dengan penyakit TB paru aktif dan laten. Namun, sampai saat ini belum ada datamengenai hubungan kadar 25(OH)D dan status vitamin D dengan derajat lesi TB paru. Tujuanpenelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dankadar 25(OH)D dengan derajat lesi TB paru ringan, sedang dan berat. Desain penelitianpotong lintang, terdiri dari 137 pasien TB paru terbagi menjadi kelompok derajat lesi TB paruringan, sedang dan berat masing-masing 46, 47 dan 44 pasien. Diagnosis TB paruberdasarkan Pedoman Nasional Pengendalian Tuberkulosis, Kementerian Kesehatan RepublikIndonesia. Derajat lesi TB paru dinilai secara radiologis berdasarkan klasifikasi dari NationalTuberculosis and Respiratory Disease Association, New York. Status vitamin D ditetapkanmenurut rekomendasi Holick. Pada ketiga kelompok dicatat data karakteristik subjek dandilakukan pemeriksaan 25(OH)D. Status vitamin D pada subjek penelitian ini didapatkansebanyak 122(89,1%) defisiensi dan 15(10,9%) insufiensi vitamin D. Proporsi defisiensi daninsufisiensi vitamin D kelompok TB paru ringan, sedang dan berat tidak didapatkanperbedaan bermakna, masing-masing dengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan9,1%. Kadar 25(OH)D kelompok TB paru ringan, sedang dan berat tidak berbeda bermakna,masing-masing dengan rerata 12,96 (SB±5,83)ng/mL, 12,42 (SB±5,13)ng/mL, dan 11,29(SB±5,61)ng/mL. Kami menyimpulkan status vitamin D dan kadar 25(OH)D tidakberhubungan dengan derajat lesi TB paru. Proporsi defisiensi dan insufisiensi vitamin Dkelompok TB paru ringan, sedang dan berat tidak didapatkan perbedaan bermakna, masingmasingdengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan 9,1%.

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ABSTRACTMost recent epidemiological, clinical and in vitro studies indicate that there is a therelationship between vitamin D and pulmonary tuberculosis (TB). Low concentration of 25-hydroxyvitamin D (25(OH)D) is associated with active and latent pulmonary TB disease.Nevertheless, there is no data about the relationship between vitamin D status andconcentrations of 25(OH)D with severity of pulmonary TB. The aim of this study was toobtain the relationship between proportions of vitamin D and concentrations 25(OH)D withmild, moderate and severe degrees of pulmonary TB lesions. This was a cross-sectional study,137 patients with pulmonary TB and 46, 47 and 44 patients each of mild, moderate and severedegree of pulmonary TB lesions, respectively. Diagnosis of pulmonary TB was based onNational Tuberculosis Control Guideline, Ministry of Health of the Republic of Indonesia.The degree of pulmonary TB lesion was radiologically assessed based on classifications of theNational Tuberculosis and Respiratory Disease Association, New York. Vitamin D status wasdefined according to Holick recommendations. Baseline characteristics of subjects wererecorded and 25(OH)D concentrations were measured in subjects of each groups. Vitamin Dstatus of the subjects were 122 (89.1%) deficiency and 15 (10.9%) insufficiency of vitamin D.The proportions of vitamin D deficiency and insufficiency at mild, moderate and severedegree of pulmonary TB lesions were also not significantly different, i.e. 84.8% and 15.2%,91.5% and 8.5%, 90.9% and 9.1%, respectively. Concentrations of 25 (OH) D in each groupof mild, moderate and severe pulmonary TB lesions were not significantly different, with amean (SD) 12.96 (5.83)ng/mL, 12.42 (5.13)ng/mL, and 11.29 (5.61)ng/mL respectively. It isconcluded that vitamin D status and serum 25 (OH) D were not related to the degree ofpulmonary TB lesion. The proportion of vitamin D deficiency and insufficiency at mild,moderate and severe degree of pulmonary TB lesions were also not significantly different, i.e.84.8% and 15.2%, 91.5% and 8.5%, 90.9% and 9.1%, respectively."

"Sinar ultraviolet B adalah sumber utama vitamin D, tetapi wanita usia suburyang bekerja di dalam ruangan mempunyai vitamin D yang rendahmeskipun Indonesia negara tropis. Tujuan penelitian ini untuk mengevalua-si peranan paparan sinar matahari pada wanita usia subur terhadap statusvitamin D dan tekanan darah. Desain penelitian yang digunakan adalaheksperimen tanpa kelompok kontrol pada 21 wanita sehat. Penelitian inimembandingkan status vitamin D dan tekanan darah sebelum dan setelahmendapat paparan sinar matahari pada wajah dan lengan tiga kali seming-gu selama 12 minggu. Analisis data menggunakan uji t-berpasangan.Paparan sinar matahari dapat meningkatkan vitamin D. Serum 25(OH)Dmeningkat 15,9% dari 15.7 ng/dL menjadi 18,2 ng/dL. Paparan sinar mata-hari menurunkan tekanan darah sistolik (nilai p = 0,004) dan diastolik (ni-lai p = 0,011). Ultraviolet B dari sinar matahari 30 menit tiga kali semingguselama 12 minggu dapat memperbaiki status vitamin D dan tekanan darah.Ultraviolet B sunlight exposure is a primary source of vitamin D, but womenof childbearing age who worked in room every day had low serum vitaminD despite Indonesia is a tropical country. The objective of this study was toevaluate the role of sun exposure in women of childbearing age on vitaminD status, and blood pressure. An intervention before-after study withoutgroup control was conducted on 21 healthy women. This study comparedvitamin D status, and blood pressure before and after receiving ultravioletB (UVB) from sun exposure on the face and both arms three times a weekfor 12 weeks. Anthropometric parameter and blood pressure were mea-sured, were determined at baseline and after 12 weeks of sun exposure.The effect of sun exposure can improve vitamin D. Serum 25 (OH)D in-crease 15.9% from 15.7 ng/dL to 18.2 ng/dL. Sun exposure significantly re-duced systolic blood pressure (p value = 0.004), and diastolic blood pres-Peranan Ultraviolet B Sinar Matahari terhadap StatusVitamin D dan Tekanan Darah pada Wanita Usia SuburThe Role of Ultraviolet B from Sun Exposure on Vitamin D Status andBlood Pressure in Women of Childbearing AgeBetty Yosephin* Ali Khomsan** Dodik Briawan** Rimbawasure (p value = 0.011). Ultraviolet B from sun exposure for 30 minutes, 3times a week for 12 weeks improves the vitamin D status, and blood pres-sure."

"ABSTRAKBerbagai studi terkini menunjukkan hubungan antara vitamin D dan sepsis. Vitamin D berperan sebagai stimulator produksi peptida antimikroba dan mencegah inflamasi yang berlebihan. Insufisiensi dan defisiensi vitamin D berhubungan dengan risiko terjadinya sepsis. Saat ini belum terdapat data mengenai hubungan status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Tujuan penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat.Desain penelitian potong lintang, terdiri dari 60 pasien infeksi terbagi menjadi kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing 20 pasien. Diagnosis sepsis berdasarkan modifikasi SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Status vitamin D ditetapkan menurut rekomendasi Holick. Pada ketiga kelompok tersebut dicatat data karakteristik subjek dan dilakukan pemeriksaan 25(OH)D.Status vitamin D pada subjek penelitian ini didapatkan sebanyak 5 (8,33%) orang insufisiensi dan 55 (91,67%) orang defisiensi vitamin D Proporsi insufisiensi pada kelompok infeksi tanpa sepsis adalah 5%, sepsis 10%, dan sepsis berat 10%. Proporsi defisiensi pada kelompok infeksi tanpa sepsis adalah 95%, sepsis 90%, dan sepsis berat 90%. Didapatkan perbedaan tidak bermakna proporsi insufisiensi dan defisiensi vitamin D pada kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat.Kami menyimpulkan status vitamin D tidak berhubungan dengan beratnya sepsis. Proporsi insufisiensi dan defisiensi pada pasien infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing didapatkan 5% dan 95%; 10% dan 90%; 10% dan 90%.

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ABSTRACTRecent studies have shown that there is a relationship between vitamin D and sepsis. Vitamin D has a a role as a potent stimulator of antimicrobial peptides and prevent an over reaction of the inflammatory response. Insufficiency and deficiency of vitamin D have been associated with sepsis event. Nevertheless, there is no data about the relationship between vitamin D status with infection without sepsis, sepsis, and severe sepsis patient. The aim of this study was to obtain the relationship between proportions of vitamin D with infection without sepsis, sepsis, and severe sepsis patient.This was a cross-sectional study, 60 patients with infection were divided into groups of infection without sepsis, sepsis, and severe sepsis, each consisted of 20 patients. Diagnosis of sepsis was based on modified SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Vitamin D status was defined according to Holick recommendations. Baseline characteristics of subjects were recorded and 25(OH)D concentrations were measured in subjects of each groups.According to status of Vitamin D, 5 (8,33%) subjects were insufficiency and 55 (91,67%) were deficiency. The proportions of vitamin D insufficiency at infection without sepsis group were 5%, sepsis 10%, and severe sepsis 10%. The proportions of vitamin D deficiency at infection without sepsis group were 95%, sepsis 90%, and severe sepsis 90%. The proportions of insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis patient were not significantly different (p > 0.05).It is concluded that vitamin D status were not related to infection severity. The proportions of vitamin D insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis, i.e. 5% and 95%; 10% and 90%; 10% and 90%, respectively."