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"Telah dilakukan penelitian samar ganda acak untuk menilai manfaat pemberian Asam Traneksamat pada 54 penderita hemoroid interna yang baru berdarah. Umur, kelamin, berat badan, tinggi badan, beratnya hemoroid serta lamanya onset perdarahan telah dibuat sebanding pada kedua kelompok. Efek hemostatik berupa berhentinya perdarahan didapatkan pada 100% (23/23) kelompok Asam Traneksamat pada hemoroid grade 2 sementara hanya 78.26% (18/23) pada kelompok plasebo. Setelah obsevasi 3 hari perdarahan berhenti lebih awal pada kelompok Asam Traneksamat dan secara statistik bermakna. Sejak hari ke empat kedua kelompok berbeda dalam hal perdarahan ulang. Pada kelompok plasebo rerata median perdarahan ulang setelah 36 hari, sementara kelompok Asam Traneksamat tidak pernah mencapai nilai median tertentu sampai akhir observasi. Kesimpulan: Asam Traneksamat efektif untuk menghentikan perdarahan pada hemoroid berdarah, dan mencegah perdarahan ulang.

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Double blind randomized placebo controlled trial was conducted to evaluate the efficacy of Tranexamic acid in 54 patients with recent hemorrhoid bleeding. Age, gender, body weight, height, grade of hemorrhoid, time of onset of recent bleeding were comparable between two groups. Analysis of haemostatic effect or stop bleeding as an immediate outcome of this study revealed that in the grade 2 patients, 23/23 (100%) of tranexamic group and 18/23(78.26%) of placebo group the bleeding stop. After 3 days of observation, there was statistically significant different for the rate of stop bleeding as well as at the end of observation. Bleeding stop earlier in the Tranexamic group with median 4 days (3-5 days), compare to placebo, median 11(9.55-12.45). Analysis of recurrent bleeding as an outcome of this study revealed that in the placebo group 9/18(50%) of grade 2 patients and all grade 3 (100%)patients suffered from recurrent bleeding. Since the days 4, both group have significant different time for recurrent bleeding and at the end of observation, cumulative probability of free of bleeding between two groups significantly different. Median still stop bleeding in the placebo group was 36 days, and the tranexamic group never reaches the median until the end of observation. Conclusion: tranexamic acid was an effective drug to stop recent hemorrhoid bleeding and prevent further recurrent bleeding, significantly better than placebo."

"Backgrounds: Gastrointestinal bleeding such as hematemesis or melena are common conditions in clinical practice and endoscopic service. The mortality rate due to gastrointestinal bleeding is relatively high. In this study, we evaluate the causes of hematemesis melena for the last 5 years and the factors associated with the bleeding.Methods: The study was done retrospectively. We obtained data from medical record of patients that performed endoscopy of upper gastrointestinal tract in Division of Gastroenterology, Department of Internal medicine, Cipto Mangunkusumo hospital (Jakarta, Indonesia) during the period of 2001 to 2005.Results: Of 4.154 patients who underwent upper gastrointestinal tract endoscopy from 2001 to 2005, we found that 837 patients (20.1%) were due to upper gastrointestinal bleeding. They were 552 male (65.9%) and 285 female patients (34.1%). Mean age of male patients was 52.7 ± 15.82 years, while for female patients was 54.46 ± 17.6 years. Of 837 patients who came due to hematemesis were 150 patients (17.9%), melena were 310 patients (37.8%), both melena and hematemesis were 371 patients (44.3%), 557 cases (66.5 %) due to non varices. Endoscopic results showed that 280 cases (33.4%) were due to esophageal varices. In general, this study had demonstrated that esophageal varices was the most frequent cause of upper gastrointestinal bleeding. We found 229 cases of esophageal varices were coincidence with portal hypertensive gastropathy. While ulcer was found in 225 cases (26.9%) and most of them were gastric ulcer (51.1%). Of gastrointestinal bleeding caused by esophageal varices, most were grade HI in 138 cases (49.3%). The incidence of bleeding of bleeding were found more frequently in patients age group of 40 - 60 years (389 cases; 46.5%), > 60 years (305 cases; 36.2%), < 40 years (242 cases; 16.8%). The causes of bleeding in patients whose age > 60 years, most were caused by ulcer (37.4%). In this study, we also found that cancer as the cause of gastrointestinal bleeding in 26 cases (3.1%). Gastrointestinal cancer comprised of gastric cancer in 15 cases (57.7%), duodenal cancer in 7 cases (26.9%), and esophageal cancer in 4 patients (15.4%).Conclusion: The most frequent cause of upper gastrointestinal bleeding was esophageal varices and usually had reached stage HI. The non variceal cause of bleeding was gastric cancer. Upper gastrointestinal malignancy was also found to be the etiology of bleeding in this study."

"Skripsi ini membahas frekuensi distribusi perdarahan dan dry socket pada pasien usia 17-76 tahun di Rumah Sakit Gigi dan Mulut - Pendidikan Fakultas Kedokteran Gigi Universitas Indonesia periode Januari 2003 ? Oktober 2008. Penelitian ini adalah penelitian kuantitatif yang bersifat retrospektif dengan desain deskriptif. Hasil penelitian ini menyatakan bahwa tidak ditemukan komplikasi pasca ekstraksi berupa perdarahan, namun ditemukan kasus komplikasi pasca ekstraksi berupa dry socket, dimana komplikasi ini terjadi pada pasien berjenis kelamin perempuan, pada tindakan ekstraksi dengan teknik ekstraksi sederhana, dan terjadi pada tindakan ekstraksi gigi di regio posterior.

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The focus of this study is the distribution and frequency of bleeding and dry socket post tooth extraction, in patients with age 17-76 years old at RSGM-P Faculty of Dentistry University of Indonesia, period of January 2003 - October 2008. This research is a quantitative and retrospective research with descriptive design. The results prove that bleeding after tooth extraction was not found in this research, meanwhile dry socket post tooth extraction were found in women, by using the simple technique of tooth extraction, and found in the posterior region of tooth extraction. "

"Angka kejadian kanker kolorektal sebagai penyakit keganasan menduduki urutan kedua setelah kanker payudara pada wanita dan kanker paru pada pria.Karsinoma pada daerah kolon asenden dan tranversus biasanya menyebabkan perdarahan sedikit demi sedikit dan tidak dapat dideteksi oleh mata serta tidak menyebabkan rasa sakit.Tes kolon albumin merupakan tes imunokimia pertama untuk menentukan adanya albumin yang berasal dari darah pada penyakit kolorektal dan tes ini tidak memerlukan persiapan diit. Sampai saat ini pemeriksaan darah samar dalam tinja masih banyak menggunakan bensidin, o-tolidin, guaiak, tetapi untuk pemeriksaan dengan cara tersebut banyak kendalanya.Dalam penelitian ini dilaporkan hasil penelitian banding kedua pemeriksaan di atas terhadap 18 tinja penderita dengan suspek keganasan kolorektal. Kahan penelitian diambil dari 11 orang laki-laki dan 7 orang perempuan yang berusia antara 21-54 tahun. Dilakukan pula uji diagnostik dengan memakai kontrol pasangan penderita. Dengan tabel kontingensi 2 X 2 diperoleh sensitivitas 100%, spesifisitas 93,7% dan akurasi 96,77%

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Colon Albumin Test as a Screening Test for Colorectal Cancer

Colorectal cancer is the second most cancer found preceded by breast cancer in woman and lung cancer in men. Cancer of the ascending and transverse colon usually did not cause profuse bleeding that could be observed macroscopically and did not cause pain.

The colon albumin test is a novel immunochemical test to detect albumin caused by bleeding in the colorectal regions. ND diet restriction is required before performing this test. Although the gold standard tests using benzidine, o-tolidin or guaiac were still commonly used, many obstacles were also reported.

In this study, a comparative examination was done on 18 stool amples were obtained from 18 subjects with suspicious of colorectal cancer. Specimens were taken from 11 males and 7 females, 21 until 54 years old. Diagnostic test was done using matched controls. Using 2 X 2 contingency table it was found a 100%, sensitivity, 93,7% spesificity and 96,7% accuracy."

"ABSTRACT As most often advocated, treatment of intestinal bleeding caused by typhoid fever is by conservative means. Although it requires meticulous and intensive care, treatment by surgery is rarity Four cases which are treated by surgery was reported and was decided upon after failure of conservative treatment. The fourth cases had resections of the distal ileum extended to a right hemicolectomy. The histopathologic examination of the all cases, revealed alcerative plaques of Peyer's patches in the distal ileum and caeceum, confirming the diagnosis of typhoid fever. "