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"ABSTRACTNothopanax scutellarium is one of plant that has several biological activities such asobstetrics, kidney disease, inflammatory disease, and promotion of hair growth. Ethosomes arethe ethanolic phospholipid vesicles which are used mainly for transdermal drug delivery ofdrugs. Ethosomes have higher penetration rate through skin. It contains soft vesicle, composedof hydroalcoholic or hydroglycolic phospholipid in which concentration of alcohol is relativelyhigh. Ethosomes are a novel carrier for enhanced skin delivery. The aims of this research wereto formulate and obtain ethosome which formed by thin layer hydration method and to knowthe safety of gel ethosome which contain ethyl acetate fraction. Safety test measured by scoringand categorizing within chorioallantoins membran. (HET CAM). The formulation of ethosomethat using 20% ethanol and the ratio of phosphatidylcholine and ethyl acetate fraction were 1:2.The characterization from the ethosome suspension indicated that the entrapment efficiencyvalue of 52.79% with particle size distribution value (Z-Average) 110.5 nm, polydispersityindex (PdI) 0.393 and zeta potential value -11.0 mV. The result of safety test showed that 0.5%and 1% gel ethosome contain ethyl acetate fraction of scutellarium leaves have mild irritationeffect."

"ABSTRAKKerontokan rambut yang sering diakhiri kebotakan merupakan problema estetisyang sangat dikhawatirkan setiap orang. Daun dan bunga kembang sepatu telahdiakui memiliki aktivitas pertumbuhan rambut berdasarkan penggunaantradisional. Pada penelitian ini, 2,5%, 5% dan 10% ekstrak daun kembang sepatudiformulasikan dalam bentuk hair tonic karena penggunaannya lebih mudah dantidak lengket seperti sediaan semisolid. Tujuan penelitian ini adalah untukmengetahui aktivitas pertumbuhan rambut ektrak etanol daun kembang sepatustabilitas fisik dan keamanannya. Uji aktivitas pertumbuhan rambut dilakukandengan mengoleskan sediaan hair tonic pada punggung kelinci dan diukurpanjang rambut, ketebalan rambut (diameter rambut), kelebatan rambut (bobotrambut) dan kepadatan rambut (densitas rambut). Uji stabilitas fisik dilakukanpada penyimpanan suhu rendah (4oC±2oC), suhu ruang (25oC±2oC) dan suhutinggi (40oC±2oC) serta cycling test. Uji keamanan dilakukan dengan uji iritasimata dengan metode HET-CAM dan uji iritasi kulit dengan metode patch test.Hasil menunjukkan bahwa sediaan hair tonic ekstrak daun kembang sepatu 10%memiliki aktivitas pertumbuhan rambut yang lebih baik dibandingkan kontrolpositif minoksidil 2%. Hasil uji stabilitas fisik menunjukkan sediaan hair tonicekstrak daun kembang sepatu memiliki stabilitas fisik yang baik. Dari hasil ujikeamanan iritasi kulit tidak terjadi iritasi, sedangkan hasil uji iritasi matamenunjukkan sediaan mengiritasi mata.

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ABSTRACTHair loss is often terminated to alopecia is a very aesthetic problems of everyonefeared. Leaves and hibiscus flowers have been recognized to have hair growthactivity based on traditional use. In this study, 2.5%, 5% and 10% of hibiscus leafextract in the form of hair tonic formulated for use easier and not sticky likesemisolid dosage. The purpose of this study was to determine the activity of theethanol extract of hair growth hibiscus leaves, physical stability and safety. Hairgrowth activity test carried out by applying hair tonic on the rabbit's back andmeasured hair length, hair thickness, hair weight and hair density. Physicalstability test performed at low temperature storage (4 °C ± 2 °C), roomtemperature (25 ° C ± 2 ° C) and high temperature (40 ° C ± 2 ° C) as well as thecycling test. Safety test was done by eye irritation test with HET-CAM methodand skin irritation test with patch test method. The results showed that extract ofhibiscus leaf hair tonic 10% have hair growth activity better than the positivecontrol minoxidil 2%. Physical stability test showed extract of hibiscus leaf hairtonic has good physical stability. From the results of safety test showed there’s noskin irritation, meanwhile eye irritation test show that extrac of hibiscus leaf hairtonic irritating to the eyes."

"Wanita pada umumnya menginginkan bulu mata yang panjang, tebal dan lebat. Rambut kepala dan bulu mata pada umumnya adalah sama dimana sel papilla dermal yang berperan dalam pertumbuhannya. Tujuan dari penelitian ini adalah memformulasikan ekstrak daun teh hijau yang sudah sering digunakan dalam produk penumbuh rambut, yang memiliki stabilitas yang baik, aman, dan efektif dalam menumbuhkan bulu mata. Ekstrak daun teh hijau diformulasikan dalam sediaan gel. Uji stabilitas dilakukan dengan penyimpanan pada suhu tinggi, kamar, rendah, cycling, dan uji sentrifugasi. Uji in vitro hen rsquo;s egg test-chorioallantoic membrane HET-CAM dilakukan untuk mengevaluasi potensial terjadinya iritasi mata. Uji tempel dilakukan pada lengan atas semua relawan sebelum memulai memakai gel bulu mata. Pengujian pertumbuhan bulu mata dilakukan dengan pengukuran panjang bulu mata relawan sebelum dan sesudah 2 bulan pemakaian yang diukur setiap 2 minggu dengan memakai penggaris bulu mata. Gel yang dibuat stabil dalam penyimpanan pada suhu tinggi 40 2 C , kamar 25 2 C , rendah 4 2 C , cycling, uji sentrifugasi, dan tidak menyebabkan iritasi pada kulit dan mata. Pertumbuhan bulu mata terlihat hasil yang berarti pada grup uji dibandingkan dengan grup plasebo setelah 2 bulan pemakaian.

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Women often consider longer, thicker, fuller eyelashes. As eyelash hair and scalp hair is nearly the same which is the dermal papilla cell as the main role of the hair growth. The aim of this study was to formulate a green tea extract GTE , which is often used as a hair growth product, to produce an eyelash gel with good stability, effectiveness, and safety for growing eyelashes. GTE was formulated into a gel. A stability test was performed at a high temperature 40 2 C , room temperature 25 2 C , low temperature 4 2 C , a cycling temperature, and sentrifuge test. An in vitro hen rsquo s egg test chorioallantoic membrane HET CAM assay was performed to evaluate potential eye irritation. Pacth test on upper arm was conducted to all the volunteers before they began using the eyelash gel. An eyelash growth test was conducted by length measurement using an eyelash ruler before and after 2 mo of application in human volunteers. The GTE gel was stable in storage at high, room, and low temperatures, at cycling temperatures, sentrifuge test and did not cause skin and eye irritation. Eyelashes grew significantly more in the test group than in the placebo group after 2 mo of application P 0.05 . GTE gel provides a new, safe, and effective option for growing natural eyelashes."