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A Peni Kusumastuti
Jakarta: Fakultas Kedokteran Universitas Indonesia, 1994
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Emmelia Ratnawati
"[ABSTRAK
Stroke pada lansia mengakibatkan keterbatasan kemandirian. Salam Trendi
merupakan latihan fisik untuk mengurangi keterbatasan yang dilakukan di rumah
dan bersifat individual. Penelitian ini bertujuan mengidentifikasi pengaruh latihan
terhadap kekuatan otot, kecepatan berjalan, dan kemampuan fungsional lansia
paska stroke di Kota Depok. Penelitian menggunakan desain Quasi Eksperimen
pre dan post test design. Besar sampel 44 responden, dipilih dengan tehnik
consecutive sampling. Hasil penelitian menunjukkan bahwa kekuatan otot lengan
(p=0.042) dan kaki (p=0.005); kecepatan berjalan (p=0.002) berubah secara
signifikan setelah diberikan latihan. Latihan ini direkomendasikan sebagai salah
satu intervensi keperawatan pada lansia paska stroke di komunitas.

ABSTRACT
Stroke in older person resulted in dependency. A combined of deep breathing,
stretching and Range of Motion is one of physical exercise to increase
independence. This study aimed to measure effects of this exercise to muscle
strength, walking speed, and functional ability of older person with post-stroke. A
quasi-experimental with pre and post-test design was applied. Sample of 44
respondents were selected by consecutive sampling technique. Results showed
that strength of arm and legs muscle and walking speed increased significantly
after intervention given (p = 0.042; 0.005; 0.002). It is recommended to provide
this exercise as nursing intervention at community., Stroke in older person resulted in dependency. A combined of deep breathing,
stretching and Range of Motion is one of physical exercise to increase
independence. This study aimed to measure effects of this exercise to muscle
strength, walking speed, and functional ability of older person with post-stroke. A
quasi-experimental with pre and post-test design was applied. Sample of 44
respondents were selected by consecutive sampling technique. Results showed
that strength of arm and legs muscle and walking speed increased significantly
after intervention given (p = 0.042; 0.005; 0.002). It is recommended to provide
this exercise as nursing intervention at community.]"
2015
T43579
UI - Tesis Membership  Universitas Indonesia Library
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Harfan Sakti
"[ABSTRAK
Pengembangan sebuah wilayah perkotaan sudah seharusnya mempertimbangkan
berbagai zona yang padat dan sibuk dengan aktivitas ekonomi termasuk stasiun
kereta. Moda transportasi ini mempunyai kapasitas dapat mengangkut
penumpang dalam jumlah yang besar, beroperasi secara cepat, nyaman, aman dan
terjadwal dengan frekwensi operasi yang tinggi. Keselamatan jiwa penumpang
dan orang yang bekerja di area tersebut harus menjadi prioritas utama dalam tahap
desain, konstruksi, operasi dan pemeliharaan sistem. Kebakaran yang terjadi pada
area padat dan sibuk seperti stasiun masih menjadi permasalahan besar, termasuk
di Jakarta, Indonesia. Kebakaran di sistem transportasi massal memberikan
dampak yang serius karena dapat membawa korban jiwa dan kerugian ekonomi
yang besar. Kondisi keramaian dan padat yang berakibat orang terluka atau tewas
tidak terbatas hanya pada keadaan darurat kebakaran. Bahkan kondisi ini dapat
terjadi dalam keadaan yang nampak seperti normal. Dalam tahap desain stasiun
komuterline dan mass rapid transit yang baru, karakteristik pergerakan
penumpang lokal harus menjadi pertimbangan utama. Tulisan ini menampilkan
hasil analisis pergerakan penumpang berdasarkan survey dari tiga stasiun
komuterline tersibuk di Jakarta. Survey dilaksanakan selama jam-jam sibuk pada
pagi hari dan sore hari. Hasil survey menunjukkan bahwa pergerakan penumpang
dipengaruhi oleh kepadatan di berbagai lokasi di stasiun, di peron, di concourse
dan tiket gate. Nilai aliran spesifik yang optimum juga diperoleh untuk dijadikan
kerangka acuan yang dapat dipertimbangkan selama tahap desain. Secara umum,
hasil penelitian memperlihatkan bahwa rata-rata kecepatan berjalan dan aliran
spesifik penumpang lokal dalam tingkat kepadatan tertentu sedikit lebih rendah
dibanding standard dinegara yang telah berpengalaman dengan sistem tranportasi
sejenis (Singapura, USA dan Jepang). Analisis teknik keselamatan kebakaran
digunakan untuk mendapatkan tingkat keselamatan optimum di stasiun, jumlah,
luasan, panjang/lebar lintasan evakuasi dan sistem pendukung lainnya. Hasil
analisis diaplikasikan sebagai masukan dalam menyusun tingkatan optimum
dalam peningkatan layanan normal dan darurat kebakaran di stasiun.

ABSTRACT
The development of an urban area have to include the consideration of various
zone which crowded by economic activity. Railway have become the most
popular transportation mode due to by its capacity in carrying large number of
passengers, rapid operation, comfort, safety and high frequency of operation. Life
safety of the passenger is the main consideration during the design stage,
construction, operation and maintenance of the whole systems. In this issue, a fire
disaster that occurs in crowded and busy areas is still major problem, including in
the city of Jakarta, Indonesia. A fire disaster in a mass public transportation
system could cause serious impact due to thousand of pupils may be affected.
During design stage of a new mass rapid transit lines, the walking characteristics
of the local passengers should be greatly considered. This paper presented the
result of passenger movement based on survey of three busiest commuterline
stations in Jakarta. The survey was carried out during the peak hours both in the
morning and in the evening. It is observed that the walking of the passenger was
affected by density at various locations measured on the platform and concourse
levels as well as at the ticket gates. The corresponding value of the specific flow
was also derived to frame the average value that could be considered during the
design stage of a new line. In general, the study show that both the average
walking speed and the specific flow of the local passengers at certain density are
slightly lower than the average value given in the international standards such as
Standard for Fire Safety in Rapid Transit System (Singapore), NFPA 130 (USA)
and MLIT (Technical Standard Requirement for Japan Railway). The study show
that fire engineering analysis is necessary to determine system means of escape,
number means of escape, area means of escape, width/distance means of escape
and others ancylary system. Result of analysis applied as inputs in prepeparing the
optimum level in improving services normal condition and fire mergency at
railstation.;The development of an urban area have to include the consideration of various
zone which crowded by economic activity. Railway have become the most
popular transportation mode due to by its capacity in carrying large number of
passengers, rapid operation, comfort, safety and high frequency of operation. Life
safety of the passenger is the main consideration during the design stage,
construction, operation and maintenance of the whole systems. In this issue, a fire
disaster that occurs in crowded and busy areas is still major problem, including in
the city of Jakarta, Indonesia. A fire disaster in a mass public transportation
system could cause serious impact due to thousand of pupils may be affected.
During design stage of a new mass rapid transit lines, the walking characteristics
of the local passengers should be greatly considered. This paper presented the
result of passenger movement based on survey of three busiest commuterline
stations in Jakarta. The survey was carried out during the peak hours both in the
morning and in the evening. It is observed that the walking of the passenger was
affected by density at various locations measured on the platform and concourse
levels as well as at the ticket gates. The corresponding value of the specific flow
was also derived to frame the average value that could be considered during the
design stage of a new line. In general, the study show that both the average
walking speed and the specific flow of the local passengers at certain density are
slightly lower than the average value given in the international standards such as
Standard for Fire Safety in Rapid Transit System (Singapore), NFPA 130 (USA)
and MLIT (Technical Standard Requirement for Japan Railway). The study show
that fire engineering analysis is necessary to determine system means of escape,
number means of escape, area means of escape, width/distance means of escape
and others ancylary system. Result of analysis applied as inputs in prepeparing the
optimum level in improving services normal condition and fire mergency at
railstation., The development of an urban area have to include the consideration of various
zone which crowded by economic activity. Railway have become the most
popular transportation mode due to by its capacity in carrying large number of
passengers, rapid operation, comfort, safety and high frequency of operation. Life
safety of the passenger is the main consideration during the design stage,
construction, operation and maintenance of the whole systems. In this issue, a fire
disaster that occurs in crowded and busy areas is still major problem, including in
the city of Jakarta, Indonesia. A fire disaster in a mass public transportation
system could cause serious impact due to thousand of pupils may be affected.
During design stage of a new mass rapid transit lines, the walking characteristics
of the local passengers should be greatly considered. This paper presented the
result of passenger movement based on survey of three busiest commuterline
stations in Jakarta. The survey was carried out during the peak hours both in the
morning and in the evening. It is observed that the walking of the passenger was
affected by density at various locations measured on the platform and concourse
levels as well as at the ticket gates. The corresponding value of the specific flow
was also derived to frame the average value that could be considered during the
design stage of a new line. In general, the study show that both the average
walking speed and the specific flow of the local passengers at certain density are
slightly lower than the average value given in the international standards such as
Standard for Fire Safety in Rapid Transit System (Singapore), NFPA 130 (USA)
and MLIT (Technical Standard Requirement for Japan Railway). The study show
that fire engineering analysis is necessary to determine system means of escape,
number means of escape, area means of escape, width/distance means of escape
and others ancylary system. Result of analysis applied as inputs in prepeparing the
optimum level in improving services normal condition and fire mergency at
railstation.]"
2015
T42924
UI - Tesis Membership  Universitas Indonesia Library
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Marissa Putri Pratama
"Pendahuluan: Diabetes mellitus (DM) adalah penyakit metabolik yang ditandai dengan peningkatan gula darah yang disebabkan karena gangguan sekresi insulin, kerja insulin, atau keduanya. Komplikasi DM dapat menyerang banyak organ. Komplikasi yang mengenai pembuluh darah dan saraf menyebabkan morbiditas dan disabilitas yang tinggi. Neuropati perifer ditemukan pada setengah penderita DM. Neuropati menyebabkan gangguan fungsi sensorik, motorik, dan autonomik. Hal tersebut dapat mengganggu sensasi protektif pada kaki, menurunkan kekuatan otot, keseimbangan, dan gangguan pola jalan. Penelitian ini bertujuan melihat perbedaan kekuatan otot dorsifleksor dan plantarfleksor, aktivasi otot tibialis anterior dan gastroknemius medial, serta kecepatan berjalan antara kelompok DM dengan neuropati dan tanpa neuropati.
 
Metode: Penelitian ini menggunakan metode potong lintang dan melibatkan 58 subjek, yang terdiri atas 29 subjek neuropati diabetik dan 29 subjek DM tanpa neuropati. Skrining untuk neuropati menggunakan monofilamen Semmes-Weinstein 10 gram. Luaran yang diukur dalam penelitian ini adalah kekuatan otot, aktivasi otot, dan kecepatan berjalan. Pengukuran kekuatan otot dorsifleksor dan plantarfleksor menggunakan hand-held dynamometer. Pengukuran aktivasi otot tibialis anterior dan gastroknemius medial menggunakan surface EMG. Pengukuran kecepatan berjalan dilakukan dengan uji jalan 4 meter. Seluruh luaran dibandingkan antara kelompok neuropati diabetik dan DM tanpa neuropati.
 
Hasil: Kekuatan otot dorsifleksor secara signifikan lebih rendah pada kelompok neuropati diabetik (nilai p 0.019). Aktivasi otot tibialis anterior secara signifikan lebih rendah pada kelompok neuropati diabetik (nilai p 0.029). Kekuatan otot plantarfleksor, aktivasi otot gastroknemius medial, dan kecepatan berjalan tidak berbeda signifikan antar kedua kelompok.
 
Kesimpulan: Terdapat perbedaan yang signifikan pada kekuatan otot dorsifleksor dan aktivasi otot tibialis anterior antara kelompok neuropati diabetik dan DM tanpa neuropati.
......Background: Diabetes mellitus (DM) is a metabolic disease characterized by increased blood sugar that caused by abnormality of insulin secretion, insulin action, or both. DM complications may affect many organs. Complications that affect blood vessels and nerves cause high morbidity and disability. Peripheral neuropathy is found in almost half of total DM patients. Neuropathy causes impairment in sensory, motor, and autonomic function. It can impair protective sensation of foot, decrease muscle strength, balance and gait disturbance. This study aims to see the differences of dorsiflexor and plantarflexor muscle strength, activation of tibialis anterior and medial gastrocnemius, and gait speed between neuropathy diabetic patient and DM without neuropathy.
 
Methods: The research method is rcross-sectional on 58 DM subjects, that consist of 29 subjects neuropathy and 29 subjects without neuropathy. Neuropathy screening method use Semmes-Weinstein monofilament 10 gram. 3 outcomes measured in this study, muscle strength, muscle activation, and gait speed. Measurement of dorsiflexor and plantarflexor muscle strength used hand-held dynamometer. Muscle activation measurement used surface EMG on tibialis anterior and medial gastrocnemius. Gait speed was measured on 4 meter distance. All outcomes was compared between neuropathy diabetic and DM without neuropathy group.
 
Results: Dorsiflexor muscle strength significantly lower in neuropathy diabetic group (p value 0.019). Plantarflexor muscle strength and medial gastrocnemius muscle activation do not different significantly. Tibialis anterior muscle activation significantly lower in neuropathy diabetic group (p value 0.029). There is no significant different in gait speed between groups.
 
Conclusion: There are significant different in dorsiflexor muscle strength and tibialis muscle activation between neuropathy diabetic and DM without neuropathy."
Depok: Fakultas Kedokteran Universitas Indonesia, 2023
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Purwita Wijaya Laksmi
"ABSTRAK
Terapi metformin berpotensi untuk memperbaiki sindrom frailty dengan memodifikasi resistensi insulin, inflamasi, dan konsentrasi miostatin.
Penelitian ini bertujuan untuk mengkaji peran metformin terhadap kekuatan genggam tangan, kecepatan berjalan, konsentrasi miostatin serum, dan kualitas hidup terkait kesehatan pada pasien usia lanjut dengan pre-frail.
Uji klinis acak tersamar ganda dilakukan pada pasien rawat jalan berusia 60 tahun dengan status pre-frail yang direkrut secara konsekutif Maret 2015 ndash;Juni 2016 di RSCM. Pasien dieksklusi bila menyandang diabetes melitus, skor Geriatric Depression Scale ge; 10, skor Abbreviated Mental Test < 8, fase akut penyakit, dan kontraindikasi terhadap metformin. Evaluasi luaran penelitian dilakukan sebelum dan pasca-intervensi selama 16 minggu.
Randomisasi terhadap 120 subjek menempatkan 60 subjek untuk tiap kelompok perlakuan. Sebanyak 43 subjek kelompok metformin 3 x 500 mg dan 48 subjek kelompok plasebo menyelesaikan penelitian. Terdapat peningkatan kecepatan berjalan yang bermakna dengan rerata sebesar 0,39 0,77 detik atau 0,13 0,24 meter/detik pada kelompok metformin dan tetap bermakna setelah dilakukan penyesuaian terhadap faktor prognostik penting yang tidak setara p = 0,024 . Pada analisis ITT ada tidaknya peningkatan kecepatan berjalan > 0,1 meter/detik didapatkan ARR 8,3 IK95 -7,9 ndash;24 , dengan NNT sebesar 12. Tidak terdapat perbedaan bermakna kekuatan genggam tangan, konsentrasi miostatin serum, dan kualitas hidup terkait kesehatan antara kedua kelompok perlakuan. Konsentrasi miostatin serum berkorelasi negatif lemah r = -0,247; p = 0,018 dengan kecepatan berjalan, namun tidak berkorelasi dengan kekuatan genggam tangan. Skor indeks EQ-5D berkorelasi positif sedang dengan kecepatan berjalan r = 0,566; p = 0,000 dan berkorelasi positif lemah dengan kekuatan genggam tangan r = 0,355; p = 0,001.
Sebagai simpulan, pemberian metformin 3 x 500 mg selama 16 minggu secara statistik dan klinis bermakna dalam meningkatkan kecepatan berjalan sebagai salah satu dimensi kualitas hidup terkait kesehatan, namun belum dapat meningkatkan skor indeks EQ-5D, tidak meningkatkan kekuatan genggam tangan, dan belum menurunkan konsentrasi miostatin serum.
Kata kunci. kecepatan berjalan, kekuatan genggam tangan, kualitas hidup terkait kesehatan, metformin, miostatin, pre-frail, usia lanjut.

ABSTRACT
Metformin is considered to have potential effects to improve frailty syndrome by modifying insulin resistance, inflammation, and myostatin serum level.
This study aimed at investigating the effect of metformin on handgrip strength, gait speed, myostatin serum level, and health related quality of life HR QoL in pre frail elderly.
A double blind randomized controlled trial was conducted on elderly outpatients aged 60 years and older with pre frail status consecutively recruited from March 2015 to June 2016 at Cipto Mangunkusumo Hospital. Patients with history of diabetes mellitus, Geriatric Depression Scale score ge 10, Abbreviated Mental Test score 8, acute phase of diseases, and contraindication s to metformin were excluded. The measurement of study outcomes was conducted at baseline and after 16 weeks of intervention.
One hundred twenty subjects were randomized and equally assigned into metformin 3 x 500 mg or placebo group. There were 43 subjects in metformin group and 48 subjects in placebo group completed the intervention. The mean gait speed in metformin group significantly improved by 0.39 0.77 second or 0.13 0.24 meter second, even after adjusted for importance prognostic factors p 0,024 . Intention to treat analysis on the presence or absence of increased gait speed 0.1 meter second showed ARR 8.3 95 CI 7.9 ndash 24 , with NNT of 12. There were no significant differences on handgrip strength, myostatin serum level, and HR QoL between the two intervention groups. Myostatin serum level had weak negative correlation with gait speed r 0.247 p 0.018 , but did not correlate with handgrip strength. EQ 5D index had moderate positive correlation with gait speed r 0.566 p 0.000 and weak positive correlation with handgrip strength r 0.355 p 0.001.
In conclusion, metformin 3 x 500 mg for 16 weeks significantly improved gait speed as one of the HR QoL dimensions, but not significantly improved the EQ 5D index score and handgrip strength nor decreased myostatin serum level.
Keywords. gait speed, handgrip strength, health related quality of life, metformin, myostatin, pre frail, elderly."
2017
D-Pdf
UI - Disertasi Membership  Universitas Indonesia Library
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Naldo Sofian
"Latar Belakang
Peningkatan kasus diabetes melitus tipe 2 (DMT2) dengan berbagai komplikasinya memberikan dampak gangguan fungsional seseorang dalam bentuk gangguan kognitif dan kapasitas fisik. Keduanya masih reversibel dan baru diketahui berhubungan sehingga disebut sebagai PhysioCognitive Decline Syndrome (PCDS). Kondisi PCDS baru dipelajari pada lansia dan belum spesifik pada penyandang DMT2.
Tujuan
Mengetahui korelasi antara kendali glikemik dengan komponen physiocognitive decline syndrome pada penyandang DMT2 dewasa usia pertengahan.
Metode
Studi potong lintang menggunakan consecutive sampling dari pasien di poliklinik metabolik endokrin dan poli jantung terpadu sejak Januari 202-November 2022. Subjek DMT2 berusia 40-59 tahun diinklusi. Pemeriksaan kekuatan genggam tangan, dan kecepatan berjalan 6-meter diperiksakan di ruangan standar. MoCA-Ina dilakukan oleh dokter yang telah dilatih. Data HbA1c subjek yang diperiksa adalah HbA1c 3 bulan terakhir. Analisis korelasi Pearson’s atau Spearman’s pada SPSS 20.0 dilakukan sesuai sebaran data.
Hasil
Sebanyak 133 subjek telah dianalisis. Usia median mencapai 53 tahun dengan proporsi laki-laki dan perempuan serta komplikasi pada masing-masing kateori kendali glikemik (batas HbA1c 7,0%) serupa. Subjek didominasi dengan pendidikan SMA dan Sarjana/Diploma. Median durasi terdiagnosisnya diabetes melitus mencapai 7 tahun dengan HbA1c median 7.6%. Nilai MoCA-Ina pada subjek mencapai nilai median 24 dengan kecepatan berjalan rerata 1.02 + 0.23 m/detik dan median kekuatan genggam tangan 24 kg. Terdapat korelasi bermakna hanya pada HbA1c dengan kekutan genggam tangan (r = -0.24, R2 = 0.06, p value <0.01), terutama pada perempuan
Kesimpulan
Terdapat korelasi bermakna antara kendali glikemik dan kekuatan genggam tangan.
......Background
Increasing cases of type 2 diabetes melitus (T2DM) including its complication have caused functional dysfunction consisted of cognitive decline and physical incapacity. Both cognitive decline and physical incapacity had been just known to be reversible and related to each other, so it is termed as PhysioCognitive Decline Syndrome (PCDS). However, it had been just evaluated in geriatric and not specific to T2DM patient.
Aim
To investigate the correlation between glycaemic correlation and component of physiocognitive decline syndrome in middle-aged adult with T2DM.
Methods
A cross sectional study with consecutive sampling in our metabolic and endocrine clinic and integrated heart centre in January 2021-November 2022 had been conducted. Inclusion criteria was 40-59 years old subjects with T2DM. Measurement of HbA1c in the last 3 month were analysed, while hand grip strength and gait speed were done in standard room. MoCA-Ina had been conducted by trained doctor. Correlation analysis using Pearson’s or Spearman’s in SPSS 20.0 was done according to data distribution.
Result
133 subjects were analysed. Median age was 53 years old with both sex and complication within each glycaemic control category (HbA1c 7,0% cut off) were similar. Subjects were dominated by high school and undergraduate/diploma education level. Most subjects were diagnosed in up to 7 years of T2DM. Median of HbA1c levels in our study was 7.6%. MoCA-Ina score was 24 in median with mean of gait speed was 1.02 + 0.23 m/s. Our median for hand grip was 24 kg. Significant correlation was only found in relationship of HbA1c and hand grip strength (r = -0.24, R2 = 0.06, p value <0.01).
Conclusion
There was significant correlation between glycaemic control and hand grip strength."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Risca Marcelena
"Latar Belakang: Sarkopenia dan obesitas sering ditemukan pada populasi lanjut usia (lansia). Kombinasi sarkopenia dan obesitas, yaitu obesitas sarkopenia, memiliki morbiditas dan mortalitas lebih tinggi dibandingkan salah satu entitas saja.
Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara obesitas perifer dan sentral dengan komponen sarkopenia.
Metode: Studi potong-lintang ini memakai data sekunder dari penelitian validasi skor Sarcopenia Quality of Life (SARQoL) terhadap lansia ≥60 tahun di Poliklinik Geriatri Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia, periode April–Juni 2018. Analisis multivariat dilakukan terhadap obesitas (indeks massa tubuh [IMT] dan lingkar pinggang [LP]) dan komponen sarkopenia (kekuatan genggam tangan [KGT], indeks massa otot [appendicular skeletal muscle mass per tinggi badan kuadrat, ASMM/TB2], dan kecepatan berjalan) untuk disesuaikan dengan perancu (usia, diabetes melitus, dan aktivitas fisik). Nilai potong diagnostik masing-masing komponen sarkopenia memakai panduan the Asian Working Group on Sarcopenia (AWGS) 2019.
Hasil: Rerata usia dari 120 subjek adalah 71,89 (6,11) tahun, dengan proporsi wanita 61,70%. Seluruh subjek menunjukkan rerata IMT 22,48 (4,60) kg/m2; median LP 91,48 (65,40-113,00) cm; rerata ASMM/TB2 6,88 (0,96) kg/m2; median KGT 20 (10,00-40,00) kg; dan rerata kecepatan berjalan 0,76 (0,23) meter/detik. KGT rendah ditemukan lebih sedikit pada kelompok obesitas perifer dibandingkan nonobesitas perifer (adjusted odds ratio OR 0,419; interval kepercayaan IK 95% 0,183-0,959; p=0,040). ASMM/TB2 rendah lebih sedikit pada kelompok obesitas sentral dibandingkan nonobesitas sentral (adjusted OR 0,087; IK 95% 0,029-0,262; p <0,001).
Simpulan: Terdapat efek protektif obesitas perifer dan sentral terhadap sarkopenia, tetapi hubungan ini terbatas pada IMT <30 kg/m2.
......Background: Increasing number of elderly is accompanied by increasing prevalence of sarcopenia and obesity. Combination of sarcopenia and obesity, which is called as sarcopenic obesity, associated with higher morbidity and mortality compared to either obesity or sarcopenia alone. Objectives: This study aimed to determine the association between obesity profiles and sarcopenia components.
Methods: This cross-sectional study was using data from the validation study of Sarcopenia Quality of Life (SARQoL) score, of which conducted in geriatric outpatient clinic of Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Multivariate analysis between obesity (body mass index [BMI] and waist circumference [WC]) and sarcopenia components (handgrip strength [HGS], muscle mass index [appendicular skeletal muscle mass/ height square, ASMM/h2], and gait speed was adjusted to age, diabetes mellitus, and physical activities.
Results: Out of 120 subjects, there was 61.70% women. All subjects had mean of age 71.89 (6.11) years old; mean of BMI 22.48 (4.60) kg/m2; median of WC 91.48 (65.40-113.00) cm; mean of ASMM/h2 6.88 (0.96) kg/m2; median of HGS 20 (10.00-40.00) kg; and mean of gait speed 0.76 (0.23) meter/second. Low HGS was found statistically significant in lower proportion for peripheral obesity group than non-peripheral obesity group (adjusted odds ratio OR 0.419, 95% confidence interval CI 0.183-0.959, p=0.040); and low muscle mass index was lower in central obesity group than non-central obesity group (adjusted OR 0.087, 95% CI 0.029-0.262, p <0.001).
Conclusion: There were protective effects of peripheral and central obesity against sarcopenia"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library