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"Penelitian ini merupakan penelitian dengan menggunakan desain potong lintang (comparative cross sectional) yang bertujuan untuk menilai dan membandingkan ketebalan lapisan serabut saraf retina/retinal nerve fiber layer (RNFL) peripapil antara kelompok normal dan kelompok glaukoma dengan cup disk ratio (CDR) vertikal 0,4 sampai dengan 0,7 di poliklinik mata Rumah Sakit Cipto Mangunkusumo (RSCM) kirana. Sebanyak 40 mata kelompok normal dan 34 mata kelompok glaukoma mengikuti pemeriksaan Humphrey field analyzer dan Optical Coherence Tomography (OCT). Kemudian ketebalan RNFL peripapil kelompok normal dan glaukoma dianalisis untuk mendapatkan perbandingan ketebalan RNFL peripapil antara kelompok normal dan glaukoma. Pada penelitian ini didapatkan hasil tidak ada perbedaan perubahan ketebalan lapisan serabut saraf retina peripapil seiring dengan penambahan CDR vertikal namun secara klinis ketebalan RNFL peripapil pada kelompok glaukoma lebih tipis dibandingkan kelompok normal dengan CDR vertikal yang sama kecuali pada kuadran temporal.

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This was a comparative cross-sectional study. The purpose of this study was to assess and compare the peripapillary retinal nerve fiber layer (RNFL) thickness between the normal and glaucoma eyes with vertical cup disc ratio (CDR) 0.4 to 0.7 in eye clinic Cipto Mangunkusumo Hospital (RSCM) Kirana. A total of 40 eyes of normal group and 34 eyes of glaucoma following Humphrey field analyzer examination and Optical Coherence Tomography (OCT). Peripapillary RNFL thickness between normal and glaucoma eyes were analysed and compared each other. The result of this study was no difference in changes of peripapillary RNFL along with the progression of vertical CDR but clinically, peripapillary RFNL thickness in glaucoma group is thinner than that of normal group with the same vertical CDR except in temporal quadr."

"Koroid memiliki peran dalam mengatur metabolisme fotoreseptor dan epitel pigmen retina (EPR) serta sumber perdarahan ke lapisan luar retina. Pada miopia terjadi elongasi aksial yang berdampak pada penipisan ketebalan koroid dan memengaruhi prognosis visual. Studi ini bertujuan mengetahui hubungan antara ketebalan koroid dengan derajat miopia dan ketebalan fotoreseptor-EPR. Studi ini merupakan studi potong lintang yang dilakukan pada 102 mata. Setiap subjek dikelompokkan menjadi empat kelompok, yaitu emetropia, miopia ringan, sedang, dan berat. Setiap subjek dilakukan pemeriksaan mata menyeluruh dan pemindaian makula menggunakan spectral domain optical coherence tomography (SD-OCT), dengan pengaturan HD-1-Line100x dan enhanced depth imaging (EDI). Gambar pemindaian dinilai secara manual dan dikelompokkan berdasarkan Early Treatment of Diabetic Retinopathy Study (ETDRS) grid. Hasil studi menunjukkan ketebalan koroid terbesar ditemukan di subfovea atau lingkar superior bergantung pada kelompok, dan ketebalan terendah ditemukan pada regio nasal setiap kelompok. Terdapat perbedaan signifikan ketebalan koroid dengan derajat miopia pada setiap kelompok. Korelasi signifikan ketebalan koroid dan ketebalan lapisan fotoreseptor-EPR hanya ditemukan pada lingkar inferior dalam (r=0,34; p<0,001). Penelitian ini menunjukkan ketebalan koroid yang beragam dan signifikan tiap derajat miopia, serta korelasi negatif lemah antara ketebalan koroid dan ketebalan lapisan fotoreseptor-EPR pada di regio inferior.

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The choroid is crucial for regulating the metabolism of photoreceptors and the retinal pigment epithelium (RPE) while supplying blood to the outer retinal layer. Myopia, characterized by axial elongation, is linked to choroidal thinning, impacting visual prognosis. This study investigates the relationship between choroidal thickness (CT), different myopia degrees, and photoreceptor-RPE thickness. In a cross-sectional study of 102 eyes, categorized into emmetropia, mild, moderate, and high myopia groups, comprehensive eye exams and macular scans using spectral domain optical coherence tomography (SD-OCT) with HD-1-Line100x settings and enhanced depth imaging (EDI) were conducted. Manual evaluations of scan images based on the Early Treatment of Diabetic Retinopathy Study (ETDRS) grid revealed varied and significant CT across myopia degrees. The thickest CT found either in the subfovea or superior ring depending on the group, and the thinnest consistently in the nasal region for all groups. A significant correlation between choroidal thickness and photoreceptor-RPE layer thickness was noted in the inner inferior circle (r=0.34; p<0.001). In summary, this study unveils varying and significant CT across myopia degrees, emphasizing weak negative correlations between choroidal thickness and photoreceptor-RPE layer thickness, specifically in the inferior region."

"This book presents the fundamental physics of optical interferometry as applied to biophysical, biological and medical research. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure in interfererence microscopy and in optical coherence tomography. It is also the root cause of speckle and other imaging artefacts that limit range and resolution. For biosensor applications, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics. In this book, emphasis is placed on the physics of light scattering, beginning with the molecular origins of refraction as light propagates through matter, and then treating the stochastic nature of random fields that ultimately dominate optical imaging in cells and tissue. The physics of partial coherence plays a central role in the text, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds.Optical Interferometry for Biology and Medicine is divided into four sections. The first covers fundamental principles, and the next three move up successive scales, beginning with molecular interferometry (biosensors), moving to cellular interferometry (microscopy), and ending with tissue interferometry (biomedical). "