Hasil Pencarian  ::  Simpan CSV :: Kembali

"Kecepatan gelombang nadi (Pulse wave velocity, PWV) diukur pada 25 subyek laki-laki bukan perokok dan dibandingkan dengan subyek perokok sebelum dan segera sesudah merokok. Tekanan darah, frekuensi nadi dan PWV tidak berbeda pada kedua kelompok sebelum merokok. Setelah merokok terjadi peningkatan tekanan darah, frekuensi nadi dan PWV pada segmen Aorta-Radialis (Ao-Rad) dan Femoral-Dorsalis pedis (Fem-Dp), tapi pada segmen Aorta-Femoralis (Ao-Fem) terjadi penurunan PWV. Hal ini menunjukkan segmen arteri sentral dan perifer memberi respons yang berbeda terhadap merokok. (Med J Indones 2002; 11: 207-10)

---

Pulse wave velocity (PWV) was recorded in different arterial segments in 25 male nonsmokers and compared with age and sex matched smokers before and after smoking. Blood pressure (BP), Heart rate (HR) and PWV were comparable between nonsmokers and smokers before smoking. Just after cigarette smoking there was rise in HR, BP and PWV in Aorta to Radial (Ao-Rad), and femoral to Dorsalis Pedis (Fem-Dp) arterial segments, but the PWV was reduced in Aorta to Femoral (Ao-Fem) arterial segment, indicating that both peripheral and central arterial segments show different response to smoking. (Med J Indones 2002; 11: 207-10)"

"ABSTRAKBackground: periodontitis is a major cause of chronic infection in diabetic patients. Diabetic patients have four-fold risk of having cardiovascular disease. Chronic inflammation caused by periodontitis, a non-traditional cardiovascular risk factor is widely known to play a major role in atherogenesis. Among non-diabetics, an association has been found between periodontitis and arterial stiffness, but in diabetic patients the result is inconsistent. No study has investigated either the proportion of periodontitis or its correlation with arterial stiffness in type 2 diabetes population in Indonesia. Methods: this study was a cross-sectional study involving 97 patients with type 2 diabetics, who were recruited on Endocrinology Clinic from April to August 2017. Periodontitis was measured for pocket depth, clinical attachment loss and bleeding on probing by a periodontist. Carotid-femoral PWV (Pulse Wave Velocity) was measured using SphygmoCor Xcel with cuff-based tonometry technique. Results: periodontitis was found in 99% type 2 diabetic subjects and 78% of them had severe periodontitis. There was no significant correlation found between pocket depth, clinical attachment loss and cfPWV (r=0.024, p=0.407 and r=0.011, p=0.456); whereas there was a weak positive correlation between pocket depth and PWV (r=0.294, p=0.041) in well-controlled type 2 diabetics. Conclusion: most of type-2 diabetics had severe periodontitis; however, the correlation between periodontitis and arterial stiffness could not be concluded in this study."

"Pendahuluan: Kekakuan arteri merupakan prediktor mortalitas pasien hemodialisis. Hemodialisis merupakan proses yang menginduksi inflamasi, ditandai dengan peningkatan penanda inflamasi, Pentraxin 3 (PTX3), intradialisis. Rerata kekakuan arteri pada pasien HD dua kali seminggu di Indonesia menunjukkan hasil yang lebih rendah daripada literatur. Tujuan: Mengetahui faktor risiko kekakuan arteri pada pasien hemodialisis kronik dengan berfokus pada frekuensi hemodialisis dan PTX3.Metode: Penelitian ini merupakan penelitian potong lintang di RS Cipto Mangunkusumo, RS Fatmawati, dan RS Medistra pada pasien yang menjalani hemodialisis minimal 1 tahun dengan frekuensi dua dan tiga kali seminggu. Kekakuan arteri diukur dengan carotid-femoral pulse wave velocity. Pemeriksaan PTX3 dilakukan sebelum hemodialisis dimulai.Hasil: Penelitian dilakukan pada 122 subjek, 82 subjek diantaranya menjalani hemodialisis dua kali seminggu. Tidak ada perbedaan kekakuan arteri antara pasien HD 2x dan 3x seminggu. PTX3 > 2,3 ng/ml berhubungan dengan kekakuan arteri (p=0,021). Pada analisis multivariat, PTX3 berhubungan dengan kekakuan arteri (adjusted OR 5,18; IK 95% 1,07-24,91), demikian juga penyakit kardiovaskular (adjusted OR 3.67; IK 95% 1.40-10.55), kolesterol LDL (adjusted OR 3.10; IK 95% 1.04-9.24), dan dialysis vintage (adjusted OR 2.72; IK 95% 1.001-7.38).Simpulan: PTX >2,3 ng/ml berhubungan dengan kekakuan arteri. Tidak terdapat perbedaan kekakuan arteri antara pasien HD dua kali dan tiga kali seminggu.

---

Introduction: Arterial stiffness is a mortality predictor in hemodialysis patients. Hemodialysis induces inflammation, marked by intradialysis increment of inflammatory marker, Pentraxin 3 (PTX3). The mean arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than studies done in thrice-weekly patients.

Objective: To determine factors associated with arterial stiffness in hemodialysis patients, focusing on the role of hemodialysis frequency and PTX3.

Methods: This study is a cross-sectional study conducted in Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital Jakarta in twice- and thrice-weekly hemodialysis patients. Arterial stiffness is measured by carotid-femoral pulse wave velocity.

Results: The study is conducted in 122 subjects, 82 of them undergo twice-weekly hemodialysis. There is no difference in arterial stiffness between twice- and thrice-weekly subjects. PTX3>2.3 ng/ml is associated with arterial stiffness (p= 0.021). In multivariate analysis, PTX3 is associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07-24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40-10.55), LDL cholesterol (adjusted OR 3.10; 95% CI 1.04-9.24), and dialysis vintage (adjusted OR 2.72; 95%CI 1.001-7.38).

Conclusions: Predialysis PTX3 level above 2.3 ng/ml is associated with arterial stiffness. There is no difference in arterial stiffness between twice- and thrice-weekly hemodialysis patients."

"ABSTRAK Latar Belakang: Periodontitis merupakan penyebab infeksi kronis terbanyak pada penyandang diabetes. Periodontitis adalah penyakit inflamasi kronis yang menyerang jaringan penyanggah gigi yang disebabkan oleh organisme spesifik. Periodontitis secara klinis bermanifestasi sebagai pembentukan poket pada gingiva dan kehilangan perlekatan gingiva yang dapat memfasilitasi kebocoran mediator inflamasi dari rongga mulut. Inflamasi sistemik derajat rendah ini telah diketahui berperan dalam aterogenesis. Hubungan periodontitis dengan insiden aterosklerosis telah banyak dilaporkan dengan hasil yang konsisten. Di lain pihak hubungan periodontitis dengan aterosklerosis subklinis, khususnya kekakuan arteri, tanda awal dari aterosklerosis menunjukkan hasil yang beragam. Studi-studi sebelumnya yang menilai periodontitis dengan kekakuan arteri dilakukan pada populasi umum, hanya sedikit yang dilakukan pada populasi diabetes.Tujuan: Mengetahui korelasi derajat periodontitis dengan kekakuan arteri pada penyandang DM tipe 2.Metode: Penelitian ini adalah penelitian potong lintang terhadap 97 penyandang DM tipe 2 dewasa ddi poliklinik metabolik endokrin RSCM pada bulan April hingga Agustus 2017. Periodontitis dinilai secara klinis dengan kedalaman poket periodontal dan jarak kehilangan perlekatan gingiva. Kekakuan arteri dinilai dengan PWV karotis-femoral menggunakan SphygmoCor.Hasil penelitian: Sembilan puluh sembilan persen penyandang DM tipe 2 mengalami periodontitis dan 78 penyandang DM tipe 2 mengalami periodontitis berat sesuai dengan kriteria AAP 1999. Korelasi antara menifestasi periodontitis kedalaman poket dan kehilangan perlekatan dengan kekakuan arteri tidak terbukti pada penelitian ini karena baik kedalaman poket dan kehilangan perlekatan menunjukkan korelasi sangat lemas dan keduanya tidak menunjukkan hasil yang bermakna PD, r= 0,024 p= 0,403 CAL, r= 0,011 p=0,456 .Kesimpulan: Sebagian besar penyandang DM tipe 2 mengalami periodontitis berat dan tidak ada korelasi positif bermakna antara derajat periodontitis dengan kekakuan arteri pada penyandang DM tipe 2. ABSTRACT Background Periodontitis is an inflammatory disease affecting tissue teeth supporting tissue caused by specific organism and is a major cause of chronic infection in diabetic population. Periodontitis is clinically manifested by gingival bleeding, pocket formation and attachment loss that facilitated systemic leakage of oral inflammatory mediators. These low grade systemic inflammation is known to play a role in atherogenesis. Association on periodontitis and atherosclerosis incident is established and showed consistent results in previous studies. The association of periodontitis and subclinical atherosclerosis however, showed conflicting result, specially in studies involving arterial stiffness, the early sign of atherosclerosis. These studies were conducted in general population, very few were performed in type 2 diabetes population. Objective To learn about the correlation between periodontitis and arterial stiffnes.Method This is a cross sectional study involving 97 type 2 diabetics recruited in endocrinology clinic fin ciptomangunkusumo general hospital from April to August 2017. Periodontitis were defined by clinical measures such as pocket depth and clinical attachment loss, those measures reflected disease activity and gingival destruction. Arterial stiffness were measured by carotid femoral PWV using cuff based tonometry device, SphygmoCor.Result Periodontitis is found in 99 type 2 diabetics and 78 of them had severe periodontitis. Correlation coefficient for both pocket depth and clinical attachment loss showed very weak positive result, but none of them is statistically significant PD, r 0,024 p 0,403 CAL, r 0,011 p 0,456 .Conclusion Most of type 2 diabetics has severe periodontitis and correlation between periodontitis and arterial stiffness can rsquo t be concluded in this study. "

"Latar Belakang: Kekakuan arteri merupakan prediktor morbiditas dan mortalitas kardiovaskular pasien menjalani dialisis. Beberapa studi yang membandingkan kekakuan arteri antara pasien yang menjalani hemodialisis dengan continuos ambulatory peritoneal dialysis CAPD masih kontroversi. Pelaksanaan hemodialisis yang dilakukan dua kali seminggu di Indonesia akan meningkalkan kekakuan arteri.Tujuan: Membandingkan kekakuan arteri antara pasien menjalani yang CAPD dengan hemodialisis dua kali seminggu.Metode: Studi komperatif membandingkan kekakuan arteri pasien yang menjalani CAPD dengan hemodialisis. Penelitian ini terdiri dari 30 subjek CAPD dan 30 subjek hemodialisis selanjutnya dilakukan pemeriksaan kekakuan arteri menggunakan SphygmoCor. Hasil: Karakteristik subjek yang menjalani CAPD dan hemodialisis tidak terdapat perbedaan pada usia, jenis kelamin, tekanan darah, lama menjalani dialisis dan diabetes melitus. Kadar fosfat subjek yang menjalani CAPD 5,09 1,83 mg/dL lebih rendah dibandingkan hemodialisis 6,07 1,83 mg/dL dan bermakna secara stastistik p = 0,046. Subjek yang menjalani CAPD mempunyai PWV 8,04 1,54 m/s lebih rendah dibandingkan hemodialisis 9,05 1,98 m/s dan bermakna secara stastistik p = 0,03.Simpulan: Pasien yang menjalani CAPD mempunyai kekakuan arteri yang lebih rendah dibandingkan hemodialisis dua kali seminggu.

---

Background: Arterial stiffness is a predictor of cardiovascular morbidity and mortality in dialysis patients. Several studies comparing arterial stiffness among patients undergoing continuous ambulatory peritoneal dialiyis CAPD and hemodialysis are still controversial. In, Indonesia hemodialysis is still performed twice a week that can cause the arterial stiffness higher than CAPD.Objective: This study is aimed to compare arterial stiffness between CAPD and hemodialysis that performed twice a week patients. Method: The comparative study between CAPD and hemodialysis patients. This study consisted of 30 CAPD and 30 hemodialysis patients. The examination of arterial stiffness used SphygmoCor. Result: The CAPD and hemodialysis patients were no different in age, sex, blood pressure, dialysis duration and diabetes mellitus. Phosphate levels in CAPD 5.09 1.83 mg/dL were lower than hemodialysis patients 6.07 1.83 mg/dL and stastically significant p = 0.046. CAPD patients have lower PWV 8.04 1.54 m/s than hemodialysis 9.05 1.98 m/s and stastically significant p = 0.03. Conclusion: The CAPD patients have lower arterial stiffness than hemodialysis patients that performed twice a week."

"Latar Belakang: Penyakit ginjal tahap akhir (PTGA) memiliki mortalitas dan morbiditas yang utamanya disebabkan oleh gangguan kardiovaskular. Salah satu penyebab gangguan kardiovaskular tersebut adalah kekakuan arteri. Hemodialisis merupakan salah satu intervensi pada pasien PTGA. Namun, faktor-faktor yang memengaruhi kekakuan arteri pada pasien PTGA yang menjalani hemodialisis masih belum banyak diteliti.Tujuan: Mengetahui proporsi kekakuan arteri pada pasien PGTA yang menjalani hemodialisis dua kali seminggu dan faktor-faktor yang mempengaruhinya.Metode: Studi observasional dengan desain potong lintang dilakukan di Unit Hemodialisis Divisi Ginjal-Hipertensi Rumah Sakit Umum Pusat dr. Cipto Mangunkusumo (RSUPN-CM) pada bulan April-Mei 2019. Pasien penyakit ginjal tahap akhir yang menjalani hemodialisis dua kali per minggu minimal selama 3 bulan terakhir diikutsertakan dalam penelitian. Pasien yang mengalami penyakit akut atau tidak kooperatif dieksklusi dari penelitian. Kekakuan arteri dinilai dalam bentuk Pulse Wave Velocity (PWV) menggunakan alat SphygmoCor dengan cutoff PWV 10 m/s.Hasil: Sebanyak 83 subyek penelitian yang terdiri dari 22 (26,5%) subyek dengan kekakuan arteri dan 61 (73,5%) subyek tanpa kekakuan arteri diikutsertakan dalam studi. Faktor-faktor yang berhubungan secara indenden dengan kekakuan arteri adalah kadar gula darah puasa (odds ratio 6,842 (IK95% 1,66-28,24)) dan kadar LDL (odds ratio 4,887 (IK95% 1,59-16,58)).Simpulan: Proporsi kekakuan arteri pada pasien PGTA yang menjalani hemodialisis dua kali seminggu adalah sebesar 26,5%. Faktor-faktor yang berhubungan dengan kekakuan arteri pada pasien PGTA dengan hemodialisis kronik dua kali per minggu adalah kadar gula darah puasa dan kadar LDL.

---

Introduction: End stage renal disease (ESRD) mortalities and morbidities are mainly occurred in association with cardiovascular disease. One of which is arterial stiffness. Hemodialysis is one of the intervention for ESRD patients. However, factors affecting arterial stiffness in ESRD patients having hemodialysis have not been studied much in Indonesia.Aim: Investigating the proportion of arterial stiffness in ESRD patients having hemodialysis two times a week and factors affecting it.Methods: An observational study with cross-sectional design was performed in Hemodialysis Unit, Kidney and Hypertension Division, National General Hospital Cipto Mangunkusumo (RSUPN-CM) on April to May, 2019. ESRD patients having hemodialysis two times a week for at least 3 months were included in the study. Patients with acute disease or uncooperative were excluded from the study. Arterial stiffness was measured as pulse wave velocity (PWV) using SphygmoCor® with PWV cutoff of 10m/s.Results: There were 83 study samples included in this study, 22 (26,5%) of which were patients with arterial stiffness and 61 (73,5%) of which were patients without arterial stiffness. Factors independently affecting arterial stiffness were fasting glucose level (odds ratio 6,842 (CI95% 1,66-28,24)) and LDL level (odds ratio 4,887 (CI95% 1,59-16,58)).Conclusion: The proportion of arterial stiffness in ESRD patients having hemodialysis two times a week was 26,5%. Factors affecting arterial stiffness in ESRD patients were fasting glucose level and LDL level."

"Background: arterial stiffness is a mortality predictor in hemodialysis patients, hemodialysis induces inflammation, marked by an intradialysis increase in the inflammatory marker pentraxin 3 (PTX3). Arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than has been found in studies of thrice-weekly patients. This study therefore aims to determine the factors associated with arterial stiffness, focusing on the role of hemodialysis frequency and PTX3. Methods: a cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital involving patients with twice- and thrice-weekly hemodialysis. Arterial stiffness was measured by carotid-femoral pulse wave velocity after hemodialysis, and blood samples for PTX3 testing were taken before hemodialysis. Bivariate and multivariate analyses were performed using chi-squared tests and logistic regression. Results: out of 122 subjects, 82 underwent twice-weekly hemodialysis. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. In bivariate analysis, PTX3, cardiovascular disease, dialysis vintage had p values of <0.05, while the subsequent multivariate analysis showed that PTX3>2.3 ng/ml was associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07–24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40–10.55), LDL (adjusted OR 3.10; 95% CI 1.04–9.24), and dialysis vintage (adjusted OR 2.72; 95% CI 1.001–7.38). Conclusion: predialysis PTX3 levels above 2.3 ng/ml were associated with arterial stiffness. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis."