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"Varian gen TMPRSS6 berasosiasi dengan status besi diplasma, tetapi efek tersebut belum dijelaskan pada anak Indonesia. Penelitian ini bertujuan menganalasis apakah SNP rs855791 (G>A) dan rs4820268 (A>G) gen TMPRSS6 berhubungan dengan status besi dan hemoglobin yang rendah dengan mengontrol asupan zat besi pada anak baduta suku Sasak. Studi crossectional ini mengeksplorasi baseline data dari randomized trial di Kabupaten Lombok Timur, sebanyak 121 subyek memenuhi syarat dalam penelitian ini. Real Time PCR, metode Taqman Assay digunakan untuk menganalisis genotip. Hasil Penelitian menunjukkan bahwa varian TMPRSS6 secara signifikan berhubungan dengan feritin, tetapi asupan zat besi lebih berkontribusi terhadap feritin dibandingkan genotipe.

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Variants in TMPRSS6 were associated with plasma iron, but their effects in Indonesian children remain elucidated. This study aim to analyze whether the TMPRSS6 SNPs rs855791 (G>A) and rs4820268 (A>G) were associated with low iron status and hemoglobin controlling for iron intake among Sasaknese. A crossectional study explored the baseline of a randomized trial in East Lombok district, 121 subjects were eligible in the study. Real Time PCR using Taqman-assay method was used for analysis of SNPs genotype. The researcher suggests that TMPRSS6 variants were significantly associated with plasma ferritin, but iron intake still more contribute to ferritin than genotype."

"ABSTRAKLatar belakang : Sebanyak 70% dari anemia pada anak merupakan anemiamikrositik hipokrom, dan yang terbanyak adalah anemia defisiensi besi (ADB).Anemia defisiensi besi pada anak sekolah berkaitan dengan penurunan prestasibelajar. Anak dengan masalah nutrisi berisiko mengalami defisiensi besi. Asupanzat besi, pemacu dan penghambat absorpsi besi memengaruhi kadar besi. Sekolahdasar (SD) Pegangsaan 01 Jakarta Pusat merupakan sekolah negeri denganmayoritas siswa berasal dari sosial ekonomi rendah.Tujuan : Mengetahui status besi pada anak usia 6-12 tahun serta hubungannyadengan status gizi dan asupan diet.Metode : Studi potong lintang dilakukan di SD Negeri Pegangsaan 01, JakartaPusat antara bulan Maret-April 2016. Asupan pemacu absorpsi zat besi (vitaminC) dan penghambat (fitat, teh, kopi, susu) dinilai dengan food record selama tigahari, diolah dengan NutriSurvey®. Darah tepi lengkap, feritin, besi serum, totaliron binding capacity (TIBC), saturasi transferin, dan high sensitivity C-reactiveprotein (hs-CRP) diperiksakan di laboratorium.Hasil : Terdapat 115 subyek berpartisipasi dalam penelitian. Prevalens deplesibesi sebesar 4,3%, defisiensi besi tanpa anemia sebesar 14,8%, ADB sebesar1,7%. Tidak terbukti ada hubungan antara status gizi kurang dengan status besi[p=0,094; OR=2,29(0,86-6,10)], gizi lebih dan obesitas dengan status besi[p=0,050; OR=0,30(0,09-1,00)], asupan besi total dengan status besi (p=0,260),vitamin C dengan status besi (p=0,740), fitat dengan status besi (p=0,901), tehdengan status besi (p=0,931), kopi dengan status besi (p=0,624), dan susu denganstatus besi (p=0,277).Simpulan : Prevalens deplesi besi, defisiensi besi tanpa anemia, dan ADB padaanak usia 6-12 tahun berturut-turut adalah 4,3%, 14,8%, dan 1,7%. Tidak terbuktiada hubungan antara status gizi, asupan zat besi, vitamin C, fitat, teh, kopi, dan susu dengan status besi pada anak usia 6-12 tahun.

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ABSTRACTBackground : Prevalence of anemia in Indonesian school-age children is high.Approximately 70% cases are microcytic hypochromic anemia which irondeficiency anemia (IDA) are the most frequent. Iron deficiency anemia associatedwith decreased learning achievement. Children with nutritional problems at riskfor iron deficiency. Intake of enhancer and inhibitor of iron absorption affects ironbody level. Pegangsaan 01 Public School is primary school in Central Jakarta,which most of the students come from low socioeconomic family.Objective: To measure iron status in children aged 6-12 years and its relationshipwith nutritional status and dietary intake.Methods: A cross-sectional study was conducted in Pegangsaan 01 PrimarySchool, Central Jakarta, on March-April 2016. Dietary iron enhancer (vitamin C)and inhibitor (phytate, tea, coffee, milk) were obtained using a 3-days food recordand analyzed with NutriSurvey®. Complete blood count, ferritin, serum iron, totaliron binding capacity, transferrin saturation and high sensitivity C-reactive proteinwere examined.Results: A total of 115 children were studied. Prevalence of iron depletion, irondeficiency without anemia, and iron deficiency anemia were 4,3%, 14,8%, and1,7% respectively. No evidence of relationship between undernourished and ironstatus (p=0,094), overweight-obesity and iron status (p=0,050), iron intake andiron status (p=0,260), vitamin C and iron status (p=0,740), phytate and iron status(p=0,901), tea and iron status (p=0,931), coffee and iron status (p=0,624), milkand iron status (p=0,277).Conclusion: Prevalence of iron depletion, iron deficiency without anemia andiron deficiency anemia in children aged 6-12 years were 4,3%, 14,8%, and 1,7%respectively. No evidence of relationship between nutritional status, dietary intake and iron status"

"Penelitian ini mencoba meneliti hubungan masing-masing status besi yang terdiri dari hematokrit, hemoglobin, local iron binding capacity, serum iron, feritin dan saturasi transfer in dan faktor-faklor lain yaitu ketekunan, percaya diri, privat les dan menonton televisi dengan prestasi belajar siswa. Prestasi belajar diukur dari nilai rata-rata raport cawu I dan cawu II siswa-siswa kelas I angkatan tahun 1997/1998 SMUK II BPK Pcnabur Jakarta Pusat yang prestasinya bermasalah dan banyak yang kurang dibandingkan dengan Si\IUK lain di Jakarta.Tujuan penelitian adalah mendapat informasi apakah ada hubungan antara status besi dan faktor-faklor lain yang telah disebutkan di atas dengan prestasi belajar siswa. Hal ini akan bermanfaat dalam memberikan bantuann bagi siswa-siswi yang bermasalah dalam prestasi belajarnya dengan mempeibaiki status besi.Desain penelitian adalah cross sectional. Pengambilan sampel sccara acak dari siswa-siswa yang bersedia diamibil darah dan mendapat izin orang lta. Jumlah sanipel 99 orang terdiri dari 38 siswi dan 61 siswa yang berusia antara 15-18 tahun. Analisis menggunakan regresi linear ganda.Hasil penelitian menunjukkan adanya korelasi positif antara kadar Hb dcngan prestasi belajar walaupun tidak bermakna.Kesimpulan:Model terakhir yang didapat dari analisis multivariat adalah : Y - 5,8 + 0.03 Hb - 0,48 sexMemperhatikan model tersebut hemoglobin dapat dipertimbangkan sebagai diagnosa prestasi belajar rendah, dimana setiap kenaikan kadar Hb 1 unit, prestasi belajar hanya bisa ditingkatkan 0 ,03.

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This study tries to examine correlation among iron status respectively a.o. hematocrit, haemoglobin. total iron binding capacity, serum iron, feritin, transferin saturation and the other factors a.o. tenacity. self confidence, lesson privat and television watching with student educational achievement. Educational achievement are measured from mean value report of caw u 1 and cawu II of the first class SMUK II BPK Penabur Jakarta which have the lowest achievement compare with other SMUK BPK Penabur in Jakarta.The aim of the study to get information about the correlation among iron status and other factors which was described above. The result will help the student who have problem of achievement by reparing iron status.Study design is cross-sectional , total sample are 99 people : 38 girls and 61 boys. Range of age between 15 - 18 years old. The sample used simple random sampling from the student who were willing to donate blood for iron status lest. Statistic analysis used multiple linear regression.The result showed that correlation between hemoglobin and educational achievement was positif but not significantConclusion :Multiple regression model is as followedY - 5,8 + 0.03 Hb - 0,48 sexwhich means that haemoglobin could he considered lo be used tool for diagnose educational achievement only 1 unit increased of haemoglobin for an increase of 0,03 unit of achievement."

"Latar belakang: Sindrom nefrotik (SN) idiopatik merupakan penyakit glomerulus dengan proteinuria akibat peningkatan permeabilitas glomerulus. Transferin merupakan salah satu protein yang keluar di urin dan dapat mengganggu homeostasis besi. Keadaan ini dapat menyebabkan defisiensi besi dan anemia defisiensi besi (ADB). Tujuan: Mengetahui perbedaan status besi, transferin urin, proporsi defisiensi besi dan ADB pada pasien SN idiopatik aktif dan remisi. Metode: Penelitian potong lintang pada pasien SN idiopatik aktif dan remisi usia 1-18 tahun di RSCM. Pengukuran status besi menggunakan Hb,MCV, MCH, Ret-He, SI, TIBC, ferritin, dan saturasi transferin. Pengukuran transferin urin menggunakan metode enzyme-linked immunosorbent assay (ELISA). Hasil: Terdapat 65 subyek, dengan 32 pasien SN idiopatik aktif dan 33 pasien remisi. Kadar SI antara kelompok aktif dan remisi adalah 60,7±33,5 µg/dL dan 84,6±35,3 µg/dL (p<0,05). Kadar TIBC antara kelompok aktif dan remisi adalah 220±90,7 µg/dL dan 309,4(±47,7) µg/dL (p<0,05). Kadar transferin urin antara kelompok aktif dan remisi adalah 435,3(7,7-478,4) ng/mL dan 23,4 (0-358) ng/mL (p<0,05). Proporsi defisiensi besi dan ADB pada kelompok aktif adalah 7(21,9%) dan 5 (15,6%) subyek, sedangkan pada kelompok remisi adalah 4(12,6%) dan 1(3%) subyek. Perbedaan proporsi tersebut tidak bermakna (p=0,04; RR 2,47; IK95% 0,98-6,23). Kesimpulan: Kelompok SN idiopatik aktif memiliki nilai SI dan TIBC yang rendah serta transferin urin yang tinggi. Proporsi defisiensi besi dan ADB pada kelompok SN idiopatik aktif lebih tinggi walaupun tidak bermakna secara statistik.

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Background: Idiopathic nephrotic syndrome (NS) is a common glomerular disease in children, which cause increased glomerular permeability resulting in proteinuria. Transferrin is one of the protein that is excreted in the urin, thus disturbing iron homeostasis and may lead to iron deficiency (ID) or iron deficiency anemia (IDA).

Objective: To know the differences in iron status, urinary transferrin, and the proportion of ID and IDA in children with active and remission idiopathic NS.

Methods: A cross-sectional design study was conducted on patients with active and remission idiopathic NS aged 1-18 years at RSCM. Measurement of iron status using Hb, MCV, MCH, Ret-He, SI, TIBC, ferritin, and transferrin saturation. Measurement of urinary transferrin using enzyme-linked immunosorbent assay (ELISA).

Result: There were 65 study subjects, with 32 patients with active idiopathic NS and 33 subjects were in remission.The SI levels between the active and remission groups were 60.7±33.5 g/dL and 84.6±35.3 g/dL (p<0.05). The TIBC levels between the active and remission groups were 220±90.7 g/dL and 309.4(±47.7) g/dL (p<0.05). The median of urinary transferrin levels between the active and remission groups were 435.3(7.7-478.4) ng/mL and 23.4 (0-358) ng/mL (p<0.05). The proportions of ID and IDA in the active group were 7(21.9%) and 5(15.6%) subjects, while in the remission group were 4(12.6%) and 1(3%) subjects. Nonetheless the difference were not statistically significant (p=0.04; RR 2.47; CI95% 0.98-6.23).

Conclusion. Active idiopathic NS had significant lower values of SI and TIBC, and higher urinary transferrin levels. The proportion of ID and IDA in the active group was higher, although not significant."

"ABSTRAKDefisiensi besi menganggu proses eritropoiesis sehingga dapat berlanjut menjadi anemia defisiensi besi. Defisiensi besi dan anemia didefinisikan berdasarkan indikator status besi, berupa parameter hematologi dan biomarka darah, yaitu hemoglobin, hematokrit, ferritin, MCV, MCH, MCHC, dan retikulosit. Salah satu faktor penyebab terjadinya defisiensi besi pada ibu hamil adalah kurangnya asupan zat besi. Penelitian ini bertujuan untuk mengetahui hubungan antara asupan zat besi dan status besi ibu hamil trimester 1 yang diukur melalui kadar hemoglobin, hematokrit, ferritin, MCV, MCH, MCHC, dan retikulosit. Rancangan penelitian adalah potong-lintang pada trimester 1 kehamilan. Asupan zat besi diukur menggunakan metode food frequency questionnaire dan 24 hour recall. Uji korelasi Spearman digunakan untuk mengetahui hubungan kedua variabel. Terdapat 120 sampel ibu hamil, 53,3 berpendidikan tinggi, 58,3 bekerja, dan median usia 28 tahun. Nilai median asupan zat besi pada seluruh sampel adalah 10,64 mg. Sebanyak 86,67 sampel tidak memenuhi kecukupan asupan zat besi pada ibu hamil trimester 1 berdasarkan AKG 26 mg/hari. Sebanyak 8,33 sampel mengalami anemia Hb0,05 . Disimpulkan bahwa tidak terdapat hubungan antara asupan zat besi dan status besi ibu hamil pada trimester 1.

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ABSTRACTIron deficiency disrupts erythropoiesis process that leads to iron deficiency anemia. Iron deficiency and anemia are defined by iron status indicator, in the form of hematological parameters and blood biomarkers, such as hemoglobin, hematocrite, ferritin, MCV, MCH, MCHC, and reticulocyte count. One of the factors causing iron deficiency in pregnant women is inadequate iron intake. This research aims to assess the relationship between iron dietary intake and iron status of pregnant women in 1st trimester. Iron status is measured by the value of hemoglobin, hematocrite, ferritin, MCV, MCH, MCHC, and reticulocyte. This research implemented a cross sectional design during the 1st trimester of pregnancy. Iron dietary intake was assessed by food frequency questionnaire and 24 hour recall. Spearman correlation analysis was used to identify the relationship between the two variables. There were 120 samples of pregnant women, 53.3 were high educated, 58.3 were employed, with the age median of 28 years old. The median of iron dietary intake is 10.64 mg, with 86.67 of samples did not meet the Recommended Dietary Allowance of 26 mg. There were 8,33 of pregnant women with anemia Hb0.05 . It was concluded that iron dietary intake is not related to iron status of pregnant women in 1st trimester."