Hasil Pencarian  ::  Simpan CSV :: Kembali

"[Penduduk di daerah kumuh memiliki kemungkinan terpajan mikroba patogenyang lebih besar daripada penduduk yang tinggal di daerah di daerah non kumuh.Hal ini dapat dipengaruhi oleh gaya hidup mereka. Apabila terpajan mikrobapatogen sistem imun tubuh akan terpicu untuk melawan patogen tersebut. Salahsatu bagian dari sistem imun tubuh manusia adalah imunoglobulin atau antibodi,salah satu jenis globulin. Pembentukan globulin ini akan menekan sintesis jenisjenisprotein lain, salah satunya adalah albumin yang sangat diperlukan tubuh.Oleh karena itu, dilakukan penelitian untuk membandingkan rasio albuminglobulin pada penduduk daerah kumuh dan non kumuh. Penelitian cross sectionaldilakukan pada bulan Desember 2014 yang melibatkan 40 orang sampel daridaerah kumuh dan 40 orang dari daerah non kumuh dengan metode consecutivesampling. Berdasarkan hasil pemeriksaan darah yang diuji dengan metode uji Tindependen, rasio albumin globulin penduduk di daerah non kumuh lebih tinggidibanding rasio albumin globulin penduduk yang tinggal di daerah kumuh denganp = 0,000. Dari uji korelasi, didapatkan bahwa terdapat perbedaan antara rasioalbumin globulin dari sampel yang terinfeksi sejumlah jenis patogen dengan yangtidak terinfeksi namun tidak bermakna secara statistik dengan p = 0,169 dankoefisien korelasi ?0,113. Rasio prevalensi didapatkan 0,63 CI 95% (0,25-1,60).;People living inside of landfill area have a higher chance of being exposed topathogens compared to people living outside of landfill area. This can be affectedby their lifestyle. When exposed to pathogen, human?s immune system will betriggered to combat the pathogens. Immunoglobulin or antibody, a kind ofglobulin, is a part of the immune system. The synthesis of globulin will repress thesynthesis of other kinds of protein, one of them being albumin which is highlyneeded in the human body. Therefore, a research was conducted to compare thealbumin globulin ratio in people living inside and outside of landfill area. Thecross sectional study was conducted on December 2014 and involved 40 subjectsfrom inside landfill area and 40 subjects from outside landfill areas usingconsecutive sampling method. From blood examination result that has been testedusing T-test independent method, the albumin globulin ratio in people livingoutside of landfill area was higher compared to people living inside of landfillarea with p = 0.000. From correlation test, there was a difference of albuminglobulin ratio between people infected with certain pathogens and those who werenot but was not considered statistically significant with p = 0.169 and correlationcoefficient of ?0.113. Prevalence ratio was 0.63 CI 95% (0.25-1.60)., People living inside of landfill area have a higher chance of being exposed topathogens compared to people living outside of landfill area. This can be affectedby their lifestyle. When exposed to pathogen, human’s immune system will betriggered to combat the pathogens. Immunoglobulin or antibody, a kind ofglobulin, is a part of the immune system. The synthesis of globulin will repress thesynthesis of other kinds of protein, one of them being albumin which is highlyneeded in the human body. Therefore, a research was conducted to compare thealbumin globulin ratio in people living inside and outside of landfill area. Thecross sectional study was conducted on December 2014 and involved 40 subjectsfrom inside landfill area and 40 subjects from outside landfill areas usingconsecutive sampling method. From blood examination result that has been testedusing T-test independent method, the albumin globulin ratio in people livingoutside of landfill area was higher compared to people living inside of landfillarea with p = 0.000. From correlation test, there was a difference of albuminglobulin ratio between people infected with certain pathogens and those who werenot but was not considered statistically significant with p = 0.169 and correlationcoefficient of –0.113. Prevalence ratio was 0.63 CI 95% (0.25-1.60).]"

"ABSTRAKBerbagai studi terkini menunjukkan hubungan antara vitamin D dan sepsis. Vitamin D berperan sebagai stimulator produksi peptida antimikroba dan mencegah inflamasi yang berlebihan. Insufisiensi dan defisiensi vitamin D berhubungan dengan risiko terjadinya sepsis. Saat ini belum terdapat data mengenai hubungan status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Tujuan penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat.Desain penelitian potong lintang, terdiri dari 60 pasien infeksi terbagi menjadi kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing 20 pasien. Diagnosis sepsis berdasarkan modifikasi SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Status vitamin D ditetapkan menurut rekomendasi Holick. Pada ketiga kelompok tersebut dicatat data karakteristik subjek dan dilakukan pemeriksaan 25(OH)D.Status vitamin D pada subjek penelitian ini didapatkan sebanyak 5 (8,33%) orang insufisiensi dan 55 (91,67%) orang defisiensi vitamin D Proporsi insufisiensi pada kelompok infeksi tanpa sepsis adalah 5%, sepsis 10%, dan sepsis berat 10%. Proporsi defisiensi pada kelompok infeksi tanpa sepsis adalah 95%, sepsis 90%, dan sepsis berat 90%. Didapatkan perbedaan tidak bermakna proporsi insufisiensi dan defisiensi vitamin D pada kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat.Kami menyimpulkan status vitamin D tidak berhubungan dengan beratnya sepsis. Proporsi insufisiensi dan defisiensi pada pasien infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing didapatkan 5% dan 95%; 10% dan 90%; 10% dan 90%.

---

ABSTRACTRecent studies have shown that there is a relationship between vitamin D and sepsis. Vitamin D has a a role as a potent stimulator of antimicrobial peptides and prevent an over reaction of the inflammatory response. Insufficiency and deficiency of vitamin D have been associated with sepsis event. Nevertheless, there is no data about the relationship between vitamin D status with infection without sepsis, sepsis, and severe sepsis patient. The aim of this study was to obtain the relationship between proportions of vitamin D with infection without sepsis, sepsis, and severe sepsis patient.This was a cross-sectional study, 60 patients with infection were divided into groups of infection without sepsis, sepsis, and severe sepsis, each consisted of 20 patients. Diagnosis of sepsis was based on modified SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Vitamin D status was defined according to Holick recommendations. Baseline characteristics of subjects were recorded and 25(OH)D concentrations were measured in subjects of each groups.According to status of Vitamin D, 5 (8,33%) subjects were insufficiency and 55 (91,67%) were deficiency. The proportions of vitamin D insufficiency at infection without sepsis group were 5%, sepsis 10%, and severe sepsis 10%. The proportions of vitamin D deficiency at infection without sepsis group were 95%, sepsis 90%, and severe sepsis 90%. The proportions of insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis patient were not significantly different (p > 0.05).It is concluded that vitamin D status were not related to infection severity. The proportions of vitamin D insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis, i.e. 5% and 95%; 10% and 90%; 10% and 90%, respectively."