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Abstrak :
Masalah di dalam dunia kedokteran bertambah dengan meningkatnya berbagai penyakit yang disebabkan oleh jamur Candida, terutama oleh Candida albicans. Candida albicans dianggap sebagai spesies terpatogen dan menjadi penyebab utama kandidosis. Jamur ini tidak terdapat di alam bebas, tetapi dapat tumbuh sebagai saproba pada berbagai alat tubuh manusia, terutama yang mempunyai hubungan dengan dunia luar. Ketokonasol sebagai antimikotik pertama yang bekerja efektif secara oral menjadi pilihan untuk menguji sensitivitas Candida albicans. Tujuan penelitian ini adalah menguji sensitivitas Candida albicans terhadap ketokonasol dengan metode Minimum Inhibitory Concertation (MIC). Hasil penelitian menunjukkan bahwa 84,50% Candida alb/cans (60 dari 71 sampel) bersifat resisten terhadap ketokonasol. Diharapkan dengan dilakukannya penelitian ini dapat memberikan sumbangan pengetahuan bagi klinisi dalam hal pengobatan kandidosis.

Abstrak :
ABSTRACT
Background: early detection of H. pylori is essential to prevent the development of infections into gastric malignancies. The coccoid form of H. pylori is difficult to detect either by culture or histopathology; however, it can be detected using molecular methods, such as real-time PCR. The study was expected to provide new information on the development of H. pylori detection. Methods: a cross-sectional study was conducted at the Gastrointestinal Endoscopy Center of Cipto Mangunkusumo Hospital between October 2016 and August 2017. The sampling method used was consecutive sampling. Biopsy from gastric antrum and corpus were performed in 64 patients. We collected 2 specimens from each site to be examined using real-time PCR and histopathology. Initially, we conducted real-time PCR optimization followed by application of clinical samples from gastric biopsy. Data analysis using McNemars χ2 and Kappa tests. Results: the real-time PCR showed 25% positivity, while the positive proportion of histopathological examination was 14%. Real-time PCR has a sensitivity and specificity 88.9% dan 85.5%, respectively. The McNemars x2 test showed that there is significantly different (p=0.039) between the two tests; kappa value (p=0.561). Conclusion: the real-time PCR examination is more sensitive than histopathology. This technique can improve diagnosis by 11% compared to histopathological examination.

Abstrak :
ABSTRACT
Aim: to assess the immunogenicity and safety of CYD-tetravalent dengue vaccine (CYD-TDV) in children. Methods: comprehensive literature searches were conducted on various databases. Randomized-controlled trials on children with CYD-TDV as intervention were selected based on inclusion and exclusion criteria. Data extracted from selected trials included safety of vaccine and immunogenicity in terms of Geometric Mean Titres (GMT) of antibodies. Results: A six clinical trials were selected based on preset criteria. GMT values were obtained using 50% Plaque Reduction Neutralization Test (PRNT) and safety was semi-quantitatively assessed based on adverse effects. Additional data processing was done to obtain a better understanding on the trends among the studies. The results showed that the groups vaccinated with CYD-TDV showed higher immunogenicity against dengue virus antigens than the control groups. Safety results were satisfactory in all trials, and most severe side effects were unrelated to the vaccine. Conclusion: CYD-TDV is both effective and safe for patients in endemic regions. This gives promise for further development and large-scale research on this vaccine to assess its efficacy in decreasing dengue prevalence, and its pervasive implementation in endemic countries, such as Indonesia.