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Ditemukan 2 dokumen yang sesuai dengan query
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Irma Nareswari
"ABSTRAK
Ulkus kaki diabetik mengakibatkan mortalitas yang semakin meningkat terutama
pasca amputasi, beban yang signifikan pada pembiayaan kesehatan dan
menyebabkan hilangnya produktivitas. Penelitian ini bertujuan untuk mengetahui
efektivitas terapi kombinasi dari laserpunktur dan perawatan luka konvensional
dibandingkan dengan laserpunktur sham dan perawatan luka konvensional
terhadap penyembuhan ulkus kaki diabetik. Uji klinis acak tersamar ganda dengan
pembanding dilakukan terhadap 36 pasien yang dialokasikan ke dalam kelompok
kasus atau kelompok kontrol. Tindakan laserpunktur dilakukan pada titik LI4
Hegu, ST36 Zusanli, SP6 Sanyinjiao, dan KI3 Taixi bilateral serta penyinaran
pada ulkus dua kali seminggu, selama empat minggu. Rerata ukuran ulkus kaki
diabetik sebagai keluaran primer diukur setiap minggu. Hasil penelitian
menunjukkan perbedaan yang bermakna antara penurunan luas luka akhir di
kelompok laserpunktur dan perawatan luka konvensional dengan kelompok
laserpunktur sham dan perawatan luka konvensional (p=0,006). Dapat
disimpulkan bahwa terapi kombinasi laserpunktur dan perawatan luka
konvensional efektif mempercepat penyembuhan ulkus kaki diabetik dengan
frekuensi terapi dua kali seminggu. ABSTRACT
Diabetic foot ulcers result in mortality is increasing, especially after the
amputation, a significant burden on health financing and lead to loss of
productivity. This study aims to determine the effectiveness of the combination
therapy between laserpuncture and conventional wound care compared with
sham laserpuncture and conventional wound treatment for healing diabetic foot
ulcers. Double-blind randomized clinical trial with a control carried out on 36
patients allocated to the case group or control group. Laserpuncture actions
performed on LI4 point Hegu, Zusanli ST36, SP6 Sanyinjiao and Taixi KI3
bilateral as well as exposure to ulcers twice a week, for four weeks. The mean size
of diabetic foot ulcers as the primary output is measured every week. The results
showed a significant difference between the reduction in wound area at the end of
the group laserpuncture and conventional wound care compare with
laserpuncture sham group and conventional wound treatment (p = 0.006). It can
be concluded that the combination therapy laserpuncture and conventional wound
care effectively accelerate the healing of diabetic foot ulcers with frequency
therapy twice a week.;Diabetic foot ulcers result in mortality is increasing, especially after the
amputation, a significant burden on health financing and lead to loss of
productivity. This study aims to determine the effectiveness of the combination
therapy between laserpuncture and conventional wound care compared with
sham laserpuncture and conventional wound treatment for healing diabetic foot
ulcers. Double-blind randomized clinical trial with a control carried out on 36
patients allocated to the case group or control group. Laserpuncture actions
performed on LI4 point Hegu, Zusanli ST36, SP6 Sanyinjiao and Taixi KI3
bilateral as well as exposure to ulcers twice a week, for four weeks. The mean size
of diabetic foot ulcers as the primary output is measured every week. The results
showed a significant difference between the reduction in wound area at the end of
the group laserpuncture and conventional wound care compare with
laserpuncture sham group and conventional wound treatment (p = 0.006). It can
be concluded that the combination therapy laserpuncture and conventional wound
care effectively accelerate the healing of diabetic foot ulcers with frequency
therapy twice a week.;Diabetic foot ulcers result in mortality is increasing, especially after the
amputation, a significant burden on health financing and lead to loss of
productivity. This study aims to determine the effectiveness of the combination
therapy between laserpuncture and conventional wound care compared with
sham laserpuncture and conventional wound treatment for healing diabetic foot
ulcers. Double-blind randomized clinical trial with a control carried out on 36
patients allocated to the case group or control group. Laserpuncture actions
performed on LI4 point Hegu, Zusanli ST36, SP6 Sanyinjiao and Taixi KI3
bilateral as well as exposure to ulcers twice a week, for four weeks. The mean size
of diabetic foot ulcers as the primary output is measured every week. The results
showed a significant difference between the reduction in wound area at the end of
the group laserpuncture and conventional wound care compare with
laserpuncture sham group and conventional wound treatment (p = 0.006). It can
be concluded that the combination therapy laserpuncture and conventional wound
care effectively accelerate the healing of diabetic foot ulcers with frequency
therapy twice a week."
Fakultas Kedokteran Universitas Indonesia, 2016
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Hasan Ali Alhabsyi
"Pendahuluan. Adenoma pituitari atau pituitary neuroendocrine tumor (PitNET)
meliputi 10% hingga 15% dari seluruh tumor intrakranial. Sekitar 30%-40% pasien
adenoma pituitari membutuhkan tatalaksana pembedahan. Dari pasien yang
dilakukan operasi tersebut sekitar 25%-40% memiliki luaran yang kurang baik
seperti menginvasi secara lokal, resisten terhadap terapi konvensional, memiliki
tingkat rekurensi yang tinggi serta dapat mengalami metastasis. Tujuan penelitian
ini untuk mengetahui apakah faktor-faktor klinikopatologi tertentu yaitu ukuran
adenoma, tipe/ subtipe adenoma, sifat invasif, sifat proliferatif (Ki-67, mitosis, dan
p53), dan grade adenoma mempengaruhi luaran yang agresif pada adenoma
pituitari pasca operasi.
Metode. Penelitian ini merupakan studi meta analisis dengan menggunakan sumber
data elektronik maupun pencarian manual. Studi-studi yang disertakan adalah studi
observasional. Pemilihan studi didasarkan pada strategi penelusuran literatur sesuai
panduan PRISMA dan kriteria eligibilitas yang telah ditentukan sebelumnya.
Variabel bebas yang dinilai antara lain ukuran adenoma, tipe/ subtipe, sifat invasif,
sifat proliferatif, ki-67, tingkat mitosis, p53, dan grade. Luaran yang dinilai adalah
agresivitas pasca operasi yang terdiri atas rekurensi atau progresi. Penilaian kualitas
dan risiko bias pada tiap studi terpilih mengunakan perangkat Newcastle Ottawa
Scale. Analisis data dilakukan baik secara kualitatif maupun kuantitatif. Semua
tahapan dalam penelitian ini dilakukan oleh setidaknya 2 peneliti.
Hasil. Dari 736 studi awal yang terjaring terdapat 10 studi terpilih. Jumlah subjek
penelitian 2727 orang dengan 632 orang kasus. Durasi pemantauan berkisar antara
3 hingga 11 tahun. Seluruh studi memiliki kualitas sedang hingga baik. Meta
analisis dilakukan pada masing-masing variabel bebas terhadap agresivitas
adenoma pituitari pasca operasi dengan hasil ukuran adenoma ≥10mm dengan
<10mm OR 1,79 (CI 1,29-2,48), tipe kortikotrof dengan non kortikotrof OR 1,91
(CI 1,41-2,58), sifat invasif dengan non invasif OR 3,67 (CI 1,95-6,90), sifat
proliferatif dengan non proliferatif OR 4,78 (CI 3,61-6,32), Ki-67 ≥ 3% dengan <
3% OR 4,13 (CI 2,94-5,81), tingkat mitosis > 2 dengan ≤2 OR 3,91 (CI 2,74-5,57),
p53 positif dengan negatif OR 1,92 (CI 1,28-2,90), dan grade 2b dengan non 2b
OR 4,56 (CI 3,0-6,91).
Simpulan. Faktor-faktor klinikopatologi tertentu yaitu ukuran adenoma, tipe/
subtipe adenoma, sifat invasif, sifat proliferatif (Ki-67, mitosis, dan p53), dan grade
adenoma mempengaruhi luaran yang agresif pada adenoma pituitari pasca operasi.

Introduction. Pituitary adenoma/ pituitary neuroendocrine tumor (PitNET)
comprise of 10% up to 15% of intracranial tumor. About 30%-40% of pituitary
adenoma patients need surgery. For those who have undergone surgery about 25%-
40% will have bad outcomes like locally invasive, resistant to conventional
treatment, high rate of recurrence, and malignant tendency. The aim of this study
was to determine whether certain clinicopathologic factors consisting of size, type/
subtype, invasiveness, proliferative (ki-67, mitotic rate, and p53), and grade
influenced the aggressive outcome of post-operative pituitary adenoma.
Methods. This meta-analysis study used electronic and manual data source.
Included studies were observational studies. Study selection was based to literature
searching strategy according to PRISMA guideline and predetermined eligibility
criteria. Independent variables reviewed were size, type/ subtype, invasiveness,
proliferative, ki-67, mitotic rate, p53, and grade. Outcome reviewed were postoperative
aggressiveness comprised of recurrence or progressive. Quality and risk
of bias assessment to each study included were based on Newcastle Ottawa Scale.
Data analysis was carried out both qualitatively and quantitatively. All stages in this
study were carried out by at least 2 reviewers.
Results. Of the 736 initial studies, 10 were selected. The number of research
subjects were 2727 people with 632 cases. The duration of monitoring ranged from
3 to 11 years. All studies had moderate to good quality. Meta-analysis were carried
out on each independent variable on the aggressiveness of post-operative pituitary
adenoma with the results were size ≥10mm vs <10mm OR 1,79 (CI 1,29-2,48),
corticotroph vs non-corticotroph OR 1,91 (CI 1,41-2,58), invasive vs non-invasive
OR 3,67 (CI 1,95-6,90), proliferative vs non proliferative OR 4,78(CI 3,61-6,32),
Ki-67 ≥ 3% vs < 3% OR 4,13 (CI 2,94-5,81), mitotic rate > 2 vs ≤2 OR 3,91 (CI
2,74-5,57), p53 positive vs negative OR 1,92 (CI1,28-2,90), and grade 2b vs non
2b OR 4,56 (CI 3,0-6,91).
Conclusions. Certain clinicopathologic factors consisting of size, type/ subtype,
invasiveness, proliferative (ki-67, mitotic rate, and p53), and grade influenced the
aggressive outcome of post-operative pituitary adenoma.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
PR-Pdf
UI - Tugas Akhir  Universitas Indonesia Library