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Viviana Kusuma Dewi
Hubungan antara Status Gizi dan Perkembangan pada Anak Balita = Association of Nutritional Status and Neurodevelopment in Children Under Five Years of Age
"Perkembangan otak yang signifikan terjadi hingga usia 5 tahun. Salah satu faktor yang mempengaruhi perkembangan ini adalah nutrisi, yang dapat digambarkan dengan status gizi. Penelitian ini bertujuan untuk mengetahui hubungan status gizi dan perkembangan pada usia lima tahun pertama. Penelitian potong lintang ini dilaksanakan di Pancoran Mas, Depok pada tahun 2018 dan Kampung Garungsang dan Kampung Tapos, Bogor pada tahun 2019. Status gizi diukur dengan antropometri dan perkembangan dinilai dengan KPSP. Dari 50 subjek penelitian, 26% anak masing-masing memiliki status gizi berat badan/umur (BB/U) dan tinggi badan/umur (TB/U) yang tidak normal, dan 22% anak dengan tinggi badan/berat badan (TB/BB) yang tidak normal. Lebih dari 60% anak dengan gangguan gizi memiliki perkembangan yang meragukan atau kurang. Sebaliknya, lebih dari 70% anak dengan status gizi normal memiliki perkembangan yang sesuai. Parameter BB/U dan BB/TB berhubungan dengan perkembangan (p = 0.001; p = 0.006), namun tidak TB/U. Faktor lainnya yang berhubungan dengan perkembangan adalah kelompok usia, berat badan lahir, pemeriksaan kesehatan rutin, dan pengasuh (p < 0.05). Perkembangan anak perlu dipantau secara berkala dengan memperhatikan kecukupan gizi, kesehatan prenatal, dan pengasuhan ibu yang baik untuk perkembangan otak yang optimal.
Major neurodevelopment happens until the age of 5. One of the factors that influence neurodevelopment is nutrition, which can be depicted by nutritional status. This research is to find the association between nutritional status and neurodevelopment in the first five years of age. This cross-sectional research was conducted in Pancoran Mas, Depok in 2018 and Kampung Garungsang and Kampung Tapos, Bogor in 2019. Nutritional status was assessed by anthropometry and neurodevelopment was evaluated using KPSP. Of 50 subjects, there were each 26% of children with abnormal weight for age and abnormal height for age, and 22% of children with abnormal weight for height. More than 60% of undernourished children had poor or questioned neurodevelopment. In contrast, more than 70% of children with normal nutritional status had proper neurodevelopment. Weight for age and weight for height had significant association with neurodevelopment (p = 0.001; p = 0.006), but not height for age. Other factors that were associated with neurodevelopment were age group, birth weight, health check-up, and primary caregiver (p < 0.05). Child development should be monitored regularly and good nutrition, prenatal health, and maternal care should be taken into account for optimal neurodevelopment"
Depok: Fakultas Kedokteran Universitas Indonesia, 2019
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UI - Skripsi Membership  Universitas Indonesia Library
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Mery Krismanto
Hubungan antara kadar protein S100B dengan keluaran pasien cedera kepala ringan dan sedang = The relationship between S100B protein level and the outcome of patients with mild and moderate head injuries
"Latar Belakang: Protein S100B merupakan protein yang berikatan dengan kalsium pada sel-sel astroglial jaringan otak. Peningkatan kadar protein S100B dalam serum disebabkan karena aktivasi kerusakan astrosit dan sel glial, dan kerusakan integritas sawar darah otak. Beberapa studi prospektif terakhir, para ahli menghubungkan protein S100B dengan prediksi keluaran pasien cedera kepala.
Tujuan: Mengetahui hubungan kadar Protein S100B 6 jam pasca trauma terhadap skala keluaran GOSE 3 bulan pada penderita CKR dan CKS.
Metode: Penelitian ini bersifat deskriptif analitik dengan data dikumpulkan secara prospektif pada pasien cedera kepala ringan dan sedang yang dirawat di UGD RSCM.
Hasil: Dari 45 sampel, didapatkan kelompok yang paling banyak adalah laki-laki (65.7%), usia 15-20 tahun (45.7%), tingkatp endidikan SMA (48.6%), CT scan normal (54.3%), kadar protein S100B < 0.403 μg/L (54.3%) dan GOSE >= 7 (71.4%). Terdapat hubungan yang bermakna antara derajat cedera kepala dengan GOSE, CT scan dengan GOSE dan kadar protein S100B dengan GOSE.
Kesimpulan: Protein S100B merupakan prediktor yang sensitif terhadap keluaran, dimana pasien dengan protein S100B tinggi memperlihatkan keluaran yang buruk dibandingkan pasien dengan kadar protein S100B rendah.
Backgrounds: S100B protein is a protein that binds with calcium in brainastroglial cell. The increase in S100B serum level can be caused caused byastrocyte and glial cell damage and disturbance of blood brain barrier. Several prospective studies have elooked into the relationship of S100B protein with headinjury patents outcome.
Aim: To investigate the relationship between S100B protein level 6 hours aftertrauma and the outcome of patients with mild and moderate head injury using GOSE 3 months after trauma.
Method: This is an analytic descriptive study using data collected prospectivelyin mild and moderate head injury patients admitted to the emergency departmentof Cipto Mangunkusumo hospital.
Result: The majority of patients were male 65 7 aged between 15 20 yearsold 45 7 senior high school graduates 48 6 with normal CT scan 54 3 with S100B protein level 0 403 g L 54 3 and with GOSE 7 71 4. There was a significant relationship between the severity of head injury and GOSE CT scan finding and GOSE and S100B protein level and GOSE.
Conclusion: S100B protein level is a sensitive predictor for head injury patientoutcome in which patients with higher S100B protein level correlates with pooreroutcome."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T58555
UI - Tesis Membership  Universitas Indonesia Library
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Hendra Samanta
Protein S 100b sebagai prediktor tingkat keparahan cidera kepala = Protein S 100b as predictor severity traumatic brain injury
"[ABSTRAK
Nama Hendra SamantaProgram Studi Pendidikan Dokter Spesialis NeurologiJudul Protein S 100B sebagai prediktor tingkat keparahan cedera kepala Latar Belakang Cedera kepala merupakan salah satu masalah kesehatan masyarakat yang serius yang dapat menyebabkan kematian kecacatan fisik dan kecacatan mental Cedera kepala dapat menyebabkan sel astrosit rusak sehingga mengeluarkan protein S 100B yang dapat dideteksi didalam darah perifer sehingga dapat dipakai untuk memprediksi tingkat keparahan cedera kepala yang terjadi Penelitian ini bertujuan untuk mencari hubungan antara kadar protein S 100B dengan tingkat keparahan cedera kepala Metode Desain penelitian adalah potong lintang untuk mengetahui kadar protein S 100B pada pasien cedera kepala akut onset kurang dari 24 jam Subyek penelitian sejumlah 85 pasien yang datang berobat ke Instalasi Gawat Darurat RSCM sejak bulan maret ndash juni 2015 Dilakukan penilaian GCS lamanya tidak sadarkan diri lamanya amnesia pasca trauma dengan bantuan alat TOAG pemeriksaan CT Scan dan pemeriksaan serum protein S 100B Hasil Didapatkan kadar rerata protein S 100B serum 0 77 g L rerata durasi amnesia 21 22 jam rerata nilai GCS 13 Terdapat perbedaan kadar protein S 100B pada CKR rerata 0 4175 dibandingkan dengan pada CKS dan CKB 1 0722 p 0 020 nilai titik potong kadar protein S 100B pasien yang meninggal 0 765 g L p 0 002 Simpulan Kadar rerata protein S 100B pada cedera kepala ringan lebih rendah dibandingkan dengan kadar protein S 100B pada cedera kepala sedang dan berat semakin tinggi kadar protein S 100B akan semakin tidak baik keluaran pasien cedera kepala ABSTRACT Name Hendra SamantaStudy program Neurology Specialization Educational ProgrammedTitle Protein S 100B as Predictor Severity Traumatic Brain Injury Background Traumatic brain injury is still a serious community health problem can cause death physical and mental disability Protein S 100B release from destructive astrocyte from brain injury and detected in the peripheral blood so that protein S 100B can serve as predictor of severity traumatic brain injury This research aimed to find association between protein S 100B with traumatic brain injury severity Method This was a cross sectional study focusing to protein S 100B value from acute traumatic brain injury patients with onset 24 hours Eighty five patients were recruited from emergency room RSCM GCS value duration of post traumatic amnesia with TOAG tools duration loss of consciousness brain CT scan and concentration serum protein S 100B were record Results The mean concentration serum Protein S 100B were 0 77 mean PTA duration were 21 22 hours and the mean GCS were 13 There is a significant differentiation value of concentration protein S 100B from mild trumatic brain injury compare moderate and severe traumatic brain injury p 0 020 cut off point for death patients was 0 765 g LConclusion The mean serum Protein S 100 B from mild trumatic brain injury lower than moderate and severe traumatic brain injury higher consentration of protein S 100B have bad outcome ;ABSTRACT Name Hendra SamantaStudy program Neurology Specialization Educational ProgrammedTitle Protein S 100B as Predictor Severity Traumatic Brain Injury Background Traumatic brain injury is still a serious community health problem can cause death physical and mental disability Protein S 100B release from destructive astrocyte from brain injury and detected in the peripheral blood so that protein S 100B can serve as predictor of severity traumatic brain injury This research aimed to find association between protein S 100B with traumatic brain injury severity Method This was a cross sectional study focusing to protein S 100B value from acute traumatic brain injury patients with onset 24 hours Eighty five patients were recruited from emergency room RSCM GCS value duration of post traumatic amnesia with TOAG tools duration loss of consciousness brain CT scan and concentration serum protein S 100B were record Results The mean concentration serum Protein S 100B were 0 77 mean PTA duration were 21 22 hours and the mean GCS were 13 There is a significant differentiation value of concentration protein S 100B from mild trumatic brain injury compare moderate and severe traumatic brain injury p 0 020 cut off point for death patients was 0 765 g LConclusion The mean serum Protein S 100 B from mild trumatic brain injury lower than moderate and severe traumatic brain injury higher consentration of protein S 100B have bad outcome , ABSTRACT Name Hendra SamantaStudy program Neurology Specialization Educational ProgrammedTitle Protein S 100B as Predictor Severity Traumatic Brain Injury Background Traumatic brain injury is still a serious community health problem can cause death physical and mental disability Protein S 100B release from destructive astrocyte from brain injury and detected in the peripheral blood so that protein S 100B can serve as predictor of severity traumatic brain injury This research aimed to find association between protein S 100B with traumatic brain injury severity Method This was a cross sectional study focusing to protein S 100B value from acute traumatic brain injury patients with onset 24 hours Eighty five patients were recruited from emergency room RSCM GCS value duration of post traumatic amnesia with TOAG tools duration loss of consciousness brain CT scan and concentration serum protein S 100B were record Results The mean concentration serum Protein S 100B were 0 77 mean PTA duration were 21 22 hours and the mean GCS were 13 There is a significant differentiation value of concentration protein S 100B from mild trumatic brain injury compare moderate and severe traumatic brain injury p 0 020 cut off point for death patients was 0 765 g LConclusion The mean serum Protein S 100 B from mild trumatic brain injury lower than moderate and severe traumatic brain injury higher consentration of protein S 100B have bad outcome ]"
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Yann Penduff
A comparison of structural changes in brain MRI between controlled and uncontrolled hypertensive patients = Perbandingan gambaran struktur otak pada MRI pasien hipertensi terkontrol dan tidak terkontrol
"ABSTRACT
Hypertension has been shown to be a risk factor for cerebral structural changes, but there is currently no evidence that hypertension control prevents their occurrence. We aimed to demonstrate whether controlling hypertension delays the occurrence of cerebral structural changes. We performed a cross sectional study comparing controlled and uncontrolled hypertensive patients to investigate whether structural changes occurred more in uncontrolled hypertensive patients, compared to controlled hypertensive patients. Data from 57 patients at RSUPN Dr. Ciptomangunkusumo was collected between March and April 2017, in which we compared the occurrence of cerebral structural changes between the controlled and uncontrolled groups. Cerebral atrophy.
ABSTRACT
Hipertensi diketahui dapat mengakibatkan perubahan struktur di otak, namun sampai saat ini tidak ada bukti jelas bahwa hipertensi yang terkontrol dapat mencegah terjadinya perubahan struktural pada otak. Tujuan dari penelitian ini adalah untuk mengetahui keuntungan pengendalian tekanan darah dalam mencegah perubahan struktural otak pada pasien hipertensi. Penelitian ini dilakukan dengan metode potong lintang, dengan membandingkan perubahan struktural otak pada pasien hipertensi terkontrol dan pasien hipertensi tidak terkontrol dan menilai apakah perubahan structural akan terjadi lebih banyak pada pasien tidak terkontrol dibandingkan dengan pasien terkontrol, Data pada penelitian diambil dari 57 pasien di RSUPN dr. Ciptomangunkusumo yang dikumpulkan pada periode Maret sampai April 2017. Pada grup pasien hipertensi tidak terkontrol, atropi otak."
2017
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UI - Skripsi Membership  Universitas Indonesia Library
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Dennis Oh
Depiction of the difference of battelle developmental inventory-2 screening test and kuesioner pra skrining perkembangan in detecting deviations of normal development of children aged 0-5 years old = Gambaran perbedaan battelle developmental inventory-2 dan kuesioner pra skrining perkembangan dalam menilai penyimpangan tumbuh kembang normal anak usia 0-5 tahun
"Latar Belakang: Prevalensi keterlambatan tumbuh kembang di Indonesia masih cukup tinggi. Kuesioner Pra Skrining Perkembangan merupakan alat skrining yang digunakan untuk mendeteksi dini gangguan tumbuh kembang anak. Sensitifitas KPSP adalah 60%, yang merupakan nilai yang cukup rendah. Maka dari itu, alat skrining lain diperlukan untuk mencegah tidak terdeteksi anak yang mengalami keterlambatan tumbuh kembang.
Metode: Penelitian ini merupakan penelitian diagnostik potong lintang 101 anak sehat usia 0-5 tahun yang memenuhi kriteria inklusi di Kampung Lio, Kampung Gangsang, Kampung Tapos dan mal di Jakarta.
Hasil: Hasil menunjukkan bahwa KPSP dan BDI-2 ST tidak memiliki perbedaan yang bermakna (p=0.078). Sensitifitas dan Spesifisitas BDI-2 ST masing-masing adalah 34.78% dan 92.31%. Umur dan jenis kelamin tidak menunjukkan perbedaan yang bermakna (p>0.05) bagi nilai KPSP maupun BDI-2 ST. Pendidikan anak menunjukkan perbedaan yang bermakna (p<0.05) untuk nilai KPSP tetapi tidak dengan nilai BDI-2 ST. Sebagian anak dengan KPSP skor pass tetap memiliki gangguan di 1 atau lebih domain BDI-2 ST (39.7%).
Konklusi: Penelitian ini menemukan bahwa tidak ada perbedaan yang bermakna dari nilai KPSP dan BDI-2 ST. Sensitifitas BDI-2 ST yang rendah diakibatkan oleh pemeriksaan yang hanya membandingkan skor total sedangkan seharusnya disertakan skor domain. Penggunaan KPSP sebagai reference test juga kurang memadai. Anak yang sudah melakukan skrining menggunakan KPSP sebaiknya dilanjutkan dengan pemeriksaan skrining dengan BDI-2 screening test untuk mendeteksi gangguan di area perkembangan tertentu.
Background: The prevalence of developmental delays in Indonesia is still high. Kuesioner Pra Screening Perkembangan is a questionnaire used to screen for developmental delays. The sensitivity of Kuesioner Pra Screening Perkembangan is 60%, which is still considered low. Therefore, different screening tests are required to prevent under-detection.
Methods: A diagnostic cross-sectional study of 101 healthy children aged 0-5 years old was done at Kampung Lio, Kampung Gangsang, Kampung Tapos, and malls in Jakarta.
Results: KPSP and BDI-2 ST does not have a significant difference (p=0.078). The sensitivity and specificity of BDI-2 ST is 34.78% and 92.31% respectively. Age and gender both do not show a significant correlation (p>0.05) with both KPSP and BDI-2 ST scores. Education, however, shows a significant correlation (p<0.05) with KPSP scores while not with BDI-2 ST scores. Some children with KPSP score pass still had at least 1 domain in BDI-2 ST that is refer (39.7%).
Conclusion: There is no significant difference between the scores of KPSP and BDI-2 ST. The low sensitivity of BDI-2 ST was caused by the assessment which compares only the total score when the domain scores needed to be taken into account. Usage of KPSP as a reference test also lacks in reliability. Subjects who have undergone KPSP screening should not stop there, and is recommended to continue with a BDI-2 screening test to detect developmental delays in specific areas."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
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UI - Skripsi Membership  Universitas Indonesia Library
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Jeffri Harisman
Gambaran Status Epileptikus Non Konvulsif Pada Pasien Cedera Kepala Sedang-Berat dan Faktor-Faktor yang Mempengaruhi = Non Convulsive Status Epilepticus In Adult Moderate-Severe Traumatic Brain Injury Patients and Associated Factors
"Latar belakang: Status epileptikus non konvulsif (SENK) dapat ditemukan pada
cedera kepala sedang-berat (CKS-B). Timbulnya kejang pascatrauma dapat
memperberat cedera otak yang sudah terjadi, sehingga dapat mempengaruhi luaran.
Gejala klinis SENK tidak spesifik, sehingga membutuhkan pemeriksaan
elektroensefalografi (EEG) dalam penegakkan diagnosis. Penelitian ini bertujuan
mengetahui angka kejadian SENK, faktor yang mempengaruhi, gambaran demografi
(usia, jenis kelamin dan luaran), gejala klinis, gambaran pencitraan dan EEG pada
pasien CKS-B dengan SENK.
Metode penelitian: Penelitian ini menggunakan desain potong lintang dengan sampel
terdiri dari data primer, yaitu semua CKS-B dari bulan Juli-Desember 2019 secara
consecutive sampling dan data sekunder, yaitu subjek CKS-B dengan klinis kecurigaan
SENK dari bulan Januari 2017-Juni 2019 di Rumah Sakit Umum Pusat Nasional Cipto
Mangunkusumo (RSUPNCM), Jakarta. Penegakkan diagnosis SENK dilakukan melalui
kriteria modified salzburg consensus criteria for non convulsive status epilepticus
(mSCNC).
Hasil penelitian: Sebanyak 39 sampel CKS-B masuk ke dalam penelitian yang terdiri
dari 14 data primer dan 25 data sekunder. Sebanyak 19 dari 39 sampel terdiagnosis
SENK. Proporsi insiden SENK pada CKS-B dari Juli-Desember 2019 sebesar 21,4% (3
dari 14 sampel). Pada kelompok SENK didapatkan usia lebih tua, laki-laki lebih banyak
dari perempuan (3:1) dan kecelakaan lalu lintas sebagai mekanisme utama. Manifestasi
klinis SENK, antara lain penurunan kesadaran (23,1%), agitasi psikomotor (12,8%),
delirium (5,1%) dan gangguan persepsi (5,1%). Lobus frontal dan SAH merupakan
daerah lokasi cedera dan patologi terbanyak. Hanya didapatkan 2 sampel dengan kriteria
definit SENK dan selebihnya possible SENK. Sebagian besar bangkitan SENK berasal
dari lobus temporal. Analisis multivariat menunjukkan lokasi cedera lobus temporal
bermakna berhubungan dengan kejadian SENK (p = 0,036, OR 11,45 (95% IK 1,17-
111,6).
Kesimpulan: Proporsi insiden SENK pada CKS-B di RSUPNCM sebesar 21,4%.
Penurunan kesadaran merupakan gejala klinis SENK terbanyak. Lobus temporal
merupakan faktor yang berhubungan terhadap kejadian SENK.
Background: Non convulsive status epilepticus (NCSE) can be accounted by moderatesevere
traumatic brain injury (TBI). Posttraumatic seizure can aggravate the previous
injury and produce poor outcome. Electroecephalography (EEG) was employed as
diagnostic tool because unspecified clinical symptoms. This study was aimed to find
incidence proportion, associated risk factors, demographic profiles (age, gender,
outcome), clinical symptoms, imaging and EEG patterns of NCSE in moderate-severe
TBI patients.
Method: Cross-sectional design was applied ini this study. Data is consist of primary
data which include all moderate-severe TBI since July-December 2019 by consecutive
sampling and secondary data which include moderate-severe TBI since January 2017-
June 2019 with highly suspicious NCSE symptoms in Cipto Mangunkusumo Hospital,
Jakarta. EEG was employed as diagnostic tool by using modified salzburg consensus
criteria for non convulsive status epilepticus (mSCNC) as a criteria.
Result: Of 39 samples, 19 moderate-severe TBI samples (14 primary data, 25
secondary data) were diagnosed as NCSE. Incidence proportion of NCSE from July-
December 2019 is 21,4% (3 from 14 samples). Older age, man gender, traffic accident
and worse outcome are the most common NCSE demographic profiles. Loss of
consciousness (23,1%) is a main symptom, followed by psychomotor agitation (12,8%),
delirium (5,1%) dan perception disturbance (5,1%). Frontal lobe and SAH are
consecutively as the most common injury location and pathologic finding. Only 2
samples have definite NCSE diagnosis and the remaining as possible NCSE. Most of
NCSE discharges were originated from temporal lobe. Temporal lobe injury location
has significance relation toward SENK occurance (p = 0,036, OR 11,45 (95% CI 1,17-
111,6).
Conclusion: Incidence proportion of NCSE in moderate-severe TBI is 21,4%. Loss of
consciousness is the most finding symptoms. Temporal lobe is a factor relates to NCSE
occurance."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
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UI - Tugas Akhir  Universitas Indonesia Library
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Ahdinar Rosdiana Dewi
Pengaruh Implantasi Eksosom dan Stimulasi Auditori Binaural Beat terhadap Perubahan Profil Gangguan Neurodevelopmental pada Anak = The Effect of Exosome Therapy and Binaural Beat Auditory Stimulation on Profile Changes of Neurodevelopmental Disorders in Children
"Latar Belakang. Anak dengan gangguan neurodevelopmental memerlukan upaya terapi terpadu untuk meningkatkan kualitas hidupnya. Studi ini bertujuan mengetahui pengaruh implantasi eksosom, stimulasi auditori binaural beat, dan terapi konvensional terhadap lima domain BDI-2 pada anak dengan gangguan neurodevelopmental.
Metode. Studi kohort retrospektif dengan rekam medis di RSUPN dr. Cipto Mangunkusumo dan RSAB Harapan Kita dilakukan pada anak dengan gangguan neurodevelopmental yang menjalani terapi sejak Januari 2021-April 2023. Subjek dikelompokkan menjadi kelompok perlakuan mendapatkan implantasi eksosom, stimulasi auditori binaural beat, dan terapi konvensional, sedangkan kelompok kontrol hanya mendapatkan terapi konvensional. Luaran yang dinilai yaitu domain perkembangan BDI-2. Analisis univariat dan bivariat dilakukan sesuai kebutuhan.
Hasil. Terdapat 25 subjek kelompok perlakuan dan 25 subjek kelompok kontrol. Tidak ada perbedaan karakteristik kedua kelompok sebelum perlakuan, kecuali domain motorik. Terdapat perbedaan usia developmental global maupun lima domain BDI-2 sebelum dan sesudah perlakuan pada kelompok perlakuan dan kontrol dengan median peningkatan usia developmental global masing-masing yaitu 7,5 dan 2,2 bulan. Tampak perbedaan peningkatan usia developmental global dan lima domain setelah perlakuan yang bermakna antara kelompok perlakuan dan kelompok kontrol.
Kesimpulan. Implantasi eksosom dan stimulasi auditori binaural beat dapat meningkatkan usia developmental global dan lima domain perkembangan berdasarkan penilaian BDI-2 secara signifikan pada anak dengan gangguan neurodevelopmental.
Background. Children with neurodevelopmental disorders require integrated therapeutic efforts to improve their quality of life. This study aimed to determine the effect of exosome therapy, binaural beat auditory stimulation, and conventional therapy on five BDI-2 domains in children with neurodevelopmental disorders.
Method. Retrospective cohort study using medical records at dr. Cipto Mangunkusumo National Center General Hospital and RSAB Harapan Kita was conducted for children with neurodevelopmental disorders who underwent therapy from January 2021 to April 2023. Subjects were grouped into a treatment group receiving exosome therapy, binaural beat auditory stimulation, and conventional therapy, while the control group only received conventional therapy. The BDI-2 developmental domains were assessed. Univariate and bivariate analysis were performed as needed.
Results. There were 25 subjects in the treatment group and 25 subjects in the control group. There were no differences in subjects’ characteristics between the two groups before treatment, except for the motor domain. There were differences in global and five BDI-2 domains developmental age before and after treatment in the treatment and control groups with a median increase in global developmental age, respectively, 7.5 and 2.2 months. There were significant differences in the increase of global and five domains developmental age after treatment between the treatment group and the control group.
Conclusion. Exosome therapy and auditory binaural beat stimulation improve global and five domains developmental age significantly based on BDI-2 assessment in children with neurodevelopmental disorders."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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Fadhlan Rusdi
Hubungan Kadar Neuroglobin Serum dengan Luaran Jangka Pendek Stroke Iskemik Akut = Association between Serum Neuroglobin Concentrations and Short-Term Outcomes of Acute Ischemic Stroke
"Latar Belakang: Penanda prognostik dapat menunjang tata laksana stroke iskemik (SI) akut. Protein neuroglobin (Ngb), yang berperan dalam transpor oksigen intrasel neuron dan mengurangi dampak hipoksia, adalah salah satu penanda potensial memenuhi fungsi tersebut.
Metode: Studi potong lintang dilakukan pada pasien SI akut yang dirawat di RSUPN dr. Cipto Mangunkusumo pada Maret-April 2023. Sampel serum untuk pemeriksaan Ngb diambil pada tiga hari pasca awitan stroke, sedangkan modified Rankin scale (mRS), National Institutes of Health Stroke Scale (NIHSS), indeks Barthel (BI) dan Montreal Cognitive Assessment (MoCA-Ina) diperiksa pada hari ketujuh. Analisis kemaknaan dan kurva receiver operating characteristic (ROC) digunakan untuk mengetahui hubungan Ngb dengan luaran stroke iskemik akut.
Hasil: Sebanyak 42 subjek menjalani analisis. Kadar Ngb serum lebih tinggi pada kelompok dengan skor mRS 3-6 dibandingkan 0-2 (12,42 ng/mL [3,57-50,43] vs 4,79ng/mL [2,25-37,32], p=0,005), dengan skor area di bawah kurva ROC sebesar 0,75. Kadar Ngb juga lebih tinggi pada kelompok dengan NIHSS pulang lebih tinggi (p=0,03), serta BI dan MoCA-Ina yang lebih rendah (p=0,01 dan p=0,002).
Kesimpulan: Kadar Ngb serum pada SI akut yang lebih tinggi berkaitan dengan luaran fungsional jangka pendek yang lebih buruk. Penelitian lebih lanjut dibutuhkan sebelum terapan klinis.
Background: Prognostic markers can optimize the management of acute ischemic stroke (AIS). The neuroglobin (Ngb), which plays a role in intraneuronal oxygen transport and reduces the effects of hypoxia, is a marker that may perform this function.
Methods: A cross-sectional study was conducted on AIS patients who were treated at RSUPN dr. Cipto Mangunkusumo in March-April 2023. Serum samples for Ngb examination were taken three days after the onset of stroke, while modified Rankin scale (mRS), National Institutes of Health Stroke Scale (NIHSS), Barthel index (BI) and Montreal Cognitive Assessment (MoCA-Ina) were examined on the seventh day. Significance analysis and receiver operating characteristic (ROC) curve were used to determine the relationship between Ngb and AIS outcomes.
Results: A total of 42 subjects underwent analysis. Serum Ngb levels were higher in subjects with mRS score of 3-6 than 0-2 (12.42 ng/mL [3.57-50.43] vs 4.79 ng/mL [2.25-37.32], p=0.005). The area under the ROC curve score was 0.75. Ngb levels were also higher in the group with higher NIHSS at discharge (p=0.03), lower BI (p=0.01) and lower MoCA-Ina score (p=0.002).
Conclusion: Higher serum Ngb levels in AIS are associated with poorer short-term functional outcomes. Further research is needed before clinical application."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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Ilham Nurdin
Uji Validasi Dan Reliabilitas Oxford Cognitive Screen Versi Bahasa Indonesia (OCS-INA) Sebagai Instrumen Penapisan Gangguan Fungsi Kognitif = Validity And Reliability Test Of Oxford Cognitive Screen Indonesian Version (OCS-INA) As A Screening Instrument For Cognitive Function Disorders
"Latar belakang. OCS merupakan instrumen yang dapat digunakan untuk penapisan ganguan fungsi kognitif. Instrumen ringkas, domain spesifik, dan mampu untuk penapisan afasia dan pengabaian. Penelitian ini bertujuan melakukan uji validitas dan reliabilitas OCS-INA.
Metode. Proses adaptasi dan translasi OCS sesuai kaidah WHO, kemudian dilakukan uji validitas dan reliabilitas OCS-INA. Populasi penelitian subjek berumur > 18 tahun dengan fungsi kognitif normal menggunakan Moca-INA. Penelitian dilakukan di panti sosial dan fasilitas kesehatan yang memenuhi kriteria inklusi.
Hasil. 104 subjek memenuhi kriteria inklusi. Sebagian besar laki-laki (51,92%). Usia berkisar antara 20 sampai 87 tahun dengan prevalensi usia tertinggi > 60 tahun (60%), tingkat pendidikan Sekolah Menengah Atas (35,58%) dan kebanyakan tidak bekerja (62,5%). Uji validitas menggunakan rumus koefisien korelasi spearman, nilai valid pada hampir semua domain yaitu nilai r hitung > r tabel (0,1927). Uji reliabilitas Kappa p didapatkan interpretasi kesepakatan dominan sangat baik pada 6 tugas pemeriksaan, yaitu tugas semantik (0,874), orientasi (0,842) memori verbal (0,822), memori episodik (0,870) dan tes lapang pandang (1,000). Nilai baik didapatkan pada tes penamaan gambar (0,774), membaca (0,726) dan kalkulasi (0,774).
Kesimpulan. OCS-INA valid dan reliabel sebagai instrumen untuk penapisan gangguan kognitif dan bisa melengkapi instrumen yang sudah digunakan sebelumnya.
Background. OCS is an instrument that can be used to screen impaired cognitive function. This is a compact, domain specific and capable instrument for aphasia and neglect screening. This study aims to test the validity and reliability of OCS-INA.
Method. The process of adaptation and translation of OCS according to WHO rules, then tested the validity and reliability of OCS-INA. The study population was subjects > 18 years old with normal cognitive function using Moca-INA. The study was conducted in social institutions and health facilities that met the inclusion criteria.
Results. 104 subjects met the inclusion criteria. Most of the subjects were men (51.92%). Age of subjects ranged from 20 to 87 years with the highest age prevalence > 60 years (60%), high school education level (35.58%) and most of them were not working (62.5%). The validity test uses the Spearman correlation coefficient formula, the valid value in almost all domains is the calculated r value > r table (0.1927). Kappa p reliability test showed that the dominant agreement interpretation was very good on 6 examination tasks: semantic (0.874), orientation (0.842) verbal memory (0.822), episodic memory (0.870) and visual field test (1,000). Good scores were obtained in the picture naming test (0.774), sentence reading (0.726) and calculation (0.774).
Conclusion. OCS-INA is valid and reliable instrument for cognitive impairment screening and can complement the instruments that have been used previously."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
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UI - Tesis Membership  Universitas Indonesia Library
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Yusuf Allan Pascana
Karakteristik Fungsi Kognitif Pada Anak Dengan Attention Deficit Hyperactivity Disorder (Adhd) Dan Hubungannya Dengan Faktor Demografis = Characteristics of Cognitive Function in Children with Attention Deficit Hyperactivity Disorder (ADHD) and Their Correlation with Demographic Factors
"Latar Belakang: Attention Deficit Hyperactivity Disorder (ADHD) adalah gangguan neurodevelopmental pada anak dan remaja. Prevalensi ADHD di seluruh dunia pada usia 3-12 tahun, mencapai 7,6%, di Indonesia mencapai 15,8 % pada anak usia 3-18 tahun, dan sebesar 15,5% di Jakarta. ADHD adalah peringkat pertama penyebab anak dibawa ke psikolog di Indonesia, yang terkait dengan gangguan fungsi kognitif hingga menyebabkan terganggunya prestasi akademis dan kualitas hidup anak. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik gangguan kognitif pada anak ADHD di Indonesia dan hubungannya dengan faktor demografis. Metode: Penelitian ini memiliki desain potong lintang yang dilakukan pada anak SD usia 7-12 tahun dengan menggunakan metode total sampling pada populasi terjangkau. Hasil: Subyek penelitian ini terdiri dari 34 anak dengan rata-rata usia subjek 9,68 (1,32) tahun, dengan 25 anak (73,5%) memiliki tipe inatensi. Delapan anak (23,5%) tipe kombinasi inatensi dan hiperaktivitas, dan 1 anak (2,9%) hiperaktif. Total skor rata-rata SYSTEMS-R yang diukur adalah 24,94 (8,21), 18 anak (52,9%) memiliki kemampuan kognitif normal, 16 anak (47,1%) defisit kognitif. Terdapat perbedaan bermakna pada domain atensi, kalkulasi, remote memory, bahasa, abstraksi dan visuospasial (p < 0,05) dengan abstraksi (91,2%), atensi (79,4%), kalkulasi (76,5%) dan bahasa (61,8%) adalah domain yang paling banyak memiliki angka di bawah rata-rata populasi umum. Faktor usia menunjukkan variasi signifikan (nilai p 0,024) berhubungan dengan skor total SYSTEMS-R pada anak ADHD. Tidak terdapat faktor demografis yang berhubungan secara statistik. Kesimpulan: Domain yang paling banyak memiliki nilai dibawah rata-rata populasi umum adalah domain atensi, domain yang termasuk dalam fungsi eksekutif yaitu abstraksi dan kalkulasi, Fungsi kognitif hanya berhubungan bermakna dengan faktor demografis usia dan subtipe ADHD.
Background: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder in children and adolescents. The prevalence of ADHD worldwide in children aged 3-12 years 7.6%, while in Indonesia it reached 15.8%, and 15.5% in Jakarta. ADHD is the number one reason children are taken to psychologists in Indonesia, which is related to impaired cognitive function, causing disruption to children's academic performance and quality of life. The aim of this research is to determine the characteristics of cognitive disorders in ADHD children in Indonesia and their relationship with demographic factors. Method: This study had a cross-sectional design which was conducted on elementary school children aged 7-12 years using a total sampling method in an accessible population. Results: The subjects of this study consisted of 34 children with an average subject age of 9.68 (1.32) years, with 25 children (73.5%) having the inattention type. Eight children (23.5%) showed a combination of inattention and hyperactivity, and only 1 child (2.9%) as hyperactive. The total mean SYSTEMS-R score measured was 24.94 (8.21), 18 children (52.9%) has normal cognitive abilities, while 16 children (47.1%) has cognitive deficits. There is significant differences in attention, calculation, remote memory, language, abstraction dan visuospasial (p < 0,05) with the domains of abstraction (91.2%), attention (79.4%), calculation (76.5%) and language (61.8%) are the domains that have the most numbers below the general population average. The age factor is a demographic factor showing significant variation (p value 0.024) associated with the total SYSTEMS-R score in ADHD children. When associated with cognitive function deficits in ADHD children, there were no demographic factors that were statistically related. Conclusion: The domain that has the most scores below the general population average is the attention domain, a domain that is included in executive function, namely abstraction and calculation. as well as the language and visuospatial domains. Cognitive function was only significantly related to age in demographic factors and ADHD subtype."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Tugas Akhir  Universitas Indonesia Library
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