Ditemukan 51 dokumen yang sesuai dengan query
This book about protein-protein Interactions as drug targets, targeting the MDM2-p53 protein-protein interaction for new cancer therapeutics, the development of small-molecule IAP antagonists for the treatment of cancer, protein-protein interaction targets to inhibit HIV-1 infection, inhibitors of protein-protein interactions paramyxovirus fusion ? a focus on respiratory syncytial virus, rational design...
Berlin: Springer, 2012
e20406020
eBooks Universitas Indonesia Library
Mark von Itzstein, editor
This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with...
Netherlands: [, Springer], 2012
e20417994
eBooks Universitas Indonesia Library
This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and...
Hoboken, New Jersey: John Wiley & Sons, 2010
e20394416
eBooks Universitas Indonesia Library
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability...
Weinheim, Germany: Wiley-VCH, 2003
e20394591
eBooks Universitas Indonesia Library
This book contains case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Contains chapters on combinatorial chemistry, molecular biology-based drug discovery,...
Hoboken, New Jersey: Wiley-Interscience, 2006
e20395928
eBooks Universitas Indonesia Library
This book the only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development from initial conceptualization to commercialization to clinicians and medical practitioners.
Volume 2 : drug development delves into the nitty-gritty details of optimizing the...
Hoboken, New Jersey: John Wiley & Sons, 2007
e20395858
eBooks Universitas Indonesia Library
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. The authors discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining...
Weinheim: Wiley-VCH, 2006
e20395921
eBooks Universitas Indonesia Library
Post genomics drug discovery and research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical...
Hoboken, New Jersey: John Wiley & Sons, 2007
e20395863
eBooks Universitas Indonesia Library
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.
This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design.
With the combined expertise of 20...
Weinheim: Wiley-VCH Verlag, 2004
e20376579
eBooks Universitas Indonesia Library
This book describes the way that pharmaceutical projects and programs are currently managed, and offers views from many highly experienced practitioners from within the industry on future directions for drug program management. The book integrates portfolio, program, and project management processes as fundamental for effective and efficient drug product development....
Hoboken: John Wiley & Sons, 2010
e20394503
eBooks Universitas Indonesia Library
