Optimasi dan validasi metode bioanalisis kurkumin plasma manusia secara kromatografi cair kinerja ultra tinggi-tandem spektrometer massa (KCKUT-SM/SM) dan aplikasinya secara in vivo = Optimatization and validation bioanalytical method of curcumin in human plasma by ultra perfomance liquid chromatography mass spectrometry (UPCL-SM/MS and it s application to in vivo study