Hasil Pencarian  ::  Simpan CSV :: Kembali

Hasil Pencarian

Ditemukan 127783 dokumen yang sesuai dengan query
cover
Damara Andalia
Evaluasi ketebalan lapisan serabut saraf retina peripapil dan lapisan sel ganglion makula sebagai faktor diagnostik primary angle closure dan primary angle closure glaucoma = Role of peripapillary retinal nerve fiber layer and ganglion cell inner plexiform layer thickness as diagnostic factors in primary angle closure and primary angle closure glaucoma
"ABSTRAK
Latar belakang Glaukoma masih merupakan salah satu penyebab kebutaan
terbesar di dunia. Belakangan ini, ketebalan RFNL dan GCIPL diketahui memiliki
hubungan terhadap perubahan struktural yang disebabkan oleh glaukoma.
Tujuan untuk mengkaji kemampuan diagnostik dari pengukuran ketebalan RFNL
dan GCIPL dalam mendeteksi glaukoma pada tahap awal.
Metode Enam puluh empat mata dengan sudut bilik mata sempit (32 glaukoma,
32 non-glaukoma) dari 48 pasien menjalani pengukuran menggunakan Cirrus
OCT dengan protokol 3,4 mm pemindaian cepat RFNL peripapilar. Pengukuran
dilakukan pada sisi superior, inferior, nasal, temporal dari GCIPL dan RFNL,
begitu juga dengan GCIPL superotemporal, superonasal, inferotemporal,
inferonasal, dan minimal.
Hasil Semua parameter yang diuji pada studi ini menunjukkan angka yang lebih
rendah pada kelompok PACG dibandingkan kelompok PAC. Rerata ketebalan
RFNL dan ketebalan GCIPL inferotemporal masing-masing memiliki nilai
spesifitias dan sensitifitas yang paling baik. Parameter dengan determinan terbaik
adalah ketebalan GCIPL inferotemporal dengan sensitifitas dan spesifitas masingmasing
75%
dan
75%.
Kesimpulan
Ketebalan GCIPL dan RFNL peripapil memiliki potensi besar
sebagai parameter diagnostik seperti skrining dan evaluasi respon terapi.
ABSTRACT
Background Glaucoma remains one of the biggest causes of blindness
worldwide. Recently, RFNL and GCIPL thickness were shown to be correlated
with early structural changes caused by glaucoma.
Objective to evaluate the diagnostic performance of RFNL and GCIPL thickness
measurement in detecting early glaucoma
Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)
of
48
patients underwent peripapillar scanning using Cirrus OCT
using 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurement
includes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well as
superotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL.
Result All parameters studied were significantly thinner in PACG group
compared to PAC group. Mean RFNL thickness and inferotemporal GCIPL has
the highest specificity and sensitivity, respectively, in detecting glaucoma.
Parameter with the best determinant is inferotemporal GCIPL thickness with
sensitivity and specificity, 75% and 71.9%, respectively.
Conclusion Peripapillary RFNL and GCIPL could be a potential diagnostic
parameter in detecting early glaucoma and monitoring therapy response in
glaucoma patients. ;Background Glaucoma remains one of the biggest causes of blindness
worldwide. Recently, RFNL and GCIPL thickness were shown to be correlated
with early structural changes caused by glaucoma.
Objective to evaluate the diagnostic performance of RFNL and GCIPL thickness
measurement in detecting early glaucoma
Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)
of
48
patients underwent peripapillar scanning using Cirrus OCT
using 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurement
includes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well as
superotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL.
Result All parameters studied were significantly thinner in PACG group
compared to PAC group. Mean RFNL thickness and inferotemporal GCIPL has
the highest specificity and sensitivity, respectively, in detecting glaucoma.
Parameter with the best determinant is inferotemporal GCIPL thickness with
sensitivity and specificity, 75% and 71.9%, respectively.
Conclusion Peripapillary RFNL and GCIPL could be a potential diagnostic
parameter in detecting early glaucoma and monitoring therapy response in
glaucoma patients. ;Background Glaucoma remains one of the biggest causes of blindness
worldwide. Recently, RFNL and GCIPL thickness were shown to be correlated
with early structural changes caused by glaucoma.
Objective to evaluate the diagnostic performance of RFNL and GCIPL thickness
measurement in detecting early glaucoma
Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)
of
48
patients underwent peripapillar scanning using Cirrus OCT
using 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurement
includes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well as
superotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL.
Result All parameters studied were significantly thinner in PACG group
compared to PAC group. Mean RFNL thickness and inferotemporal GCIPL has
the highest specificity and sensitivity, respectively, in detecting glaucoma.
Parameter with the best determinant is inferotemporal GCIPL thickness with
sensitivity and specificity, 75% and 71.9%, respectively.
Conclusion Peripapillary RFNL and GCIPL could be a potential diagnostic
parameter in detecting early glaucoma and monitoring therapy response in
glaucoma patients. "
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Ferry Valentino
Korelasi nilai rim area dengan nilai rerata retinal nerve fiber layer sebagai alat diagnostik glaukoma primer sudut terbuka di RSCM Kirana = Correlation between rim area and average of retinal nerve fiber layer as diagnostic tool for primary open angle glaucoma in RSCM Kirana
"ABSTRAK
Glaukoma merupakan penyakit multifaktorial dan penyebab kematian terbesar kedua di dunia. Riskesdas 2007, menyatakan sekitar 4.6 penduduk Indonesia menderita glaukoma. Baku emas penegakkan diagnosis glaukoma menggunakan nilai rerata RNFL. Tujuan penelitian ini untuk melihat korelasi nilai rim area dengan rerata RNFL sebagai alat diagnostik glaukoma primer sudut terbuka. Penelitian ini menggunakan metode studi potong-lintang dengan jumlah sampel sebanyak 55 subjek yang diambil dari total data rekam medis bulan februari 2015 hingga juni 2016. Hasil penelitian menunjukkan sebagian besar pasien glaukoma primer sudut terbuka berusia >58 tahun 56.4 , laki-laki 61.8 , cup-disk rasio >0.7 63.6 , nilai rerata RNFL 60.76 19.86 ?m, dan nilai rim area 0.73 0.56 mm2. Hasil uji korelasi pearson antara Rim area dengan rerata RNFL didapatkan nilai r 0,734 dan nilai p< 0,05 yang menyatakan kedua variabel memiliki korelasi kuat dan secara statistik bermakna. Pengukuran menggunakan ROC curve didapatkan nilai cut-off rim area sebasar 1.049 dengan nilai sensitivitas 81.8 dan spesifisitas 95.5 . Berdasarkan hasil tersebut dapat disimpulkan bahwa nilai Rim area memiliki korelasi dengan nilai rerata RNFL dan dapat digunakan sebagai alat diagnostik glaukoma primer sudut terbuka.
ABSTRAK
Glaucoma is a multifactorial disease and the second biggest cause of death in the world. Riskesdas 2007 report rsquo s stated around 4.6 population in Indonesia was diagnosed with glaucoma. The gold standard in diagnosing glaucoma is using the average RNFL.The purpose of this research is finding the correlation of rim area with average of RNFL as a diagnostic tools for primary open angle glaucoma. The method used in this research is a cross sectional study, the samples of which use 55 patient medical records from 2015 February until 2016 June. The result consist of the data that most of the patient with primary open angle glaucoma are older than 58 years old 56.4 , male 61.8 , cup disk ratio 0.7 63.6 , the average RNFL 60.76 19.86 m and rim area 0.73 0.56 mm2. Rim area and average RNFL are analyzed with pearson corelation test and the result of which are r value 0,734 and p value less than 0,05 which represent a strong correlation and statistically significant result. Measurement with ROC curve found that the cut off of rim area is 1.049 with 81.8 sensitivity and 95.5 specificity. As the conclution, rim area has corelation with average RNFL and can be used as a diagnostic tool for primary open angle glaucoma. "
2016
S70378
UI - Skripsi Membership  Universitas Indonesia Library
cover
Felix Kurniawan
Hubungan mean deviation lapang pandang dengan ketebalan rerata retinal nerve fiber layer pada pasien glaukoma primer sudut terbuka di RSCM Kirana, Jakarta = Correlation between visual field mean deviation and retinal nerve fiber layer average thickness in primary open angle glaucoma patients in RSCM Kirana, Jakarta
"Glaukoma berada di peringkat kedua sebagai penyebab kebutaan di Indonesia. Penurunan lapang pandang yang ditandai dengan penurunan nilai mean deviation MD dan penipisan retinal nerve fiber layer RNFL adalah dua dari beberapa hal yang sering dikaitkan dengan glaukoma. Namun, kedua hal tersebut belum ditemukan secara jelas hubungannya satu sama lain. Penelitian ini bertujuan untuk mengetahui hubungan MD lapang pandang dengan ketebalan rerata RNFL pada pasien glaukoma primer sudut terbuka di RSCM kirana, Jakarta. Desain dari penelitian ini adalah cross-sectional dengan mengambil data dari rekam medis pasien RSCM Kirana dari Januari 2015 hingga Juni 2016 yang memiliki data hasil pemeriksaan optical coherence tomography OCT dan tes Humphrey. Terdapat 95 buah bola mata yang datanya diambil untuk sampel. Dari hasil analisa korelasi antara nilai MD lapang pandang dan ketebalan RNFL yang dilakukan pada data yang diperoleh, didapatkan nilai signifikansi.
Glaucoma is the second leading cause of blindness in Indonesia. Visual field loss which is indicated by reduced mean deviation MD value and retinal nerve fiber layer RNFL depletion are two of several things frequently related to glaucoma. However, the correlation between the two variables is yet to be clearly discovered. The objective of this research is to know the correlation between visual field MD and RNFL average thickness in primary open angle glaucoma patients in RSCM kirana, Jakarta. The design which is used in this research is cross sectional by retrieving data from RSCM Kirana patients rsquo medical record from January 2015 to June 2016 which have optical coherence tomography OCT and Humphrey test results. There were 95 eyes whose data was retrieved as samples. After analyzing the correlation between visual field MD value and RNFL thickness retrieved from the samples, it was found that the significance value is"
Depok: Universitas Indonesia, 2016
S70377
UI - Skripsi Membership  Universitas Indonesia Library
cover
Miratasya
Perbandingan Hasil Pemeriksaan Pattern Erg (PERG) Pada Primary Open Angle Glaucoma (POAG) Derajat Early, Moderate, Dan Severe Dan Korelasinya Dengan Ketebalan Retinal Nerve Fiber Layer (RNFL) Dan Ganglion Cell – Inner Plexiform Layer (GCIPL) = Comparison of Pattern ERG (PERG) Result in Early, Moderate, and Severe Primary Open Angle Glaucoma (POAG) and The Correlation with Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell - Inner Plexiform Layer (GCIPL) Thickness
"Latar belakang. Penelitian ini bertujuan mendapatkan gambaran data dasar nilai normal pERG, ketebalan RNFL dan GCIPL pada subjek normal dan subjek dengan POAG derajat early, moderate dan severe serta menilai korelasi antara masing-masing modalitas pemeriksaan.
Metode. Penelitian potong lintang yang dilakukan pada 36 mata normal dan 42 mata dengan POAG (derajat early, moderate dan severe) usia 18-60 tahun di RSCM. Semua subjek menjalani pemeriksaan oftalmologi dasar dan pemeriksaan penunjang yaitu Humphrey standard automated perimetry, OCT peripapil dan makula menggunakan CirrusTM dan pERG menggunakan MonPack One dari Metrovision.
Hasil. Berdasarkan data normal didapatkan ketebalan rerata RNFL 106,3 ± 11,0 μm, ketebalan rerata GCIPL 83,3 ± 3,5 μm, waktu implisit P50 52,7ms , amplitudo P50 7,9 (3,4 – 15,6) μV, waktu implisit N95 101,3 ± 5,2 ms, amplitudo N95 10,6 (6,0 – 18,7) μV. Dibandingkan dengan kelompok POAG early didapatkan perbedaan bermakna pada ketebalan RNFL (p = 0,007), amplitudo P50 (p = 0,005) dan amplitudo N95 (p = 0,004), tanpa perbedaan bermakna pada ketebalan GCIPL, sedangkan pada kelompok moderate dan severe didapatkan perbedaan pada semua variabel (p<0,05). Korelasi positif sedang dan lemah ditemukan pada kelompok normal antara ketebalan RNFL dengan amplitudo P50 dan N95, tidak ada korelasi hasil pemeriksaan pERG dengan ketebalan GCIPL.
Kesimpulan. Pattern ERG adalah pemeriksaan objektif yang dapat membedakan antara kelompok normal dengan POAG, pemeriksaan pERG pada POAG harus memperhatikan floor effect.
Introduction. The study aims to evaluate and compare the pERG result, RNFL and GCIPL thickness in normal group to the groups with early, moderate and severe POAG and evaluate its correlation.
Methods. Cross-sectional study was done on 36 normal eyes and 42 eyes with POAG (mild, moderate and severe),subjects with age range of 18-60 years old in RSCM Kirana. Each group underwent complete basic ophthalmology examinations, Humphrey standard automated perimetry, peripapillary and macular OCT CirrusTM and MonPack One pERG from Metrovision.
Results. The data on normal group were as follow: RNFL thickness 106,3 ± 11,0 μm, GCIPL thickness 83,3 ± 3,5 μm, P50 implicit time 52,7 ms , P50 amplitude 7,9 (3,4 – 15,6) μV, N95 implicit time 101,3 ± 5,2 ms, N95 amplitude 10,6 (6,0 – 18,7) μV. Significant differences were found in RNFL thickness (p = 0,007), P50 amplitude (p = 0,005) and N95 amplitude (p = 0,004) in the early POAG group compared to the normal group, meanwhile on moderate and severe group all of the variable examination result including the GCIPL thickness were significantly different (P<0,05). Positive moderate and weak correlations were found between RNFL thickness in normal group with P50 and N95 amplitude, no correlation between pERG result with GCIPL thickness.
Conclusion. Pattern ERG is an objective tools to differentiate between normal and POAG subjects, pERG examination in POAG group especially the severe group needs to evaluate the floor effect by doing the prior OCT examination."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Astriviani Widyakusuma
Pengaruh pemberian suplementasi mirtogenol terhadap perubahan ketebalan lapisan serabut saraf retina dan lapang pandang pada glaukoma primer sudut terbuka = The effect of mirtogenol towards the changes in retinal nerve fiber layer thickness and visual field in primary open angle glaucoma
"[ABSTRAK
Tujuan: Untuk mengevaluasi pengaruh pemberian suplementasi Mirtogenol terhadap perubahan ketebalan lapisan serabut saraf retina dan lapang pandang pada pasien dengan glaukoma primer sudut terbuka (GPSTa) dengan tekanan intraokular (TIO) terkontrol.
Metode: Penelitian ini merupakan penelitian prospektif, acak, tersamar ganda. Empat puluh satu pasien dengan GPSTa dengan TIO ≤ 18 mmHg diacak untuk mendapatkan Mirtogenol atau plasebo. Perubahan ketebalan RNFL dan MD lapang pandang diperiksa sebelum penelitian, 4 minggu serta 8 minggu setelah pemberian obat. Efek samping pengobatan ditanyakan kepada pasien selama penelitian.
Hasil: Rerata ketebalan RNFL kelompok Mirtogenol mengalami penurunan sebesar -0.70±1.63 μm dari 87.29±19.39 μm di awal penelitian menjadi 86.58±19.43 μm setelah 8 minggu, namun perubahan yang terjadi tidak bermakna secara statistik (p=0.121). Rerata ketebalan RNFL kelompok plasebo mengalami penurunan sebesar -1.74±1.79 μm dari 97.14±17.19 μm di awal penelitian
menjadi 95.40±18.56 μm setelah 8 minggu, perubahan yang terjadi bermakna secara statistik (p< 0.001). Rerata MD lapang pandang kelompok Mirtogenol mengalami peningkatan 0.542±1.93 dB setelah 8 minggu sedangkan rerata MD lapang pandang kelompok plasebo mengalami penurunan sebesar -0.083±1.36 dB setelah 8 minggu. Namun perubahan rerata MD lapang pandang kedua kelompok
tidak bermakna secara statistik (p>0.05). Selama penelitian tidak didapatkan adanya efek samping.
Kesimpulan: Mirtogenol dapat mempertahankan ketebalan lapisan serabut saraf retina, dan MD lapang pandang pada pemberian Mirtogenol cenderung meningkat.
ABSTRACT
Objective: To evaluate the effect of Mirtogenol towards the changes in retinal nerve fiber layer (RNFL) thickness and visual field in patients with primary open angle glaucoma (POAG) with controlled IOP.
Methods: This is a prospective, double blind, randomized study. Forty one POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after the treatment. Patients were asked for any side effects during the treatment period.
Results: The average RNFL thickness in the Mirtogenol group decreased 0.70±1.63 μm from 87.29±19.39 μm before the treatment to 86.58±19.43 μm after 8 weeks of treatment, however the change was not significant (p=0.121). The average RNFL thickness in the placebo group decreased -1.74±1.79 μm from 97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of treatment, the change was statistically significant (p< 0.001). The average MD of visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of
treatment while the MD of visual field in the placebo group decreased 0.083 ± 1.36 dB after 8 weeks of treatment. Hoewever the changes in MD of visual field was not significant (p>0.05). No side effect was found throughout the study.
Conclusions: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields.;Objective: To evaluate the effect of Mirtogenol towards the changes in retinal
nerve fiber layer (RNFL) thickness and visual field in patients with primary open
angle glaucoma (POAG) with controlled IOP.
Methods: This is a prospective, double blind, randomized study. Forty one
POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either
Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual
fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after
the treatment. Patients were asked for any side effects during the treatment period.
Results: The average RNFL thickness in the Mirtogenol group decreased 0.70±1.63
μm
from
87.29±19.39
μm
before
the
treatment
to
86.58±19.43
μm
after
8
weeks of treatment, however the change was not significant (p=0.121). The
average RNFL thickness in the placebo group decreased -1.74±1.79 μm from
97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of
treatment, the change was statistically significant (p< 0.001). The average MD of
visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of
treatment while the MD of visual field in the placebo group decreased 0.083±1.36
dB
after
8
weeks
of
treatment.
Hoewever
the
changes
in
MD
of
visual
field
was
not
significant
(p>0.05).
No
side effect
was
found throughout
the
study.
Conclusions: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields., Objective: To evaluate the effect of Mirtogenol towards the changes in retinal
nerve fiber layer (RNFL) thickness and visual field in patients with primary open
angle glaucoma (POAG) with controlled IOP.
Methods: This is a prospective, double blind, randomized study. Forty one
POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either
Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual
fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after
the treatment. Patients were asked for any side effects during the treatment period.
Results: The average RNFL thickness in the Mirtogenol group decreased 0.70±1.63
μm
from
87.29±19.39
μm
before
the
treatment
to
86.58±19.43
μm
after
8
weeks of treatment, however the change was not significant (p=0.121). The
average RNFL thickness in the placebo group decreased -1.74±1.79 μm from
97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of
treatment, the change was statistically significant (p< 0.001). The average MD of
visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of
treatment while the MD of visual field in the placebo group decreased 0.083±1.36
dB
after
8
weeks
of
treatment.
Hoewever
the
changes
in
MD
of
visual
field
was
not
significant
(p>0.05).
No
side effect
was
found throughout
the
study.
Conclusions: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields.]"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
T58688
UI - Tesis Membership  Universitas Indonesia Library
cover
Seruni Era Lestari
Akurasi wide field digital retinal imaging system (RetCam®) dibandingkan oftalmoskopi indirek binokuler dalam skrining retinopathy of prematurity (ROP) pada bayi lahir prematur = The accuracy of wide field digital retinal imaging system (RetCam®) versus binocular indirect ophthalmoscopy in screening of retinopathy of prematurity
"ABSTRAK
Penelitian ini bertujuan untuk menilai akurasi skrining ROP bayi prematur dengan
menggunakan wide field retinal imaging system (RetCam
vi
®
) yang dilakukan oleh
dokter umum terlatih dibandingkan dengan menggunakan oftalmoskopi indirek
binokuler (BIO). Penelitian ini merupakan penelitian potong lintang dan bersifat uji
diagnostik. Semua bayi prematur yang memenuhi kriteria skrining menurut workshop
ROP dan bayi prematur di Indonesia diikutsertakan pada penelitian ini. Pada
penelitian ini didapatkan hasil bahwa WFDRI (RetCam
®
) yang dilakukan oleh dokter
umum yang terlatih secara baku sama akuratnya dengan oftalmoskopi indirek
binokuler (BIO) dalam skrining ROP pada bayi lahir prematur.ABSTRACT
The aim of this study was to evaluate the accuracy of wide field digital retinal
imaging (RetCam
®) conducted by trained general practitioner in comparison with
binocular indirect ophthalmoscopy (BIO). The design of this study was a cross
sectional, diagnostic trial study. Preterm infants that met the inclusion criteria
according to Indonesia retinopathy of prematurity workshop were included in the
study. The result of this study revealed that the accuracy of WFDRI (RetCam
)
performed by trained general practitioner were similar to those performed using BIO
in ROP screening.;The aim of this study was to evaluate the accuracy of wide field digital retinal
imaging (RetCam
®
) conducted by trained general practitioner in comparison with
binocular indirect ophthalmoscopy (BIO). The design of this study was a cross
sectional, diagnostic trial study. Preterm infants that met the inclusion criteria
according to Indonesia retinopathy of prematurity workshop were included in the
study. The result of this study revealed that the accuracy of WFDRI (RetCam
)
performed by trained general practitioner were similar to those performed using BIO
in ROP screening.;The aim of this study was to evaluate the accuracy of wide field digital retinal
imaging (RetCam
®
) conducted by trained general practitioner in comparison with
binocular indirect ophthalmoscopy (BIO). The design of this study was a cross
sectional, diagnostic trial study. Preterm infants that met the inclusion criteria
according to Indonesia retinopathy of prematurity workshop were included in the
study. The result of this study revealed that the accuracy of WFDRI (RetCam
)
performed by trained general practitioner were similar to those performed using BIO
in ROP screening.;The aim of this study was to evaluate the accuracy of wide field digital retinal
imaging (RetCam
®
) conducted by trained general practitioner in comparison with
binocular indirect ophthalmoscopy (BIO). The design of this study was a cross
sectional, diagnostic trial study. Preterm infants that met the inclusion criteria
according to Indonesia retinopathy of prematurity workshop were included in the
study. The result of this study revealed that the accuracy of WFDRI (RetCam
)
performed by trained general practitioner were similar to those performed using BIO
in ROP screening."
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Asri Setiawati
Kesesuaian diagnosis retinopati prematuritas antara peserta Program Pendidikan Dokter Spesialis (PPDS) mata dengan konsultan Pediatric Ophthalmology (PO) berdasarkan interpretasi foto wide field digital retinal imaging (RetCam) = Agreement of image based retinopathy of prematurity diagnosis between ophthalmology residents and pediatric ophthalmologists
"ABSTRAK
Latar Belakang: Banyaknya jumlah kasus ROP yang terlambat dirujuk ke RSCM-Kirana menunjukkan bahwa penanganan ROP di Indonesia masih
merupakan tantangan. Keterlambatan diagnosis ROP yang ditemukan di RSCM tersebut dapat disebabkan oleh terbatasnya dokter mata ahli retina dan pediatric ophthalmologist (PO) dan kurangnya pengetahuan dokter mata umum dalam
mendiagnosis ROP. Pengetahuan dan keterampilan mendiagnosis ROP
merupakan salah satu mata ajar dalam program pendidikan dokter spesialis mata
di FKUI. Data mengenai seberapa baik pengetahuan PPDS tersebut dalam
mendiagnosis ROP belum tersedia.
Tujuan: Mengevaluasi kemampuan PPDS mata dalam mendiagnosis ROP
berdasarkan pembacaan hasil foto wide field digital retinal imaging (WFDRI)
bayi prematur.
Metode: Sebanyak 25 set foto WFDRI dibaca dan diinterpretasi oleh 15 subjek
PPDS mata, dan digolongkan ke dalam 4 klasifikasi: tidak ada ROP, ROP ringan,
ROP tipe 2, dan ROP yang memerlukan terapi. Pembacaan oleh subjek tersebut
dihitung nilai kesesuaiannya (Kappa) terhadap pembacaan oleh 3 konsultan PO
sebagai referensi, kemudian ditentukan tingkat kesesuaian berdasarkan
penggolongan nilai Kappa. Tingkat kesesuaian yang diharapkan adalah ?sangat
baik?, khusus untuk penentuan ROP perlu terapi, nilai Kappa yang diharapkan
adalah 1,00.
Hasil: Dalam penentuan adanya ROP, seluruh subjek memiliki tingkat kesesuaian
?sangat baik? (Kappa 1,00); dalam penentuan ROP ringan atau lebih berat, hanya
1 dari 15 subjek memiliki tingkat kesesuaian ?sangat baik?, 9 subjek memiliki
kesesuaian ?baik?, dan 5 subjek memiliki kesesuian ?sedang? (Kappa 0,65+0,15);
dalam penentuan ROP tipe 2 atau lebih berat, 10 dari 15 subjek memiliki tingkat
kesesuaian ?sangat baik?, 3 subjek memiliki kesesuaian ?baik?, dan 2 subjek
memiliki kesesuaian ?sedang? (Kappa 0,45-1,00); dalam penentuan ROP yang
memerlukan terapi, hanya 7 dari 15 subjek yang memiliki nilai Kappa 1,00,
namun 12 dari 15 subjek memiliki tingkat kesesuaian ?sangat baik?, dan 3 subjek
memiliki kesesuaian ?baik? (Kappa 0,75-1,00). Dalam penentuan zona dan
stadium, hanya sebagian kecil subjek yang memiliki tingkat kesesuaian ?sangat
baik? (Kappa 0,35-0,81 dan 0,32-0,91); sedangkan dalam penentuan plus disease,
hanya 6 dari 15 subjek yang memiliki nilai Kappa 1,00.
Kesimpulan: Kemampuan PPDS mata dalam mendiagosis ROP belum
seluruhnya mencapai target yang diharapkan. ABSTRACT
Background: Numerous late-stage ROP cases that referred to Cipto
Mangunkusumo Hospital (Kirana) showed us that ROP management in Indonesia
is still a challenge. The delayed management might be caused by limited number
of vitreoretinal specialist or pediatric ophthalmologist, and inadequate diagnostic
knowledge of ROP of the general ophthalmologists. In condition of limited
number of vitreoretinal and pediatric ophthalmologists, the general
ophthalmologists are suggested to be taking part in ROP screening program. In
FKUI, ROP screening has been a part of residency training program, however,
there was no available data of ROP diagnostic knowledge of the residents.
Purpose: To measure agreement of image-based ROP diagnosis between
ophthalmology residents and pediatric ophthalmologist.
Methods: Twenty-five sets of retinal photographs of premature infants were
interpreted by 15 ophthalmology residents and pediatric ophthalmologists, and
classified into 4 categories: no ROP, mild ROP, type 2 ROP, and treatmentrequiring
ROP.
Agreements
are
measured
for
diagnosis
classification,
stage,
zone,
and
plus disease detection. Level of agreement was measured based on Kappa
value of each subjects. The expected level of agreement for each category was
?very good agreement?. For treatment-requiring ROP and plus disease, the
expected Kappa value was 1.00.
Results: For detection of no ROP, agreement of all subjects was ?very good?
(Kappa 1,00); for detection of mild or worse ROP, only 1 of 15 subjects has ?very
good agreement?, 9 of 15 subjects have ?good agreement?, and 5 subjects have
?moderate agreement? (Kappa 0,65+0,15); for detection of type 2 or worse ROP,
10 of 15 subjects have ?very good agreement?, 3 subjects have ?good agreement?,
and 2 subjects have ?moderate agreement? (Kappa 0,45-1,00); for detection of
requiring-therapy ROP, only 7 of 15 subjects that have Kappa value of 1.00,
however, 12 of 15 subjects have ?very good agreement?, and only 3 subjects have
?good agreement? (Kappa 0,75-1,00). For detection of stage and zone of ROP,
only a little number of subjects have ?very good agreement? (Kappa 0.35-0.81,
and 0.32-0.91, respectively); and for plus disease detection, only 6 of 15 subjects
have Kappa value of 1.00.
Conclusion: Agreement of image-based ROP diagnosis between ophthalmology
residents and pediatric ophthalmologist has not achieved the expected target yet. ;Background: Numerous late-stage ROP cases that referred to Cipto
Mangunkusumo Hospital (Kirana) showed us that ROP management in Indonesia
is still a challenge. The delayed management might be caused by limited number
of vitreoretinal specialist or pediatric ophthalmologist, and inadequate diagnostic
knowledge of ROP of the general ophthalmologists. In condition of limited
number of vitreoretinal and pediatric ophthalmologists, the general
ophthalmologists are suggested to be taking part in ROP screening program. In
FKUI, ROP screening has been a part of residency training program, however,
there was no available data of ROP diagnostic knowledge of the residents.
Purpose: To measure agreement of image-based ROP diagnosis between
ophthalmology residents and pediatric ophthalmologist.
Methods: Twenty-five sets of retinal photographs of premature infants were
interpreted by 15 ophthalmology residents and pediatric ophthalmologists, and
classified into 4 categories: no ROP, mild ROP, type 2 ROP, and treatmentrequiring
ROP.
Agreements
are
measured
for
diagnosis
classification,
stage,
zone,
and
plus disease detection. Level of agreement was measured based on Kappa
value of each subjects. The expected level of agreement for each category was
?very good agreement?. For treatment-requiring ROP and plus disease, the
expected Kappa value was 1.00.
Results: For detection of no ROP, agreement of all subjects was ?very good?
(Kappa 1,00); for detection of mild or worse ROP, only 1 of 15 subjects has ?very
good agreement?, 9 of 15 subjects have ?good agreement?, and 5 subjects have
?moderate agreement? (Kappa 0,65+0,15); for detection of type 2 or worse ROP,
10 of 15 subjects have ?very good agreement?, 3 subjects have ?good agreement?,
and 2 subjects have ?moderate agreement? (Kappa 0,45-1,00); for detection of
requiring-therapy ROP, only 7 of 15 subjects that have Kappa value of 1.00,
however, 12 of 15 subjects have ?very good agreement?, and only 3 subjects have
?good agreement? (Kappa 0,75-1,00). For detection of stage and zone of ROP,
only a little number of subjects have ?very good agreement? (Kappa 0.35-0.81,
and 0.32-0.91, respectively); and for plus disease detection, only 6 of 15 subjects
have Kappa value of 1.00.
Conclusion: Agreement of image-based ROP diagnosis between ophthalmology
residents and pediatric ophthalmologist has not achieved the expected target yet. ;Background: Numerous late-stage ROP cases that referred to Cipto
Mangunkusumo Hospital (Kirana) showed us that ROP management in Indonesia
is still a challenge. The delayed management might be caused by limited number
of vitreoretinal specialist or pediatric ophthalmologist, and inadequate diagnostic
knowledge of ROP of the general ophthalmologists. In condition of limited
number of vitreoretinal and pediatric ophthalmologists, the general
ophthalmologists are suggested to be taking part in ROP screening program. In
FKUI, ROP screening has been a part of residency training program, however,
there was no available data of ROP diagnostic knowledge of the residents.
Purpose: To measure agreement of image-based ROP diagnosis between
ophthalmology residents and pediatric ophthalmologist.
Methods: Twenty-five sets of retinal photographs of premature infants were
interpreted by 15 ophthalmology residents and pediatric ophthalmologists, and
classified into 4 categories: no ROP, mild ROP, type 2 ROP, and treatmentrequiring
ROP.
Agreements
are
measured
for
diagnosis
classification,
stage,
zone,
and
plus disease detection. Level of agreement was measured based on Kappa
value of each subjects. The expected level of agreement for each category was
?very good agreement?. For treatment-requiring ROP and plus disease, the
expected Kappa value was 1.00.
Results: For detection of no ROP, agreement of all subjects was ?very good?
(Kappa 1,00); for detection of mild or worse ROP, only 1 of 15 subjects has ?very
good agreement?, 9 of 15 subjects have ?good agreement?, and 5 subjects have
?moderate agreement? (Kappa 0,65+0,15); for detection of type 2 or worse ROP,
10 of 15 subjects have ?very good agreement?, 3 subjects have ?good agreement?,
and 2 subjects have ?moderate agreement? (Kappa 0,45-1,00); for detection of
requiring-therapy ROP, only 7 of 15 subjects that have Kappa value of 1.00,
however, 12 of 15 subjects have ?very good agreement?, and only 3 subjects have
?good agreement? (Kappa 0,75-1,00). For detection of stage and zone of ROP,
only a little number of subjects have ?very good agreement? (Kappa 0.35-0.81,
and 0.32-0.91, respectively); and for plus disease detection, only 6 of 15 subjects
have Kappa value of 1.00.
Conclusion: Agreement of image-based ROP diagnosis between ophthalmology
residents and pediatric ophthalmologist has not achieved the expected target yet. "
Fakultas Kedokteran Universitas Indonesia, 2016
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Vivi Rizka Yandri
Pengaruh fotokoagulasi laser terhadap hypoxia inducible factor-1? hif-1? dan intercellular adhesive molecule-1 icam-1 pada retinopati diabetik proliferatif = Effect of laser photocoagulation to hypoxia inducible factor 1 hif 1 and intercellular adhesive molecule 1 icam 1 in proliferative diabetic retinopathy
"Tujuan: Mengetahui pengaruh fotokoagulasi laser terhadap kadar Hypoxia-inducible Factor-1α (HIF-1α) vitreus dan kadar Intercellular Adhesive Molecule-1 (ICAM-1) vitreus pada Retinopati Diabetik Proliferatif.
Metode: Penelitian ini adalah uji klinis acak terbuka. Desain penelitian adalah uji klinis acak terbuka. Dua puluh dua mata dirandomisasi menjadi 2 kelompok, yaitu yang mendapatkan fotokoagulasi laser panretinal 1-2 minggu pre-vitrektomi dan kontrol. Kadar HIF-1α dan ICAM-1 dihitung menggunakan enzyme-linked immunosorbent assay (ELISA). Central macula thickness (CMT) diukur saat baseline, pre-vitrektomi, follow-up 2, 4, dan 12 minggu paska vitrektomi.
Hasil: Analisis hasil didapatkan rerata kadar HIF-1α vitreus (dalam ng/mL) pada kelompok kontrol dan fotokoagulasi laser masing-masing 0,152±0,015 dan 0,164±0,033 sedangkan kadar ICAM-1 vitreus(dalam ng/mL) adalah 17,840±14,140 dan 27,027±10,452. Tidak terdapat perbedaan bermakna rerata kadar HIF-1α dan ICAM-1 vitreus serta CMT di setiap waktu follow up antara kedua kelompok. Terdapat korelasi antara kadar HIF-1α dan HbA1c (r=0,463, p=0,03). Pengukuran CMT pre-vitrektomi dan kadar HIF-1α vitreus pada penelitian ini mempunyai korelasi positif pada kedua kelompok (r = 0,447 dan r = 0,32).
Simpulan: Fotokoagulasi laser 1-2 minggu pre-vitrektomi tidak menyebabkan kadar HIF-1α dan ICAM-1 yang lebih rendah dibandingkan dengan yang tidak mendapatkan laser. Kadar HIF-1α vitreus berkorelasi dengan tebalnya CMT, sedangkan kadar ICAM-1 vitreus tampak tidak berhubungan. Kontrol glikemik yang lebih buruk pada kelompok fotokoagulasi laser mempengaruhi hasil dari kadar HIF-1α maupun ICAM-1 vitreus.
Purpose: to determine the effect of pre-treatment of laser panretinal photocoagulation (PRP) before vitrectomy to Hypoxia-inducible Factor-1α (HIF-1α) and Intercellular Adhesive Molecule-1 (ICAM-1) in the vitreous fluid of patients with diabetic retinopathy proliferative.
Methods: This is post-test only randomized clinical trial open label study. Twenty two eyes were recruited, and 11 eyes had pre-treatment of PRP pre-vitrectomy and other 11 eyes were served as control. HIF-1α and ICAM-1 were measured by enzyme-linked immunosorbent assay (ELISA). At the beginning of PRP and just before vitrectomy (1-2 week after PRP), and at the time of follow-up of 2,4, and 12 week after vitrectomy, central macular thickness (CMT) was measured.
Results: Mean of HIF-1α(ng/mL) were 0,152±0,015 and 0,164±0,033in control and photocoagulation group, respectively. Mean of ICAM-1(ng/mL) were 17,840±14,140 and 27,027±10,452. There were no statistically significant differences in the comparison of both HIF-1α and ICAM-1 in each group and CMT at each time of follow up. The positive correlation between ICAM-1 in the vitreous body and HbA1c was clinically significant (r=0,463, p=0,03). The positive correlation between both level of HIF-Iα the vitreous body of both groups and CMT was found (r = 0,447 dan r = 0,32).
Conclusion: Laser photocoagulation 1-2 weeks before vitrectomy did not cause lower concentration of vitreous level of HIF-1α dan ICAM-1. Glycemic control status that worse in laser photocoagulation group could influence the level of HIF-1α and ICAM-1 vitreus."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2016
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Lumbantobing, Joshua Partogi Ferdinand
Pengaruh sitikolin terhadap proses apoptosis sel ganglion retina pada Kelinci model traumatic optic neuropathy = Effects of citicoline on apoptosis process of retina ganglion cells in traumatic optic neuropathy Rabbit model
"Tujuan: Membandingkan efek sitikolin pada hewan coba model traumatic optic neuropathy(TON) ditinjau dari gambaran histopatologi dan ekspresi imunohistokimia.
Metode: Penelitian dengan desain eksperimental terhadap 4 kelompok hewan coba. Sebanyak 12 mata dari 12 hewan coba kelinci jenis New Zealand White menjalani optic nerve crush injury(ONC) untuk menciptakan model TON. Tindakan ONC dilakukan dengan menggunakan Hartmann Mosquito Clamp. Evaluasi histopatologi berupa pemeriksaan densitas sel ganglion retina dengan pewarnaan hematoksilin-eosin dan pemeriksaan imunohistokimia dengan antibodi bcl-2 serta caspase-3.
Hasil: Densitas sel ganglion retina pada setiap kelompok menunjukkan perbedaan yang bermakna dengan nilai normal. Perbandingan berdasarkan periode waktu, baik periode 3 hari dan 7 hari, menunjukkan perbedaan yang bermakna bila dibandingkan dengan periode yang sama pada subjek tanpa terapi (p<0.001). Pemeriksaan imunohistokimia pada kelompok terapi bila dibandingkan dengan kelompok tanpa terapi menunjukkan peningkatan ekspresi bcl-2 secara signifikan pada hari-3 (p=0.012) dan hari-7 (p=0.046).Pemeriksaan imunohistokimia pada kelompok terapi bila dibandingkan dengan kelompok tanpa terapi menunjukkan penurunan ekspresi caspase-3 secara signifikan pada hari-3 (p=0.046) namun tidak pada hari ke-7 (p=0.072).
Kesimpulan: Pemberian sitikolin mampu menurunkan tingkat kematian sel ganglion retina dibandingkan tanpa terapi pada TON dan didukung dengan peningkatan ekspresi bcl-2 sebagai anti-apoptosis yang bermakna serta penurunan dari ekspresi caspase-3 sebagai pro-apoptosis.
Aims: Comparing citicoline effect in animal model of traumatic optic neuropathy (TON) in histopathology and immunohistochemical evaluation.
Methods: This is an experimental research for 4 groups of animal model. Twelve eyes from 12 New Zealand White rabbits underwent optic nerve crush injury (ONC) to create TON. The ONC was done using the Hartmann Mosquito clamp. Histopathological evaluation of retinal ganglion cell density by hematoxylin-eosin staining and immunohistochemical examination with bcl-2 and caspase-3 antibodies.
Results: Retinal ganglion cell density in each group showed a significant difference when compared with normal values. For comparisons based on the time period, 3 days and 7 days, both showed a significant difference when compared to the non-citicoline subjects in same period (p <0.001). Immunohistochemical examination in citicoline group, when compared to the non-citicoline group, showed a significant increase in bcl-2 expression on day-3 (p = 0.012) and day-7 (p = 0.046). Immunohistochemical examination in the citicoline group, when compared with the non-citicoline group, showed a significant decrease in caspase-3 expression on day-3 (p = 0.046) but not on day-7 (p = 0.072).
Conclusions: Citicoline is able to reduce the rate of retinal ganglion cell death and supported by a significant increase in the expression of bcl-2 as anti-apoptosis and a decrease in caspase-3 expression as pro-apoptosis."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Grariani Nufadianti
Penentuan diagnosis uveitis berdasarkan goldmann whitmer coefficient dan hubungannya dengan faktor genetik HLA-B27 = Determination of uveitis diagnosis based on goldmann whitmer coefficient and its correlation with hla-b27 genetic factor.
"Uveitis adalah inflamasi intraokular yang terjadi pada saluran uvea mata ataupun jaringan yang berada di dekatnya, diantaranya retina atau vitreous. Uveitis merupakan penyebab kebutaan nomor tiga di dunia dengan prevalensi tertinggi pada kelompok umur pekerja aktif 20-50 tahun . Selama ini diagnosis uveitis infeksi dan non-infeksi di Indonesia ditegakkan secara klinis dan didukung pemeriksaan serologi darah. Pemeriksaan antibodi pada cairan akuos dan serum serta marka genetik, khususnya HLA B-27 belum pernah dilakukan. Penelitian ini dilakukan untuk memberikan alternatif pendukung diagnosis klinis yaitu pemeriksaan deteksi molekuler HLA B-27 dan deteksi antibodi dengan perhitungan koefisien Goldmann-Witmer. Subjek penelitian adalah pasien uveitis aktif di Poliklinik Infeksi dan Imunologi RSCM Kirana yang berjumlah 79 orang. Berdasarkan koefisien Goldmann-Witmer, mikroba penyebab uveitis adalah Toxoplasma gondii dan virus Varicella zoster. Gen HLA-B27 ditemukan pada enam subjek penelitian dan terdapat kesesuaian dengan kasus uveitis non-infeksi tetapi belum dapat dibuktikan kemaknaannya secara statistik.
Uveitis is an intraocular inflammation which occurs on the uvea or its surrounding tissue such as retina or vitreous. Uveitis is known as the third major cause of blindness in the world with the highest prevalence is productive age group 20 50 years old . To date, infectious and non infectious uveitis stipulation in Indonesia is based on clinical examination and serology test. The aqueous and serum antibody titer measurement as well as genetic marker examination, especially on HLA B27, has never been done before. In this research we perform HLA B27 detection through molecular analysis and antibody titer measurement to know the Goldmann Whitmer coefficient. Sample size used in this research is 79 patients with active uveitis obtained from ldquo Poliklinik Infeksi dan Imunologi RSCM Kirana rdquo . The analysis of Goldmann Whitmer coefficient showed that the pathogens responsible for uveitis are Toxoplasma gondii and Varicella zoster. HLA B27 were found in six patients and there is similiarity between non infectious uveitis but this value does not have prove statistically. "
2018
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
<<   1 2 3 4 5 6 7 8 9 10   >>