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"Latar belakang: Insufisiensi vena kronis IVK derajat berat atau C5-C6 membutuhkan penatalaksanaan yang lebih kompleks dan membawa dampak morbiditas yang lebih berat akibat lamanya waktu pengobatan dan angka rekurensi yang tinggi. Hal ini menyebabkan biaya pengobatan yang tinggi dan menurunkan kualitas hidup penderita. Tata laksana definitif IVK C5-C6 telah mengalami pergeseran dari terapi non operatif terapi kompresi dan medikamentosa menjadi terapi operatif dengan teknik non invasif seperti ablasi endovena. Namun karakteristik pasien IVK di Indonesia berbeda dengan di negara maju, dimana sebagian besar pasien datang pada stadium lanjut atau C5-C6. Penelitian ini bertujuan untuk melakukan evaluasi terhadap jenis terapi yang diberikan baik terapi definitif maupun terapi perawatan luka, sehingga didapatkan penanganan IVK C5-C6 yang sesuai dengan karakteristik pasien di Indonesia. Metode penelitian: Studi potong lintang analitik dilakukan dengan mengambil total sampel 54 pasien IVK C5-C6 yang datang ke RSCM pada periode Januari 2014-Desember 2015. Pasien IVK yang disertai dengan insufisiensi arteri, insufisiensi vena dalam, dan kelainan kulit akibat penyakit kulit primer, keganasan, trauma dieksklusi. Analisis statistik diolah dengan SPSS 21 for windows, untuk menilai keluaran dari terapi definitif berupa angka rekurensi dan lama rawat. Hasil penelitian: Angka kekambuhan pasien IVK C5-C6 dengan terapi operatif lebih rendah dibandingkan dengan terapi non operatif yakni 7,1 berbanding 30,8 dalam follow up selama 2 tahun dengan nilai p 0,02 dan OR 0,17 95 IK 0,03-0,91 . Lama perawatan rerata pasien IVK C5-C6 pada kelompok terapi operatif selama 10,6 hari dan kelompok non operatif selama 14,8 hari. Kesimpulan: Angka kekambuhan pasien IVK C5-C6 yang memperoleh terapi definitif operatif lebih rendah dari yang hanya memperoleh terapi non operatif dalam evaluasi selama 1-2 tahun.

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Background: Severe degree C5 C6 of chronic venous insufficiency CVI require complex management and bring severe morbidity due to long duration of treatment and high recurrence rate. This leads to high treatment costs and interfered quality of patients life. Management of CVI C5 C6 in developed countries has changed from non operative therapy to operative therapy with non invasive technique, i.e. endovascular treatment. In Indonesia CVI patient characteristics differ from developed countries, where the majority of patients come at advanced stage or C5 C6. This study aims to evaluate the management of CVI C5 C6, both definitive therapy and also wound care techniques, to afford an appropriate treatment in accordance with the characteristics of the patients in Indonesia.

Method: a cross sectional analytic study carried out by taking the total sample of 54 patients who came with CVI C5 C6 to Cipto Mangunkusumo Hospital in the period of January 2014 December 2015. Those accompanied by arterial insufficiency, deep venous insufficiency, and skin disorders due to primary skin disease, malignancy, trauma were excluded. Statistical analysis is processed with SPSS 21 for windows, to assess the outcome of the definitive therapy in the form of recurrence rates and length of stay.

Results: Recurrence rate of CVI C5 C6 patients with operative therapy is lower than non operative therapy which is 7.1 versus 30,8 in 2 year follow up with p value of 0.02 and OR 0.17 95 CI 0, 03 .91 . The mean treatment duration CVI C5 C6 patients in the operative therapy group is 10.6 days and non operative group is 14.8 days.

Conclusions: Recurrence rate of CVI C5 C6 patients who obtain definitive operative therapy was lower than non operative therapy group in the evaluation for 1 2 years."

"Latar belakang: Insufisiensi vena kronis IVK derajat berat atau C5-C6 membutuhkan penatalaksanaan yang lebih kompleks dan membawa dampak morbiditas yang lebih berat akibat lamanya waktu pengobatan dan angka kekambuhan yang tinggi. Tata laksana definitif IVK C5-C6 telah mengalami pergeseran dari terapi non operatif terapi kompresi dan medikamentosa menjadi terapi operatif dengan teknik non invasif seperti ablasi endovena. Penelitian ini bertujuan untuk melakukan evaluasi terhadap jenis terapi yang diberikan baik terapi definitif maupun terapi perawatan luka dengan keluaran berupa angka rekurensi dan lama rawat.Metode penelitian: Studi potong lintang analitik dilakukan dengan mengambil total sampel 54 pasien IVK C5-C6 yang datang ke RSCM pada periode Januari 2014-Desember 2015. Pasien IVK yang disertai dengan insufisiensi arteri, insufisiensi vena dalam, dan kelainan kulit akibat penyakit kulit primer, keganasan, trauma dieksklusi. Analisis statistik diolah dengan SPSS 21 for windows, untuk menilai keluaran dari terapi definitif berupa angka kekambuhan dan lama rawat.Hasil penelitian: Angka kekambuhan pasien IVK C5-C6 dengan terapi operatif lebih rendah dibandingkan dengan terapi non operatif yakni 7,1 berbanding 30,8 dalam follow up selama 2 tahun dengan nilai p 0,02 dan OR 0,17 95 IK 0,03-0,91. Lama perawatan rerata pasien IVK C5-C6 pada kelompok terapi operatif selama 10,6 hari dan kelompok non operatif selama 14,8 hari.Kesimpulan: Angka kekambuhan pasien IVK C5-C6 yang memperoleh terapi definitif operatif lebih rendah dari yang hanya memperoleh terapi non operatif dalam evaluasi selama 1-2 tahun

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Background: Severe degree C5-C6 of chronic venous insufficiency CVI require complex management and bring severe morbidity due to long duration of treatment and high recurrence rate. This leads to high treatment costs and interfered quality of patients life. Management of CVI C5-C6 in developed countries has changed from non operative therapy to operative therapy with non-invasive technique, i.e. endovascular treatment. In Indonesia CVI patient characteristics differ from developed countries, where the majority of patients come at advanced stage or C5-C6. This study aims to evaluate the management of CVI C5-C6, both definitive therapy and also wound care techniques, to afford an appropriate treatment in accordance with the characteristics of the patients in Indonesia. Method: a cross sectional analytic study carried out by taking the total sample of 54 patients who came with CVI C5-C6 to Cipto Mangunkusumo Hospital in the period of January 2014-December 2015. Those accompanied by arterial insufficiency, deep venous insufficiency, and skin disorders due to primary skin disease, malignancy, trauma were excluded. Statistical analysis is processed with SPSS 21 for windows, to assess the outcome of the definitive therapy in the form of recurrence rates and length of stay. Results: Recurrence rate of CVI C5-C6 patients with operative therapy is lower than non-operative therapy which is 7.1 versus 30,8 in 2-year follow-up with p-value of 0.02 and OR 0.17 95 CI 0, 03-.91. The mean treatment duration CVI C5-C6 patients in the operative therapy group is 10.6 days and non-operative group is 14.8 days Conclusions: recurrence rate of CVI C5-C6 patients who obtain definitive operative therapy was lower than non-operative therapy group in the evaluation for 1-2 years."

"ABSTRAK Penatalaksanaan Fistel Enterokutan masih sangat beragam dan sulit dengan tingkat kekambuhan dan kematian pasca pembedahan yang masih tinggi. Tujuan dari penatalaksanaan pasien dengan fistel enterokutan adalah koreksi defisit metabolik dan nutrisi, penutupan fistel dan mengembalikan kesinambungan saluran cerna. Tujuan dari penelitian ini adalah untuk melakukan evaluasi penatalaksanaan bedah pada fistel enterokutan yang dirawat di RSUPN Cipto Mangunkusumo selama tahun 2014-2015. Penelitian ini dirancang secara retrospektif analitik dengan mengambil data rekam medik penderita di RSUPN Cipto Mangunkusumo pada periode 2014-2015. Ditemukan 27 kasus fistel enterokutan, dimana 21 kasus yang di evaluasi, rentang umur 27-65 tahun, terbanyak pada kelompok 40-60 tahun (52,38%), letak fistel terbanyak di ileum (57,14%), high output (71,43%), gizi buruk (52,38%), dilakukan tindakan operatif (85,71%), lama rawat <20 hari (66,67%), rekurensi fistel (19,05%) dan angka kematian (14,29%).ABSTRACT Management of enterocutaneous fistula still varies and frustrating with high recurrence and mortality rate. The goal of management for patient with enterocutaneous fistula are correct metabolic and nutritional deficits, close the fistula and reestablish continuity of the gastrointestinal tract. The purpose of this study was to evaluate the surgical management of the enterocutaneous fistula treated at Cipto Mangunkusumo Hospital during 2014-2015. This study designed analytic retrospectively by taking the patient medical record data at Cipto Mangunkusumo Hospital ini the period 2014-2015. Found 27 cases of enterocutaneous fistula which 21 cases were evaluated, age range 40-60 years (52,38%), the location of the fistula largest in the ileum (57,14%), high output (71,43%), malnutrition (52,38%), operative management (85,71%), length of stay in hospital <20 days (66,67%), fistula recurrence (19,05%) and mortality rate (14,29%).;Management of enterocutaneous fistula still varies and frustrating with high recurrence and mortality rate. The goal of management for patient with enterocutaneous fistula are correct metabolic and nutritional deficits, close the fistula and reestablish continuity of the gastrointestinal tract. The purpose of this study was to evaluate the surgical management of the enterocutaneous fistula treated at Cipto Mangunkusumo Hospital during 2014-2015. This study designed analytic retrospectively by taking the patient medical record data at Cipto Mangunkusumo Hospital ini the period 2014-2015. Found 27 cases of enterocutaneous fistula which 21 cases were evaluated, age range 40-60 years (52,38%), the location of the fistula largest in the ileum (57,14%), high output (71,43%), malnutrition (52,38%), operative management (85,71%), length of stay in hospital <20 days (66,67%), fistula recurrence (19,05%) and mortality rate (14,29%).;Management of enterocutaneous fistula still varies and frustrating with high recurrence and mortality rate. The goal of management for patient with enterocutaneous fistula are correct metabolic and nutritional deficits, close the fistula and reestablish continuity of the gastrointestinal tract. The purpose of this study was to evaluate the surgical management of the enterocutaneous fistula treated at Cipto Mangunkusumo Hospital during 2014-2015. This study designed analytic retrospectively by taking the patient medical record data at Cipto Mangunkusumo Hospital ini the period 2014-2015. Found 27 cases of enterocutaneous fistula which 21 cases were evaluated, age range 40-60 years (52,38%), the location of the fistula largest in the ileum (57,14%), high output (71,43%), malnutrition (52,38%), operative management (85,71%), length of stay in hospital <20 days (66,67%), fistula recurrence (19,05%) and mortality rate (14,29%)."

"Latar Belakang : Sindroma Guillain Barre SGB , menyebabkan pasien gagal napas dan memerlukan perawatan dan pengawasan di unit ruang rawat intensif. Beberapa faktor risiko dipikirkan terhadap terjadinya gagal napas pada SGB, berdasarkan gejala klinis yang timbul saat pasien masuk rumah sakit. Metode : Penelitian ini berdesain potong lintang dengan mengambil data sekunder dari pasien SGB yang menjalani perawatan inap di RSUPNCM sejak Januari 2010-Mei 2018. Data dianalisa dan dilakukan penghitungan dengan multivariat regresi logistik. Hasil : Sebanyak 59 pasien memenuhi kriteria inklusi. Insiden terjadinya gagal napas pada pasien SGB sebesar 25. Kelemahan bulbar OR 26,964; IK 95 2,050-354,616 , disotonomia OR 71,646;IK 3,039-1689,312, dan total skor Medical Research Council MRC OR 0,871; IK 95 0,776-0,978 merupakan 3 variabel yang secara independen berisiko tinggi untuk terjadinya gagal napas pada SGB. Faktor risiko yang tidak berhubungan secara bermakna terhadap kejadian gagal napas adalah usia, riwayat antesenden infeksi, durasi awitan hingga admisi, arefleksia, kelemahan fasial, oftalmopegia, dan tipe patologi SGB. Kesimpulan : Kelemahan bulbar, disotonomia dan total skor MRC merupakan faktor risiko untuk terjadinya gagal napas pada pasien SGB dan disarankan agar mendapatkan perawatan di Intensive Care Unit ICU.

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Background Guillain Barre Syndrome GBS may cause respiratory insufficiency and requires care and supervision in the Intensive Care Unit. Several risk factors are thought to be the occurrence of respiratory failure in GBS, based on clinical characteristics at hospital admission.

Methods: A cross sectional study was conducted by taking secondary data from GBS patients who were admitted to the Cipto Mangunkusumo hospital from January 2010 to May 2018. Data were analyzed and calculated by multivariate logistic regression.

Results: A total of 59 patients met the inclusion criteria. The incidence of respiratory failure in GBS patients was 25 . Bulbar weakness OR 26,964 95 CI 2,050 354,616 , dysotonomia OR 71,646 95 CI 3,039 1689,312 , and total score of Medical Research Council MRC OR 0,871 95 CI 0,776 0,978 are 3 variables that are independently high risk for the occurrence of respiratory failure in GBS. Risk factors that are not significantly associated with respiratory failure are age, antecedent infection history, duration of onset to admission, areflexia, facial weakness, ophthalmopegia, and type of GBS pathology.

Conclusions: Bulbar weakness, dysotonomia and total MRC score were risk factors for respiratory failure in GBS patients and were advised to receive treatment in the Intensive Care Unit ICU."

"ABSTRAKLatar belakang: Penggunaan antibiotik profilaksis bedah bertujuan untuk mencegah infeksi daerah operasi pada pasien yang dianggap mempunyai risiko tinggi. Meskipun kebijakan penggunaan antibiotik profilaksis dalam operasi telah ditetapkan, masih terdapat penggunaan yang tidak sesuai yang dapat menyebabkan peningkatan risiko resistensi antibiotik dan peningkatan biaya perawatan di rumah sakit.Tujuan: Mengevaluasi ketepatan penggunaan antibiotik profilaksis serta efisiensi biaya penggunaan antibiotik profilaksis pada pasien bedah digestif di RSUPN-CMMetode: Penelitian ini merupakan studi retrospektif. Data sekunder diambil dari rekam medik pasien rawat inap Departemen Bedah RSUPN-CM selama periode Januari hingga Desember 2015. Pada penelitian ini 102 pasien yang mendapatkan antibiotik profilaksis dievaluasi berdasarkan panduan NHS Lanaskhire untuk ketepatan dosis dan waktu pemberian pada tindakan pembedahan dan panduan antibiotik profilaksis divisi bedah digestif RSUPN-CM untuk pemilihan antibiotik berdasarkan indikasi tindakan.Hasil: Dari 102 pasien penelitian 81,4 pasien mendapatkan antibiotik profilaksis dengan indikasi sesuai tindakan dan 90,8 pasien mendapatkan antibiotik profilaksis tepat dosis. Berdasarkan ketepatan waktu pemberian antibiotik profilaksis, sebanyak 52 pasien mendapatkan antibiotik profilaksis tepat waktu 30 menit . Sementara itu, pasien yang mendapatkan antibiotik profilaksis lebih dari satu dosis yang berarti bukan lagi profilaksis sebanyak 15,7 . Tambahan biaya obat akibat pemberian antibiotik profilaksis yang tidak sesuai pedoman sebesar Rp. 16.016.007,-.Kesimpulan: Hasil penelitian menunjukkan masih adanya penggunaan antibiotik profilaksis yang tidak sesuai pedoman pada pasien bedah digestif RSUPN-CM. Pemberian antibiotik profilaksis yang tidak sesuai pedoman dapat menyebabkan peningkatan biaya perawatan rumah sakit. Diperlukan upaya untuk meningkatkan kepatuhan terhadap pedoman yang digunakan.hr>b>ABSTRACT"Background Prophylactic antibiotic is used to prevent surgical wound infections in surgery patients who are considered to have high risk of contamination. Despite established guideline, some studies reported inappropriate use of prophylactic antibiotic which potentially increase the risk of antibiotic resistance and hospitalization cost.Aim To evaluate the appropriateness and cost of prophylactic antibiotic usage in digestive surgery patients at Cipto Mangunkusumo hospital.Methods This was a retrospective study conducted on digestive surgery patients. Secondary data were collected from medical records of hospitalized patients in Surgery Department of Cipto Mangunkusumo hospital during the periode January to Desember 2015. In this study, 102 patients receiving prophylactic antibiotics were evaluated based on NHS Lanaskhire guideline for dosage and timimg in accordance with surgical types and guideline of digestive surgery division Cipto Mangunkusumo hospital for antibiotic selection.Results In 102 patients 81,3 patients received prophylactic antibiotics with appropriate indications and 91,2 patients received prophylactic antibiotics with appropriate doses. While 52 patient received prophylactic antibiotic with appropriate timing of 30 minutes. Meanwhile, patients that received prophylactic antibiotics more than once, which means not prophylactic anymore, were accounted for 15,7 . The estimated extra cost due to of inappropriate use of prophylactic antibiotics was Rp. 16.016.007, .Conclusion The results showed that inappropriate use of antimicrobial prophylaxis was still found in digestive surgery Cipto Mangunkusumo hospital and it increased drug cost. The most frequent inappropriateness was the timing of administration followed by inappropriate indication and dose. More work is needed in order to increase the adherence to the guidelines. "

"Penelitian ini membahas mengenai Pengorganisasian akreditasi JCI pengelolaan akreditasi JCI di RSUP Nasional Dr Cipto Magunkusumo Jakarta Tahun 2012. Pengorganiasaian akreditasi JCI berdasarkan pada standar pelaksanaan akreditasi JCI yaitu tahap Initial Assessment, Preparation, Tracer, Implementasi, Evaluasi, Milestone, Mock Survey, Survey akreditasi dan Keputusan akreditasi. Penelitian ini menggunakan metode penelitian kualitatif dengan wawancara mendalam, observasi, dan telaah data sekunder.Penelitian menunjukkan bahwa pengorganisasian akreditasi JCI di RSCM sudah berjalan cukup optimal. Walaupun dalam Penatalaksanaannya penyelenggara menghadapi banyak tantangan seperti kurangnya dukungan dari Depkes dalam hal pendanaan, besarnya kapasitas dan ruang lingkup rumah sakit, budaya organisasi yang belum sepenuhya berubah dan kurangnya dukungan dari SDM lain diluar kepanitiaan.

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This study discuss the organization overview of JCI accreditation in Dr. Cipto Mangunkusumo hospital Jakarta 2012. This JCI accreditation organization based on the JCI standard of organizing which start with Initial assessment, Preparation process, Tracer Method, Implementation of the program, Evaluation, Mock survey and survey accreditation / full survey, the milestone, the decision of accreditation . This study uses qualitative research methods with in-depth interviews, observations, and review of the secondary data.

Research shows that the organization of JCI accreditation already been running optimally, even though in conducting the organization of JCI accreditation, the organizer faced many challenges. Some of these challenge being the obstacles for the success of this program. Research result seen from the result of in-depth interviews, all the tables which indicates factual data, and guidelines for review of secondary data."

"Latar belakang: Pneumotoraks merupakan kondisi terjadinya akumulasi udara di pleura yang dapat menyebabkan kolaps pada paru, dan paling lebih sering terjadi pada periode neonatus dibandingkan dengan periode kehidupan lainnya. Angka insidens pneumotoraks meningkat menjadi 6-7% pada kelahiran bayi berat lahir rendah (BBLR). Saat ini sudah banyak kemajuan dalam perawatan intensif neonatus, tetapi pneumotoraks tetap menjadi komplikasi pernapasan utama yang menyebabkan kematian. Identifikasi faktor risiko yang berhubungan dengan pneumotoraks pada neonatus penting agar dapat dilakukan tatalaksana yang tepat dan sebagai evaluasi pencegahan dan tata laksana yang saat ini sudah diterapkan.Metode: Penelitian kasus kontrol ini melibatkan neonatus usia <28 hari yang lahir cukup bulan di RSCM yang diambil retrospektif secara consecutive sampling mulai perawatan 1 Januari 2021 hingga 31 Desember 2022. Subjek dibagi menjadi kelompok kasus (dengan pneumotoraks) dan kontrol (tanpa pneumotoraks) berdasarkan klinis dan radiologis selama perawatan. Faktor risiko yang ada pada masing-masing kelompok diidentifikasi dari rekam medis. Data kemudian dianalisis menggunakan program SPSS.Hasil: Total 116 subjek yang diteliti terdiri atas 58 subjek pada kelompok kasus dan 58 subjek pada kelompok kontrol. Angka kejadian pneumotoraks pada bayi di RSCM yaitu 2%. Faktor yang terbukti menjadi risiko terhadap insidens pneumotoraks adalah ventilasi mekanik invasif (OR 3,19; IK 1,01-10,11; p=0,048). Faktor yang tidak terbukti berhubungan dengan pneumotoraks adalah ventilasi tekanan positif saat resusitasi, sindrom distres napas, dan sepsis neonatorum. Angka kematian bayi dengan pneumotoraks adalah 72,4%.Kesimpulan: Faktor risiko yang mempunyai hubungan bermakna dengan pneumotoraks pada bayi usia <28 hari yang lahir cukup bulan adalah penggunaan ventilasi mekanik invasif.

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Background: Pneumothorax is a condition where air accumulation in the pleura can lead to lung collapse, and is more common in the neonatal period compared to other periods of life. The incidence of pneumothorax increases to 6-7% in low birth weight (LBW) neonates. There have been many advances in the intensive care of neonates, but pneumothorax remains a major respiratory complication leading to death. Identification of risk factors associated with pneumothorax in neonates is important for appropriate management and to evaluate current prevention and management.

Method: This case-control study involved neonates aged <28 days who were born at full term at RSCM who were taken retrospectively by consecutive sampling from January 1st 2021 to December 31st 2022. Subjects were divided into case groups (with pneumothorax) and controls (without pneumothorax) based on the clinical and radiology during treatment. The risk factors in each group were identified from medical records. The data were then analysed using the SPSS program.

Result: A total of 116 subjects were studied, consisting of 58 subjects in the case group and 58 subjects in the control group. The incidence rate of pneumothorax in neonates at RSCM was 2%. The factor that proved to be a risk factor for the incidence of pneumothorax in neonates was invasive mechanical ventilation (OR 3.19; IK 1.01-10.11; p=0.048). Factors not associated with pneumothorax were positive pressure ventilation during resuscitation, respiratory distress syndrome, and neonatal sepsis. The mortality rate of neonates with pneumothorax was 72.4%.

Conclusion: Risk factor that significantly associated with pneumothorax in neonates aged <28 days who were born at full term is invasive mechanical ventilation."

"Pelayanan farmasi klinik merupakan kegiatan pelayanan yang dilakukan oleh apoteker yang bertujuan untuk meningkatkan keberhasilan terapi pasien dan meminimalkan risiko terjadinya efek samping obat sehingga keselamatan dan kualitas hidup pasien dapat terjamin. Apoteker diharapkan dapat terus meningkatkan kompetensinya agar dapat memenuhi hak pasien. Sebelum menjadi apoteker, mahasiswa apoteker harus memiliki keterampilan dan wawasan dibidang kefarmasian. Salah satu upaya agar mahasiswa apoteker mampu melakukan praktik kefarmasian secara profesional, legal, dan etik, yakni melalui kegiatan PKPA (Praktik Kerja Program Apoteker). Pelaksanaan praktik kerja profesi ini berlangsung selama dua bulan dengan tugas khusus, yakni Evaluasi Data Interaksi Obat pada Sepuluh Zat Aktif dengan Pemakaian Terbesar di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo. Metode yang dilakukan dengan membandingkan data interaksi obat sebelumnya dengan literatur terpercaya untuk melihat apakah terjadi perubahan dalam kategori interaksi obat. Dari data interaksi sepuluh zat aktif pemakaian terbesar di RSUPN Cipto Mangunkusumo diperoleh total data interaksi sebanyak 1280 data, sebanyak 262 data kategori interaksi obat tidak perlu dilakukan revisi, sebanyak 264 data perlu dilakukan revisi karena perubahan kategori interaksi obat, sebanyak 739 data perlu dihapus dari daftar interaksi obat dikarenakan setelah dievaluasi tidak ditemukan interaksi.

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Clinical pharmacy services are service activities carried out by pharmacists that aim to increase the success of patient therapy and minimize the risk of drug side effects so that the safety and quality of life of patients can be guaranteed. Pharmacists are expected to continue to improve their competence in order to fulfill patient rights. Before becoming a pharmacist, pharmacist students must have skills and insight in the pharmaceutical field. One of the efforts so that pharmacist students are able to practice pharmacy in a professional, legal and ethical manner is through internship.The implementation of this professional work practice lasts for two months with a special assignment, namely Evaluation of Drug Interaction Data for the Top Ten Most Frequently Used Active Substances at Cipto Mangunkusumo Government-run General Hospital. The method is carried out by comparing previous drug interaction data with reliable literature to see if there is a change in the category of drug interactions. From the interaction data of the ten active substances used the most at Cipto Mangunkusumo General Hospital, a total of 1280 interaction data was obtained, 262 data in the category of drug interactions did not need to be revised, 264 data needed to be revised due to changes in the category of drug interactions, 739 data needed to be removed from the list drug interactions caused after being evaluated no interactions were found."

"Tuberkulosis (TB) adalah suatu penyakit infeksi menular yang disebabkan oleh bakteri M. tuberculosis yang dapat menyerang berbagai organ, terutama paruparu. Lamanya pengobatan tuberkulosis yang berlangsung minimal 6 bulan serta efek samping yang ditimbulkan menyebabkan tidak patuhnya pasien menjalani pengobatan. Tujuan penelitian ini yaitu untuk mengevaluasi penggunaan obat antituberkulosis dan melihat hasil pengobatan dengan menggunakan obat antituberkulosis di Instalasi Rawat Jalan RSUPN dr. Cipto Mangunkusumo Jakarta periode Januari 2014 ? Oktober 2015. Metode penelitian ini dilakukan secara deskriptif analitik retrospektif dan mengevaluasi catatan rekam medis dari 223 pasien tuberkulosis paru dengan kasus baru. Analisis dilakukan pada 223 pasien dimana jumlah penderita perempuan lebih tinggi dari pada laki-laki yaitu sebesar 53% dan paling banyak diderita oleh pasien dengan umur produktif yaitu pasien dengan rentang umur 46-55 tahun dan pasien dengan rentang umur 26-35 tahun. Sesuai dengan Pedoman Nasional Pengobatan Tuberkulosis, jenis OAT (Obat Antituberkulosis) yang paling banyak digunakan adalah OAT-KDT sebanyak 99,1% dan hanya 0,9% yang menggunakan OAT-Lepasan karena pasien memiliki riwayat hepatotoksis. 49,8% pasien yang menjalani pengobatan selama ≥ 6 bulan dan 43% pasien mendapatkan pengobatan secara rasional. 95% pasien menjalani pengobatan ≥ 6 bulan mendapatkan pengobatan lengkap, dan 95% pasien menjalani pengobatan < 6 bulan merupakan pasien putus berobat.

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Tuberculosis (TB) is a contagious infectious disease caused by M. tuberculosis that can affect various organs, especially the lungs. The duration of treatment for tuberculosis at least 6 months. Side effects caused disobedience by patients undergoing treatment. The purpose of this study is to evaluate the use of antituberculosis medicines and see the results of treatment using anti-tuberculosis medicines in RSUPN dr. Cipto Mangunkusumo the period January 2014 - October 2015. This research method is a descriptive analytic retrospective and evaluate the medical record of 223 patients with new cases of pulmonary tuberculosis.

Analysis was conducted on 223 patients in which the number of female patients is higher than in men that is equal to 53% and most suffered by patients with productive age in which patients with a lifespan of 46-55 years and patients with a lifespan of 26-35 years. In accordance with the National Guidelines for Treatment of Tuberculosis, the most widely used the OAT-KDT as much as 99.1% and only 0.9% using OAT-Removable because the patient had a history of hepatotoxic. 49.8% of patients undergoing treatmen't 6 months and 43% of patients receiving treatment in a rational way. 95% of patients undergoing treatment ≥ 6 months get a complete treatment, and 95% patients undergoing treatment < 6 months patients defaulting treatment."

"Penegakkan diagnosis sepsis lebih dini perlu dilakukan agar tepat dalam inisiasi penatalaksanaan sepsis, terutama saat di instalasi gawat darurat. Insidens sepsis cenderung meningkat, di Indonesia mortalitas pada tahun 2000 mencapai 84,5%. Penyebab dari sepsis bersifat multifaktorial. Tujuan penelitian untuk mengetahui faktor yang memengaruhi peningkatan risiko mortalitas berdasarkan jumlah sumber infeksi, asal infeksi (komunitas atau nosokomial), jumlah komorbid, sistem skor, albumin, kalium, dan kreatinin darah pada pasien terdiagnosis sepsis. Desain studi adalah kohort retrospektif dengan data rekam medis RSCM dan penelitian sepsis Divisi Penyakit Tropik dan Infeksi Departemen Ilmu Penyakit Dalam FKUI/RSCM. Kriteria inklusi meliputi pasien dewasa berusia > 18 tahun terdiagnosis sepsis sesuai kriteria Surviving Sepsis Campaign 2012 (SCCM/ESICM/ACCP/ATS/SIS) tahun 2012 dan dirawat inap di RSCM dari Januari 2014?Desember 2015. Studi dianalisis dengan SPSS ver 12.0. Dari 286 pasien, 75,9% memiliki jumlah sumber infeksi tunggal dan 53,5% berasal dari infeksi nosokomial. Selain itu, 80,8% dilaporkan dengan jumlah komorbid multipel. Dari pemantauan selama 28 hari, peningkatan kalium, skor qSOFA > 2, dan skor MSOFA > 11 meningkatkan risiko terjadinya mortalitas akibat sepsis dengan HR kalium > 5,0 mEq/l 1,91 (IK 95% 1,32?1,78, p 0,001) ; HR qSOFA > 2 1,19 (IK 95% 0,92-1,54, p 0,17) dan HR MSOFA > 11 1,38 (IK 95% 0,96?1,98, p 0,07). Median lama rawat inap dari pasien dengan sepsis hari ke-3 (IK 95% 2,53?3,47). Semakin lama pemantauan, maka probabilitas kesintasan akan semakin menurun. Kalium darah, skor qSOFA, dan skor MSOFA merupakan faktor yang memengaruhi mortalitas pasien sepsis di IGD dan dirawat di RSCM selama pemantauan 28 hari.

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Early diagnosis of sepsis is essential to initiate sepsis management especially in emergency room. Sepsis incidence rate tends to increase, in Indonesia the mortality rate year 2000 reached 84.5%. The cause of sepsis is multifactorial. The objectives are to determine factors associated with increased mortality risk based on single/multiple infection sources and comorbidity, community/nosocomial infection, scoring system, albumin/potassium/creatinine concentration in patients with sepsis. This is a cohort retrospective study based on medical records and research tree of sepsis from Division of Tropic and Infection, Internal Medicine Department, FMUI-RSCM. Inclusion criteria includes patients aged > 18 years diagnosed with sepsis based on Surviving Sepsis Campaign 2012 (SCCM/ESICM/ACCP/ATS/SIS), hospitalized in RSCM within January 2014- December 2015. Analysis is based on SPSS ver 12.0. From 286 patients, there were 75.9% suffered from single source of infection and 53.5% due to nosocomial infection. There were 80.8% of septic patients had > 1 comorbidities. Within 28 days, increased potassium, qSOFA score > 2, and MSOFA score > 11 tended to increase mortality risk due to sepsis with HR of potassium > 5,0 mEq/l 1.91 (95% CI 1.32?1.78, p .001) ; HR qSOFA > 2 1.19 (95% CI 0.92?1.54, p .17) dan HR MSOFA > 11 1.38 (95% CI 0.96?1.98, p .07). Median lifetime within 28 days was 3 days (95% CI 2.53?3.47). The longer the duration of survival analysis, the lower the probability of survival. Potassium, qSOFA and MSOFA scoring system were factors associated with increased risk of mortality in patients with sepsis admitted in emergency room and hospitalized in RSCM within 28 days of survival analysis."