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"atar Belakang: Balans energi positif pada obesitas ditandai dengan hiperadipositosis dan merangsang proses inflamasi kronik yang berdampak pada komplikasi penyakit pasien obesitas. Salah satu penatalaksaan obesitas adalah pemberian diet restriksi kalori. Diet restriksi kalori diduga menyebabkan penurunan kondisi inflamasi kronik yang salah satunya ditandai dengan kadar c-reactive protein (CRP). Namun demikian, berbagai studi memberikan hasil yang inkonsisten.Tujuan: Menilai efek diet restriksi kalori terhadap perubahan kadar CRP dan menilai pengaruh durasi diet tertentu terhadap perubahan kadar CRP pasien obesitas.Sumber Data: Pencarian utama dilakukan pada basis data PubMed, ProQuest, EBSCOhost, Embase dan Scopus hingga 30 Oktober 2020. Pencarian sekunder juga dilakukan secara snowballing, Google Scholar, Global Index Medicus, portal basis data nasional, dan perpustakaan digital 40 universitas di Indonesia.Seleksi Studi: Studi uji klinis acak melibatkan pasien dewasa obes yang menilai efek diet restriksi kalori (tanpa mengkombinasikan dengan terapi nondiet lain) terhadap kadar CRP. Tidak ada batasan tahun publikasi dan bahasa. Penilaian terhadap judul, abstrak dan studi dilakukan oleh dua peninjau independen. Dari 2087 artikel, 11 studi diantaranya memenuhi kriteria eligibilitas.Ekstraksi Data: Ekstraksi data dilakukan oleh kedua peninjau. Korespondensi dilakukan dengan menghubungi peneliti dan tidak didapatkan adanya data tambahan.Hasil: Diet restriksi kalori memiliki efek terhadap penurunan kadar CRP pada pasien obesitas dengan nilai Mean Difference -0.22 (IK 95% -0.40 - -0.04, p 0.006). Intervensi restriksi diet ≤ 12 minggu tidak menunjukkan penurunan bermakna pada kadar CRP, sedangkan intervensi restriksi diet > 12 minggu menunjukkan penurunan bermakna pada kadar CRP.KesimpulanDiet restriksi kalori memiliki efek menurunkan kadar CRP pada pasien obesitas.

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Background: Positive energy balance in obesity is characterized by hyperadipocytosis, which stimulates chronic inflammatory processes in obese patients. Management of obesity includes a calorie restriction diet thought to improve chronic inflammatory conditions, characterized by reduced c-reactive protein (CRP). However, studies have yielded inconsistent results.

Objective: To assess the effect of a calorie-restricted diet on changes in CRP levels and the duration of a particular diet that is significant for its effect on changes in CRP levels in obese patients

Data Source: We searched PubMed, ProQuest, EBSCOhost, Embase and Scopus through October 30,2020. Secondary searching was done by snowballing method including references of qualifying articles and manual searching through google scholar, global index medicus, national databases, and digital library of 40 universities in Indonesia

Study Selection: A randomized controlled trial involving obese adult patients assessed the effect of a calorie-restricted diet (without combination with other nondiet therapy) on CRP levels. No restriction regarding year of publication and language. Titles, abstracts, and articles were reviewed by two independent reviewer. Of the 2087 studies identified in our original search, 11 of them met the eligibility criteria.

Data Extraction: Data extraction was done by two reviewers. Correspondence was done by contacting the authors to confirm additional data. No additional data was obtained

Result: The calorie restriction diet has an effect on reducing CRP levels in obese patients with a Mean Difference value of -0.22 (95% CI -0.40 - -0.04, p 0.006). Dietary restriction interventions ≤ 12 weeks did not show a significant decrease in CRP levels, while dietary restriction interventions > 12 weeks showed a significant decrease in CRP levels

Conclusion: A calorie restriction diet has the effect of lowering CRP levels in obese patients"

"Obesitas merupakan masalah epidemik di dunia. Obesitas menyebabkan inflamasi kronik derajat rendah dan meningkatkan risiko beberapa penyakit kronis dengan komplikasi seperti aterosklerosis, dan masalah kardiovaskuler. Penanda inflamasi yang dianggap terbaik saat ini adalah high sensitivity C-Reactive Protein hsCRP . HsCRP juga merupakan prediktor terbaik untuk mengetahui risiko penyakit kardiovaskuler. Diperlukan penanganan secara interdisiplin untuk mengatasi masalah obesitas ini. Akupunktur merupakan terapi pelengkap yang paling cepat berkembang dan diakui oleh National Institutes of Health dan WHO. Penelitian ini bertujuan mengetahui efektivitas terapi kombinasi elektroakupunktur dan intervensi diet terhadap kadar HsCRP dan body fat pada pasien obesitas. Uji klinis acak tersamar tunggal terhadap 36 pasien obesitas yang dialokasikan secara acak menjadi 2 kelompok yaitu kelompok kombinasi elektroakupunktur dan intervensi diet kelompok perlakuan dan kelompok kombinasi elektroakupunktur sham dan intervensi diet kelompok kontrol. Hasil penelitian menunjukkan penurunan kadar hsCRP sebelum dan sesudah perlakuan tetapi belum terdapat perbedaan yang bermakna secara statistik p= 0.476. Terdapat perbedaan yang bermakna terhadap perbandingan kadar body fat sebelum dan sesudah perlakuan pada kelompok perlakuan p=0.002. Kesimpulan penelitian ini terapi kombinasi elektroakupunktur dan intervensi diet memiliki pengaruh terhadap kadar hsCRP dan body fat pada pasien obesitas.

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Obesity is an epidemic problem in the world. Obesity causes low grade chronic inflammation and increases the risk of some chronic diseases with complications such as atherosclerosis, and cardiovascular problems. The best current inflammatory marker is the high sensitivity of C Reactive Protein hsCRP . HsCRP is also the best predictor of risk of cardiovascular disease. Interdisciplinary treatment is needed to overcome this obesity problem. Acupuncture is the most rapidly growing complementary therapy and is recognized by the National Institutes of Health and WHO.

This study aims to determine the effectiveness of electroacupuncture combination therapy and dietary intervention on HsCRP and body fat levels in obese patients. Single blinded randomized clinical trials of 36 obese patients were randomly assigned to 2 groups, electroacupuncture combined with dietary intervention group treatment group and sham electroacupuncture combined with dietary intervention group control group.

The results showed decrease of hsCRP levels before and after treatment but there was no statistically significant difference p 0.476 . There was a significant difference to the body fat content before and after treatment in the treatment group p 0.002.

The conclusions of this study combined electroacupuncture and dietary intervention therapy have an influence on levels of hsCRP and body fat in obese patients."

"Latar Belakang : Prevalensi obesitas pada populasi dewasa di dunia pada tahun 2014 hampir mencapai 13, sementara di Indonesia telah mencapai 32,9 pada tahun yang sama. Obesitas merupakan faktor risiko berbagai penyakit tidak menular yaitu diabetes tipe 2 ataupun penyakit kardiovaskular. Sebagian besar orang yang berhasil menurunkan berat badan gagal mempertahankannya dan mengalami kenaikan berat badan berulang weight cycling. Berbagai penelitian tentang program diet memberikan hasil yang berbeda-beda. Tujuan dari penelitian ini adalah untuk mengevaluasi perubahan komposisi tubuh dengan diet kalori rendah protein tinggi dibandingkan dengan protein standar pada penyandang obesitas dengan riwayat weight cycling. Metode: Penelitian ini merupakan uji coba klinis acak terbuka pada penyandang obesitas dengan weight cycling. Sebanyak 61 penyandang obesitas mengikuti penelitian ini. Subjek diberikan diet kalori rendah dan secara acak didistribusikan ke dalam dua kelompok intervensi, yaitu kelompok protein tinggi 22 ndash;30 dari total asupan kalori dan kelompok protein seimbang 12 ndash;20 . Antropometri dan data komposisi tubuh diambil pada awal dan akhir penelitian. Subyek diikuti hingga 8 minggu, diberikan buku catatan makan harian dan konseling seminggu sekali. Hasil: 54 peserta menyelesaikan penelitian. Terdapat penurunan yang signifikan dalam berat badan dan indeks massa tubuh IMT , massa lemak, persentase massa lemak, massa otot, dan kenaikan persentase massa otot terjadi pada kedua kelompok protein seimbang: p

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Background: The world prevalence of obesity in the adult population in 2014 was nearly 13 while in Indonesia, it has reached 32.9 in the same year. Obesity is an established risk factor for cardiovascular diseases. A large proportion of people who had succeeded to reduce body weight failed to maintain it and underwent weight gain repeatedly weight cycling. Studies have been inconclusive about the best diet programme for such people. The purpose of this research was to evaluate the body composition changes resulting from low calorie high protein and standard protein diet programme in obese people with a history of weight cycling.

Methods: This is an open randomized clinical trial of a weight loss program in obese individuals with weight cycling. A total of 61 adult obese individuals with a history of weight cycling were recruited. Subjects were assigned to a low calorie diet and were randomly distributed into two intervention groups, namely high protein group 22 ndash 30 of total caloric intake and standard protein group 12 ndash 20. Anthropometry and body composition data were taken at baseline and at the end of the study. Subjects were followed up to 8 weeks, with daily reminders and weekly counselling.

Results: 54 participants completed the study. Significant reductions in body weight and body mass index BMI , fat mass, fat mass percentage, muscle mass, and gain in muscle mass percentage occurred in both groups Standard protein p"

"ABSTRAKPenelitian dengan rancangan uji klinis paralel acak tersamar ganda ini bertujuanmengetahui perubahan kadar apo B pada penyandang obes I setelah suplementasiserat psyllium husk (PH) 8,4 g/hari dan diet rendah kalori seimbang (DRKS) 1200kkal/hari selama 4 minggu. Berdasarkan kriteria penelitian, didapat 31 orangsubyek yang dibagi menjadi dua kelompok, 15 orang kelompok perlakuan (KP)dan 16 orang kelompok kontrol (KK). Subyek KP mendapat PH 8.4 g/hari danDRKS, sedangkan KK mendapat plasebo dan DRKS. Data yang diperolehmeliputi sebaran dan karakteristik subyek, asupan energi, makronutrien, serat, danair, serta kadar apo B awal dan akhir penelitian. Analisis data menggunakan uji ttak berpasangan dan Mann-Whitney, batas kemaknaan 5%. Sejumlah 28 subyekdapat mengikuti penelitian hingga selesai (KP dan KK masing-masing 14). Tidakdilaporkan efek samping berbahaya selama perlakuan. Sebagian besar subyekperempuan, median usia subyek KP dan KK berturut-turut 35,0 (30−45) tahun dan34,50 (30−48) tahun, IMT 28,0 ± 1,1 kg/m2 dan 27,2 ± 1,4 kg/m2. Jumlah asupanenergi total subyek KP 1130,9 ± 221,9 kkal/hari lebih tinggi signifikan (p = 0,02)daripada KK 1024,3 ± 269,9 kkal/hari. Karbohidrat sederhana pada KP (35,6(8,3−69,9)) g/hari lebih tinggi signifikan dibandingkan KK (13,8 (3,4−55,5))g/hari. Asupan serat subyek belum mencukupi anjuran (20–35 g/hari), yaitu KP17,2 ± 2,8 g/hari dan KK 8,6 (5,2−15,2) g/hari walaupun dengan suplementasiPH. Asupan protein, lemak total, dan kolesterol dalam rentang yang dianjurkan,tetapi tidak pada asupan asam lemak tak jenuh tunggal dan jamak. Penurunankadar apo B pada KK (-6,1 ± 8,9 mg/dL) lebih besar tidak signifikan (p = 0,13)dibandingkan pada KP (-1,3 ± 7,3 mg/dL). Dari penelitian ini disimpulkansuplementasi PH 8,4 g/hari dan DRKS 1200 kkal/hari selama 4 minggu tidaklebih baik dalam menurunkan kadar apo B dibandingkan plasebo dan DRKS 1200kkal/hari penyandang obes I.

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ABSTRACTThis double blind randomized clinical trial aims to investigate the change of apoB level in obese I after given supplementation psyllium husk (PH) 8.4 g/day andlow-calorie balanced diet (LCBD) for 4-weeks. By study criteria, 31 subjects wererandomly allocated to one of two groups; 15 subjects for treatment (T) group and16 subjects for plasebo (P) group. The T subjects received psyllium husk (PH) 8.4g/day and LCBD 1200 kcal/day and the P subjects received placebo and LCBD1200 kcal/day. Data collected in this study consist of subject distribution andcharacteristic, intake of energy, macronutrient, fiber, water and apo B level thatassessed before and after treatment. Level of statistical analyses significance was5%, independent t-test and Mann-Whitney. A total 28 subjects (14 subjects ineach group) had completed the intervention. There were no serious adverse eventswere reported along the intervention. Mean of age in T and P groups respectivelywas 35.0 (30.0−45.0) years and 34.5 (30.0−48.0) years, and BMI was 28.0 ± 1.1kg/m2 and 27.2 ± 1.4 kg/m2. The energy intake in T group 1130.9 ± 221.9 kcal/daywas significantly higher (p = 0.02) than P group 1024.3 ± 269.9 kcal/day. Simplecarbohydrate intake in T group (35.6 (8.3−69.9) g/day) was significantly higher (p<0.000) than in P group (13.8 (3.4−55.5) g/day). Intake of dietary fiber in T groupwas 17.2 ± 2.8 g/day had significantly higher than P group 8.6 (5.2−15.2) g/day,even adding PH supplementation cannot meet the recommendation of fiber intake(20-35 g/day). Intake protein and fat in both groups was meet recommendation,differ for intake of mono and polyunsaturated fatty acids. Decreasing of apo Blevel in P group was -6.1 ± 8.9 mg/dL that statistically insignificant difference (p= 0.13) with T group -1.3 ± 7.3 mg/dL. As a conclusion in this study shows, thatPH supplementation 8.4 g/day and LCBD 1200 kcal/day in obese I for 4 weekswasn’t proven to decrease the apo B level."

"Uji klinis acak tersamar ganda paralel ini merupakan penelitian pendahuluan, bertujuan mengetahui pengaruh suplementasi serat larut dan diet rendah kalori seimbang (DRKS) selama 4 minggu terhadap kadar kolesterol low-density lipoprotein (LDL) serum pada obes I usia 30−50 tahun. Sejumlah 31 subyek dipilih dengan kriteria tertentu dan dibagi menjadi dua kelompok dengan randomisasi blok, 15 orang kelompok perlakuan (KP) dan 16 orang kelompok kontrol (KK). Subyek KP mendapat serat larut psyllium husk (PH) 8,4 g/hari dan DRKS 1200 kkal/hari, sedangkan subyek KK mendapat plasebo dan DRKS 1200 kkal/hari. Data terdiri atas usia, indeks massa tubuh (IMT), asupan zat gizi, serta kadar kolesterol LDL serum. Pemeriksaan kolesterol LDL dilakukan pada awal dan akhir penelitian. Analisis data menggunakan uji t tidak berpasangan dan Mann-Whitney, batas kemaknaan 5%. Karakteristik data dasar dan sebaran subyek kedua kelompok sebanding. Analisis lengkap dilakukan pada 28 subyek (KP dan KK masing-masing 14 subyek). Suplementasi ditoleransi baik dan tidak ditemukan efek samping serius. Median usia subyek KP dan KK berturut-turut 35,0 (30−45) tahun dan 34,50 (30−48) tahun serta rerata IMT 28,0 ± 1,1 kg/m2 dan 27,2 ± 1,4 kg/m2. Rerata kadar kolesterol LDL serum awal KP 137,0 ± 37,0 mg/dL dan KK 134,4 ± 29,1 mg/dL. Defisit energi KP lebih rendah tidak signifikan (p = 0,62) dibandingkan KK, berturut-turut -282,0 ± 482,6 kkal/hari dan -331,8 ± 578,3 kkal/hari. Persentase asupan energi terhadap anjuran KP (94,2 ± 18,5%) lebih tinggi signifikan (p = 0,02) daripada KK (85,4 ± 22,9%). Asupan karbohidrat (KH) total KP (613,1 ± 134,5 kkal/hari) lebih tinggi signifikan (p = 0,02) dibandingkan KK (545,4 ± 161,1 kkal/hari). Asupan protein, lemak total, dan kolesterol KP dan KK sesuai rekomendasi NCEP-ATP III. Pada kedua kelompok, asupan asam lemak jenuh cenderung tinggi, tetapi asupan asam lemak tak jenuh tunggal dan jamak rendah. Asupan serat subyek KP 17,2 ± 2,8 g/hari dan KK 8,6 (5,2−15,2) g/hari. Dengan suplementasi PH tidak tercapai rekomendasi asupan serat. Persentase asupan KH sederhana terhadap energi total KP 11,5±5,4% lebih tinggi signifikan (p = 0,00) dibandingkan KK 6,0 (1,2524,2)%. Penurunan kadar kolesterol LDL serum KP -2,1 ± 16,2 mg/dL lebih sedikit tidak signifikan (p = 0,15) dibandingkan pada KK -10,9 ± 15,3 mg/dL. Penelitian ini belum dapat membuktikan suplementasi PH 8,4 g/hari dan DRKS 1200 kkal/hari selama 4 minggu lebih baik dalam menurunkan kadar kolesterol LDL serum dibandingkan plasebo pada subyek obes I.

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This parallel double blind randomized clinical trial is a preliminary study that aims to investigate the effect of soluble fiber supplementation 8.4 g/day and lowcalorie balanced diet (LCBD) for 4 weeks on serum low-density lipoprotein (LDL) cholesterol level in obese I, aged 30−50 years old. A total of 31 subjects were selected using certain criteria and randomly allocated to one of two groups using block randomization; 15 subjects for treatment (T) group and 16 subjects for control (C) group, respectively. The T group received psyllium husk (PH) 8.4 g/day and LCBD 1200 kcal/day, and the C group received placebo and LCBD 1200 kcal/day. Data include age, body mass index (BMI), intake of energy, macronutrient, and fiber, as well as serum LDL cholesterol level. Serum LDL cholesterol level was examined before and after treatment. Statistical analyses include independent t-test and Mann-Whitney with significance level of 5%. Subjects characteristics of the two groups at baseline was not statistically different. Twenty eight subjects (14 subjects in each group) completed the intervention. Supplementation was well tolerated and there were no serious adverse events. The mean age in T and C group was 35.0 (30.0−45.0) and 34.5 (30.0−48.0) years, respectively, and BMI was 28.0 ± 1.1 and 27.2 ± 1.4 kg/m2, respectively. The pretreatment serum LDL cholesterol level in T and C group was 137.0 ± 37.0 and 134.4 ± 29.1 mg/dL, respectively. Energy deficit in T group was insignificantly lower (p = 0.62) than in C group; -282.0 ± 482.6 and -331.8 ± 578.3 kcal/day, respectively. Percentage of energy intake to recommendation in T group (94.2 ± 18.5%) was significantly higher (p = 0.02) than that in C group (85.4 ± 22.9%). Total carbohydrate (CHO) intake in T group (613.1 ± 134.5 kcal/day) was significantly higher (p = 0.02) than in C group (545.4 ± 161.1 kcal/day). Total protein, fat, and cholesterol intake were similar to the NCEP-ATP III recommendation in both groups. Intake of SAFA was higher than recommended, meanwhile PUFA and MUFA intake were lower than those recommended in both groups. Dietary fiber intake in T and C group was 17.2 ± 2.8 and 8.6 (5.2−15.2) g/day, respectively. During the intervention, PH supplementation did not meet the recommendation. Percentage of simple CHO to total energy in T group 11.5±5.4% was significantly higher (p = 0.00) than in C group 6.0 (1.2524.2)%. PH supplementation decreased serum LDL cholesterol level (-2.1 ± 16.2 mg/dL) lower than placebo (-10.9 ± 15.3 mg/dL), but not significant different (p = 0.15). This study shows that PH supplementation 8.4 g/day in combination with LCBD 1200 kcal/day for 4 weeks in obese I aged 30−50 years old is not proven to decrease the serum LDL cholesterol level."

"Penelitian ini menggunakan metode kuasi eksperimental. Waktu pelaksanaan survey pendahuluan dilaksanakan pada tanggal 6 Desember 2003. sampai dengan 10 Februari 2004. Sedangkan penelitian dilakukan pada tanggal 21 April 2004 sampai dengan 10 Mei 2004. Cara pengambilan sampel dengan purposive random sampling pada pasien yang sesuai dengan kriteria sampel. Hasil penelitian menunjukkan 52,8% patuh terhadap asupan zat gizi makro. Rentang usia pasien yang mengalami DM TIPE 2 berada pada 30-50 tahun sebesar 51,4%. Perempuan ditemui 70,8% merupakan kelompok terbesar mengalami DM TIPS 2 sedangkan tingkat pendidikan tinggi terbanyak mengalami DM TIPE 2 sebesar 61,1%. Terlihat hasil yang sama pada penyuluhan gizi dengan media food model atau tanpa media food model.Sebagai kesimpulan dari penelitian ini pada asupan protein terlihat pengaruh penyuluhan gizi terhadap kepatuhan diet dengan nilai P < 0,05 sedangkan asupan energi, karbohidrat dan lemak tidak terlihat pengaruh penyuluhan gizi terhadap kepatuhan diet dengan nilai P > 0.05.Hendaknya frekuensi pemberian penyuluhan gizi di rumah sakit ditingkatkan agar terbentuk sikap dan pengetahuan pasien terhadap gizi cukup baik untuk melaksanakan diet dengan kepatuhan yang tinggi. Profesioualisme para penyuluh harus terus ditingkatkan dengan mengikuti pelatihan-pelatihan, melakukan diskusi-diskusi teutang kasus yang terjadi. Kunjungan rumah yang dilakukan oleh petugas gizi 1 kali dalam sebulan berguna untuk memonitor pelaksanaan diet pada penyandang DM Tipe 2.Kepustakaan : 60 (1985 - 2003)

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Nutrient Illumination Influence Concerning Diet Compliance to NIDDM Sufferer Outpatient at Mohammad Hoesin and Palembang Bari Hospital 2004Diet compliance lower to diabetic patient not depend on insulin (NIDDM) is shown an unknowingly patient's circumstance, not has a high attitude and knowledge yet, healthy attitude to diet compliance. It is appear at patient who not capable to decrease amount of food calorie and incompliance for doctor's suggestion and other healthy official. Therefore, is needed to illuminate nutrient approach in order that NIDDM patient has a healthy attitude, to bring about food arrangement with orderly, discipline and compliance.

This research purpose to observe nutrient illumination influent that use food model nor not use food model toward diet compliance NIDDM patient at M. Hoesin and Palembang Hospital BARI 2004 also to see other factors influent such as age, sex, education, food reserve and diet consumption.

This research used quasi-experimental method. Initial survey carry out period begins at December 6, 2003 until February 10, 2004. Meanwhile, research progress at April 21, 2004 to May 10, 2004. Carry out sample by purposive random sampling way on patient as proper as with sample criterion. The result of research shown 52,8% macro nutrient reserve with compliance at total energy. Patient's age part of the way in NIDDM at 30-50 is 51,4%. Woman found 70,8% as biggest group as NIDDM, meanwhile education level as biggest in NIDDM is 61,1%. Shown as same as at nutrient illumination with media food model or non-media food.

As conclude from this research at total energy and protein reserve appears nutrient illumination on diet compliance as value P < 0,05 while energy reserve, carbohydrate and fat not appear nutrient illumination effluent toward diet compliance in value P > 0,05.

Be desirable that nutrient illumination giving frequency in hospital can improve it in order to form patient attitudes and knowledge toward nutrient is good enough to bring about diet with high compliance. Illuminators professionalism has to improve with trainings, discussion on cases happened. Home visit done/conducted by gizi officer once in a month good for monitoring diet execution at patient DM Type 2.

Bibliography: 60 (1985 - 2003)"

"Proprotein convertase subtilisin/kexin type 9 adalah protein yang utamanya berasal dari hati dan berperan dalam degradasi reseptor low-density lipoprotein, sehingga menjadikannya target terapeutik yang menjanjikan untuk menunrunkan kolesterol. Pengembangan obat yang menargetkan proprotein convertase subtilisin/kexin type 9 telah menarik banyak perhatian, namun adanya keterbatasan penelitian model in vivo dengan hewan wild type yang mampu merepresentasikan kondisi manusia dapat menghambat proses pengembangan obat. Sebuah studi menunjukkan diet tinggi fruktosa dapat meningkatkan proprotein convertase subtilisin/kexin type 9 pada manusia. Pada penelitian ini dilakukan pengembangan model hewan proprotein convertase subtilisin/kexin type 9 dengan tikus wistar jantan yang diinduksi diet tinggi fruktosa menggunakan variasi durasi induksi selama 3, 4, dan 5 minggu. Parameter yang dinilai adalah kadar Proprotein convertase subtilisin/kexin type 9 di plasma dan hati yang diukur dengan ELISA, serta ekspresinya di hati yang dievaluasi dengan western blot. Pada tikus yang diinduksi fruktosa, terdapat peningkatan signifikan kadar Proprotein convertase subtilisin/kexin type 9 di plasma dan hati dibandingkan dengan kontrol (p<0,05) pada durasi 3 dan 4 minggu untuk plasma, serta durasi 3 minggu untuk hati. Western blot menunjukkan mature proprotein convertase subtilisin/kexin type 9 tereskpresi pada kelompok dengan induksi fruktosa, serta terjadi penurunan ekspresi di minggu ke-3 dan ke-5 jika dibandingkan dengan kontrol. Penelitian ini menunjukkan tikus yang diinduksi fruktosa dapat menjadi pilihan sebagai model hewan proprotein convertase subtilisin/kexin type 9 dengan durasi induksi selama 4 minggu untuk memberikan hasil yang optimal.

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Proprotein convertase subtilisin/kexin type 9 is a liver-derived protein with an ability to promote degradation of low-density lipoprotein receptor, making it a promising therapeutic target in cholesterol-lowering therapy. The development of drugs targeting proprotein convertase subtilisin/kexin type 9 has attracted considerable attention, but the limited studies of in vivo model with wild type animals that exhibit similarities to that of a human situation could inhibit the drug development process. Recent study has revealed high fructose diet increased proprotein convertase subtilisin/kexin type 9 in humans. In this study, the development of animal model of proprotein convertase subtilisin/kexin type 9 was carried out using rats induced by fructose with duration of induction variation. Plasma and hepatic proprotein convertase subtilisin/kexin type 9 were measured with ELISA, while hepatic proprotein convertase subtilisin/kexin type 9 expression was detected with western blot. A significant increase in plasma and hepatic proprotein convertase subtilisin/kexin type 9 levels were observed in fructose-induced rats following treatment for 3 and 4 weeks, and 4 weeks, respectively, compared to the control group (p<0,05). Western blot showed proprotein convertase subtilisin/kexin type 9 was expressed in fructose-induced groups, and there was a decrease in expression in frucotse- induced group treated for 3 and 5 weeks. This study demonstrate that fructose-induced rat has a potential to be animal model of proprotein convertase subtilisin/kexin type 9, with an induction duration of 4 weeks to provide an optimal result."

"Fiber is not digested or absorbed in the small intestine. The main site of action of fiber is in the colon. Inthe colon, fiber will increase stool output and frequency. Increase stool water, dilute the colonic content,reduce the toxins, bile acid, increase colonic fermentation and also stimulate probiotic growth.Some meta-analysis of observational epidemologic and case contro studies have faund a protectiveeffect of dietary fiber against colon cancer that increase with intake. Therefore, the high fiber diet is healthy recommendation to prevent various gastrointestinal disorders."

"Pengaruh dari media sosial serta permasalahan terkait penampilan dan citra tubuh yang dialami remaja putri membuat mereka mempunyai keinginan yang kuat untuk mendapatkan berat badan ideal serta penampilan diri yang menarik dengan cara yang mudah dan cepat (fad diets). Namun, umumnya fad diets tidak didasari oleh dasar ilmiah yang jelas (pseudoscientif) sehingga keamanannya tidak terjamin dan dapat menyebabkan masalah gizi seperti malnutrisi dan anemia yang dapat mengarah ke status gizi serta prestasi belajar. Tujuan dari penelitian ini adalah untuk mengetahui hubungan paparan informasi fad diets di media sosial dan faktor lainnya terhadap perilaku diet mahasiswa fakultas non kesehatan di Universitas Indonesia pada tahun 2022. Desain penelitian yang digunakan adalah cross sectional melibatkan 175 responden dari mahasiswa fakultas non-kesehatan Universitas Indonesia semester 2 dan 4. Data diambil dengan pengisian kuesioner online dan diolah menjadi analisis data univariat, bivariat, dan multivariat berupa uji Chi Square dan uji Regresi Logistik Ganda yang dilakukan menggunakan perangkat lunak SPSS. Hasil penelitian menunjukkan 74,3% responden pernah atau sedang melakukan upaya penurunan berat badan dengan metode fad diets. Hasil analisis bivariat menyatakan bahwa jenis kelamin, citra tubuh, dorongan diet dari keluarga, dorongan diet dari teman sebaya, frekuensi paparan infromasi fad diets di media sosial, serta pengaruh paparan informasi fad diets di media sosial secara signifikan berhubungan dengan perilaku fad diets. Variabel citra tubuh merupakan faktor dominan dari perilaku fad diets dengan OR sebesar 9,6 setelah dikontrol dengan variabel frekuensi paparan informasi fad diets di media sosial sebagai variabel perancu.

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The influence of social media and problems related to appearance and body image experienced by young women make them have a strong desire to get ideal body weight and attractive appearance in an easy and fast way (fad diets). However, generally, fad diets are not based on a clear scientific basis (pseudoscientific) so their safety is not guaranteed. It can cause nutritional problems such as malnutrition and anemia that can lead to nutritional status and learning achievement. This study aimed to determine the relationship between exposure to fad diets information on social media and other factors on the dietary behavior of non-health faculty students at the University of Indonesia in 2022. The research design used was cross-sectional involving 175 respondents from non-health faculty students at the University of Indonesia. semesters 2 and 4. The data were taken by filling out online questionnaires and processed into univariate, bivariate, and multivariate data analysis in the form of Chi Square test and Multiple Logistics Regression test which were carried out using SPSS software. The results showed that 74.3% of respondents had or are currently trying to lose weight using the fad diet method. The results of the bivariate analysis stated that gender, body image, dietary encouragement from family, dietary encouragement from peers, frequency of exposure to fad diets information on social media, and the influence of exposure to fad diets information on social media was significantly related to fad diets behavior. Body image is the dominant factor in fad diet behavior with an OR of 9.6 after controlling for the frequency of exposure to fad diet information on social media as a confounding variable."