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"Penyakit gagal ginjal kronik (CKD) adalah kondisi yang terjadi karena kerusakan pada ginjal dan/atau penurunan laju filtrasi glomerulus (GFR) di bawah 60 mL/menit/1,73 m2 selama lebih dari tiga bulan. Prevalensi CKD meningkat secara global, termasuk di Indonesia, dengan hipertensi dan nefropati diabetik sebagai penyakit penyerta utama. Terapi untuk pasien CKD dengan komplikasi hipertensi dan diabetes melitus sering kali melibatkan terapi polifarmasi, meningkatkan risiko masalah terkait obat atau drug-related problems (DRPs). Pemantauan terapi obat (PTO) merupakan proses penting untuk memastikan keamanan, efektivitas, dan rasionalitas pengobatan yang diterima pasien. PTO dilakukan pada pasien dengan diagnosis CKD yang menjalani hemodialisis dengan penyakit penyerta hipertensi dan diabetes melitus tipe 2. PTO dilakukan melalui pengumpulan data primer dari wawancara pasien dan keluarganya, serta data sekunder dari rekam medis dan catatan medis lainnya. Metode Hepler dan Strand digunakan dalam menganalisis DRPs. Hasil PTO menunjukkan tiga kategori DRP teridentifikasi, di antaranya dosis obat terlalu tinggi, indikasi tanpa obat, dan pemilihan obat yang kurang tepat. Semua DRP yang ditemukan telah diatasi dengan rekomendasi terapi alternatif yang sesuai dengan persetujuan dokter penanggung jawab.

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Chronic kidney disease (CKD) is a condition that occurs due to damage to the kidneys and/or a decrease in the glomerular filtration rate (GFR) below 60 mL/min/1.73 m2 for more than three months. The prevalence of CKD is increasing globally, including in Indonesia, with hypertension and diabetic nephropathy as the main comorbidities. Therapy for CKD patients with complications of hypertension and diabetes mellitus often involves polypharmacy, increasing the risk of drug-related problems (DRPs). Drug therapy monitoring (DTM) is an essential process to ensure the safety, efficacy, and rationality of the treatment received by patients. DTM was conducted on patients with a diagnosis of CKD undergoing hemodialysis with comorbidities of hypertension and type 2 diabetes mellitus. DTM was conducted by collecting primary data from interviews with patients and their families, as well as secondary data from medical records and other medical documents. The Hepler and Strand method was used to analyze DRPs. The results of DTM showed three categories of DRPs identified, including excessive drug dosage, indication without medication, and inappropriate drug selection. All DRPs found have been addressed with recommendations for alternative therapies in accordance with the approval of the responsible physician."

"Revolusi industri 4.0 membawa transformasi signifikan melalui digitalisasi, otomatisasi, dan konektivitas, yang berdampak pada berbagai industri, termasuk industri farmasi. PT Bintang Toedjoe, dalam rangka mendukung program Making Indonesia 4.0, mengadopsi teknologi digital dengan mengembangkan aplikasi QC Cikarang Apps. Aplikasi ini memudahkan pemantauan pemantauan real-time inventaris, sampel dan pengawasan data di Departemen Quality Control (QC). Tugas khusus ini bertujuan untuk memvalidasi sistem komputer QC Cikarang Apps guna memastikan fungsi pengendalian yang cukup, mencegah akses tidak sah dan menjamin integritas data sesuai prinsip ALCOA (Attributtable, Legible, Contamporaneous, Original, Accurate). Metode yang digunakan meliputi observasi, wawancara dengan administrator dan user, dan penyusunan berbagai dokumen kualifikasi dan validasi. Hasil validasi sistem komputer menunjukkan bahwa Analytical Worksheet pada Aplikasi QC Cikarang Apps memenuhi spesifikasi dan standar kualitas yang ditetapkan sesuai dengan pedoman CPOB 2018 dan CPOTB 2021 tentang sistem komputerisasi dan dokumentasi. Pengoperasian aplikasi ini juga memenuhi prinsip data integrity ALCOA, memastikan semua aspek pada laporan Analytical Worksheet yang digunakan oleh Departemen QC PT Bintang Toedjoe sesuai dengan standar ALCOA.

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The Industry 4.0 revolution has brought significant transformation through digitalization, automation, and connectivity, impacting various industries, including the pharmaceutical industry. PT Bintang Toedjoe, in support of the Making Indonesia 4.0 program, has adopted digital technology by developing the QC Cikarang Apps application. This application facilitates real-time monitoring of inventory, samples, and data supervision in the Quality Control (QC) Department. This special project aims to validate the Analytical Worksheet in QC Cikarang Apps computer system to ensure adequate control functions, prevent unauthorized access, and guarantee data integrity in accordance with the ALCOA (Attributable, Legible, Contamporaneous, Original, Accurate) principles. The methods used include observation, interviews with administrators and users, and preparation of various qualification and validation documents. The computer system validation results show that the Analytical Worksheet in the QC Cikarang Apps Application meets the specifications and quality standards set in compliance with the 2018 Good Manufacturing Practices (CPOB) and 2021 CPOTB guidelines on computerized systems and documentation. The operation of this application also adheres to the ALCOA data integrity principle, ensuring that all aspects of the Analytical Worksheet reports used by the QC Department of PT Bintang Toedjoe comply with ALCOA standards."

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"Penelitian ini bertujuan untuk mengetahui pengaruh mediasi dari problem-focused coping pada hubungan antara job insecurity dan manajemen impresi. Dengan menggunakan Transactional Stress Theory sebagai acuan, individu dengan job insecurity tinggi akan mempersepsikan bahwa dirinya masih bisa mengubah keadaan di tempat kerjanya menjadi lebih baik dengan cara mengaktifkan problem-focused coping yang pada gilirannya akan meningkatkan perilaku proaktif berupa manajemen impresi. Data diperoleh dari karyawan yang berasal dari berbagai organisasi di Jakarta N = 286, dan dianalisis dengan macro Hayes pada SPSS versi 20. Hasil penelitian menunjukkan bahwa tidak terdapat pengaruh positif yang signifikan antara job insecurity dan manajemen impresi, tidak terdapat pengaruh positif yang signifikan antara job insecurity dengan problem-focused coping, terdapat pengaruh positif antara problem-focused coping terhadap manajemen impresi. Secara lebih lanjut, problem focused coping secara signifikan memediasi hubungan antara job insecurity dan manajemen impresi. Implikasi teoritis dan praktis akan dibahas selanjutnya dalam penelitian ini.

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The study aims to investigate the mediating effect of problem focused coping on the relationship between job insecurity and impression management. Using Transactional Stress Theory to explain the relationship, it is suggested that a person with high job insecurity will perceive situation at work as something that can be modified, thus will lead them to perform impression management. Data were collected among employees from various organizations in Jakarta N 286, and were analyzed using the Hayes's PROCESS macro on SPSS version 20.

The results showed that there is no significant relationship between job insecurity and impression management, there is a negative and significant relationship between job insecurity and problem focused coping, and there is a significant positive relationship between problem focused coping and impression management. Furthermore, the indirect effect of job insecurity and impression management via problem focused coping was found significant. Theoretical and practical implications will be discussed later in this study. "