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Abstrak :
ABSTRAK
Bawang putih (Alliuw. sativu Linn.) biasa digunakan sebagai bumbu untuk bermacam masakan, dan sebagai obat tradisional untuk beberapa penyakit tertentu. Walaupun informasi ilmiah mengenai efek farmakologi bawang putih telah banyak diketahui, namun informasi mengenai mekanisme kerjanya masih sangat sedikit. Pada penelitian iini akan dilihat pengaruh pemberian bawang putih (A11iui sativum Linn.) terhadap kadar senyawa-senyawa yang mengandung gugus sulfhidril pada hati dan darah tikus yang diberi karbon tetrakiorida. Delapan belas ekor tikus jantan, Strain Wistar, berumur + 3 bulan, dan berat 120 - 160 gram, dibagi secara acak dalam tiga kelompok. Kelompok I adalah kelompok kontrol; kelompok II adalah kelompok yang diberi Cd 4 0055 mg/g BB pada hari kedelapan; kelompok III adalah kelompok yang diberi sari air bawang putih 10 g/kg BB selama delapan Mari berturut-turut dan pada Mari ice aeLapan setelah diberi sari air bawang putih, 2 jam kemudian diberi CC1 4 0,55 mg/g BB. Pada hari ke sepuluh ketiga kelompok tikus ini dibedah. Pengaruh pemberian bawang putih dilihat melalui perubahan aktivitas GPT plasma, kadar senyawa-senyawa yang mengandung gugus sulfhidril pada hati dan kadar senyawa-senyawa yang mengandung gugus sulfhidril pada plasma darah. HasH penelitian menunjukkan tidak adanya perbedaan yang bermakna antara kelompok III dengan kelompok I dan adanya perbedaan bermakna antara kelompok III dengan kelompok II. Maka dapat disimpulkan bahwa pemberian bawang putih dapat melindungi hati dari kerusakan akibat Cd4 dengan mencegah penurunan kadar senyawa-senyawa yang mengandung gugus sulfhidril pada hati dan plasma darah tikus yang diberi karbon tetrakiorida.

Abstrak :
Hiperkolesterolemia adalah salah satu faktor risiko mayor yang dapat memicu berkembangnya penyakit kardiovaskular, khususnya penyakit jantung koroner. Salah satu obat tradisional yang digunakan untuk hiperkolesterolemia adalah kombinasi herba seledri (Apium graveolens) dan bawang putih (Allium sativum). Penelitian ini bertujuan untuk mengetahui gambaran efek ekstrak terhadap profil lipid pada subjek hiperkolesterolemia. Subjek terdiri atas pasien klinik pengobatan tradisional di Jakarta. Masing-masing subjek mendapatkan tablet terapi yang berisi ektrak dan tabel placebo sesuai kelompok. Pada subjek diperiksa profil lipid, yaitu kadar kolesterol total darah, HDL, LDL, dan trigliserida. Dilakukan paired t-test dua ekor untuk menguji perbedaan antara profil lipid dari kelompok terapi dan kelompok placebo. Subjek sejumlah 44 orang. Perubahan profil lipid pada antara kelompok terapi dan kelompok placebo untuk kadar kolesterol total, HDL, LDL, dan trigliserida adalah 14,82±6,946, 1,45±2,945, 6,98±8,105, 2,48±6,504 mg/dL. Campuran ektrak berefek menurunkan kolesterol darah dan kadar LDL secara bermakna (P<0,05). Hypercholesterolemia is one of the major risk factors that can trigger the development of cardiovascular disease, especially coronary heart disease. One of the traditional drugs used for hypercholesterolemia is a combination of herbs celery (Apium graveolens) and garlic (Allium sativum). This study aims to describe the effects of the extract on lipid profile in hypercholesterolemic subjects. Subjects consisted of patients with traditional medicine clinic in Jakarta. Each subject received treatment tablets containing extract and placebo table corresponding groups. On the subject examined lipid profile, ie blood levels of total cholesterol, HDL, LDL, and triglycerides. Do paired two-tailed t-test to test the difference between lipid profile of the therapy group and the placebo group. The subject of a number of 44 people. Changes in the lipid profile between the treatment groups and the placebo group for total cholesterol, HDL, LDL, and triglycerides was 14,82 ± 6,946;1.45 ± 2,945;6,98 ± 8,105;2,48 ± 6,504 mg/dL. A mixture of extracts affect blood cholesterol and LDL levels were significantly (P <0.05).

Abstrak :
ABSTRAK Hiperkolesterolemia adalah salah satu faktor risiko mayor yang dapat memicu berkembangnya penyakit kardiovaskular, khususnya penyakit jantung koroner. Salah satu obat tradisional yang digunakan untuk hiperkolesterolemia adalah kombinasi herba seledri (Apium graveolens) dan bawang putih (Allium sativum). Penelitian ini bertujuan untuk mengetahui gambaran efek ekstrak terhadap profil lipid pada subjek hiperkolesterolemia. Subjek terdiri atas pasien klinik pengobatan tradisional di Jakarta. Masing-masing subjek mendapatkan tablet terapi yang berisi ektrak dan tabel placebo sesuai kelompok. Pada subjek diperiksa profil lipid, yaitu kadar kolesterol total darah, HDL, LDL, dan trigliserida. Dilakukan paired t-test dua ekor untuk menguji perbedaan antara profil lipid dari kelompok terapi dan kelompok placebo. Subjek sejumlah 44 orang. Perubahan profil lipid pada antara kelompok terapi dan kelompok placebo untuk kadar kolesterol total, HDL, LDL, dan trigliserida adalah 14,82±6,946, 1,45±2,945, 6,98±8,105, 2,48±6,504 mg/dL. Campuran ektrak berefek menurunkan kolesterol darah dan kadar LDL secara bermakna (P<0,05).

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ABSTRACT Hypercholesterolemia is one of the major risk factors that can trigger the development of cardiovascular disease, especially coronary heart disease. One of the traditional drugs used for hypercholesterolemia is a combination of herbs celery (Apium graveolens) and garlic (Allium sativum). This study aims to describe the effects of the extract on lipid profile in hypercholesterolemic subjects. Subjects consisted of patients with traditional medicine clinic in Jakarta. Each subject received treatment tablets containing extract and placebo table corresponding groups. On the subject examined lipid profile, ie blood levels of total cholesterol, HDL, LDL, and triglycerides. Do paired two-tailed t-test to test the difference between lipid profile of the therapy group and the placebo group. The subject of a number of 44 people. Changes in the lipid profile between the treatment groups and the placebo group for total cholesterol, HDL, LDL, and triglycerides was 14,82 ± 6,946;1.45 ± 2,945;6,98 ± 8,105;2,48 ± 6,504 mg/dL. A mixture of extracts affect blood cholesterol and LDL levels were significantly (P <0.05).

Abstrak :
Tanaman bawang putih (Allium sativum L) termasuk dalam genus Allium yang diperbanyak secara vegetatif melalui umbi. Virus merupakan salah satu penyakit penting yang perlu dipecahkan pada pembiakan vegetatif ini. Teknik inkonvensional kultur jaringan yang dikombinasikan dengan kemoterapi dapat membantu menghilangkan penyakit virus. Penelitian ini bertujuan untuk melihat pengaruh dari beberapa konsentrasi antiviral ribavirin di media MS terhadap pertumbuhan dan perkembangan shoot tip Bawang putih cv Lumbu Hijau, cv. Lumbu Kuning, cv. Tawangmangu. Percobaan dilakukan di laboratorium kultur jaringan, Balai Penelitian Tanaman Sayur (Balitsa), pada bulan Mei hingga Juli 2015. Sasaran penelitian adalah untuk menghasilkan tanaman bebas virus dengan menggunakan teknik kultur jaringan yang dikombinasikan dengan kemoterapi. Varibel yang diamati adalah pertumbuhan dan perkembangan planlet bawang putih. Hasil dari penelitian (1) Kontaminasi kultur umumnya disebabkan oleh bakteri dan jamur dengan persentase 10 % sampai dengan 30%. (2) Penambahan antiviral ribavirin, semakin tinggi konsentrasi persentase tumbuh dan berkembang semakin rendah untuk ketiga kultivar (3) Pengamatan secara visual penambahan antiviral ribavirin dan kultivar tidak berpengaruh pada jumlah tunas, rata-rata dari satu eksplan tumbuh satu tunas untuk ketiga kultivar (4). Penambahan antiviral ribavirin dan kultivar tidak mempengaruhi pertumbuuhan daun, akar ketiga kultivar (5).Hasil pengujian virus dengan teknik DAS ELISA persentase kultur yang terinfeksi 54.55% sampai dengan 100 %.

Abstrak :
[Senyawa bahan alam yang mengandung banyak senyawa pereduksi dan gugus-gugus organik kurang termanfaatkan dengan baik untuk sintesis nanopartikel. Ekstrak bawang putih (EBP) (allium sativum L) dapat dimanfaatkan sebagai reaktan dalam pembuatan nanopartikel Au (AuNP). EBP dapat mereduksi dan menstabilkan AuNP. AuNP di karakterisasi menggunakan spektrofotometer UV-Vis dan TEM sedangkan EBP dikarakterisasi menggunakan FTIR, dan LCMS. AuNP optimum yang di karakterisasi menggunakan TEM memiliki ukuran 15 nm dan memiliki kestabilan hingga 33 hari. Berdasarkan hasil FTIR dan LCMS, senyawa aktif yang diduga berperan sebagai agen pereduksi adalah asam askorbat (vitamin C), gula bebas seperti, surosa, glukosa, dan fruktosa, allin, alicin, dan s-alilsitein dan senyawa aktif yang diduga berperan sebagai agen penstabil adalah -glutamilsistein, -glutamil-s-alilsistein, -glutamil phenil alanin, s-alil mercaptosistein, metil alil tiosulfonat, dan prophenil alil tiosulfonat. AuNP yang terbentuk dapat dimanfaatkan sebagai pendeteksi terhadap formalin dan melamin pada kondisi pH 3,6.

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Compounds of natural product that many contain reducing compounds and organic groups are less well utilized for the synthesis of nanoparticles. Garlic exstract (EBP) (allium sativum L) can be used as a reactant in the manufacture of nanoparticles Au (AuNP). EBP can reduce dan stabilize AuNP. AuNP characterized using spectrophotometer UV-Vis and TEM while EBP characterized using FTIR and LCMS. AuNP optimum that characterized by TEM has size 15 nm and has stability up to 33 days. Based on the results of FTIR and LCMS, the active compounds are expected have role as reducing agent is ascorbic acid (vitamin C), free sugar such as, sukrose, glucose, and fructose, allin, Alicin, and s-alilsitein and the active compounds are thought to act as a stabilizing agent is γ-glutamilsistein, γ-glutamyl-s-alilsistein, γ-glutamyl phenil alanine, s-allyl mercaptosistein, allyl methyl tiosulfonat, and allyl prophenil tiosulfonat. Aunp formed can be used as a detector of the formaldehyde and melamine at pH 3.6.;Compounds of natural product that many contain reducing compounds and organic groups are less well utilized for the synthesis of nanoparticles. Garlic exstract (EBP) (allium sativum L) can be used as a reactant in the manufacture of nanoparticles Au (AuNP). EBP can reduce dan stabilize AuNP. AuNP characterized using spectrophotometer UV-Vis and TEM while EBP characterized using FTIR and LCMS. AuNP optimum that characterized by TEM has size 15 nm and has stability up to 33 days. Based on the results of FTIR and LCMS, the active compounds are expected have role as reducing agent is ascorbic acid (vitamin C), free sugar such as, sukrose, glucose, and fructose, allin, Alicin, and s-alilsitein and the active compounds are thought to act as a stabilizing agent is γ-glutamilsistein, γ-glutamyl-s-alilsistein, γ-glutamyl phenil alanine, s-allyl mercaptosistein, allyl methyl tiosulfonat, and allyl prophenil tiosulfonat. Aunp formed can be used as a detector of the formaldehyde and melamine at pH 3.6.;Compounds of natural product that many contain reducing compounds and organic groups are less well utilized for the synthesis of nanoparticles. Garlic exstract (EBP) (allium sativum L) can be used as a reactant in the manufacture of nanoparticles Au (AuNP). EBP can reduce dan stabilize AuNP. AuNP characterized using spectrophotometer UV-Vis and TEM while EBP characterized using FTIR and LCMS. AuNP optimum that characterized by TEM has size 15 nm and has stability up to 33 days. Based on the results of FTIR and LCMS, the active compounds are expected have role as reducing agent is ascorbic acid (vitamin C), free sugar such as, sukrose, glucose, and fructose, allin, Alicin, and s-alilsitein and the active compounds are thought to act as a stabilizing agent is γ-glutamilsistein, γ-glutamyl-s-alilsistein, γ-glutamyl phenil alanine, s-allyl mercaptosistein, allyl methyl tiosulfonat, and allyl prophenil tiosulfonat. Aunp formed can be used as a detector of the formaldehyde and melamine at pH 3.6.;Compounds of natural product that many contain reducing compounds and organic groups are less well utilized for the synthesis of nanoparticles. Garlic exstract (EBP) (allium sativum L) can be used as a reactant in the manufacture of nanoparticles Au (AuNP). EBP can reduce dan stabilize AuNP. AuNP characterized using spectrophotometer UV-Vis and TEM while EBP characterized using FTIR and LCMS. AuNP optimum that characterized by TEM has size 15 nm and has stability up to 33 days. Based on the results of FTIR and LCMS, the active compounds are expected have role as reducing agent is ascorbic acid (vitamin C), free sugar such as, sukrose, glucose, and fructose, allin, Alicin, and s-alilsitein and the active compounds are thought to act as a stabilizing agent is γ-glutamilsistein, γ-glutamyl-s-alilsistein, γ-glutamyl phenil alanine, s-allyl mercaptosistein, allyl methyl tiosulfonat, and allyl prophenil tiosulfonat. Aunp formed can be used as a detector of the formaldehyde and melamine at pH 3.6.;Compounds of natural product that many contain reducing compounds and organic groups are less well utilized for the synthesis of nanoparticles. Garlic exstract (EBP) (allium sativum L) can be used as a reactant in the manufacture of nanoparticles Au (AuNP). EBP can reduce dan stabilize AuNP. AuNP characterized using spectrophotometer UV-Vis and TEM while EBP characterized using FTIR and LCMS. AuNP optimum that characterized by TEM has size 15 nm and has stability up to 33 days. Based on the results of FTIR and LCMS, the active compounds are expected have role as reducing agent is ascorbic acid (vitamin C), free sugar such as, sukrose, glucose, and fructose, allin, Alicin, and s-alilsitein and the active compounds are thought to act as a stabilizing agent is γ-glutamilsistein, γ-glutamyl-s-alilsistein, γ-glutamyl phenil alanine, s-allyl mercaptosistein, allyl methyl tiosulfonat, and allyl prophenil tiosulfonat. Aunp formed can be used as a detector of the formaldehyde and melamine at pH 3.6., Compounds of natural product that many contain reducing compounds and organic groups are less well utilized for the synthesis of nanoparticles. Garlic exstract (EBP) (allium sativum L) can be used as a reactant in the manufacture of nanoparticles Au (AuNP). EBP can reduce dan stabilize AuNP. AuNP characterized using spectrophotometer UV-Vis and TEM while EBP characterized using FTIR and LCMS. AuNP optimum that characterized by TEM has size 15 nm and has stability up to 33 days. Based on the results of FTIR and LCMS, the active compounds are expected have role as reducing agent is ascorbic acid (vitamin C), free sugar such as, sukrose, glucose, and fructose, allin, Alicin, and s-alilsitein and the active compounds are thought to act as a stabilizing agent is γ-glutamilsistein, γ-glutamyl-s-alilsistein, γ-glutamyl phenil alanine, s-allyl mercaptosistein, allyl methyl tiosulfonat, and allyl prophenil tiosulfonat. Aunp formed can be used as a detector of the formaldehyde and melamine at pH 3.6.]