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"Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus anggur 300 gram per hari selama dua minggu terhadap kadar kolesterol LDL laki danperempuan dengan kolesterol total batas tinggi. Penelitian ini merupakan uji klinik para!el, membandingkan 18 orang dalam kelompok yang mendapat jus anggur disertai penyuluhan gizi dengan 17 orang daJam kelmnpok yang hanya mendapat penyuluhan gizi. Subyek yang memenuhi kriteria penelitian dibagi menjadi dua kelompok dengan randomisasi sederhana. Data yang diambil meliputi usia. jenis kelamin1 tingkat pendidikan, indeks massa tubuh (IMT), aktivitas ftSik, riwayat hiperkolesterolemia, asupan energi, lemak, serat kolesterol dan polifenol. Pemeriksaan IMT, asupan energi) lemak, serat, kofesterol, dan polifenol serta kolesterol LDL dlakukan pada awal, selama dan akhir perlakuan. Analisis data dilakukan dengan menggunakan uji t tidak berpasangan dan Mann wliitncy dengan batas kemaknaan 5%. Sebanyak l8 orang kelompok P dan 14 orang ke!ompok K dengan usia 25-44 tahun dapat mengikuti penelitian seear.t. fengkap, Indeks aktivitas fisik rata rata termasuk eukup. Data awal menunjukkan perbedaan yang tidak bermakna (p>0,05). Setelah 14 hari perlakuan. diketahui persentase asupan energi subyek terhadap kebutuhan energi total termasuk kategori cub.'Up pada kelompok perlakuan (89,1 ± 21,6%) dan kurang pada kelompok kontrol (78,8 ± 17,2%). Asupan lemak kedua kelompok seiama pedakuan tergolong cukup. Tidak terdapat perbedaan bermakna antara kedua kelompok. Asupan serat dan kolesterol kedua kelompok selama perlakuan tidak berbeda bermakna. Asupan polifenol lebih tinggi pada kelompok perlakuan 631,9 (594,4-753,4) mg/hari dibandingkan dengan asupan kelompok kontrol 63,1 (4,5-140,4) mg/hari Pada kedua kelompok didapatkan penurunan kadar kolesterol LDL. Penurunan yang lebih besar teijadi pada kelompok perlakuan, namun tidak berbeda bermakna (p>0,05) dengan penurunan pada kelompok kontrol. Dengan pemberian 300 gram jus anggur scJama dua minggu tidak didapatkan perbedaan bermakna penurunan kolestcrot LDL antara kelompok perlakuan dan kelompok kontrol.

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The aim of this study was to investigate the effect of 300 gram per day grape juice for two weeks on LDL-cholesterol le""is in borderline total cholesterol of male and female subjects. The study is a parallel! randomized clinical trial. The subjects random were divided into two groups using simple randomization. The treatment group was given grape juice and nutrition counseling (n = 18) and the control group received nutrition counseling alone, n=l7. Data collected including age, sex, Jevel of education, physical activity, body mass index (BMl), hypercholesterolemic intake of energy, fat, fiber, cho!esteroand polyphenol. Laboratory findings of LDL­ cholesterol levels and BMI examination were done before and after treatment Intake of energy, fut, fiber, cholesterol, and polyphenoi were examined before) during, and after the treatment Statistical analysis, was done using unpaired t and Mann Whitney tests with the signnficant level of 5%. Eighteen subjects. were age 25-44 years old, in the treatment group and fourteen subjects in the control group completed the study. The physical activity index in both groups is categorized as sufficient. The characteristics of the two groups not significantly different at base line (p >0,05). After fourteen days of treatment, ail subjects in the treatment group had energy intake meet the requirement of&9,1 ± 21,6 %whereas the control group average did not 7&,& ± i7.2 %. Intake off in both groups was sufficient, the control group had above recommended intake. Intake of fiber and cholesterol in both group was not significantly different. The average intake of polyphcnol in the treatment group increased significantly higher than in the control group 631,9 (594,4-753,4) and 63,12 (4,5-140,4) mg/day respectively. There was a greater decrease in LOL-cholesterol levels in the treatment group compared to the control group.although not statistically significant (p >0,05). In conclusions, the effects of 300 gram per day grape juice for two weeks decrease LDL-cholesterol the treatment group higher than the control but was not significantly."

"Penelitian uji klinik dengan one group pre-post test design bertujuan untuk mengetahui pengaruh pemberian susu bubuk kedelai terbadap peroksidasi lipid dengan mengukur kadar MDA. Terdapat 21 subyek perempuan perimenopause deugan hiperkolestero!emia yang memenuhi kriteria penelitian, mengkomsumsi susu bubuk kede!ai setiap hari sebanyak 2x30g selama delapan minggu, Data yang diambil adalah: data demografi, IMT, asupan zat gizi, isoflavon dan emioksidan. Data laboratorium meliputi kadar kolesterol LDL dan MDA serum sebelum dan sesudah empat, delapan minggu perlakuan. Uji statistik yang digunakan adalah uji t-berpasangan blla distribusi normal dan uji Wilcaxon bila distribusi tidak normal dengan tingkat kemaknaan p<0,0:5. Penelitian ini telah mendapat ijin dari Komite Etik FKUI. Dua subyek drop out, 19 subyek menyelesaikan penetitian; umumnya berlatar belakang pendidikan rendah rerata usia 49,15 tahun dan lMT tergolong berisiko. Asupan kalori subyek penelitian sebelum perlakuan tergolong kurang, tetapi kemudian tergolong cukup setelah perlalkuan. Pola dan asupan harian isollavon subyek penelitian sebelum perlakuan tergolong cukup, meningkat setelah perlakuan. Pola dan asupan harian antioksidan subyek sebelum dan selama masa perlakuan tergolong krang, Rerata kadar kolesterol LDL subyek penelitian sebelum masa perlakuan adalah 134,32 ± 23,70 mg/dl. Setelah perlakuan menurun, tetapi masih tergolong batas tinggi. Rerala kadar MDA serum subyek penelilian sebelum masa perlakuan adalah 0,82 ± 0,47 nmol/mL. Setelah empat dan delapan minggu masa perlakuan kadar MDA serum meningkat, yaitu masing­ masing sebesar 0,98 ± 0,26 umol/ml (p 0,16) dan 1,13 ± 0,40 nmol/ml (p 0,023). Beberapa faktor yang mungkin menjadi penyebab peningkatan tersebut adalah faktor subyek, biomarker MDA, bioaviabilitas dan karakteristik isoflavon serta asupan antioksidan. Bila subyek digolongkan berdasarksn status pre dan pasca menopause, maka setelah minggu IV pedakuan golongan premenopause menunjukkan penurunan kadar MDA yang lebih baik.

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The objective of this study is to investigate the effect of soy powder-milk supplementation on lipid peroxidation which is measured by the level of it's metabolite, malondialdehyde (MDA). Twenty one hypercholesterolentic pre-menopause women who fulfilled the study criteria. started ro consume 2x30g soy powder-milk everyday for eight week. Data taken were: demographic, anthropometric, nutrition intake, isoftavone, antioxidant pattern of isotlavone and antioxidant intake. Whilst laboratory data taken were level of LDL cholesterol and MDA serum before and after four and eight week supplementation. Statistical tests used were paired test if named distribution and Wilcoxon for up normal distribution with significance level of 5%.

Nineteen subjects completed the study. Most subjects had a low educational background, mean age were 49.15 years old and bed BMI classified as "risk." The subjects' calorie intake before supplementation was low, however after the forth and eighth week of supplementation was renegade as sufficient. Subjects' inkwell pattern and daily intake of isoflavoue were sufficient anti increased during supplementation. outtake pattern anti daily inkwell of antioxidant subjects before and doting supplementation were low. The subjects' mean level of LDL cholesterol before supplementation was 134,32 ± 23,70 mgldl. After four anti eight week supplementation it decrease considerably at 120,79 ± 21,30 and 122,68 ± 20,95 mgldL, which was still categorizeas "high". Subjects' mean level of MDA serum before supplementation was 0,82 ± 0,47 nmoVmL.

After fuur anti eight week of supplementation level of MDA serum was increase consecutively at 0,98 ± 0,26 mnollmL (p = 0,16) and 1,13 ± 0,40 nmollmL (p = 0,023). Several fuctJS that might cause the increase were subjects' age, menopausal status, and BMJ, MDA biomalker, bio availabilily and characteristics of isotlavoue and antioxidant intake. The g100ped of subjects in pre and post-menopause status sbowu different pattern of MDA level which is after four weeks of supplementation the pre-menopause subjects shown reduced of MDA level more than post menopausal subjects."

"Tujuan penelitian adalah diketahuinya kolerasi antara IMT dan kadar kolesterol LDL serum pada subyek dengan hiperkolesterolemia Penelitian ini menggunakan disain pre post test, pada penderita hiperkolesterolemia yang mernenuhi kriteria penerimaan dan tidak memenuhi kriteria penolakan, Serta telah mengikuti penelitian yang telah diselenggarakan di Departernen Ilmu Gizi Fakultas Kedokteran Universitas Indonesia satu tahun lalu yang beijudul ?Pengaruh Pemberian Fitosterol dan Serat terhadap Profil Lipid dan [3 Karoten pada usia 20 tahun atau lebih?. Data yang diambil meliputi, karaktcristik demografi, asupan makanan., aktivitas fisik, IMT, dan kadar kolesterol LDL serum. Jumlah subyek adalah 38 orang berusia rata-rata 43,26 ;l: 8,08 tahun dan 68,42% subyek adalah perempuan dan 44,'74% berpendidikan tinggi.Rerata pola asupan: pola asupan kalori 1388,ll i- 274,08 kkal; pola asupan 1-carbohidrat 166,13 =I= 41,39 g, pola asupan lcmak 61,76 i 17,76 g; pola asupan kolestcrol 169,31 i 71,83 mg dan pola asupan serat 7,5 i 2,22 g; Rerata asupan: asupan kalori l4l3,07 i 482,71 kkal atau 77,30 i 28,00% KKT; asupan karbohidrat 182,01 J; 67,87 g atau 34,93 4: l0,34% KKT; asupan lernak 51,58 i 26,36 g atau 17,15 3; 8,64% KKT; asupan kolesterol 145,86 i 120,44 mg dan asupan serat 16,82 t 11,38 g. Rerata Indeks aktivitas fisik 8,05 i 1,12 dan 100% subyek penelitian memiliki aktivitas tergolong scdang dan tinggi. Rerata IMT 26,84 i 4,84 kg/m2 dengan 89,5% tergolong obes sekarang. Rerata kadar kolesterol LDL 160,24 4; 27,06 mg/dL dengan 4'/,37% memiliki kadar kolesterol LDL tinggi dan sangat tinggi sekarang. Tidak terdapat korelasi antara IMT dan kadar kolesterol LDL serum.

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To determine the correlation of BMI and LDL Cholesterol Serum in hypercholesterolemia subject Research with pre post rest design in hypercholesterolernia subject that fulfill the inclusion criteria and not in exclusion criteria, and has joined last year research executed by Department of Nutrition of Medical Faculty, University of Indonesia with title ? The Effect of Phytosterol and Fibre toward Lipid Profile and [3 Karoten at the age of 20 years old or upper ?. Data taken include demographic characteristic, nutrition intake, physical activity, BMI, and LDL cholesterol scrum level. Number of subject is 38 people within average of 43,26 i 8,08 years old, 68,42% are women and 44,74% are graduated.The average intake pattern : calory intake l388,ll i 274,08 kkal; carbohydrate intake 166,13 i 41,39 g, fat intake 61,76 i 17,76 g; cholesterol intake 169,31 i 71,83 mg and fibre intake 7,5 1 2,22 g. Intake average 1 calory intake 1413,ov e 422,71 mal or 77,30 1 28,00% KKT; carbohydrate intake 182,01 :te 67,87 g or 34,93 :iz l0,34% KKT; fat intake 51,58 i 26,36 g or 17,15 :t 8,64% KKT; cholesterol intake l45,86 i 120,44 mg and fibre intake 16,82 i 11,38 g. Average of the physical activity index 8,05 i 1,12 and l00%. Research subject have middle and high activities. Average BMI 26,84 i 4,84 kg/m2 with 89,5% in obese. The average of LDL cholesterol serum 160,24 i 27,06 mg/dL with 47,37% have high and highest LDL cholesterol level. There is no correlation between BMI and LDL cholesterol serum."

"Penelitian ini adalah diketahuinya pengarub pemberian jus anggur 300 gram per hari selama dua minggu terhadap kadar NO serum laki-laki dan perempuan dengan kadar kolesterol total batas tinggi. Penelitian ini merupakan sebuab field trial, membandingkan Ul subyek dalam kelompok yang mendapatkan jus anggur disertai penyuluhan TIC (P) dengan 17 subyek dalam kelompok yang hanya mendapatkan penyuluhan 1LC (K). Subyek yang memenuhi kriteria penelitian dibagi menjadi dua kelompok dengan randomisasi sederhana. Data yang diambil melipoti usia, jenis kelamin, riwayat hiperkolesterolemia dalam keluarga, akrivitas fisik, indeks massa tubuh (IMT), asupan energi, lernak, kolesterol, serat, dan polifenol dengan food record. Pemeriksaan kadar kolesterol total dan NO serum dilekukan di awal dan ekhir perlekuan. Analisis data menggunakan uji t tidak berpasangan dan uji Mann Whitney dengan batas kernaknaan 5%. Sebanyak 18 subyek pada kelompok P dan 14 subyek pada kelompok K, dengan rerata usia 35,57±5,20 tahun mengikuti penelitian secara lengkap. Indeks akrivitas fisik subyek kedua ke!ompok termasuk di bawah rata-rata. Data awal tidak didapatkan perbedaan bermakna (p>O,OS). Setelah dua minggu perlakuan, didapatkan persentase asupan energi terbadap kebutuhan energi total termasuk kategori cukup pada kelompok perlakuan dan kurang pada kontrol. Asupan lemak total dan kolesterol kadua kelompok adalah tergolong cukup. Asupan serat tergolong kurang. Terdapat perbadaan bermakna asupan polifenol pada kedua kelompok selama perlakuan (p<0,05). Terdapat peningkatan kadar NO serum sesudab perlekuan pada kedua kelompok yang tidak berbeda bermakna (p>O,OS), bahkan terdapat penurunan kadar kolesterol total serum pada kedua kelompok sesudah perlekuan meskipun tidak berbeda bermakna (p>0,05) dan masih dalam kategori batas tinggi. Pemberian jus anggur 300 gram per han tidak didapatkan perbedaan bermakna peningkatan kadar NO serum antara kelompok perlakuan dan kontrol.

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The aim of this study was to investigate the effect of grape juice (that made from 300 grams of grapes per day) during two weeks on serum NO level in male and female subjects with borderline high total cholesterol level. The study was a field trial Thirty five subjects were selected using certain criteria and randomly (simple randomization) divided into two groups. The treatment group (n=18) received grape juice and nutrition counseling; the control group (n=l7) received nutrition counseling. Data obtained directly from the subjects were age, gender, history of hypercholesterolemia in .subject's family, physical activity, and body mass index, intake of energy, fat, cholesterol~ fiber and polyphenol using food record. Laboratory findings of serum NO level and total cholesterol level were done before and after intervention. For statistical analysis, unpaired t-test and Mann Whitney were used with the level of significance was S%. Eighteen subjects in the treatment group and fourteen subjects in the control group completed the study and analyzed. Mean of age was 35.57±5.20 years old. The physical activity index of bath groups were low. The characteristics of the two groups were closely matched at base line (p>O.OS). After two weeks intervention, subjects? energy consumed in the treatment group achieved the recommended diet, while in the control group was below. The average intake of total fat and cholesterol in both groups achieved the recommended diet, but the fiber intake were below. The average intake of polyphenol in the treatment group was increased significantly than the control group (pQ.05). There were decreased on serum total cholesterol level in bath groups, although not statistically significant (p>O.OS). The effect of gyape juice for two weeks did not significantly increase serum NO level in the treatment group."