Hasil Pencarian  ::  Simpan CSV :: Kembali

"Latar belakang: Alopesia androgenetika merupakan kelainan kerontokan rambut yang paling sering ditemukan, dengan karakteristik kebotakan yang berpola. Kelainan ini sering ditemui pada pria. Hubungan alopesia androgenetika dengan penyakit kronik antara lain resistensi insulin terutama pada pasien pria alopesia androgenetika awitan dini telah dilaporkan pada beberapa penelitian tetapi dengan hasil yang beragam.Tujuan: Untuk mengetahui proporsi resistensi insulin menggunakan indeks homeostasis model assestment (HOMA), serta korelasi resistensi insulin dengan derajat keparahan alopesia androgenetika pada kelompok pria alopesia androgenetika awitan dini.Desain: Penelitian deskriptif analitik dengan rancangan potong lintangHasil: Didapatkan 41 subyek penelitian (SP), skala Norwood Hamilton paling banyak adalah skala III (41,5 %), diikuti oleh skala IV (26,8 %), dan skala V (12,2 %). Pada penelitian ini terdapat 10 SP (24,4%) dengan resistensi insulin. Berdasarkan analisis statistik, tidak terdapat hubungan yang bermakna antara derajat alopesia dengan resistensi insulin. (r2 = 0.14, p > 0.05).Kesimpulan: Resistensi insulin dapat ditemukan 24,4 % pasien pria alopesia androgenetika awitan dini tetapi tidak didapatkan korelasi derajat alopesia dengan tingkat resistensi insulin.

---

Background: Androgenetic alopecia is the most commonly found hair loss with patterned baldness. This disorder usually found in men. The relation between androgenetic alopecia with chronic disease among others is insulin resistance in male early onset androgenetic alopecia patient has been reported by several studies with varied results.

Purpose: This study is to investigate the proportion of insulin resistance based on homeostasis model assestment (HOMA) index and its correlation with the degree of alopecia in male early onset androgenetic alopecia.

Study design: This is an analytic descriptive study, sampling method is cross sectional.

Result: The subjects are 41 men with androgenetic alopecia, aged 18-35 years. The percentage of the Norwood Hamilton scale among the patients is 41,5 % for grade III, 26,8 % for grade IV, and 12,2 % for grade V. The insulin resistance is present in 10 subject (24,4%). Based on statistical analysis, there is no significant correlation between alopecia’s degree with insulin resistance (r2 = 0.14, p > 0.05).

Conclusion: the insulin resistance can be found on 24,4 % of male with early onset androgenetic alopecia patients. However there is no correlation between alopecia’s degree and insulin resistance level."

"Latar belakang: Data kualitas hidup pasien kulit di Indonesia masih terbatas, antara lain disebabkan belum ada instrumen penilai kualitas hidup untuk kelainan dermatologi berbahasa Indonesia yang valid dan reliabel. Tujuan penelitian ini adalah ingin menilai validitas dan reliabilitas Dermatology Life Quality Index (DLQI) berbahasa Indonesia sebagai suatu alat untuk menilai kualitas hidup pasien dengan berbagai penyakit kulit di Indonesia. Metode: Dermatology Life Quality Index orisinal berbahasa Inggris diterjemahkan mengikuti prosedur standar ke dalam bahasa Indonesia. DLQI versi Indonesia yang telah disetujui oleh pihak pembuat DLQI orisinal diisi oleh 100 pasien rawat jalan dengan berbagai diagnosis (akne, dermatitis atopik, kusta, psoriasis, dan vitiligo) di poliklinik Ilmu Kesehatan Kulit dan kelamin Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo Indonesia. Analisis validitas menggunakan validitas konstruksi, dilakukan dengan menghitung korelasi antara tiap pernyataan dengan skor total (korelasi Pearson). Konsistensi internal menggunakan Cronbach α digunakan untuk analisis reliabilitas. Hasil: Usia pasien pada penelitian ini antara 18 hingga 59 tahun (median 30 tahun). Skor DLQI rata-rata yaitu 9,75±6,319. Validitas DLQI berbahasa Indonesia dinilai cukup baik, dengan koefesien korelasi tiap pertanyaan dengan skor total yaitu 0,310 - 0,699. Reliabilitas DLQI berbahasa Indonesia dinilai baik, dengan Cronbach α 0.858. Kesimpulan: DLQI versi Indonesia merupakan instrumen yang valid dan reliabel untuk menilai kualitas hidup pasien dengan berbagai penyakit kulit.

---

Background: The dermatology patient’s quality of life data in Indonesia is limited, partly because unavailability of valid and reliable dermatology specific quality of life measuring tool in Indonesian language. The aim of this study is to assess validity and reliability of Dermatology Life Quality Index (DLQI) to measure the quality of life of patients with various skin diseases in Indonesia.

Methods: The English version of DLQI was translated according to standard procedures to Indonesian language. The approved Indonesian version of DLQI by its developer was administered to 100 outpatients with various dermatological diagnoses (acne, atopic dermatitis, leprosy, psoriasis, vitiligo) attending the dermatovenereology clinic at the national general hospital of Indonesia, dr. Cipto Mangunkusumo Hospital. Construct validity analysis was carried out by using item–total score correlations (Pearson correlation). Internal consistency using Cronbach α were used for reliability analysis.

Results: Age of patients in this study ranged from 18 to 59 years (median 30 years). The mean score of DLQI was 9,75±6,319. Validity of Indonesian version of DLQI considered moderate, with item-total score correlation coefficient 0.310-0.699. Reliability of Indonesian version of DLQI considered good, with Cronbach α 0.858.

Conclusion: Indonesian version of the DLQI is a valid and reliable instrument for assessing the quality of life of patients with various skin diseases."

"[ABSTRAKLatar belakang dan tujuan: Akne vulgaris (AV) adalah penyakit peradangan menahun unit pilosebasea yang bersifat swasirna, ditandai dengan lesi pleomorfik berupa papul, komedo, pustul, dan nodul. Pengobatan AV memerlukan waktu yang cukup lama. Penyakit menahun dengan waktu pengobatan yang lama, berdampak terhadap kepatuhan pasien. Kepatuhan pengobatan topikal lebih rendah daripada sistemik. Hanya akne vulgaris ringan (AVR) yang diterapi menggunakan obat-obatan topikal saja. Layanan pesan singkat merupakan salah satu cara yang praktis dan efisien dalam upaya meningkatkan kepatuhan pengobatan AV, dengan pertimbangan prevalensi AV lebih banyak pada usia remaja dan dewasa muda yang merupakan pengguna terbanyak layanan tersebut. Dengan layanan ini, diharapkan pasien tidak lupa menggunakan obat topikal pada AVR. Penelitian ini dilakukan untuk mengetahui efektivitas penggunaan pesan singkat elektronik terhadap kepatuhan pengobatan AVR.Metode: Studi eksperimen dengan desain randomized controlled trial (RCT) terhadap pasien AVR usia 15-25 tahun yang berobat ke Poliklinik Ilmu Kesehatan Kulit dan Kelamin (IKKK) Rumah Sakit dr. Cipto Mangunkusumo (RSCM). Penelitian ini melibatkan 2 kelompok, yaitu: kelompok intervensi yang mendapat pesan singkat elektronik dan kelompok kontrol. Kedua kelompok diberi pengobatan tretinoin krim 0,05% dan/atau klindamisin gel 1,2% selama 6 minggu.Hasil: Tidak terdapat perbedaan bermakna antara kepatuhan pengobatan AVR kelompok kontrol dengan kelompok intervensi pada minggu kedua (p=0,376) dan keempat (p=0,432). Namun pada minggu keenam, kelompok intervensi secara bermakna lebih patuh daripada kelompok kontrol (p=0,032).Kesimpulan: Pesan singkat elektronik meningkatkan kepatuhan pengobatan AVR terutama pada minggu keenam di Poliklinik IKKK RSCM.

---

ABSTRACTBackground and objectives: Acne vulgaris (AV) is a self limited, chronic inflammatory disease of pilosebaceous unit, characterized by pleomorphic lesions consist of papules, comedones, pustules, and nodules. Acne vulgaris requires a long duration of treatment. Chronic disease with a long duration of therapy usually has an impact on adherence. Topical therapy adherence is lower than systemic. Only mild AV is treated with topical medications. Electronic text messaging is a practical and efficient method in order to improve adherence to AV therapy, with a consideration of the AV prevalence are more on teens and young adults who are the majority users of electronic text messaging service. With this method, patients are expected not to forget the use of medication. This study was conducted to determine the effectiveness of electronic text messaging to improve adherence of mild AV therapy.Methods: Experimental study, randomized controlled trial (RCT) to mild AV patients, age 15-25 years old who came to Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital. This study involved two groups: intervention group who received electronic text messaging, and the contrary is the control group. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin 1,2% gel for six weeks.Results: There were no significant differences in adherence of mild AV therapy between both groups in the second (p = 0.376) and fourth week (p = 0.432). The intervention group was significantly higher in terms of adherence than the control group in the sixth week (p = 0.032).Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital.;Background and objectives: Acne vulgaris (AV) is a self limited, chronicinflammatory disease of pilosebaceous unit, characterized by pleomorphic lesionsconsist of papules, comedones, pustules, and nodules. Acne vulgaris requires along duration of treatment. Chronic disease with a long duration of therapyusually has an impact on adherence. Topical therapy adherence is lower thansystemic. Only mild AV is treated with topical medications. Electronic textmessaging is a practical and efficient method in order to improve adherence toAV therapy, with a consideration of the AV prevalence are more on teens andyoung adults who are the majority users of electronic text messaging service.With this method, patients are expected not to forget the use of medication. Thisstudy was conducted to determine the effectiveness of electronic text messagingto improve adherence of mild AV therapy.Methods: Experimental study, randomized controlled trial (RCT) to mild AVpatients, age 15-25 years old who came to Dermatology and Venereology Clinicdr. Cipto Mangunkusumo Hospital. This study involved two groups: interventiongroup who received electronic text messaging, and the contrary is the controlgroup. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin1,2% gel for six weeks. Results: There were no significant differences in adherence of mild AV therapybetween both groups in the second (p = 0.376) and fourth week (p = 0.432). Theintervention group was significantly higher in terms of adherence than the controlgroup in the sixth week (p = 0.032). Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital.;Background and objectives: Acne vulgaris (AV) is a self limited, chronicinflammatory disease of pilosebaceous unit, characterized by pleomorphic lesionsconsist of papules, comedones, pustules, and nodules. Acne vulgaris requires along duration of treatment. Chronic disease with a long duration of therapyusually has an impact on adherence. Topical therapy adherence is lower thansystemic. Only mild AV is treated with topical medications. Electronic textmessaging is a practical and efficient method in order to improve adherence toAV therapy, with a consideration of the AV prevalence are more on teens andyoung adults who are the majority users of electronic text messaging service.With this method, patients are expected not to forget the use of medication. Thisstudy was conducted to determine the effectiveness of electronic text messagingto improve adherence of mild AV therapy.Methods: Experimental study, randomized controlled trial (RCT) to mild AVpatients, age 15-25 years old who came to Dermatology and Venereology Clinicdr. Cipto Mangunkusumo Hospital. This study involved two groups: interventiongroup who received electronic text messaging, and the contrary is the controlgroup. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin1,2% gel for six weeks. Results: There were no significant differences in adherence of mild AV therapybetween both groups in the second (p = 0.376) and fourth week (p = 0.432). Theintervention group was significantly higher in terms of adherence than the controlgroup in the sixth week (p = 0.032). Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital., Background and objectives: Acne vulgaris (AV) is a self limited, chronicinflammatory disease of pilosebaceous unit, characterized by pleomorphic lesionsconsist of papules, comedones, pustules, and nodules. Acne vulgaris requires along duration of treatment. Chronic disease with a long duration of therapyusually has an impact on adherence. Topical therapy adherence is lower thansystemic. Only mild AV is treated with topical medications. Electronic textmessaging is a practical and efficient method in order to improve adherence toAV therapy, with a consideration of the AV prevalence are more on teens andyoung adults who are the majority users of electronic text messaging service.With this method, patients are expected not to forget the use of medication. Thisstudy was conducted to determine the effectiveness of electronic text messagingto improve adherence of mild AV therapy.Methods: Experimental study, randomized controlled trial (RCT) to mild AVpatients, age 15-25 years old who came to Dermatology and Venereology Clinicdr. Cipto Mangunkusumo Hospital. This study involved two groups: interventiongroup who received electronic text messaging, and the contrary is the controlgroup. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin1,2% gel for six weeks. Results: There were no significant differences in adherence of mild AV therapybetween both groups in the second (p = 0.376) and fourth week (p = 0.432). Theintervention group was significantly higher in terms of adherence than the controlgroup in the sixth week (p = 0.032). Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital.]"

"ABSTRAKLatar belakang dan tujuan: Xerosis atau kulit kering merupakan masalahkesehatan yang sering dijumpai pada usia lanjut. Prevalensi xerosis pada usialanjut berkisar antar 30 ? 58%. Salah satu faktor yang dijumpai pada kulit keringadalah penurunan ekspresi aquaporin-3 (AQP3). Bahan herbal pegagan atauCentella asiatica ekstrak etanol dalam nanopartikel kitosan (CAEENPK) secara invitro diketahui dapat meningkatkan ekspresi AQP3 pada keratinosit yang berperandalam hidrasi kulit. Penelitian ini bertujuan untuk membandingkan efektivitas dankeamanan krim pelembap yang mengandung Centella asiatica ekstrak etanoldalam nanopartikel kitosan 1%, Centella asiatica ekstrak etanol (CAEE) 1%, dankrim pelembap dasar pada populasi geriatri dengan kulit kering.Metode: Penelitian uji klinis acak tersamar buta ganda dilakukan pada 43 orangpenghuni panti werdha di Jakarta. Evaluasi skin capacitance (SCap), specifiedsymptom sum score (SRRC), derajat gatal, dan efek samping dilakukan pada awalterapi, minggu kedua, dan keempat. Setelah prakondisi selama satu minggu, setiapsubjek penelitian mendapatkan tiga pelembap yang berbeda secara acak pada tigalokasi di tungkai bawah.Hasil: Tidak didapatkan peningkatan nilai SCap yang berbeda bermakna antaraketiga kelompok pengobatan. Penurunan nilai SRRC setelah empat minggu tidakberbeda bermakna antara ketiga kelompok perlakuan. Derajat gatal pada minggukedua menurun pada ketiga kelompok, hingga menjadi tidak gatal pada seluruhSP (100%) setelah minggu keempat. Tidak ditemukan efek samping subjektif danobjektif pada ketiga kelompok perlakuan.Kesimpulan: Efektivitas krim pelembap yang mengandung CAEENPK 1% tidaklebih tinggi dibandingkan dengan krim pelembap yang mengandung CAEE 1%atau krim pelembap dasar, serta memiliki keamanan yang sama dalam mengatasikekeringan kulit pada populasi geriatri.Kata kunci: Centella asiatica, nanopartikel, aquaporin-3, hidrasi kulit, geriatri

---

ABSTRACTBackground and objectives: Xerosis or dry skin is a common health issue foundin the elderly. The prevalence rate of xerosis in the elderly ranges between 30 -58%. One of the factors found on dry skin is decreased expression of aquaporin-3(AQP3). The herbal plant Centella asiatica ethanol extract in chitosannanoparticle (CAEENPK) has been found to increase the expression of AQP3 onkeratinocytes in vitro which plays a role in skin hydration. This study aims tocompare the effectiveness and safety of moisturizing cream containing 1%Centella asiatica ehanol extract in chitosan nanoparticle, 1% Centella asiaticaethanol extract (CAEE), and moisturizing cream base in geriatric population withdry skin.Methods: A double-blind randomized controlled trial was conducted on 43residents of a nursing home in Jakarta. The evaluation of skin capacitance (SCap),specified symptom sum score (SRRC), pruritic degree, and side effects weremeasured at baseline, week-2, and week-4 after therapy. After a week ofpreconditioning, each test subject received three different randomizedmoisturizing creams to be applied on three separate locations on the lower limbs.Results: There was no significant increase in SCap value among the threetreatment groups. The decrease in SRRC value after four weeks did not differamong the three treatment groups. The pruritic degree decreased at the secondweek of treatment in all three groups and completely diminished after the fourthweek among all the test subjects (100%). No objective and subjective side effectswere found among the three treatment groups.Conclusion: The efectiveness of moisturizing cream containing 1% CAEENPK isnot higher when compared to moisturizing cream containing 1% CAEE ormoisturizing cream base. It is also as safe in treating dry skin of geriatricpopulation;;ABSTRAKLatar belakang dan tujuan: Xerosis atau kulit kering merupakan masalahkesehatan yang sering dijumpai pada usia lanjut. Prevalensi xerosis pada usialanjut berkisar antar 30 ? 58%. Salah satu faktor yang dijumpai pada kulit keringadalah penurunan ekspresi aquaporin-3 (AQP3). Bahan herbal pegagan atauCentella asiatica ekstrak etanol dalam nanopartikel kitosan (CAEENPK) secara invitro diketahui dapat meningkatkan ekspresi AQP3 pada keratinosit yang berperandalam hidrasi kulit. Penelitian ini bertujuan untuk membandingkan efektivitas dankeamanan krim pelembap yang mengandung Centella asiatica ekstrak etanoldalam nanopartikel kitosan 1%, Centella asiatica ekstrak etanol (CAEE) 1%, dankrim pelembap dasar pada populasi geriatri dengan kulit kering.Metode: Penelitian uji klinis acak tersamar buta ganda dilakukan pada 43 orangpenghuni panti werdha di Jakarta. Evaluasi skin capacitance (SCap), specifiedsymptom sum score (SRRC), derajat gatal, dan efek samping dilakukan pada awalterapi, minggu kedua, dan keempat. Setelah prakondisi selama satu minggu, setiapsubjek penelitian mendapatkan tiga pelembap yang berbeda secara acak pada tigalokasi di tungkai bawah.Hasil: Tidak didapatkan peningkatan nilai SCap yang berbeda bermakna antaraketiga kelompok pengobatan. Penurunan nilai SRRC setelah empat minggu tidakberbeda bermakna antara ketiga kelompok perlakuan. Derajat gatal pada minggukedua menurun pada ketiga kelompok, hingga menjadi tidak gatal pada seluruhSP (100%) setelah minggu keempat. Tidak ditemukan efek samping subjektif danobjektif pada ketiga kelompok perlakuan.Kesimpulan: Efektivitas krim pelembap yang mengandung CAEENPK 1% tidaklebih tinggi dibandingkan dengan krim pelembap yang mengandung CAEE 1%atau krim pelembap dasar, serta memiliki keamanan yang sama dalam mengatasikekeringan kulit pada populasi geriatri.Kata kunci: Centella asiatica, nanopartikel, aquaporin-3, hidrasi kulit, geriatri

---

ABSTRACTBackground and objectives: Xerosis or dry skin is a common health issue foundin the elderly. The prevalence rate of xerosis in the elderly ranges between 30 -58%. One of the factors found on dry skin is decreased expression of aquaporin-3(AQP3). The herbal plant Centella asiatica ethanol extract in chitosannanoparticle (CAEENPK) has been found to increase the expression of AQP3 onkeratinocytes in vitro which plays a role in skin hydration. This study aims tocompare the effectiveness and safety of moisturizing cream containing 1%Centella asiatica ehanol extract in chitosan nanoparticle, 1% Centella asiaticaethanol extract (CAEE), and moisturizing cream base in geriatric population withdry skin.Methods: A double-blind randomized controlled trial was conducted on 43residents of a nursing home in Jakarta. The evaluation of skin capacitance (SCap),specified symptom sum score (SRRC), pruritic degree, and side effects weremeasured at baseline, week-2, and week-4 after therapy. After a week ofpreconditioning, each test subject received three different randomizedmoisturizing creams to be applied on three separate locations on the lower limbs.Results: There was no significant increase in SCap value among the threetreatment groups. The decrease in SRRC value after four weeks did not differamong the three treatment groups. The pruritic degree decreased at the secondweek of treatment in all three groups and completely diminished after the fourthweek among all the test subjects (100%). No objective and subjective side effectswere found among the three treatment groups.Conclusion: The efectiveness of moisturizing cream containing 1% CAEENPK isnot higher when compared to moisturizing cream containing 1% CAEE ormoisturizing cream base. It is also as safe in treating dry skin of geriatricpopulation.Keywords: Centella asiatica, nanoparticle, aquaporin-3, skin hydration,geriatrics"

"Psoriasis merupakan penyakit autoimun yang disebabkan kelainan genetik dan dipicu faktor lingkungan, penyakit ini menyerang kulit dan sistemik seperti sendi dan kuku. Sel punca mesenkim (SPM) asal tali pusat manusia memiliki kapasitas proliferasi yang tinggi, imunomodulator yang luas dan imunogenitas yang rendah. Penelitian ini menggunakan model tikus psoriasis yang diinduksi dengan krim imiquimod 5% selama 6 hari. Tikus dibagi menjadi kelompok 5 kelompok yang diberi SPM atau Phosphate Nuffer Saline (PBS) secara intradermal atau subkutan serta kontrol normal. Pemberian SPM dan PBS dilakukan sebelum pengolesan krim. Penilaian harian kulit tikus dilakukan dengan skoring modified Psoriasis Area and Severity Index (mPASI). Setelah pembedahan, kulit tikus dianalisa terhadap ekspresi relatif gen Interleukin (IL)-17 dan IL-10. Sebagian kulit difiksasi dengan formalin dan dilakukan pemeriksaan histologi dan imunohistokimia dengan antibodi Anti-CD11b. Analisa statistik memperlihatkan skor mPASI kelompok SPM mengalami penurunan bermakna dibanding kelompok PBS. Ekspresi relatif gen IL-17 menurun dan gen IL-10 meningkat pada kelompok SPM dibandingkan PBS. Pewarnaan Hematoksilin dan Eosin memperlihatkan rerata tebal epidermis dan jumlah kapiler mengalami penurunan pada kelompok SPM dibanding PBS. Rerata jumlah infiltrasi sel CD11b+ kelompok SPM menurun secara bermakna dibandingkan PBS. Penyuntikan SPM terutama intradermal mampu menyebabkan remisi pada lesi lokal kulit psoriasis pada model tikus Wistar.

---

Psoriasis is a chronic inflammatory disease affecting mainly the skin and other parts such as nails and joints. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are highly proliferative immunomodulator cells with low immunogenicity. The Psoriasis rat model was induced with 5% imiquimod cream for 6 days. The rats were divided into 5 groups receiving intradermal or subcutaneous injections of hUC-MSCs or Phosphate Buffer Saline (PBS), and a normal control group. MSCs and PBS were administered before cream application. Daily skin assessments were performed using a modified Psoriasis Area and Severity Index (mPASI) scoring system. After harvest, rat skin was analyzed for relative expression of Interleukin (IL)-17 and IL-10 genes. Some skin samples were fixed with formalin for histological examination and immunohistochemistry with Anti-CD11b antibodies. Statistical analysis showed a significant reduction in mPASI scores in the hUC-MSCs group compared to the PBS group. Histology staining revealed a decrease in epidermal thickness and capillary in the hUC-MSCs group. The infiltration of CD11b+ cells significantly decreased in the hUC-MSCs group.  The relative gen expression of IL-17 decreased, while IL-10 gene increased in the hUC-MSCs group. Particularly, intradermal injection of hUC-MSCs induced remission of local psoriasis skin lesions in the rat model."

"Latar belakang: Alopesia androgenetik (AAG) merupakan penyebab kebotakan rambut yang paling sering ditemui dan mengganggu kualitas hidup. Meskipun AAG tidak mengancam nyawa, namun berbagai studi menunjukkan bahwa AAG tidak hanya dianggap sebagai penyakit kulit/estetik semata namun berkaitan dengan kondisi-kondisi sistemik, salah satunya adalah sindrom metabolik (SM). Beberapa studi menunjukkan juga bahwa pola kebotakan pada AAG memiliki risiko yang berbeda terhadap penyakit tertentu. Penelitian ini bertujuan hubungan antara pola kebotakan AAG tipe verteks dan tipe frontal terhadap SM. Metode: Penelitian ini menggunakan desain studi potong lintang yang dilakukan terhadap 24 laki-laki dengan AAG tipe verteks dan 24 laki-laki dengan AAG tipe frontal. Dilakukan anamnesis dan pemeriksaan fisik untuk menegakkan diagnosis AAG berdasarkan skala Norwood-Hamilton, serta dilakukan pengambilan foto, pemeriksaan trikoskopi, TrichoScan® pada masing-masing subjek penelitian. Sindrom metabolik ditegakkan berdasarkan kriteria National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III melalui pemeriksaan fisik dan laboratorium darah vena. Hasil: Prevalensi SM pada kelompok AAG tipe verteks adalah sebesar 37,5%, sedangkan pada tipe frontal sebesar 20,8%. Tidak didapatkan hubungan antara SM dengan AAG tipe verteks ataupun tipe frontal (p = 0,341). Pada kelompok AAG tipe verteks didapatkan prevalensi hipertensi yang lebih tinggi secara bermakna dibandingkan kelompok AAG tipe frontal (p = 0,043). Tidak ada perbedaan bermakna gambaran trikoskopi ataupun TrichoScan® antara AAG tipe verteks dan tipe frontal. Kesimpulan: Prevalensi SM pada kelompok AAG tipe verteks lebih besar dibandingkan pada kelompok AAG tipe frontal. Tidak ada hubungan bermakna antara pola kebotakan AAG dengan SM. Tidak ada hubungan bermakna gambaran trikoskopi dan TrichoScan® antara kelompok AAG tipe verteks dengan tipe frontal.

---

Background: Androgenetic alopecia (AAG) is the most common cause of hair loss, impacting quality of life. Although AAG is not life-threatening, various studies indicate that it is not merely a cosmetic skin condition but is associated with specific systemic conditions, including metabolic syndrome (MS). Some studies also suggest that the pattern of baldness in AAG poses varying risks for specific diseases. This research aims to explore the relationship between AAG vertex and frontal patterns of baldness and metabolic syndrome.

Methods: This study adopts a cross-sectional design involving 24 males with vertex AAG and 24 males with frontal AAG. Anamnesis and physical examinations were conducted to diagnose AAG using the Norwood-Hamilton scale. Each subject underwent photography, trichoscopy, and TrichoScan®, examination. Metabolic syndrome diagnosis followed the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria through physical examination and venous blood laboratory tests.

Results: The prevalence of metabolic syndrome in the AAG vertex group is 37.5%, whereas in the frontal group, it is 20.8%. No significant relationship was found between metabolic syndrome and AAG vertex or frontal types (p = 0.341). The AAG vertex group showed a significantly higher prevalence of hypertension than the frontal group (p = 0.043). There were no significant differences in trichoscopy or TrichoScan®¸ findings between AAG vertex and frontal types.

Conclusion: The prevalence of metabolic syndrome is higher in the AAG vertex group compared to the AAG frontal group. There is no significant association between metabolic syndrome and the pattern of AAG baldness. Additionally, there is no significant difference in trichoscopy and TrichoScan®¸ findings between AAG vertex and frontal groups."

"Latar belakang: Diabetes melitus tipe 2 merupakan salah satu penyakit metabolik yang sering dijumpai dan merupakan salah satu dari empat prioritas penyakit tidak menular. Prevalensi penyakit DM meningkat dengan pesat dan akan menjadikan Indonesia peringkat ke empat dunia. Betambahnya jumlah penyandang DM dan komplikasi akibat DM menjadi beban negara terutama bagi negara berkembang seperti Indonesia. Salah satu komplikasi yang terkait dengan bidang Ilmu Kesehatan Kulit dan Kelamin adalah komplikasi mikrovaskular yakni neuropati. Neuropati otonom ditandai dengan kulit kering dan jumlah keringat yang berkurang. Kekeringan kulit yang tidak di tata laksana dengan baik mempermudah timbulnya kaki diabetik. Tujuan: Mengetahui pengaruh kadar HbA1c dan gula darah terhadap kulit kering pada pasien DM tipe 2. Metode: Penelitian ini merupakan studi potong lintang yang dilakukan terhadap pasien diabetes melitus tipe 2 di Poliklinik Endokrin Ilmu Penyakit Dalam dan Poliklinik Ilmu Kesehatan Kulit dan Kelamin RSUPN. Dr Cipto Mangunkusumo, Jakarta pada bulan Juli hingga September 2018. Dilakukan anamnesis, pemeriksaan fisik untuk menentukan derajat kekeringan kulit dengan menggunakan penilaian SRRC, dilanjutkan dengan pemeriksaan corneometer dan tewameter. Terakhir dilakukan pemeriksaan laboratorium darah untuk kadar HbA1c dan GDS. Hasil: Didapatkan total 95 subjek dengan usia rerata 54 tahun, hampir sebagian besar pasien tidak merokok, tidak menggunakan pelembap dan AC, tidak menggunakan air hangat untuk mandi, mengkonsumsi obat penurun kolesterol, mengalami neuropati dan menopause, serta durasi lama DM ≥5 tahun. Hasil utama penelitian ini didapatkan korelasi yang bermakna secara statistik antara kadar HbA1c dengan nilai SRRC berdasarkan uji nonparametrik Spearman (r = 0,224; p = 0,029). Perhitungan statistik dilanjutkan kembali dengan analisis stratifikasi dan regresi linear stepwise.

---

Background: Type 2 diabetes mellitus is one of the most common metabolic diseases and is one of the top four non-contagious priorities. DM prevalence has been increasing rapidly and would make Indonesia ranked fourth in the worldwide. The increasing number of people with DM and its associated complications are major burden, especially for developing countries such as Indonesia. One of the complications associated with Dermatology and Venereology is microvascular complications, specifically neuropathy. Autonomic neuropathy is characterized by dry skin and reduced amount of sweat. Unmanaged dry skin is a potential risk factor of developing diabetic foot.

Objective: To determine the effect of HbA1c and blood glucose level on dry skin in type 2 diabetes mellitus patient.

Methods: This study was a cross-sectional study conducted on patients with type 2 diabetes mellitus in the Endocrine outpatient clinic of the Internal Medicine and Dermatology and Venereology outpatient clinic of RSUPN. Dr. Cipto Mangunkusumo, Jakarta from July to September 2018. History taking, physical examination to determine the degree of skin dryness using SRRC assessment, followed by examination of the corneometer and tewameter. At last, blood test examination was performed for HbA1c and random blood glucose levels measurement.

Results: A total of 95 subjects were enrolled with an average age of 54 years, most if the patients were non-smoker, did not use moisturizers and air conditioning, did not use warm water for bathing, consumed cholesterol lowering agent, experienced neuropathy and menopause, and have been suffering DM for more than 5 years. The main results of this study were statistically significant correlation between HbA1c levels and SRRC values based on the Spearman nonparametric test (r = 0,224; p = 0,029). Statistical calculations were continued with stratification analysis and stepwise linear regression. "

"Latar belakang : Pruritus kronis adalah sensasi tidak menyenangkan yang mencetuskan keinginan untuk menggaruk, berlangsung enam minggu atau lebih. Pruritus sering dihubungkan dengan sejumlah kelainan sistemik. Salah satu kelainan sistemik tersering yang disertai pruritus kronis adalah kelainan hati hepatobilier kolestasis. Patofisiologi terjadinya pruritus kolestasis dihubungkan dengan peningkatan akumulasi mediator pruritogenik salah satunya yaitu asam empedu serum total (AEST) di darah perifer begitu juga di jaringan lunak termasuk kulit, yang secara normal diekskresikan ke empedu. Masih sedikit yang mengetahui kemungkinan peran peningkatan kadar AEST dengan kejadian pruritus. Tujuan : mengetahui perbedaan rerata kadar AEST pada pasien geriatri tanpa dermatosis primer yang mengalami pruritus kronis dan tanpa pruritus kronis Metode : penelitian ini merupakan penelitian potong lintang, dengan subyek penelitian sejumlah 80 orang, terdiri atas perempuan dan laki-laki usia ≥ 60 tahun. Subyek penelitian dibagi menjadi dua kelompok, yaitu kelompok pruritus terdiri atas 40 pasien pruritus kronis, dan kelompok kontrol yang terdiri atas 40 pasien tanpa pruritus kronis. Kadar AEST dinilai menggunakan metode enzimatik kolorimetri, kemudian dianalisis perbedaan kadar AEST antar kedua kelompok. Hasil: kadar AEST pada kelompok pruritus didapatkan median 4,5 μmol/L, dengan nilai minimum-maksimum yaitu 3-51 μmol/L. Kadar AEST pada kelompok non-pruritus didapatkan median empat μmol/L, dengan nilai minimum-maksimum 3-22 μmol/L, perbedaan ini tidak bermakna (p = 0,095). Kesimpulan: Kadar AEST pada kelompok pruritus lebih tinggi dibandingkan kelompok non-pruritus, namun tidak bermakna secara statistik.

---

Background : Chronic pruritus is defined as an unpleasant sensation of the skin leading to the desire to scratch, which lasting six weeks or more. Pruritus is associated with numerous systemic disorders, and it is a common symptom of any cholestatic hepatobiliary disease. Its pathophysiology is attributed to progressive accumulation of pruritogenic mediators such as bile acid in the peripheral blood as well as in soft tissues including the skin, which are normally excreted into the bile. Little is known about the potential contribution of elevated total serum bile acids (TSBA) levels to pruritus.

Objective : to differentiate TSBA levels in geriatrics patients with chronic pruritus and without chronic pruritus.

Methods : this is a cross-sectional study comprising 80 patients men and women aged ≥ 60 years old, consist of 40 patients in chronic pruritic group, and 40 patients in non-pruritic group. The serum levels of bile acid were measured by enzymatic colorimetric methods, and the level TSBA were analyzed from the two groups.

Results : TSBA levels were detected higher in chronic pruritic group patients (median 4,5 μmol/L, minimum-maximum range 3-51 μmol/L), than in the non-pruritic group (median 4 μmol/L, range 3-22 μmol/L), the difference was insignificant (p = 0,095).

Conclusions : the serum bile acid levels are elevated in chronic pruritic patients but statistically insignificant."

"Latar belakang: Diabetes melitus (DM) dapat menimbulkan komplikasi kulit kering yang berkorelasi dengan pembentukan ulkus pada pasien DM. Pemakaian pelembap sebagai bagian dari perawatan kaki dapat mencegah pembentukan ulkus. Tujuan: Mengetahui efektivitas dan keamanan pelembap yang mengandung krim urea 10% dan vaselin album untuk mengatasi kulit kering pada pasien DM tipe 2. Metode: Uji klinis acak tersamar ganda dilakukan pada 68 pasien DM tipe 2 dengan kulit kering pada bulan Juli-Oktober 2018. Setiap subjek penelitian mendapat terapi krim urea 10% atau vaselin album untuk masing-masing tungkai. Perbaikan kulit kering dilihat dari skor klinis specified symptom sum score (SRRC), hidrasi kulit (korneometer) dan fungsi sawar kulit (tewameter) pada minggu kedua dan keempat. Hasil: Tidak terdapat perbedaan efektivitas yang bermakna antara kelompok krim urea 10% dan vaselin album. Kedua pelembap ini tidak menimbulkan efek samping. Kesimpulan: Kedua jenis pelembap ini sama efektif dan dapat dipertimbangkan untuk terapi kulit kering pada pasien DM tipe 2.

---

Background: Diabetes mellitus (DM) could cause xerotic skin which correlates with ulcer formation in DM patients. Daily use of moisturizer as part of foot care were expected to prevent it. Objective: To asses the effectiveness and safety of moisturizers containing 10% urea cream and white petrolatum in overcoming dry skin in type 2 DM patients. Methods: A double blind randomized clinical trial was conducted on 68 diabetes patients with xerotic skin in July-October 2018. Each study subject received 10% urea cream or white petrolatum for each leg. Repair of xerotic skin assessed from the specified symptom sum score (SRRC), skin hydration (corneometer) and skin barrier function (tewameter) in the second and fourth weeks. Results: There was no significant difference in effectiveness between the two groups. Both moisturizers were well tolerated."

"Ulkus kaki diabetik (UKD) merupakan luka kronik pada pasien diabetes melitus (DM). Vitamin D dipercaya memiliki peran penting pada diferensiasi, proliferasi, pertumbuhan sel, dan modulasi sistem imunitas sehingga kadar yang optimal dibutuhkan untuk penyembuhan luka. Defisiensi vitamin D juga diduga mengganggu produksi dan sekresi insulin sehingga berkontribusi pada kronisitas UKD. Penelitian bertujuan membandingkan kadar vitamin D pada pasien DM dengan dan tanpa UKD; serta untuk mengetahui korelasi antara durasi UKD dan keparahan UKD berdasarkan skor PEDIS (perfusion, extension, depth, infection, sensation) dengan kadar vitamin D. Serum 25-hidroksivitamin D (25(OH)D) dianalisis menggunakan in-vitro chemiluminescent immunoassay (CLIA). Analisis statistik yang sesuai dilakukan untuk membuktikan tujuan penelitian. Perbandingan nilai median (Q1-Q3) kadar vitamin D pada pasien DM dengan dan tanpa UKD secara berurutan adalah 8,90 ng/mL (6,52-10,90) dan 16,25 ng/mL (13-19,59), serta bermakna secara statistik (p<0,001). Tidak ada korelasi antara durasi UKD dan keparahan UKD berdasarkan skor PEDIS terhadap kadar vitamin D, serta tidak bermakna secara statistik. Hasil pada penelitian ini menunjukkan bahwa kadar vitamin D pada pasien DM dengan UKD lebih rendah dibandingkan pasien tanpa UKD. Namun belum ada bukti yang cukup untuk menyimpulkan bahwa tidak ada korelasi antara durasi UKD dan keparahan UKD berdasarkan skor PEDIS terhadap kadar vitamin D.

---

Diabetic foot ulcers (DFU) are chronic wounds in patients with diabetes mellitus (DM). Vitamin D believed have important role in differentiation, proliferation, cell growth, and immune system modulation hence optimal levels are needed for wound healing. Vitamin D deficiency also thought to interfere insulin production and secretion, thereby contributing to DFU chronicity. This study aims to compare vitamin D levels in DM patients with and without DFU; and determine the correlation between DFU duration and severity by PEDIS (perfusion, extension, depth, infection, sensation) score to vitamin D levels. 25-hydroxyvitamin D serum analyzed using in-vitro chemiluminescent immunoassay. Appropriate statistical analysis was done following the study. Comparison of median values ​​(Q1-Q3) vitamin D levels in DM patients with and without DFU were 8.90 ng/mL (6.52-10.90) and 16.25 ng/mL (13-19.59) respectively, and statistically significant (p<0.001). There was no correlation between DFU duration and severity PEDIS score to vitamin D levels, and it was not statistically significant. The results of this study indicate that vitamin D levels in DM patients with DFU are lower than patients without DFU. However, there is not enough evidence to conclude that there is no correlation between DFU duration and severity by PEDIS score to vitamin D levels."