Hasil Pencarian  ::  Simpan CSV :: Kembali

Hasil Pencarian

Ditemukan 115762 dokumen yang sesuai dengan query
cover
Chorniansyah Indriyanto Rahayu
Pengaruh asupan garam terhadap tekanan darah nokturnal pada pasien hipertensi yang mendapatkan terapi penyekat EKA = Effects of salt intake to nocturnal blood pressure in hypertensive patients administered Angiotensin Converting Enzyme (ACE) inhibitors
"ABSTRAK
Latar Belakang : Hipertensi merupakan faktor resiko utama penyakit kardiovaskular,
terutama sindrom koroner akut dan stroke. Peningkatan konsumsi garam berhubungan
dengan kenaikan tekanan darah. Beberapa studi randomized-controlled trial (RCT)
menyatakan bahwa konsumsi rendah garam dapat menurunkan tekanan darah pada
populasi dewasa dengan atau tanpa hipertensi. Variabilitas tekanan darah selama 24 jam
bersifat dinamis. Peningkatan darah nokturnal memiliki makna klinis yang cukup besar,
merupakan salah satu prediktor dari penyebab kerusakan target organ, terutama kejadian
kardiovaskular dan stroke. Asupan garam dapat mempengaruhi variasi tekanan darah 24
jam, yang dalam hal ini dapat juga berpengaruh pada hipertensi nokturnal. Obat penyekat
EKA merupakan obat hipertensi lini pertama yang sering digunakan, terutama pada usia
muda dan hipertensi yang disertai sindrom metabolik, mengingat peranan Sistem Renin
Angiotensin memiliki peranan yang sangat penting dalam patofisiologi hipertensi. Asupan
garam juga memiliki peranan pada patofisiologi terjadinya hipertensi dalam sistem Renin
Angiotensin. Sedikit studi yang meneliti perpaduan obat penyekat EKA dengan asupan
rendah garam dalam menrunkan kejadian hipertensi. Oleh karena itu, Menarik untuk diteliti
pengaruh asupan garam dengan tekanan darah nokturnal pada pasien yang mengkonsumsi
obat penyekat EKA.
Tujuan : Menilai pengaruh asupan garam dengan tekanan darah nokturnal pada pasien
hipertensi yang mendapatkan terapi penyekat EKA.
Metode : Pasien poliklinik berusia 30 ? 50 tahun yang terdiagnosis hipertensi dan belum
pernah mendapatkan anti-hipertensi sebelumnya, dibagi menjadi 2 kelompok (asupan
rendah garam (Na <15 g/hari) dan asupan tinggi garam ≥15 g/hari). Kedua kelompok akan
diberikan lisinopril dan dilakukan pemeriksaan natrium urin 24 jam dan home blood
pressure monitoring..
Hasil Penelitian : Sebanyak 80 pasien hipertensi pasien hipertensi yang belum
mendapatkan terapi diikutsetakan dalam penelitian ini, yang terdiri dari 37 pasien
kelompok rendah garam dan 43 pasien kelompok tinggi garam. Kelompok pasien dengan
asupan rendah garam memliki delta penurunan darah nokturnal sistolik (p<0,001),
diastolic (p<0,001), dan rerata arteri (p<0,001) yang lebih besar dibandingkan pada
kelompok asupan tinggi garam. Rerata asupan garam pada penelitian ini sebesar 16,77
gram/hari. Pada analisa multivariat didapatkan delta penurunan tekanan darah tidak
dipengaruhi oleh usia, jenis kelamin, dislipidemia, IMT, dan durasi tidur.
Kesimpulan : Penelitian ini membuktikan asupan rendah garam dapat mempengaruhi efektivitas terapi penyekat EKA dalam menurunkan tekanan darah nokturnal. ABSTRACT
Background : Hypertension is one of important risk factor of cardiovascular
disease, especially acute coronary syndrome and stroke. High salt intake correlates
to high blood pressure. Some Randomized-Controlled-Trials stated that low salt
intake may decrease blood pressure in adult population with or without
hypertension. Blood pressure variation in 24 hours is not static but dynamically
changes. Increasing nocturnal blood pressure has significantly impacts, and become
one of predictor of target organ damage, especially cardiovascular events and
stroke. Salt intake may interferes both 24 hours blood pressure variation and
nocturnal blood pressure. Angiotensin Converting Enzyme(ACE) Inhibitors is first
drug of choice anti-hypertensive therapy, especially in young age and associated
with metabolic syndrome, due to important role of Renin Angiotensin Aldosterone
System in pathophysiology of hypertension, whereas salt intake also has role in that
system. Only few of studies that had proved combination of ACE Inhibitors and
low salt intake in decreasing blood pressure in hypertension population. Therefore,
it is so important to know the impact of low salt intake to nocturnal blood pressure
in hypertension patient treated with ACE Inhibitors.
Objectives : To know impact of low salt intake to nocturnal blood pressure in
hypertension patient treated with ACE Inhibitors.
Methods : There are 30 ? 50 years old ambulatory patients diagnosed as untreated
hypertension, divided into two groups (low salt intake (Na <15 grams/day) and high
salt intake (≥15 grams/day). Both of groups were administered Lisinopril 10mg and
underwent 24-hours sodium urine collection and home blood pressure monitoring
periodically.
Results : There are 80 ambulatory patients diagnosed as untreated hypertension,
consist of 37 patients in low salt intake group and 43 patients in high salt intake
group. Low salt intake group has lower nocturnal systolic (p<0.001), diastolic
(p<0.001), and mean arterial (p<0.001) blood pressure compared with high salt
intake group. Mean salt intake in this study was 16.77 grams/day. Multivariate
analyzes showed that the difference of decreasing nocturnal blood pressure was not
interfered by age, sex, dyslipidemia, BMI, and sleep duration.
Conclusion : This study has proved that low salt intake may interfere ACE Inhibitors therapy effectiveness in decreasing nocturnal blood pressure.;Background : Hypertension is one of important risk factor of cardiovascular
disease, especially acute coronary syndrome and stroke. High salt intake correlates
to high blood pressure. Some Randomized-Controlled-Trials stated that low salt
intake may decrease blood pressure in adult population with or without
hypertension. Blood pressure variation in 24 hours is not static but dynamically
changes. Increasing nocturnal blood pressure has significantly impacts, and become
one of predictor of target organ damage, especially cardiovascular events and
stroke. Salt intake may interferes both 24 hours blood pressure variation and
nocturnal blood pressure. Angiotensin Converting Enzyme(ACE) Inhibitors is first
drug of choice anti-hypertensive therapy, especially in young age and associated
with metabolic syndrome, due to important role of Renin Angiotensin Aldosterone
System in pathophysiology of hypertension, whereas salt intake also has role in that
system. Only few of studies that had proved combination of ACE Inhibitors and
low salt intake in decreasing blood pressure in hypertension population. Therefore,
it is so important to know the impact of low salt intake to nocturnal blood pressure
in hypertension patient treated with ACE Inhibitors.
Objectives : To know impact of low salt intake to nocturnal blood pressure in
hypertension patient treated with ACE Inhibitors.
Methods : There are 30 ? 50 years old ambulatory patients diagnosed as untreated
hypertension, divided into two groups (low salt intake (Na <15 grams/day) and high
salt intake (≥15 grams/day). Both of groups were administered Lisinopril 10mg and
underwent 24-hours sodium urine collection and home blood pressure monitoring
periodically.
Results : There are 80 ambulatory patients diagnosed as untreated hypertension,
consist of 37 patients in low salt intake group and 43 patients in high salt intake
group. Low salt intake group has lower nocturnal systolic (p<0.001), diastolic
(p<0.001), and mean arterial (p<0.001) blood pressure compared with high salt
intake group. Mean salt intake in this study was 16.77 grams/day. Multivariate
analyzes showed that the difference of decreasing nocturnal blood pressure was not
interfered by age, sex, dyslipidemia, BMI, and sleep duration.
Conclusion : This study has proved that low salt intake may interfere ACE Inhibitors therapy effectiveness in decreasing nocturnal blood pressure.;Background : Hypertension is one of important risk factor of cardiovascular
disease, especially acute coronary syndrome and stroke. High salt intake correlates
to high blood pressure. Some Randomized-Controlled-Trials stated that low salt
intake may decrease blood pressure in adult population with or without
hypertension. Blood pressure variation in 24 hours is not static but dynamically
changes. Increasing nocturnal blood pressure has significantly impacts, and become
one of predictor of target organ damage, especially cardiovascular events and
stroke. Salt intake may interferes both 24 hours blood pressure variation and
nocturnal blood pressure. Angiotensin Converting Enzyme(ACE) Inhibitors is first
drug of choice anti-hypertensive therapy, especially in young age and associated
with metabolic syndrome, due to important role of Renin Angiotensin Aldosterone
System in pathophysiology of hypertension, whereas salt intake also has role in that
system. Only few of studies that had proved combination of ACE Inhibitors and
low salt intake in decreasing blood pressure in hypertension population. Therefore,
it is so important to know the impact of low salt intake to nocturnal blood pressure
in hypertension patient treated with ACE Inhibitors.
Objectives : To know impact of low salt intake to nocturnal blood pressure in
hypertension patient treated with ACE Inhibitors.
Methods : There are 30 ? 50 years old ambulatory patients diagnosed as untreated
hypertension, divided into two groups (low salt intake (Na <15 grams/day) and high
salt intake (≥15 grams/day). Both of groups were administered Lisinopril 10mg and
underwent 24-hours sodium urine collection and home blood pressure monitoring
periodically.
Results : There are 80 ambulatory patients diagnosed as untreated hypertension,
consist of 37 patients in low salt intake group and 43 patients in high salt intake
group. Low salt intake group has lower nocturnal systolic (p<0.001), diastolic
(p<0.001), and mean arterial (p<0.001) blood pressure compared with high salt
intake group. Mean salt intake in this study was 16.77 grams/day. Multivariate
analyzes showed that the difference of decreasing nocturnal blood pressure was not
interfered by age, sex, dyslipidemia, BMI, and sleep duration.
Conclusion : This study has proved that low salt intake may interfere ACE Inhibitors therapy effectiveness in decreasing nocturnal blood pressure."
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Shofi Azzahra
Evaluasi penggunaan obat antihipertensi pada pasien hipertensi rawat jalan berdasarkan ATC/DDD di RSUD Jagakarsa pada tahun 2017 = Evaluation of antihypertensive drug utilization in hypertension outpatients using ATC/DDD at RSUD Jagakarsa in 2017
"Meningkatnya prevalensi hipertensi di Indonesia mempengaruhi jumlah penggunaan obat antihipertensi, serta masih banyak penderita hipertensi yang belum mendapatkan pengobatan yang efektif dan rasional membuat evaluasi penggunaan obat antihipertensi pada pasien hipertensi penting untuk dilakukan. Penggunaan obat antihipertensi harus mengikuti acuan yang berlaku di Indonesia yaitu Formularium Nasional. Penelitian ini bertujuan untuk mengevaluasi penggunaan obat antihipertensi. Desain penelitian adalah cross-sectional dan bersifat deskriptif. Data yang digunakan adalah data sekunder dari resep dan rekam medis dengan metode retrospektif. Pengambilan sampel dilakukan secara total sampling. Jumlah sampel penelitian ini adalah sebanyak 2814 resep. Berdasarkan hasil penelitian, hipertensi lebih banyak terjadi pada perempuan 65,79, kelompok usia 45-64 51,78, dan pasien Non BPJS 68,68. Jumlah total penggunaan obat antihipertensi sebesar 38972,03 DDD dengan peringkat tiga besar obat antihipertensi dengan penggunaan terbanyak diantaranya adalah amlodipin 24812,97 DDD, 1,4096 DDD/1000 pasien/hari, dan 0,7698 DDD/1000 penduduk/hari , valsartan 5397,22 DDD, 0,3066 DDD/1000 pasien/hari, dan 0,1674 DDD/1000 penduduk/hari, dan kaptopril 4979,64 DDD, 0,2829 DDD/1000 pasien/hari, dan 0,1545 DDD/1000 penduduk/hari. Kesesuaian penggunaan obat antihipertensi di RSUD Jagakarsa pada tahun 2017 dengan Formularium Nasional adalah 100. Penggunaan obat antihipertensi telah sesuai dengan Formularium Nasional, sehingga penggunaan obat antihipertensi yang efektif diharapkan dapat tercapai.
Increasing prevalence of hypertension in Indonesia affecting the amount of antihypertensive use, and there were still many hypertensive patients who did not receive effective and rational treatment made it necessary to evaluate the use of antihypertensive. The uses of drugs in health facilities must comply with national reference, namely the National Formulary. This study was conducted to evaluate the use of antihypertensive in hypertensive patients. The research design was cross sectional and descriptive. Data used were secondary data from prescriptions and medical records by retrospective method. Sampling was done in total sampling, with total samples of 2814 prescriptions. The results showed that 65,79 of hypertension outpatients were females, 51,78 were 44 to 64 years old, and 68,68 did not follow the BPJS Program. The total use of antihypertensive was 38972,03 DDD and the three most widely used antihypertensives were amlodipine 24812,97 DDD, 1,4096 DDD 1000 patients day, and 0,7698 DDD 1000 inhabitants day, valsartan 5397,22 DDD, 0,3066 DDD 1000 patients day, and 0,1674 DDD 1000 inhabitants day, and captopril 4979,64 DDD, 0,2829 DDD 1000 patients day, and 0,1545 DDD 1000 inhabitants day. The use of antihypertensive was 100 appropriate according to National Formulary. The use of antihypertensive was appropriate according to National Formulary, therefore effective use of antihypertensive is expected to be achieved."
Depok: Fakultas Farmasi Universitas Indonesia, 2018
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Faradina Astari Munandar
Analisis masalah terkait obat pada pasien rawat inap dengan hipertensi di RSUD Koja periode Februari-April 2019 = Analysis of drug related problem among inpatients with hypertension in Koja District Hospital from February-April 2019
"Hipertensi adalah salah satu penyakit tidak menular dengan prevalensi tertinggi di Indonesia yaitu 34,1% kasus. Sebagai faktor risiko penyakit lain, pasien hipertensi biasanya mengalami komplikasi dan membutuhkan terapi tambahan yang dapat menyebabkan polifarmasi. Tujuan dari penelitian ini adalah untuk menganalisis masalah terkait obat pada pasien rawat inap dengan hipertensi di Rumah Sakit Distrik Koja dari Februari-April 2019 berdasarkan PCNE V6.2. Penelitian ini adalah studi cross-sectional berdasarkan resep lengkap, rekam medis, dan kartu indeks yang dapat dibaca dari pasien yang menggunakan obat antihipertensi dan dirawat di rumah sakit di Rumah Sakit Distrik Koja dari Februari - April 2019. Analisis ini dilakukan untuk 90 pasien yang memenuhi kriteria. Dari penelitian ini, ada 148 masalah terkait obat yang diidentifikasi, terdiri dari masalah dengan efektivitas pengobatan (66,21%) dan reaksi obat yang merugikan (33,78%) dengan reaksi obat yang tidak alergi sebagai subdomain dengan prevalensi tertinggi (31), 75%) dan penyebab masalah terkait narkoba yang sebagian besar terjadi adalah kombinasi obat yang tidak tepat, atau obat-obatan dan makanan (48,51%). Dari penelitian ini, diketahui bahwa masalah dengan efektivitas pengobatan adalah masalah terkait obat yang paling banyak terjadi.
Hypertension is one of the non-communicable diseases with the highest prevalence in Indonesia, which is 34.1% of cases. As a risk factor for other diseases, hypertensive patients usually experience complications and require additional therapy that can cause polypharmacy. The purpose of this study was to analyze drug-related problems in hospitalized patients with hypertension at the Koja District Hospital from February to April 2019 based on PCNE V6.2. This study is a cross-sectional study based on complete prescriptions, medical records, and index cards that can be read from patients who use antihypertensive drugs and are hospitalized in the Koja District Hospital from February to April 2019. This analysis was carried out for 90 patients who met criteria. From this study, there were 148 drug-related problems identified, consisting of problems with treatment effectiveness (66.21%) and adverse drug reactions (33.78%) with non-allergic drug reactions as subdomains with the highest prevalence (31), 75%) and the most common cause of drug related problems is an improper combination of drugs, or drugs and food (48.51%). From this research, it is known that the problem with the effectiveness of treatment is the most drug-related problems."
Depok: Fakultas Farmasi Universitas Indonesia, 2019
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Aditya Retno Wijayanti
Uji efek antihipertensi ekstrak Etanol 70% buah oyong (Luffa acutangula (L) Roxb) terhadap tikus putih jantan yang diinduksi Natrium Klorida = Antihypertension effect of 70% ethanol extract of ridged gourd fruit (Luffa acutangula (L.) Roxb.) in sodium chloride induced white male rats
"Buah oyong (Luffa acutangula (L.) Roxb.) merupakan tanaman yang secara empiris memiliki efek diuretik, sehingga diduga memiliki efek antihipertensi. Penelitian ini bertujuan untuk mengetahui efek antihipertensi dari ekstrak etanol 70% buah oyong pada tikus putih jantan yang diinduksi larutan NaCl. Tiga puluh ekor tikus putih jantan galur Sprague-Dawley dibagi dalam enam kelompok yaitu kontrol normal, kontrol induksi, kontrol Tensigard®, dan tiga kelompok dosis ekstrak buah oyong. Induksi larutan NaCl (3,75g/kg bb) diberikan pada setiap kelompok perlakuan, kecuali kelompok kontrol normal, secara per oral selama 14 hari. Pada hari ke-15 dilanjutkan pemberian sediaan uji berupa larutan CMC 0,5% (kontrol normal dan induksi), Tensigard®, dan ekstrak buah oyong dengan dosis 274,5; 411,75; dan 617,62 mg/200g bb hingga hari ke-28. Pengukuran tekanan darah sistol, diastol, dan arteri rata-rata dilakukan pada hari ke-14, 21, 24, dan 28 menggunakan alat pengukur tekanan darah non-invasif CODA®. Penelitian dilanjutkan dengan pengukuran volume urin 24 jam untuk melihat efek diuretik. Hasil analisis pengukuran tekanan darah menunjukkan bahwa ekstrak etanol 70% buah oyong dapat menurunkan tekanan darah sistol, diastol, dan darah rata-rata secara bermakna pada hari ke-24 pengujian, namun hasil analisis pengukuran volume urin 24 jam tidak menunjukkan perbedaan bermakna antar kelompok.
Gourd fruit (Luffa acutangula (L.) Roxb.) is the crop that empirically has diuretic effect, so it might be had antihypertensive effect. This research aimed to know the antihypertensive effect of 70% ethanol extract of ridged gourd fruit in sodium chloride induced white male rats. Thirty male rats strain Sprague-Dawley were divided into six groups of 5 animals each were used and administered orally with CMC liquid 0,5% (normal control), NaCl liquid 3,75 g/kg bw (induced control), Tensigard ® (Tensigard® control), and three groups of gourd fruit extract. Sodium chloride liquid as inducer was administered orally for 14 days, then continued by giving the gourd fruit extract (274,5; 411,75; and 617,62 mg/200g bw), Tensigard®, and CMC 0,5%. The blood pressure (systole, diastole, and arterial blood pressure) was measured on the day 14th, 21st, 24th, and 28th using CODA® non-invasive blood pressure. After that, the research was followed by measurement of the urine volume in 24 hours to know the diuretic effect. Result from analysis of blood pressure data showed that the 70% ethanol extract of gourd fruit could significantly reduce blood pressure (systole, diastole, and average blood pressure) on hypertensive rats in days 24th, however result of the analysis urine volume in 24 hours did not show significant difference inter-group."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2012
S42854
UI - Skripsi Open  Universitas Indonesia Library
cover
Mahensi Setya Ariyanti
Hubungan kepercayaan kesehatan dengan kepatuhan minum obat pada penderita hipertensi = Relationship between health belief and medication adherence among patients with hypertension
"Kepatuhan dalam menjalankan regimen pengobatan  sangat penting bagi penderita dengan hipertensi karena dapat mencegah terjadinya komplikasi hipertensi. Kepercayaan terhadap kesehatan merupakani salah satu faktor yang dapat berhubungan dengan tingkat kepatuhan minum obat. Oleh karena itu, tujuan studi ini adalah untuk mengetahui hubungan kepercayaan kesehatan dengan kepatuhan minum obat pada penderita hipertensi. Metode penulisan yang digunakan adalah studi literatur dengan sumber database Scopus, Proquest, Science Direct, Web of Science, PubMed, Google Scholar, dan Research Gate. Hasil dari penelusuran didapat 16 artikel yang selanjutnya dianalisis menggunakan JBI Critical Appraisal. Hasil studi literaturdidapatkan bahwa sebagian besar studi (93,75%) menyatakan terdapat hubungan yang signifikan antara kepercayaan kesehatan dengan kepatuhan minum obat pasien hipertensi. Studi ini merekomendasikan agar tenaga kesehatan dapat mengidentifikasi kepercayaan kesehatan pasien terhadap regimen pengobatan sehingga diharapkan nantinya dapat mengidentifikasi intervensi yang tepat untuk meningkatkan kepatuhan minum obat.
Medication Adherence among hypertension regimens is necessary to prevent complications of hypertension. Health belief is one of the factors that can be related to medication adherence. Therefore, this study aimed to determine the relationship between health belief and medication adherence in hypertensive patients. The writing method used a literature study with database sources from Scopus, Proquest, Science Direct, Web of Science, PubMed, Google Scholar, and Research Gate. The results were 16 articles that were analyzed using the JBI Critical Appraisal. The results of the literature study found that most of the studies (93.75%) stated that there was a significant relationship between health belief and medication adherence in hypertensive patients. This study recommends that clinicians can identify the patient's health belief in the treatment regimen so that later they can identify the right intervention to improve medication adherence."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia , 2020
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Nurul Miftahul Janah
Hubungan perilaku kesehatan dengan kepatuhan minum obat dan perilaku merokok klien hipertensi di Kecamatan Cipayung Jakarta Timur = Association between health behavior with medication adherence and smoking behavior of hypertensive client in Cipayung District, East Jakarta
"Hipertensi sebagai salah satu jenis Penyakit Tidak Menular (PTM) menjadi penyumbang terbanyak penyebab kematian di dunia. Komplikasi dari hipertensi menyumbang sebagian besar kematian secara global. Perilaku kesehatan yang tidak terkontrol pada penderita hipertensi erat kaitannya dengan peningkatan angka kesakitan yang diakibatkan komplikasi dari hipertensi setiap tahunnya. Patuh minum obat dan pengendalian perilaku merokok merupakan upaya untuk membentuk perilaku kesehatan yang positif untuk mencegah komplikasi dari hipertensi. Penelitian ini bertujuan untuk mengidentifikasi hubungan perilaku kesehatan dengan kepatuhan minum obat dan perilaku merokok pada klien hipertensi di Kecamatan Cipayung Jakarta Timur. Desain penelitian ini menggunakan pendekatan cross sectional dengan 109 partisipan, yang dipilih dengan pengambilan sampel purposive sampling yaitu klien hipertensi primer usia dewasa menengah. Hasil uji chi square menunujukan ada hubungan antara perilaku kesehatan dengan kepatuhan minum obat (p value : 0,024) CI 90%. Uji chi square antara perilaku kesehatan dengan perilaku merokok pada CI 90% menujukan nilai p value 0,217 yang menujukan tidak terdapat hubungan. Berdasarkan hasil penelitian dapat disimpulkan bahwa semakin positif perilaku kesehatan maka semakin tinggi kepatuhan minum obat pada klien hipertensi. Perawat komunitas memiliki peran pening dalam memodifikasi perilaku penderita hipertensi dengan berbagai pendekatan baik sebagai individu, keluarga, mapupun masyarakat dapat mempertahankan kesejahteraan kesehatannya.
Hypertension as Non-Communicable Diseases (PTM) is the largest contributor to the causes of death in the world. Complications of hypertension account for the majority of deaths globally. Uncontrolled health behavior in patients with hypertension is closely related to an increase in morbidity rates due to complications from hypertension each year. Medication adherence and controlling smoking behavior is an effort to form positive health behaviors to prevent complications from hypertension. This study aims to identify the relationship between health behavior with medication adherence and smoking behavior in hypertensive clients in Cipayung District, East Jakarta. using cross sectional design, approach with 109 participants, who were selected by purposive sampling, are choosen primary hypertensive clients of middle adulthood. The results of the chi square test showed that there was a relationship between health behavior and medication adherence (p value: 0.024) 90% CI. Chi square test between health behavior and smoking behavior in CI 90% addressed p value 0.217 which showed no relationship. Based on the results of the study it can be concluded that the more positive the health behavior, the higher the adherence to taking medication in hypertensive clients. Community nurses have an important role in modifying the behavior of hypertensive patients with a variety of approaches both as individuals, families, and the public can maintain their health well-being."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2019
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Nurvita Ulfa Saraswati
Evaluasi penggunaan obat antihipertensi pada pasien BPJS di instalasi rawat jalan Rumah Sakit Karya Bhakti Pratiwi tahun 2016 = Evaluation of antihypertensive drugs utilization for bpjs outpatients at Karya Bhakti Pratiwi Hospital in 2016
"Hipertensi merupakan salah satu penyakit yang prevalensinya tinggi di Indonesia. Hipertensi harus diobati secara efektif untuk menghindari komplikasi yang dapat terjadi. Pengadaan obat untuk pasien BPJS pada fasilitas kesehatan harus mengacu pada Formularium Nasional. Evaluasi penggunaan obat antihipertensi pada pasien rawat jalan BPJS Rumah Sakit Karya Bhakti Pratiwi Bogor Tahun 2016 dilakukan untuk mencapai penggunaan obat yang rasional. Desain studi yang digunakan adalah cross sectional dengan pengambilan data secara retrospektif. Data yang diambil berasal dari resep pasien dan Sistem Informasi Manajemen Rumah Sakit SIMRS. Sampel merupakan resep pasien BPJS hipertensi periode Januari hingga Desember 2016.
Studi dilakukan secara kuantitatif dan kualitatif dengan metode Anatomical Therapeutic Chemical/Defined Daily Dose ATC/DDD. Berdasarkan pengolahan data dengan Microsoft Excel, secara kuantitatif penggunaan obat antihipertensi sebanyak 40.080,77 DDD dengan obat terbanyak yang digunakan adalah amlodipin 17,24 DDD/1000 pasien/hari. Secara kualitatif, obat yang menyusun segmen DU90 ada lima obat yaitu amlodipin, kandesartan, kaptopril, furosemid, dan spironolakton. Kesesuaian penggunaan obat antihipertensi dengan Formularium Nasional sebesar 91,64.
Hypertension is one of the highest prevalence disease in Indonesia. It has to be treated effectively to prevent the complications. Drug procurement in BPJS patients at health facility was based on drugs in national formulatory. Evaluation of antihypertensive drugs utilization in BPJS outpatients at Karya Bhakti Pratiwi hospital Bogor 2016 was performed to achieve rational drug use. Design of the study was cross sectional with sampling data by retrospective. Data was obtained from prescription and management information system of hospital. Sample of this study was hypertensive BPJS patient prescriptions from January to December 2016.
Study was performed with both qualitative and quantitative approach with Anatomical Theurapetic Chemical Defined Daily Dose ATC DDD method. Based on the analysis of data with Microsoft Excel, the utilization of antihypertensive drug was 40,080.77 DDD with amlodipine being the most used in antihypertensive drugs 17.24 DDD 1000 patients day. Drugs that belong to DU90 segments were amlodipine, candesartan, captoprile, furosemid, and spironolacton. The use of antihypertensive drugs was 91.64 compliance with national formulatory."
Depok: Fakultas Farmasi Universitas Indonesia, 2017
S66787
UI - Skripsi Membership  Universitas Indonesia Library
cover
Turnip, Andreas Billy Yoel
Penggunaan antihipertensi untuk hipertensi tingkat 1 dan 2 di Unit Rawat Jalan (URJ) RSUPN Ciptomangunkusumo = Antihypertensive drugs usage for grade 1 and 2 hypertension in Outpatient Department of RSUPN Ciptomangunkusumo
" ABSTRAK
Hipertensi merupakan kelainan yang menjadi masalah kesehatan di Indonesia dan seluruh dunia. Salah satu panduan yang umum digunakan dalam penanganan hipertensi adalah panduan Joint National Committee 8 JNC 8 . Selain penggunaan panduan JNC 8, Indonesia memiliki Formularium Nasional Fornas yang di dalamnya terdapat rekomendasi obat-obatan berbagai penyakit, termasuk obat-obatan antihipertensi. Penelitian ini bertujuan untuk mengetahui proporsi pasien hipertensi tingkat 1 dan 2 yang datang ke URJ RSUPN Ciptomangunkusomo dan mendapatkan obat antihipertensi yang sesuai dengan panduan JNC 8 dan Fornas. Penelitian dilakukan dengan mengamati pengobatan yang didapatkan pasien dalam rekam medis dan membandingkannya dengan panduan JNC 8 dan Fornas. Hasil penelitian menunjukkan 67,68 pasien mendapatkan pengobatan yang sesuai JNC 8 dan Fornas. Jenis obat antihipertensi yang sesuai dengan panduan JNC 8 didapatkan pada 82,83 pasien. Sedangkan 100 pasien mendapatkan obat antihipertensi yang sesuai dengan daftar obat Fornas. Dosis obat yang sesuai dengan JNC 8 ditemukan pada 81,82 pasien. Evaluasi hasil pengobatan yang sesuai dengan panduan JNC 8 ditemukan pada 100 pasien. Biaya pengobatan 99 pasien lebih murah Rp 30.588,50 /hari apabila pengobatan diberikan sesuai dengan panduan JNC 8 dan Fornas.
ABSTRACT
Hypertension is a prevalent medical problem in Indonesia or around the world. One commonly used guideline for hypertension treatment is the Joint National Committee 8 JNC 8 guideline. Aside from the JNC 8 guideline, Indonesia has Formularium Nasional Fornas which contains a list of recommended drugs for various diseases, including antihypertensive drugs. This study aims to know the proportion of grade 1 and 2 hyertensive patient who comes to outpatient department of RSUP Ciptomangunkusumo and receives antihypertensives drugs according to the JNC 8 guideline and Fornas. The study is conducted by observing the received medication of each patient in medical record and compares them to the JNC 8 guideline and Fornas. The study shows that 67.68 hypertensive patients received medication according to JNC 8 and Fornas. Antihypertensive drugs type selection which followed the JNC 8 guideline was found in 82.83 patients. While 100 patients received antihypertensive drugs which adhere to Fornas. The appropriate dosage was found in 81.82 patients. Treatment evaluation which adhere to JNC 8 was found in 100 patients. Treatment cost of 99 patients is cheaper by IDR 30,588.50 per day if the treatment was given according to JNC 8 guideline and Fornas."
2017
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Kelly Amelinda
Pengujian keaktifan antihipertensi dari jamu antiaterosklerosis dengan metode in vivo pada tikus putih (rattus norvegicus) jantan = Antihypertension activity test of jamu antiatherosclerosis with in vivo method in male rats (rattus norvegicus)
"ABSTRAK
Hipertensi merupakan salah satu penyebab kematian nomor satu di dunia. Pada umumnya masyarakat menggunakan obat farmasi untuk menurunkan tekanan darah. Namun, penggunaan obat farmasi untuk menurunkan tekanan darah seringkali memberikan efek samping yang merugikan bagi tubuh. Bangsa Indonesia telah mengenal beberapa tanaman yang telah terbukti secara empiris mampu menurunkan tekanan darah seperti daun tanjung Mimusops elengi L , daun belimbing manis Averrhoa carambola L , dan temulawak Curcuma xanthorrhizol Roxb yang dikenal sebagai jamu antiaterosklerosis. Hal tersebut disebabkan ketiga bagian tumbuhan tersebut mengandung senyawa aktif flavonoid seperti apigenin dan katekin yang memiliki efek antihipertensi. Ekstraksi jamu dengan metode refluks selama 45 menit dengan variasi ukuran partikel jamu menunjukkan bahwa ukuran partikel jamu D 60 mesh menghasilkan kandungan katekin tertinggi, yaitu sebesar 48,241 mg/g jamu. Pengujian aktivitas antihipertensi dilakukan terhadap 6 kelompok tikus putih yang terdiri atas kontrol normal tanpa perlakuan , kontrol negatif diinduksi dan diberi pakan standar , kontrol positif diinduksi dan diberi captopril 1,35 mg/200 g berat badan tikus , kontrol dosis diinduksi dan diberi ekstrak jamu antiateroklerosis masing-masing kelompok dengan dosis I 13,2 mg/200g BB , dosis II 26,4 mg/200g BB dan dosis III 52,8 mg/200g BB . Hasil dari pengukuran tekanan darah menunjukkan bahwa ekstrak jamu antiaterosklerosis memiliki efek antihipertensi yang meningkat seiring dengan peningkatan dosis ekstrak. Kelompok dosis III memberikan efek penurunan tekanan darah yang signifikan yaitu penurunan tekanan darah diastolik sebesar 29,42 mmHg atau 25,14 dan penurunan tekanan darah sistolik sebesar 34,58 mmHg atau 22,03
ABSTRACT
Hypertension is a leading cause of death in the world. Usually people used pharmaceutical drugs synthetic to lower blood pressure. However, blood pressure lowering synthetic drugs have several negative side effects to the humans body. Tanjung leaves Mimusops elengi L , belimbing manis leaves Averrhoa carambola L , and temulawak Curcuma xanthorrhiza Roxb known as jamu antiatherosclerosis has been empirically believed by the people of Indonesia has antihypertension effect. This is because they contain flavonoids such as apigenin and catechin which have an antihypertension effect. Extraction of jamu antiatherosclerosis using reflux system for 45 minutes with jamu rsquo s particles size variation showed that the D 60 mesh particles size of jamu produces the highest catechin content, which amounted to 48.241 mg g jamu. Antihypertension activity test will be conducted with 6 groups of rats consisting of normal control without treatment , negative control induced and standard feed , positive control induced and given captopril 1.35 mg 200 g body weight of rats , dosage control induced and given the extract of jamu each group with 3 different doses that is dose I 13.2 mg 200 g body weight of rats , dose II 26.4 mg 200 g body weight of rats and dose III 52.8 mg 200 g body weight of rats . The result showed that jamu antiatherosclerosis extract has antihypertension effect, where the blood reducing effect increased as the dose increased. Dose III has the highest blood pressure reducing effect that is 29.42 mmHg or 25.14 for diastolic blood pressure and 34.58 mmHg or 22.03 for systolic blood pressure."
2017
S67668
UI - Skripsi Membership  Universitas Indonesia Library
cover
Della Rosalynna Stiadi
Analisis efektivitas biaya terapi kombinasi amlodipin-kandesartan dan amlodipin-ramipril pada pasien hIpertensi dengan komorbiditas diabetes melitus tipe 2 rawat jalan di RSUPN Dr. Cipto Mangunkusumo = Cost-effectiveness analysis of combination therapy of amlodipine-candesartan and amlodipine-ramipril in hypertensive with type 2 diabetes mellitus outpatients at RSUPN Dr. Cipto Mangunkusumo
"Hipertensi dan diabetes melitus menjadi salah satu faktor risiko kejadian kardiovaskuler. Tidak terkontrolnya hipertensi dapat menyebabkan perburukan kesehatan dan ekonomi pada penderitanya. Kombinasi terapi antihipertensi dinilai adekuat untuk mencapai target tekanan darah <140/90 mmHg. Obat antihipertensi golongan ACEI, ARB, dan CCB merupakan terapi yang sesuai untuk pasien dengan diabetes melitus tipe 2 dan harganya bervariasi. Penelitian sebelumnya menunjukkan bahwa golongan ARB lebih cost-effective dibandingkan yang lainnya. Tujuan penelitian ini adalah untuk menganalisis efektivitas biaya dari kombinasi terapi amlodipin-kandesartan dibandingkan dengan amlodipin-ramipril pada pasien hipertensi dengan diabetes melitus tipe 2. Penelitian cross-sectional ini dilakukan di RSUPN dr. Cipto mangunkusumo dengan menggunakan rekam medis pasien tahun 2017-2019. Subjek penelitian yang memenuhi kriteria inklusi sebanyak 87 pasien. Pasien dibagi menjadi dua kelompok: kelompok yang mendapat terapi amlodipin-kandesartan dan kelompok yang mendapat terapi amlodipin-ramipril. Analisis efektivitas biaya diperoleh dari perhitungan biaya medik langsung, menghitung efektivitas terapi berdasarkan jumlah pasien yang mencapai target tekanan darah <140/90 mmhg, serta menghitung nilai ACER. Kombinasi amlodipin-kandesartan memiliki efektivitas terapi 48.9%, sedangkan efektivitas terapi amlodipin-ramipril 45,2%. Nilai ACER kelompok amlodipin-kandesartan dan kelompok amlodipin-ramipril adalah Rp. 1.604.736,2 per efektivitas and Rp 1.811.278,8 per efektivitas. Dapat disimpulkan bahwa amlodipin-kandesartan lebih cost-effective dibandingkan amlodipin-ramipril.
Hypertension and diabetes mellitus are risk factors for cardiovascular events. Uncontrolled hypertension can cause health and economic burdens in patients. The combination of antihypertensive therapy is considered adequate to achieve the targeted blood pressure <140/90 mmHg. Antihypertensive drugs class such as ACEIs, ARBs, and CCBs are appropriated therapies for patients with type 2 diabetes mellitus and the price differences. Previous studies have shown that the ARBs are more cost-effective than others. The aim of this study was to analyze the cost-effectiveness of combination of amlodipine-candesartan compared to amlodipine-ramipril in hypertensive patients with type 2 diabetes mellitus. This cross-sectional study was conducted at Dr. Cipto Mangunkusumo Hospital by using patient medical records in 2017-2019. Research subjects who met the inclusion criteria were 87 patients. Patients were divided into two groups: group receiving amlodipine-candesartan and group receiving amlodipine-ramipril. Cost effectiveness analysis obtained from the calculation of direct medical costs, calculated the effectiveness of therapy based on the number of patients who reached the target blood pressure <140/90 mmHg, and calculated the value of ACER. Amlodipine-candesartan has a therapeutic effectiveness of 48.9%, while the effectiveness of amlodipine-ramipril is 45.2%. The ACER value of the amlodipine-candesartan group and the amlodipine-ramipril group were Rp 1,604,736.2 per effectiveness and Rp 1,811,278.8per effectiveness. To conclude, amlodipine-candesartan is more cost-effective than amlodipine-ramipril."
Depok: Fakultas Farmasi Universitas Indonesia, 2019
T55093
UI - Tesis Membership  Universitas Indonesia Library
<<   1 2 3 4 5 6 7 8 9 10   >>