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"Pandemi COVID-19 menjadi tantangan dalam kapasitas sistem kesehatan dimana sistem kesehatan yang ada harus memastikan pasien COVID-19 dapat mengakses layanan kesehatan sekaligus menangani pandemi di masyarakat. Rekomendasi yang dikeluarkan WHO dalam menghadapi tantangan kapasitas sistem kesehatan diantaranya menambah jumlah rumah sakit rujukan dan mengupayakan sistem rujukan yang memadai terhadap lonjakan kasus COVID-19. Di Indonesia, pemerintah menggunakan Sistem Informasi Rujukan Terintegrasi (SISRUTE) dalam rujukan kasus COVID-19, meski dalam praktiknya masih bervariasi di berbagai daerah. Penggunaan SISRUTE sebelum COVID-19 dinilai masih belum optimal, sementara saat pandemi sangat sedikit pasien COVID-19 yang diterima melalui SISRUTE. Oleh karena itu, penelitian ini bertujuan memperoleh gambaran terkait efektivitas penggunaan SISRUTE dalam kasus COVID-19 di Semen Padang Hospital sebagai rumah sakit swasta pertama di Kota Padang yang menjadi rumah sakit rujuikan COVID-19 selama periode April 2020 hingga Oktober 2021. Penelitian ini merupakan penelitian kualitatif dengan proses pengumpulan data dilakukan dengan analisis data sekunder, wawancara mendalam kepada tujuh orang informan yang dipilih secara purposive sampling dan telaah dokumen. Dari penelitian ditemukan bahwa SISRUTE digunakan oleh dokter umum di UGD dan isolasi COVID-19 dan terdapat penggunaan SISRUTE berulang pada pasien yang sama karena penolakan dan rujukan yang tidak direspon. Selain itu, respon time rujukan via SISRUTE sangat lama disebabkan tidak adanya dokter yang khusus bertugas mengecek SISRUTE dan panjangnya alur konsultasi penerimaan rujukan. Banyaknya penolakan rujukan via SISRUTE disebakan oleh penuhnya ruangan, tidak tersedianya fasilitas seperti kamar operasi dan persalinan khusus COVID, ventilator mekanik dan alat hemodialisa. Selain itu, kendala dari kualitas SISRUTE yang tidak menampilkan kapasitas dan fasilitas yang tersedia, versi mobile yang tidak mudah, perlunya penambahan beberapa fitur serta belum tersedianya pencarian otomatis menyulitkan dalam melakukan rujukan. Dapat disimpulkan bahwa penggunaan SISRUTE dalam kasus COVID – 19 tidak efektif karena kemungkinan pasien diterima lewat SISRUTE jauh lebih kecil dibandingkan dengan pasien datang sendiri ke UGD.

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COVID-19 pandemic is a challenge in the capacity of the health system where the existing health system must ensure that COVID-19 patients can access health services as well as handle the pandemic in the community. Recommendations issued by WHO in facing health system capacity challenges include increasing the number of referral hospitals and seeking an adequate referral system for spikes in COVID-19 cases. In Indonesia, the government uses the Integrated Referral Information System (SISRUTE) in referring cases of COVID-19, even though in practice still varies in different regions. The use of SISRUTE before COVID-19 was considered not optimal, while during the pandemic very few COVID-19 patients were accepted through SISRUTE. Therefore, this study aims to obtain an overview regarding the effectiveness of using SISRUTE in cases of COVID-19 at Semen Padang Hospital as the first private hospital in Padang City to become a referral hospital for COVID-19 during the period April 2020 to October 2021. This research is a qualitative, data collection process was carried out by secondary data analysis, in-depth interviews with seven informants selected by purposive sampling and document review. From the study it was found that SISRUTE was used by general practitioners in the ER and COVID-19 isolation and there was repeated use of SISRUTE in the same patient due to rejection and referrals that did not respond. In addition, the response time for referrals via SISRUTE was very long due to the absence of a doctor who was specifically tasked with checking SISRUTE and the long flow of consultations for receiving referrals. Many rejections of referrals via SISRUTE are caused by full rooms, unavailability of facilities such as special COVID operating and delivery rooms, mechanical ventilators and hemodialysis labs. In addition, the constraints of the quality of SISRUTE which do not display the available capacity and facilities, the mobile version which is not easy, the need to add several features and the unavailability of automatic search make it difficult to make referrals. It can be concluded that the use of SISRUTE in the case of COVID-19 is not effective because the possibility of patients being admitted via SISRUTE is much smaller compared to patients who come alone to the ER."

"Pandemi COVID-19 di Indonesia berdampak pada implementasi Sisrute RSUD Siti Aisyah sehingga memengaruhi morbiditas dan mortalitas pasien. Penelitian ini bertujuan untuk menganalisis implementasi Sisrute yang meliputi kebijakan, kapasitas petugas, sistem jaringan, komunikasi dan pelayanan rujukan. Penelitian ini merupakan studi kasus dengan pendekatan kualitatif melalui observasi lapangan, telaah dokumen dan wawancara mendalam 13 informan RSUD Siti Aisyah. Penolakan rujukan lebih dari 80%. Response time kurang dari 60 menit terbanyak pada rujukan keluar non-COVID-19 (64%). Alasan penolakan meliputi ketidaktersediaan ruangan isolasi COVID-19-19, ketidaklengkapan berkas, kendala sistem jaringan, petugas lambat merespons dan lainnya. Informan mengatakan tidak terdapat kebijakan Sisrute dan dokumentasi sosialisasi; kapasitas petugas rujukan cukup adekuat.; Sistem Jaringan pada komputer dan konektifitas internet, SIMRS dan infrastruktur penunjang belum adekuat; Komunikasi rujukan melalui aplikasi Sisrute dan dibantu telepon dan Whatsapp; RSUD tidak memiliki SOP Sisrute, akan tetapi mengikuti prosedur klinis, administratif, dan operasional. Kendala pada implementasi Sisrute yaitu komitmen petugas, kecepatan penyampaian informasi, rangkap tugas, situasi faskes penerima, penerimaan keluarga, permasalahan biaya dan ketersediaan infrastruktur. Monitoring dan evaluasi tidak dilakukan pada implementasi Sisrute. Dengan demikian, implementasi Sisrute di RSUD Siti Aisyah Lubuklinggau perlu perbaikan dan peningkatan pada variabel diatas dapat mempercepat proses rujukan.

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The Pandemy of COVID-19 in Indonesia has a major impact in integrated referral system (IRS) implementation of Siti Aisyah (SA) General Hospital Lubuklinggau influencing patient morbidity and mortality. This study was conducted to analyse policy, officer capacity, network system, referral communication, and referral services resulting in referral system implementation. It was a case study with qualitative approach through observation, documents research, in-depth interview with 13 informants working at Siti Aisyah General Hospital. The study suggested that Sisrute referral rejection was more than 80%. Referral response time suggest less than 60 minutes only occurring in outward non-COVID-19 referral (64%). Reasons for rejection were unavailability of COVID-19 Isolation room, incomplete referral documents, network system issue, late response, etc. Informants stated that there was no referral policy and dissemination documents; officer capacity was considered adequate enough; Network system in computer and internet connectivity, hospital management information system and supporting infrastructures remained inadequate; referral communication through IRS and assistance of phone calling and Whatsapp were performed; SA General Hospital had no standard operating procedures, but it follows clinical, administrative and operational procedures. Challenges in IRS implementation were commitment, information delivery speed, multi-tasking, current situation in referred facility, family reception, extra fee and infrastructures issue. Monitoring and evaluation had not been performed in IRS implementation. Thus, SA General Hospital needs to improve and increase IRS implementation in aforementioned variable to accelerate referral process."

"Tesis ini membahas implementasi Sistem Informasi Rujukan Terintegrasi (SISRUTE) yang dinilai dari hubungan faktor manusia (human), faktor organisasi (organization), dan faktor teknologi (tekhnology) dengan manfaat bersih (net benefit) dalam kerangka evaluasi sistem model HOT-Fit untuk mendapatkan analisis optimalisasi waktu respon dan gambaran hambatan-hambatannya. Faktor manusia (human) dinilai dari pengaruh penggunaan sistem (system use) dan kepuasan pengguna (user satisfaction). Faktor organisasi (organization) dinilai dari pengaruh struktur organisasi (structure organization), lingkungan organisasi (environment organization), dukungan manajemen (management support). Faktor teknologi (tekhnology) dinilai dari pengaruh kualitas sistem (system quality), kualitas informasi (information quality), dan kualitas layanan (service quality). Penelitian ini adalah penelitian kuantitatif cross sectional dengan penguatan hasil penelitian dengan mendapatkan informasi melalui metode wawancara. Hasil penelitian menyatakan bahwa terdapat pengaruh secara positif faktor faktor manusia (human), faktor organisasi (organization), dan faktor teknologi (tekhnology) dengan manfaat bersih (net benefit),selain itu juga didapatkan gambaran hambatan implementasi SISRUTE yaitu, beberapa Rumah Sakit Daerah tidak memiliki petugas khusus yang mengoperasikan SISRUTE, kurangnya pemahaman petugas kesehatan terhadap keunggulan SISRUTE dengan sistem informasi rujukan lainnya terkait keamanan data, kurangnya kepatuhan untuk melakukan log in kembali saat akun petugas ter log out , kualitas sistem yang belum baik karena SISRUTE masih sering eror, fitur yang belum dianggap memudahkan dan terbatas, ketidakseragaman atau ketidaklengkapan informasi yang ditampilkan, belum ada layanan pengguna atau PIC dari pemilik sistem yang dapat dihubungi bila terjadi gangguan, belum ada SOP khusus dalam implementasi SISRUTE, terdapat kanal rujukan lain yang dianggap lebih cepat dan memudahkan.

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The focuss of this study is the implementation of the Integrated Referral Information System (SISRUTE) as assessed by the relationship between human factors, organizational factors, and technology factors with net benefits within the HOT-Fit system evaluation framework to obtain an analysis of response time optimization and an overview of its obstacles. Human factors are assessed based on the influence of system use and user satisfaction. Organizational factors are assessed based on the influence of organizational structure, organizational environment, and management support. Technology factors are assessed based on the influence of system quality, information quality, and service quality. This research is a quantitative cross sectional study with the strengthening of research results by obtaining information through the interview method. The results show that there is a positive influence of human factors, organizational factors, and technology factors on net benefits. In addition, it was also found that the obstacles to the implementation of SISRUTE are that some Regional Hospitals do not have special officers to operate SISRUTE, a lack of understanding among health workers regarding the advantages of SISRUTE compared to other referral information systems related to data security, a lack of compliance to log back in when the officer's account is logged out, poor system quality because SISRUTE is still often experiencing errors, features that are not considered easy and limited, inconsistencies or incompleteness of information displayed, no user services or PIC from the system owner that can be contacted if there are disturbances, no specific SOPs in the implementation of SISRUTE, there are other referral channels that are considered faster and easier."

"Sejak beralih menjadi rumah sakit yang sepenuhnya melayani pasien COVID-19, RSUD Jati Padang sudah mengubah tata kelolanya dan memiliki strategi dengan membuat beberapa kebijakan berupa surat keputusan direktur, standar prosedur operasional, pengaturan zonasi, hingga mengubah alur layanan untuk mencegah penularan COVID- 19 pada tenaga kesehatannya. Tujuan dari penelitian ini adalah untuk mengetahui seperti apa tata kelola RSUD Jati Padang yang telah diterapkan dalam mencegah penularan COVID-19 pada tenaga kesehatannya, Penelitian ini dilakukan secara kualitatif melalui telaah dokumen, observasi, wawancara mendalam, dan terakhir focus group discussion dengan manajemen RSUD Jati Padang. Hasil dari penelitian ini didapatkan terjadi perubahan dalam tata kelola RSUD Jati Padang sejak melayani pasien COVID-19. Strategi sudah dilakukan secara administratif, merubah alur pelayanan hingga pemenuhan sarana yang dibutuhkan. Masih terdapat beberapa hal yang perlu peningkatan dalam penerapan tata kelola di RSUD Jati Padang yaitu komunikasi tentang kebijakan internal antara manajemen dan petugas di RSUD Jati Padang, kedisiplinan petugas, dan menambah sarana untuk meningkatkan pencegahan penularan COVID-19 pada tenaga kesehatan. Tindak lanjut yang dapat dilakukan dalam jangka pendek ialah meningkatkan komunikasi terkait kebijakan yang ada, membentuk tim supervisi yang bertanggung jawab pada pimpinan, meningkatkan koordinasi antar unit dan menyusun kebijakan terkait yang belum dimiliki rumah sakit. Untuk tindak lanjut jangka panjangnya yang berkaitan dengan anggaran yaitu pemenuhan sarana dan prasarana dan pemberian reward and punishment untuk karyawan dalam meningkatkan kedisplinannya.

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Since turning into a hospital that fully serves COVID-19 patients, the Jati Padang Hospital has changed its governance and has a strategy by making several policies in the form of a director's decree, standard operating procedures, zoning arrangements, to changing the flow of services to prevent COVID-19 transmission in health workers. The purpose of this study was to find out what the governance of the Jati Padang Hospital has been in preventing the transmission of COVID-19 to its health workers. This research was conducted qualitatively through document review, observation, in-depth interviews, and finally a focus group discussion with the management of the Jati Hospital. The results of this study showed that there had been a change in the governance of the Jati Padang Hospital since serving COVID-19 patients. The strategy has been carried out administratively, changing the service flow to the fulfillment of the required facilities. There are still several things that need improvement, namely communication about internal policies between management and officers at the Jati Padang Hospital, officer discipline, and the fulfillment of facilities to increase the prevention of COVID-19 transmission to health workers. Follow-up that can be done in the short term is to improve communication related to existing policies, form a supervision team that is responsible to the leadership, improve coordination between units and formulate related policies that are not yet owned by the hospital. For the long-term follow-up related to the budget, namely the fulfillment of facilities and infrastructure and the provision of rewards and punishments for employees in improving their discipline."

"Penelitian ini bertujuan untuk menganalisis proses implementasi sistem informasi rumah sakit terpadu yang pertama di Indonesia. Penelitian ini menggunakan penedekatan studi kasus melalui observasi dan wawancara pihak-pihak yang terkait dengan proses implementasi sistem informasi rumah sakit ini. Observasi dan wawancara dilakukan di sebuah rumah sakit swasta di Jakarta Selatan. Hasil penelitian menunjukkan adanya peningkatan produktivitas pelayanan khususnya dalam hal medis dan mempermudah prosedur yang sudah berlaku sebelumnya.

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This research aims to analyze the first integrated hospital information system implementation in Indonesia. This research using case study approach with observation and interview with related parties in the hospital information system implementation process. The observation and interview was conducted in a private hospital in South Jakarta. The result shows that there is increase in service productivity, especially in medical operation. Also facilitating the current procedure that is conducted in the hospital."

"ABSTRAKRumah sakit pada masa pandemi berperan penting dalam pencatatan dan pelaporan kasus Covid-19. RSMY, RSHD, dan RS Bhayangkara Bengkulu menjadi rumah sakit rujukan Covid-19 di kota Bengkulu. Kemenkes mengimbau menggunakan aplikasi All Record TC-19 dan RS Online Versi-2 dalam pendataan kasus Covid-19 di rumah sakit. Sistem yang interoperable dibutuhkan dalam percepatan penanganan dan surveilans. Tujuan penelitian, yaitu menilai sistem pencatatan dan pelaporan data Covid-19 guna terciptanya interoperable di RS rujukan kota Bengkulu. Metode dalam penelitian ini adalah kualitatif dengan menggunakan data primer dari wawancara mendalam, observasi, kuesioner, dan telaah dokumen. Terdapat 26 informan dari ketiga rumah sakit dan expert judgement. Hasil penelitian menunjukkan masalah yang terjadi dalam pencatatan dan pelaporan data Covid-19, yaitu penginputan tidak real time dan duplikasi data. Berdasarkan teori RCA, didapatkan keterbatasan SDM, anggaran, infrastruktur, tidak memiliki alur pada sistem pencatatan dan pelaporan, dan belum terinterintegrasi antar aplikasi sehingga menghambat sistem pencatatan dan pelaporan data ini. Pengembangan sistem yang interoperabel pada RS Rujukan Covid-19 di kota Bengkulu belum dapat diterapkan. Solusi dalam sistem ini, yaitu membuat sistem yang terintegrasi antara SIMRS, aplikasi All-Record TC-19, dan RS Online agar terciptanya sistem yang interoperable sehingga mempermudah rumah sakit dalam sistem pencatatan dan pelaporan data Covid-19 di rumah sakit seluruh Indonesia. Pemerintah sangat perlu mengembangkan sistem ini guna peningkatan pelayanan kesehatan.

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ABSTRACTDuring the pandemic hospitals an important role in reporting and recording Covid-19 cases. RSMY, RSHD and Bayangkara Bengkulu Hospital became Covid-19 referral hospitals in Bengkulu City. The Ministry of Health urges the use of the All Record TC-19 application and the Online Hospital version-2 in collecting data on Covid-19 cases in hospitals. An interoperable system is needed to accelerate handling and surveillance. The purpose of the study was to assess the Covid-19 data recording and reporting system in order to create interoperability at the Bengkulu City referral hospital. Qualitative method using primary data from in-depth interviews, observations, questionnaires and document review. There are 26 informants from the three hospitals and expert judgment. The results of the study show problems that occur in recording and reporting Covid-19 data, namely non-real time input and data duplication. Based on the RCA theory, it is found that there are limited human resources, budget, infrastructure, no flow in the recording and reporting system, and not yet integrated between applications, thus hampering this data recording and reporting system. The development of an interoperability system at the Covid-19 Referral Hospital in Bengkulu City has not yet been implemented. The solution in this system is to create an integrated system between SIMRS, the All-Record TC-19 application and RS Online in order to create an interoperable system that makes it easier for hospitals to record and report Covid-19 data in hospitals throughout Indonesia. The government really needs to develop this system, in order to improve health services."

"Pandemi Covid-19 menjadi tantangan bagi RS UI dalam mengedepankan pelayanan kepada pasien yang bersifat holistik, demi kepentingan dan keselamatan pasien. Case manager merupakan jabatan baru di RS UI, sehingga dianggap masih memiliki banyak celah dalam penerapannya. Peran case manager dirasakan belum optimal di lapangan, terutama oleh klinisi dan manajemen. Tujuan penelitian adalah untuk merumuskan tugas pokok fungsi case manager dalam pelayanan pasien Covid-19, dan mengidentifikasi peran yang telah dilaksanakan oleh case manager. Penelitian ini merupakan penelitian non eksperimental kualitatif, menggunakan pendekatan fenomenologi dengan desain potong lintang. Peneliti menemukan bahwa case manager RS UI belum menjalankan peran sesuai rumusan tugas pokok fungsi case manager yang ada dalam standar akreditasi RS; rumusan tugas pokok fungsi case manager belum sesuai dengan kebutuhan pelayanan pasien Covid-19 di RS UI, sehingga case manager RS UI belum menjalankan peran sesuai rumusan tugas pokok fungsi case manager untuk kebutuhan pelayanan pasien Covid-19 di RS UI. Secara garis besar, terdapat tiga hambatan peran case manager, yaitu hambatan pengorganisasian, hambatan aktivitas, dan hambatan evaluasi. Peneliti merekomendasikan agar tupoksi case manager tetap memenuhi standar akreditasi, dan disesuaikan dengan karakteristik RS. Selain itu, perlu dilakukan penguatan case manager secara kualitas dan kuantitas, agar dapat berperan lebih optimal.

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The Covid-19 pandemic is a challenge for UI Hospital in prioritizing its services to patients that are holistic in nature, for the benefit and safety of patients. Case manager is a new position at UI Hospital, so it is considered that there are still many gaps in its implementation. The role of the case manager is felt to be not optimal in the field, especially by clinicians and management. The purpose of the study was to formulate the main duties and functions of the case manager in the service of Covid-19 patients, as well as to identify the roles that have been carried out by the case manager. This research was a non-experimental qualitative using a phenomenological approach with a cross-sectional design. The researcher found that the case manager of the UI Hospital had not carried out the role according to the formulation of the main duties and functions of the case manager in the hospital accreditation standard; The formulation of the main duties and functions of the case manager was not in accordance with the service needs of Covid-19 patients at the UI Hospital. Therefore, the case manager was considered not to have carried out the roles accordingly for the service needs of Covid-19 patients at the UI Hospital. Thus, in general terms, there are three barriers to the role of the case manager, namely organizational barriers, activity barriers, and evaluation barriers. The researcher recommends that the main duties of the case manager still meet accreditation standards, and are adjusted to the characteristics of the hospital. In addition, it is necessary to strengthen case managers in terms of quality and quantity, so that they can play a more optimal role."

"Profesi apoteker berperan penting dalam pekerjaan kefarmasian. Hal penting yang yang dilakukan oleh apoteker agar menjadi apoteker yang profesional salah satunya adalah melakukan praktik kefarmasian. Sehingga calon apoteker dituntut untuk menjalani praktik profesi untuk bekal dan pengalaman agar memiliki pemahaman tentang peran apoteker sebelum terjun di dunia kerja. Praktik Kerja Profesi Apoteker dilakukan di Apotek Roxy Sawangan Maret - April 2021, dan Rumah Sakit Umum Daerah Kebayoran Lama April – Juni Tahun 2021. Melalui Praktik Kerja di sektor apotek dan rumah sakit tersebut calon apoteker diharapkan dapat mendapatkan kompetensi yang dibutuhkan dalam melakukan pekerjaan kefarmasian.

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Pharmacist profession plays an important role in pharmaceutical work. One of the important things that pharmacists do to become professional pharmacists is to practice pharmacy. So that prospective pharmacists are required to undergo professional practice for provision and experience in order to have an understanding of the role of pharmacists before entering the world of work. The Pharmacist Professional Work Practice was carried out at Roxy Sawangan Pharmacy in March - April 2021, and Kebayoran Lama Regional General Hospital in April - June 2021. Through Work Practices in the pharmacy and hospital sector, prospective pharmacists are expected to gain the competencies needed to carry out pharmaceutical work."

"Ketahanan nasional suatu bangsa tidak pernah lepas dari segala bentuk ancaman yang memerlukan penanganan yang tepat. Di masa pandemi Covid-19, yang menjadi tantang besar tidak hanya Covid-19 melainkan juga sebaran disinformasi terkait Covid-19 yang disebut sebagai disinfordemik. Penyebaran disinformasi terkait vaksin Covid-19 yang masif di media sosial, seperti Twitter, jika tidak cepat segera ditangani, maka akan menjadi kendala dalam upaya pemerintah menanganggulangi pandemi Covid-19. Penelitian ini menggunakan metode deskriptif kualitatif untuk memahami fenomena dengan menganalisis gejala dan interaksi sosial yang kompleks yang sedang terjadi. Sedangkan untuk menganalisis data penelitian ini menggunakan analisis isi. Penelitian ini menggunakan data sekunder, yaitu laporan Isu Hoax terkait Vaksin Covid-19 periode Oktober 2021-Desember 2021. Hasil penelitian ini, menemukan tiga hal, yakni pertama, disinformasi yang tersebar di Twitter dapat di kelompokkan ke dalam tiga kategori, yakni rekayasa digital, otoritas medis terkait efek vaksin dan kandungan vaksin, dan otoritas non medis terkait efek vaksin. Sedangkan untuk kategori teknik propaganda, disinformasi di Twitter dapat di kelompokkan ke dalam tiga teknik propaganda, yaitu teknik transfer, teknik testimoni, dan teknik name-calling. Kedua, secara umum akar permasalahan masifnya penyebaran disinformasi di media sosial adalah kelemahan kognitif. Ketiga, penyebaran disinformasi yang masif di media sosial menjadi indikator ancaman ketahanan informasi.

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The national resilience of a nation can never be separated from all forms of threats that require proper handling. During the Covid-19 pandemic, the big challenge is not only Covid-19 but also the spread of disinformation related to Covid-19 which is known as disinfordemic. The massive spread of disinformation related to the Covid-19 vaccine on social media, such as Twitter, if not handled quickly, will become an obstacle in the government's efforts to tackle the Covid-19 pandemic. This study uses a qualitative descriptive method to understand the phenomenon by analyzing the symptoms and complex social interactions that are happening. Meanwhile, to analyze the research data using content analysis. This study uses secondary data, namely reports on Hoax Issues related to the Covid-19 Vaccine for the period October 2021-December 2021. This study found three things: first, disinformation spread on Twitter can be grouped into three categories: digital engineering, medical authorities regarding the effects of vaccines and vaccine contents, and non-medical authorities regarding the effects of vaccines. As for the category of propaganda techniques, disinformation on Twitter can be grouped into three propaganda techniques: transfer, testimonial, and name-calling. Second, in general, cognitive weakness is the root cause of the massive spread of disinformation on social media. Third, the massive spread of disinformation on social media is an indicator of the threat to information security."

"Coronavirus Disease 2019 masih menjadi permasalahan kesehatan global sampai saat ini. Pengobatan COVID-19 belum definitif sehingga penggunaan terapi yang sudah ada dengan profil keamanan yang terbukti menjadi strategi yang menjanjikan. Informasi mengenai keamanan obat sudah diketahui, tetapi data terkait interaksi obat masih terbatas. Polifarmasi, usia, dan jumlah komorbiditas juga menjadi prediktor penting dari interaksi obat yang merugikan. Penelitian ini bertujuan untuk menganalisis potensi interaksi obat dan faktor-faktor yang memengaruhi potensi interaksi obat pada pasien COVID-19 rawat inap di Rumah Sakit Universitas Indonesia periode Januari sampai Desember 2021. Penelitian ini merupakan penelitian cross-sectional retrospektif. Pengambilan sampel penelitian dari rekam medis dilakukan dengan metode konsekutif. Potensi interaksi obat diperiksa dengan referensi online Lexi-interact®. Potensi interaksi obat yang terdeteksi pada 206 pasien berjumlah 272 kasus dengan 23,9% kategori B, 61,4% kategori C, 10,7% kategori D, dan 4% kategori X. Potensi interaksi obat dengan kejadian paling tinggi pada kategori B terjadi pada parasetamol dan favipiravir (25 kasus), kategori C pada levofloksasin dan deksametason (27 kasus), kategori D pada ondansetron dan domperidon (13 kasus) dan kategori X pada kalium klorida dan loratadin dan pseudoefedrin (2 kasus). Hasil uji korelasi Spearman’s rho menunjukkan adanya korelasi positif dengan nilai p<0,05 antara usia, jumlah obat, dan komorbiditas dengan potensi interaksi obat. Kesimpulan dari penelitian ini adalah terdapat potensi interaksi obat yang beragam serta adanya hubungan antara usia, jumlah obat, komorbiditas terhadap potensi interaksi obat pada pasien COVID-19 rawat inap di Rumah Sakit Universitas Indonesia periode Januari sampai Desember 2021.

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Coronavirus Disease 2019 is still a global health issue to date. The treatment of COVID-19 is not yet definitive so the use of existing therapies with a proven safety profile is a promising strategy. Information regarding drug safety is well known, but data related to drug interactions are still limited. Polypharmacy, age, and the number of comorbidities are also important predictors of adverse drug interactions. This study aims to analyze the potential drug interactions and the factors that influence drug interactions in COVID-19 inpatients at the University of Indonesia Hospital from January to December 2021. This study is a retrospective cross-sectional study. Research sampling from medical records was performed by consecutive methods. Potential drug interactions are examined with Lexi-interact® online reference. Potential drug interactions detected in 206 patients accounted for 272 cases with 23.9% category B, 61.4% category C, 10.7% category D, and 4% category X. Potential drug interactions with the highest incidence in category B occured in paracetamol and favipiravir (25 cases), category C in levofloxasin and dexamethasone (27 cases), category D in ondansetron and domperidone (13 cases) and category X in potassium chloride and loratadine and pseudoephedrin (2 cases). The results of Spearman's rho correlation test showed a positive correlation with a p value <0.05 between age, the number of drugs, and comorbidity with the potential drug interaction. The conclusion of this study is that there are various potential drug interactions and there are relation between age, number of drugs, comorbidities to the potential drug interactions in COVID-19 inpatients at the University of Indonesia Hospital from January to December 2021."