Hasil Pencarian  ::  Simpan CSV :: Kembali

"Spondilitis tuberkulosis manifestasi tuberkulosis ekstrapulmoner hasil dari penyebaran hematogen tuberkulosis ke vertebral melalui aliran darah dan paling sering melibatkan persimpangan thorakolumbar. Tanda-tanda lanjutan penyakit ini adalah paraparesis dan paraplegia, kejadian ini dilaporkan pada 4% sampai 30% kasus. Pasien spondilitis tuberkulosis mengalami gangguan neuromuskuler sehingga mengalami gangguan mobilitas dan sangat rentan terhadap perkembangan ulkus dekubitus akibat jaringan terlalu lama terpapar oleh tekanan. Analisis dilakukan pada pasien laki-laki berusia 55 yang mengalami paraparesis akibat spondilitis tuberkulosis sehingga muncul ulkus dekubitus dan menjalani operasi debridement ulkus. Masalah keperawatan yang muncul adalah risiko infeksi, risiko ketidakseimbangan elektrolit, ketidakseimbangan nutrisi:kurang dari kebutuhn tubuh. Tujuan penulisan ini yaitu memaparkan hasil analisis asuhan keperawatan dengan perawatan luka menggunakan honey dressing pada pasien spondilitis tuberkulosis dan post debridement ulkus dekubitus. Penerapan perawatan luka dengan honey dressing ini dilakukan dari tanggal 18-20 April 2023, balutan diganti sehari sekali. Dari penerapan intervensi ini, terbukti menurunkan skor PUSH tool (Pressure Ulcer Scale for Healing) namun, perlu penilaian dengan durasi lebih lama untuk melihat kemajuan luka. Kesimpulannya perawatan luka dengan honey dressing dapat dilakukan untuk meningkatkan kesembuhan luka, selain itu honey dressing ini mudah dicari, efektif, dan ekonomis.

---

Tuberculosis spondylitis is manifestations of extrapulmonary tuberculosis result from hematogenous spread of tuberculosis to the vertebrae via the bloodstream and most commonly involve the thoracolumbar junction. Later signs of the disease are paraparesis and paraplegia, which have been reported in 4% to 30% of cases. Patients with tuberculosis spondylitis have neuromuscular disorders that cause impaired mobility and are highly susceptible to the development of decubitus ulcers due to prolonged tissue exposure to pressure. The analysis was performed on a 55-year-old male patient who had paraparesis due to tuberculosis spondylitis resulting in decubitus ulcers and underwent ulcer debridement surgery. The problems that arise are the risk of infection, the risk of electrolyte imbalance, nutritional imbalance: less than the body's needs. The purpose of this paper is to present the results of an analysis of wound care using honey dressing in patients with tuberculosis spondylitis and decubitus ulcer post debridement. The implementation of wound care with honey dressing is carried out from April 18-20 2023, the dressing is changed once a day. From the implementation of this intervention, it is proven to reduce the score of the PUSH (Pressure Ulcer Scale for Healing) tool but requires an assessment with a longer duration to see the progress of the wound. In conclusion, wound care with honey dressing can be done to improve wound healing, besides that honey dressing is easy to find, effective, and economical."

"Cairan NaCl 3% pada penelitian sebelumnya terbukti mampu menarik kelebihan eksudat dan mengurangi bau luka karena bersifat hipertonik. Penelitian eksperimen dengan penyamaran ganda dilakukan untuk mengetahui efektivitas perawatan luka dengan cairan NaCl 3% terhadap penurunan jumlah eksudat dan bau ulkus diabetik. Intervensi dilakukan selama 14 hari terhadap 15 sampel yang dibagi menjadi kelompok NaCl 0,9% dan NaCl 3% melalui randomisasi blok. Tidak terdapat perbedaan signifikan jumlah eksudat setelah intervensi antara kedua kelompok namun terdapat perbedaan signifikan pada skor bau luka. Perawatan ulkus diabetik dengan NaCl 3% tidak lebih efektif dalam menurunkan jumlah eksudat luka dibandingkan NaCl 0,9% namun lebih efektif NaCl 3% dalam menurunkan skor bau.

---

Previous studies on wound care had proved that NaCl 3% solution able to absorbs the wound exudate and reduces the odor because it is hypertonic. A randomized controlled trial with double blinded technique was conducted to determine the effectiveness of wound care using NaCl 3% solution to decrease amount of exudate and odor of diabetic ulcers. Interventions performed for 14 days on 15 subjects blocked randomly allocated to NaCl 0,9% and NaCl 3% groups.

The result showed that there was no significant difference in the amount of exudate between the groups, however there was significant difference in the odor score. Wound care using NaCl 3% is no more effective to reduce the amount of exudate than NaCl 0,9%, however NaCl 3% is effective to reduce the odor score of diabetic ulcer."

"Latar belakang: Perforasi tukak peptik PTP merupakan komplikasi penyakit tukak peptik yang memiliki angka morbiditas dan mortalitas yang cukup tinggi. Luaran pasien yang maksimal dapat dicapai dengan perawatan optimal disertai alokasi sumber daya yang sesuai dengan statifikasi pasien berdasarkan kelompok risikonya. Skor peptic ulcer perforation PULP merupakan sistem penilaian terbaru untuk prediksi prognosis pasien PTP. Penelitian ini bertujuan untuk mengetahui penerapan skor PULP dalam prediksi mortalitas pasien PTP di Rumah Sakit dr. Cipto Mangunkusumo RSCM. Metode penelitian: Studi potong lintang analitik dilakukan dengan mengambil total sampel 52 pasien PTP yang datang ke RSCM pada periode Januari 2011-Juni 2015. Pasien perforasi gaster/duodenum akibat trauma dan keganasan gaster/duodenum, pasien yang tidak menjalani pembedahan dan pasien yang sudah menjalani pembedahan di luar RSCM dieksklusi. Analisis statistik diolah dengan program SPSS 20 for windows, untuk menilai variabel apa yang secara independen memengaruhi mortalitas pasien PTP dan bagaimana akurasi skor PULP dalam prediksi mortalitas pasien PTP. Hasil penelitian: Variabel syok saat masuk rumah sakit dan awitan penyakit >24 jam merupakan prediktor independen mortalitas pasien PTP dengan nilai kemaknaan masing-masing 0,04 dan 0,03. Nilai area under the curve skor PULP dalam prediksi mortalitas pasien PTP mencapai 71,60 95 IK 53,80 -89,40. Kesimpulan: Penggunaan skor PULP dinilai cukup baik untuk prediksi mortalitas pasien PTP di RSCM. Kata kunci: Perforasi tukak peptik, skor peptic ulcer perforation PULP , mortalitas, syok, awitan penyakit.

---

Background: Perforated peptic ulcer PPU is a complication of peptic ulcer disease with high rates of morbidity and mortality. Maximum outcomes could be achieved by optimal care combined with allocation of resources in accordance with patient's risk stratification. Peptic ulcer perforation PULP score is the newest scoring systems for predicting the prognosis of PPU patients. This study aims to determine the application of PULP score in predicting mortality of PPU patient in Cipto Mangunkusumo Hospital.

Method: A cross sectional analytical study carried out by taking the total sample of 52 patients who came with PPU to Cipto Mangunkusumo Hospital in the period of January 2011 June 2015. Those with perforation at stomach duodenum due to trauma and malignancy, those who did not undergo surgery and those who have undergone surgery outside Cipto Mangunkusumo Hospital were excluded. Statistical analysis is processed with SPSS 20 for windows, to determine which variables independently afffect the mortality of PPU patients and how is the accuracy of PULP score in predicting mortality of PPU patients.

Results: Shock on admission and onset of disease 24 hours were independent predictors of mortality in PPU patients p value 0.04 and 0.03 respectively. The value of area under the curve of PULP score in predicting mortality in PPU patients was 71.60 95 CI 53.80 89.40.

Conclusions: PULP score is considered good enough to predict mortality of PPU patients in Cipto Mangunkusumo Hospital. Keywords Perforated peptic ulcer, peptic ulcer perforation PULP score, mortality, shock, onset of disease."

"Chronic kidney disease (CKD) yang prevalensinya meningkat dalam beberapa tahun terakhir, seringkali berdampak pada penurunan sensasi, edema, anemia, hingga penurunan kesadaran atau koma. Kondisi-kondisi tersebut meningkatkan risiko terjadinya pressure ulcer. Selain merugikan bagi health outcome pasien, kejadian pressure ulcer juga memberikan dampak negatif dari aspek costeffectivenes dan mutu pelayanan rumah sakit. Oleh karena itu, diperlukan upaya pencegahan terjadinya pressure ulcer, salah satunya dengan penerapan topikal ekstra virgin olive oil (EVOO) pada area-area yang berisiko tinggi pressure ulcer. Penulisan ini bertujuan untuk menggambarkan penerapan EVOO untuk mencegah pressure ulcer, khususnya pada area sakrum, regio trokanter, dan tumit. Pada karya ilmiah ini, pasien dirawat selama enam hari. Hasil pengkajian menunjukan pasien berisiko tinggi mengalami risiko gangguan integritas kulit dengan faktor risiko adanya edema, anemia, ketidakseimbangan cairan dan elektrolit, penurunan sensasi, dan imobilitas. Intervensi keperawatan yang dilakukan antara lain, evaluasi berkala integritas kulit dan reposisi dua jam sekali. Selain itu, diaplikasikan juga EVOO sebanyak dua kali sehari selama lima hari dan dilakukan setiap kali pengaplikasian. Hasil evaluasi pressure ulcer mampu dicegah pada sebagian besar area yang diintervensi, sehingga penerapan EVOO secara topikal dapat menjadi salah satu pilihan bagi perawat sebagai intervensi keperawatan mandiri untuk mencegah terjadinya pressure ulcer.

---

Chronic kidney disease (CKD), whose prevalence has increased in recent years, often results in decreased sensation, edema, anemia, and loss of consciousness or coma. These conditions increase the risk of pressure ulcers. In addition to being detrimental to the health outcomes of patients, the incidence of pressure ulcers also has a negative impact from the aspects of cost-effectivenes and quality of hospital services. Therefore, efforts are needed to prevent the occurrence of pressure ulcers, one of which is by applying topical extra virgin olive oil (EVOO) to areas at high risk of pressure ulcers. This paper aims to describe the effectiveness of EVOO application to prevent pressure ulcers, especially in the sacrum area, trochanter region, and heel. In this scientific work, the patient was treated for six days. Assessment results showed that the patient was at high risk of skin integrity impairment with risk factors for edema, anemia, fluid and electrolyte imbalance, decreased sensation, and immobility, electrolytes, decreased sensation, and immobility. Nursing interventions that carried out include periodic evaluation of skin integrity and repositioning every two hours. In addition, EVOO was also applied twice a day for five days and done every time the five days and was done every time the application was done. The evaluation results showed that pressure ulcers prevented in most of the intervened areas, so topical application of EVOO can be an option for nurses as an independent nursing intervention to prevent pressure ulcers."

"ABSTRAKLuka kaki diabetik merupakan komplikasi diabetes yang menyebabkan tingginya angka amputasi. Luka kaki diabetik membutuhkan perawatan yang efektif dan efisien untuk mecegah perluasan infeksi dan memperbaiki kerusakan jaringan. Tujuan penulisan karya ilmiah ini adalah untuk menganalisis keefektifan balutan luka modern dalam perawatan luka kaki diabetik. Metodologi yang digunakan adalah studi kasus. Hasil analisis yang didapat bahwa terdapat perbaikan pada kondisi luka berupa berkurangnya jaringan nekrotik sebanyak 75% , jumlah eksudat berkurang 80%, dan lingkungan disekitar luka tampak lembab. Studi kasus ini merekomendasikan agar perawatan luka dengan menggunakan balutan modern jenis hydrogel dapat diimplementasikan pada perawatan luka kaki diabetik untuk mempercepat proses penyembuhan luka.

---

ABSTRACT

Diabetic foot ulcer is a complication of diabetes which causes high amputation rates. Diabetic foot ulcer requires effective and efficient treatment to prevent the spread of infection and repair damaged tissue. The purpose of writing this scientific paper is to analyze the effectiveness of modern dressing Hydrogel in the treatment of diabetic foot ulcer. The methodology used is a case study. The results of the analysis found that there was an improvement in the condition of the wound in the form of 75% reduction in necrotic tissue, the amount of exudate was reduced by 80%, and the environment around the wound looked moist. This case study recommends that wound care using modern dressing hydrogel can be implemented for treatment of diabetic foot ulcer to promote the wound healing process."

"ABSTRAKLatar Belakang: Mortalitas pasien perforasi tukak peptik (PTP) masih stabil padaangka 20-50% dimana penyebab terbanyak adalah sepsis. Tantangan ini memicu paraahli bedah untuk meneliti faktor-faktor yang berhubungan dengan mortalitas danmorbiditas penyakit ini. Selain pembedahan untuk kontrol infeksi, antibiotikapreoperatif diketahui menurunkan angka mortalitas. Penelitian ini bertujuanmengetahui hubungan kesesuaian antibiotika empiris dengan hasil kultur sensitifitasantibiotika terhadap ketahanan hidup 30 hari pasien perforasi tukak peptik di RSUPNDr Cipto Mangunkusumo (RSCM) Jakarta. Metode: Studi kohort terhadap pasienPTP sejak Januari 2012 hingga Agustus 2015 di Departemen Bedah FKUI/RSCMJakarta, dimana PTP akibat keganasan dan trauma tembus dieksklusikan. Pola kumandan antibiotika pada pasien PTP disajikan sebagai studi pendahuluan. Hasil: dari 45pasien yang didapat, angka mortalitas pasien PTP di RSCM sebesar 31,1% danketahanan hidup sebesar 68,9%. Pola kuman pada pasien PTP adalah Escherichia colisebagai kuman Gram negatif terbanyak (35,85%) dan Streptococcus alfahemolyticsebagai kuman Gram positif terbanyak (15,09%). Antibiotika lini kedua yang sesuaiuntuk pasien PTP adalah Sulbactam/Ampicillin.Tidak terdapat hubungan antara skor Boey dan ketahan hidup, namun syok preoperatif memengaruhi ketahanan hidup(nilai OR 14,67). Begitu juga dengan komorbiditas memengaruhi ketahanan hidupsebesar 10,54 kali. Lama persiapan operasi tidak bermakna terhadap ketahanan hidup,sedangkan durasi operasi memengaruhi ketahanan hidup sebesar 7,5 kali. Antibiotikaempiris yang sesuai dengan hasil kultur memengaruhi ketahanan hidup sebesar 12,57kali. Kesimpulan: Pemberian antibiotika empiris yang tepat terbukti berhubungandengan ketahanan hidup pasien perforasi tukak peptik.;

---

ABSTRACT

Background: Mortality of patients with peptic ulcer perforation (PUP) was stable at

20-50%, which is the most common cause is sepsis. This challenge prompted the

surgeon to examine the factors associated with mortality and morbidity of this

disease. In addition to surgery to control infection, preoperative antibiotics are

known to reduce mortality. This study aims to determine the suitability of empiric

antibiotics relationship with antibiotic sensitivity culture results to the 30 days

survival of perforated peptic ulcer patients in Dr Cipto Mangunkusumo General

Hospital (RSCM) in Jakarta. Methods: A cohort study of patients PUP since January

2012 to August 2015 at Department of Surgery Faculty of medicine/RSCM Jakarta,

where PUP due to malignancy and penetrating trauma were excluded. Patterns of

bacteria and antibiotics in PUP patients presented as a preliminary study. Results:

45 patients were obtained, the mortality rate of patients in RSCM PUP by 31.1% and

amounted to 68.9% survival. Patterns of bacteria in a patient PUP is Escherichia

coli as most Gram-negative bacteria (35.85%) and Streptococcus alfahemolytic as

most Gram-positive bacteria (15.09%). The second line antibiotics are appropriate

for the PUP patients is sulbactam/ampicillin. There was no relationship between

Boey?s score and survivability, but the preoperative shock affect survival (OR 14.67).

Likewise with comorbidities affecting the survival of 10.54 times. Time to surgery on

survival was not significant, while the duration of surgery affecting the survival of 7.5

times. Empiric antibiotics in accordance with the culture results affects survival of

12.57 times. Conclusion: The provision of appropriate empiric antibiotic shown to be

associated with survival in patients with peptic ulcer perforation. ;Background: Mortality of patients with peptic ulcer perforation (PUP) was stable at20-50%, which is the most common cause is sepsis. This challenge prompted thesurgeon to examine the factors associated with mortality and morbidity of thisdisease. In addition to surgery to control infection, preoperative antibiotics areknown to reduce mortality. This study aims to determine the suitability of empiricantibiotics relationship with antibiotic sensitivity culture results to the 30 dayssurvival of perforated peptic ulcer patients in Dr Cipto Mangunkusumo GeneralHospital (RSCM) in Jakarta. Methods: A cohort study of patients PUP since January2012 to August 2015 at Department of Surgery Faculty of medicine/RSCM Jakarta,where PUP due to malignancy and penetrating trauma were excluded. Patterns ofbacteria and antibiotics in PUP patients presented as a preliminary study. Results:45 patients were obtained, the mortality rate of patients in RSCM PUP by 31.1% andamounted to 68.9% survival. Patterns of bacteria in a patient PUP is Escherichiacoli as most Gram-negative bacteria (35.85%) and Streptococcus alfahemolytic asmost Gram-positive bacteria (15.09%). The second line antibiotics are appropriatefor the PUP patients is sulbactam/ampicillin. There was no relationship betweenBoey?s score and survivability, but the preoperative shock affect survival (OR 14.67).Likewise with comorbidities affecting the survival of 10.54 times. Time to surgery onsurvival was not significant, while the duration of surgery affecting the survival of 7.5times. Empiric antibiotics in accordance with the culture results affects survival of12.57 times. Conclusion: The provision of appropriate empiric antibiotic shown to beassociated with survival in patients with peptic ulcer perforation.;Background: Mortality of patients with peptic ulcer perforation (PUP) was stable at20-50%, which is the most common cause is sepsis. This challenge prompted thesurgeon to examine the factors associated with mortality and morbidity of thisdisease. In addition to surgery to control infection, preoperative antibiotics areknown to reduce mortality. This study aims to determine the suitability of empiricantibiotics relationship with antibiotic sensitivity culture results to the 30 dayssurvival of perforated peptic ulcer patients in Dr Cipto Mangunkusumo GeneralHospital (RSCM) in Jakarta. Methods: A cohort study of patients PUP since January2012 to August 2015 at Department of Surgery Faculty of medicine/RSCM Jakarta,where PUP due to malignancy and penetrating trauma were excluded. Patterns ofbacteria and antibiotics in PUP patients presented as a preliminary study. Results:45 patients were obtained, the mortality rate of patients in RSCM PUP by 31.1% andamounted to 68.9% survival. Patterns of bacteria in a patient PUP is Escherichiacoli as most Gram-negative bacteria (35.85%) and Streptococcus alfahemolytic asmost Gram-positive bacteria (15.09%). The second line antibiotics are appropriatefor the PUP patients is sulbactam/ampicillin. There was no relationship betweenBoey?s score and survivability, but the preoperative shock affect survival (OR 14.67).Likewise with comorbidities affecting the survival of 10.54 times. Time to surgery onsurvival was not significant, while the duration of surgery affecting the survival of 7.5times. Empiric antibiotics in accordance with the culture results affects survival of12.57 times. Conclusion: The provision of appropriate empiric antibiotic shown to beassociated with survival in patients with peptic ulcer perforation."

"Latar belakang: Ulkus kaki diabetik adalah komplikasi umum yang terjadi pada penderita diabetes mellitus (DM). Penurunan aliran darah berkontribusi terhadap kronisitas ulkus kaki diabetik. Vibrasi diduga berdampak pada perbaikan aliran darah. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas vibrasi terhadap percepatan penyembuhan ulkus kaki diabetik. Metode: Penelitian ini merupakan penelitian eksperimen dengan desain penelitian yang digunakan adalah randomized clinical trial (RCT) non blinding. Subyek penelitian merupakan pasien dengan ulkus kaki diabetik derajat 0-2 yang dibagi menjadi 2 kelompok yaitu kelompok kontrol dan kelompok intervensi. Pada kelompok intervensi, vibrasi diberikan dengan dosis 3 kali sehari dengan lama pemberian 15 menit sampai luka dinyatakan sembuh. Hasil: Penelitian ini menunjukkan perbedaan bermakna (p<0,05) pada laju kesembuhan, rerata skor penyembuhan luka khususnya pengamatan minggu pertama dan kedua serta rerata penutupan area luka. Laju kesembuhan dan penutupan luka pada kelompok intervensi lebih cepat dibandingkan kontrol. Vibrasi juga meningkatkan kadar nitric oxide (NO) setelah intervensi diberikan dan menunjukkan perbedaan bermakna antara kedua kelompok. Sebagai luaran sekunder didapatkan hubungan antara kadar NO dengan laju kesembuhan dan penutupan area luka. Kesimpulan: Pemberian vibrasi efektif mempercepat penyembuhan ulkus kaki diabetik diukur dari laju kesembuhan, skor penyembuhan, penutupan area luka dan kadar NO.

---

Background: Diabetic foot ulcer is a common complication in patient with diabetes mellitus. The decreased blood flow has a role in the chronicity of diabetic foot ulcer. Vibration therapy was supposed to be able to improve the blood flow. The aim of this study was to evaluate the effect of vibration on the acceleration of healing of diabetic foot ulcer.

Method: This experimental study used a randomized clinical trial non blinding design. Patients with diabetic foot ulcers grade 0-2 were divided into control group and intervention group. Patients in intervention group received vibration as an adjuvant to standard therapy, three times a day, each for 15 minutes, until the wound were healed.

Results: There were significant differences (p<0.05) in terms of healing rate, wound healing score (especially at the end of week 1 and week 2), and the wound closure area. The rate of wound healing and wound closure were significantly higher in the intervention group. The level of nitric oxide (NO) was also significantly higher in the intervention group. As an additional outcome, there was a positive association between the level of NO and the rate of healing and wound closure.

Conclusion: Vibration therapy accelerated the healing of diabetic foot ulcer in terms of healing rate, healing score, wound closure area, and elevated the level of NO."

"Ulkus peptikum adalah hilangnya sel epitel yang mencapai atau menembus muskularis mukosa dengan diameter kedalaman < 5 mm. Ulkus dapat terjadi akibat produksi mukus yang terlalu sedikit atau produksi asam yang berlebihan. Lambung memiliki sistem pertahanan yang dimediasi oleh pelepasan CGRP dari serat saraf aferen dan pembentukan NO. Pada penelitian terdahulu, telah dibuktikan bahwa terdapat zat dalam capsaicin yang dapat membantu mempercepat proses penyembuhan ulkus peptikum. Capsaicin adalah suatu alkaloid yang larut dalam alkohol dan terdapat pada cabai. Capsaicin bekerja dengan merangsang pelepasan CGRP yang selanjutnya memicu pelepasan NO yang berfungsi untuk meningkatkan aliran darah ke lambung. Sedangkan dalam praktek dokter sehari-hari, terdapat beberapa obat yang dapat menimbulkan efek samping ulkus peptikum, salah satunya adalah indometasin. Indometasin mempengaruhi respon peradangan dengan menghambat enzim siklooksigenase sehingga berkurangnya sintesis prostaglandin dan leukotrien yang berfungsi sebagai suatu antiinflamasi. Namun, indometasin dalam dosis besar mempunyai efek samping merangsang produksi asam dan pepsin yang berlebihan di dalam lambung dan memudahkan timbulnya ulkus peptikum. Metode penelitian ini adalah eksperimental. Pada penelitian ini, dilakukan pemberian capsaicin bersamaan dengan suatu zat yang dapat menimbulkan ulkus seperti indometasin. Percobaan dilakukan dengan menginduksi ulkus pada lambung tikus kemudian tikus diberi capsaicin dan indometasin per oral pada hari yang sama. Hasil menunjukkan perbedaan luas ulkus pada tiap kelompok percobaan, rata-rata luas ulkus kelompok kontrol yaitu 5,3 mm2, kelompok capsaicin sebesar 2 mm2, kelompok indometasin sebesar 40,33 mm2, dan kelompok capsaicin dan indometasin sebesar 0 mm2. Hasil uji statistik: perbedaan bermakna (p = 0,034) terdapat antara kelompok yang diberi capsaicin dan kelompok yang diberi indometasin. Kesimpulan Capsaicin terbukti mampu mempercepat penyembuhan ulkus lambung pada tikus yang diberi paparan indometasin.

---

Peptic ulcer is loss of epithelial cell through muscularis mucosa with diameter of depth less than 5 mm.Peptic ulcer is caused by lack of mucous or excess of acid production. Gaster has own self-defence mechanism which mediated by CGRP release from afferent nerve and produce nitric oxide (NO). On the previous research, it has been proven that there is a substance in capsaicin which can accelerate ulcer healing process. Capsaicin is a alcohol solved material which is contained in chilli. Capsaicin stimulates the release of CGRP moreover stimulates release of nitric oxide (NO) that function to increase blood supply to the gaster. In daily clinical practice, there are some drugs which it will lead to peptic ulcer, one of them is indometachin. Indomethacin influence an inflammatory reaction by inhibit cyclooxigenase enzyme, so that decrease the synthesis of prostaglandin and leukotrien which functioned as an anti-inflammatory. However, large amount of indomethacin has side effect to increase acid and pepsin production then induce peptic ulcer. The method of this research is experimental. In this research, given capsaicin with substance that can induce peptic ulcer such as indometachin. The test was started with induction of ulcer on rat?s stomach moreover it?s given with capsaicin and indometachin per oral in the same day. The results shows the difference wide of ulcer between control which are 5,3 mm2, capsaicin 2 mm2, indomethacin 40,33 mm2, and indometchacin combine by capsaicin 0 mm2. Statistic result shows the difference is significant (p = 0,034) between capsaicin and indomethacin. This research shows capsaicin plays role in healing process of gastric ulcer in rats exposured by indomethacin."

"Pendahuluan: Ulkus dekubitus adalah suatu kerusakan jaringan lunak akibat penekanan yang berkepanjangan di atas tonjolan tulang. Sebagian besar studi menggunakan madu Manuka sebagai perawatan luka (dressing), di mana madu tersebut mahal. Atas landasan tersebut, studi ini menggunakan madu lokal, yaitu madu Nusantara, dengan tujuan untuk membuktikan penggunaan madu lokal pada pasien pressure injury memiliki luaran yang lebih baik, diobservasi dari penyembuhan luka, profil bakteri, dan harga, dibandingkan dengan dressing standar, yaitu hydrogel.Metode: Studi eksperimental ini dilakukan kepada pasien pressure injury yang dikonsultasikan ke divisi kami. Observasi dilakukan selama satu bulan. Parameter profil bakteri diambil melalui kultur jaringan. Proses penyembuhan luka dinilai berdasarkan Pressure Ulcer Scale for Healing (PUSH) Tool. Biaya diakumulasikan dari awal sampai akhir tata laksana. Analisis data menggunakan T-test atau Mann-Whitney (jika distribusi tidak normal), dengan signifikansi didefinisikan sebagai p<0,05.Hasil: Dari 26 luka, terdapat 12 luka ditata laksana dengan hydrogel dan 14 madu. Karakteristik pasien dinilai berdasarkan jenis kelamin, usia, indeks massa tubuh, tingkat kesadaran, status mobilisasi, penyebab imobilisasi, komorbiditas, derajat dan luas luka, kadar hemoglobin, leukosit, dan albumin. Terdapat reduksi luas luka yang signifikan secara klinis berdasarkan PUSH Tool (p=0,118). Profil bakteri dan reduksi bakteri serupa di antara kedua grup. Madu lebih efisien dalam hal biaya, terkait dengan harga dressing (p<0,001) dengan total biaya lebih rendah.Kesimpulan: Dressing madu lokal memiliki kemampuan penyembuhan luka yang lebih baik, walaupun tidak signifikan secara statistik. Kemampuan penurunan bakteri sama dengan dressing standar, dengan biaya yang lebih murah, terutama harga dressing. Madu lokal dapat dipakai untuk perawatan luka di area di mana tidak tersedia dressing modern.

---

Background: Pressure injury is a localized soft tissue injury caused by prolonged pressure over bony prominence. Most published papers used Manuka honey as dressing, while this product is expensive. As this reason, this study will use local product honey called Nusantara honey, to prove the use of local honey has better healing process, bacterial profile, and cost effectiveness, compared to the standard dressing, hydrogel.

Methods: This is a one-month experimental study conducted in patients with pressure injury that referred to our division. Parameter of the bacterial profile was taken from deep-tissue specimen. The healing process was examined with Pressure Ulcer Scale for Healing (PUSH) Tool. Cost was accumulated after all the treatment. Data was analyzed with T-Test or Mann Whitney (if the distribution is not normal), with statistical significance was define as p<0.05.

Results: Of 26 wounds, 12 were randomized to hydrogel and 14 to honey dressing. Characteristics were determined by sex, age, body mass index, level of consciousness, mobilization status, immobilization etiology, comorbidities, grade and location of ulcer, hemoglobin, leukocytes, and albumin level. There was clinically significant wound size reduction in honey dressing according to PUSH Tool (p=0.118). The bacterial profile and reduction were similar. Honey dressing appeared to be more cost effective in terms of dressing cost (p<0.001) and lower total cost.

Conclusion: The local honey dressing has better wound healing outcome, although it is not statistically significant. Its capability of decreasing pathogens is similar with hydrogel, with lower cost, particularly the dressing cost. This local honey dressing could be a good choice as wound dressing in areas where the modern dressings are not available."