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"Indonesia tercatat sebagai negara dengan kass demam berdarah dengue tertinggi di Asia Tenggara. Jumlah penderita dan luas daerah penyebarannya semakin bertambah seiring dengan meningkatnya mobilitas dan keadatan penduduk. Carica papaya L. yang termasuk dalam suku Caricaceae adalah tanaman yang dibudidayakan secara luas di Indonesia dan memiliki banyak manfaat untuk kesehatan. Bagian daun diyakini dapat meningkatkan jumlah trombosit dan bermanfaat bagi pasien demam dengue, namun bukti-bukti ilmiah masih sedikit.Penelitian ini bertujuan membuktikan pengaruh kapsul ekstrak daun C. papaya bagi pasien demam dengue. Penelitian menggunakan desain Expertimental Randomized Clinical Trial, dengan sampel berjumlah 80 subyek yang dibagi menjadi 2 kelompok masing-masing 40 subyek, terdiri atas kelompok kontrol dan perlakuan (mendapat kapsul ekstrak daun C. papaya 3 kali 2 kapsul sehari).Hasil penelitian menunjukkan kapsul ekstrak daun C. papaya dapat meningkatkan jumlah trombosit (p value = 0,0001), mempertahankan stabilitas hematokrit pada nilai normal, mempersingkat masa rawat inap (p value = 0,0001) pasien dengue, serta mempercepat peningkatan jumlah trombosit dibandingkan dengan kelompok kontrol."

"ABSTRACTAim: to assess the immunogenicity and safety of CYD-tetravalent dengue vaccine (CYD-TDV) in children. Methods: comprehensive literature searches were conducted on various databases. Randomized-controlled trials on children with CYD-TDV as intervention were selected based on inclusion and exclusion criteria. Data extracted from selected trials included safety of vaccine and immunogenicity in terms of Geometric Mean Titres (GMT) of antibodies. Results: A six clinical trials were selected based on preset criteria. GMT values were obtained using 50% Plaque Reduction Neutralization Test (PRNT) and safety was semi-quantitatively assessed based on adverse effects. Additional data processing was done to obtain a better understanding on the trends among the studies. The results showed that the groups vaccinated with CYD-TDV showed higher immunogenicity against dengue virus antigens than the control groups. Safety results were satisfactory in all trials, and most severe side effects were unrelated to the vaccine. Conclusion: CYD-TDV is both effective and safe for patients in endemic regions. This gives promise for further development and large-scale research on this vaccine to assess its efficacy in decreasing dengue prevalence, and its pervasive implementation in endemic countries, such as Indonesia."

"Demam berdarah dengue merupakan penyakit tular vektor. Pada tahun 2021 Indonesia memiliki IR 11,48/100.000 penduduk dan Case Fatality Rate sebesar 0,89%. Pada tahun 2021 Depok memiliki kasus tertinggi sebanyak 3.155 kasus (IR= 75,24/100.000 Penduduk). Pencegahan DBD dilakukan dengan dibentuknya Kordinator kader jumantik tiap RT untuk meningkatkan Angka Bebas Jentik (ABJ). ABJ baik jika ≥ 95%. Peningkatan Angka Bebas Jentik (ABJ) dipengaruhi oleh pengetahuan dan peran koordinator kader jumantik . Tujuan dari penelitian ini adalah untuk mengetahui hubungan pengetahuan dan peran koordinator kader jumantik terhadap angka bebas jentik (ABJ) di Kelurahan Tugu Kecamatan Cimanggis Kota Depok tahun 2022. Penelitian kuantitatif menggunakan data primer yaitu kuesioner yang telah dimodifikasi dari arahan Kemenkes RI dan penelitian sebelumnya. Desain penelitian cross sectional, sampel penelitian 101 responden. Hasil penelitian terdapat hubungan yang signifikan antara pengetahuan dengan Angka Bebas Jentik (ABJ) dan terdapat hubungan yang signifikan Peran Koordinator Kader Jumantik yaitu Pemantauan Jentik Berkala (PJB) terhadap Angka Bebas Jentik (ABJ).

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Dengue hemorrhagic fever is a vector-borne disease. In 2021 Indonesia has an IR of 11.48/100,000 population and a Case Fatality Rate of 0.89%. In 2021 Depok has the highest case of 3,155 cases (IR = 75.24/100,000 Population). Prevention of DHF is carried out by establishing a jumantik cadre coordinator for each RT to increase the larva-free rate (ABJ). ABJ is good if 95%. The increase in larva free rate (ABJ) is influenced by the knowledge and role of the jumantik cadre coordinator. The purpose of this study was to determine the relationship between knowledge and the role of the jumantik cadre coordinator on the larva-free rate (ABJ) in Tugu Village, Cimanggis District, Depok City in 2022. This quantitative study used primary data, namely a questionnaire that had been modified from the direction of the Indonesian Ministry of Health and previous research. The research design is cross sectional, the research sample is 101 respondents. The results of the study showed that there was a significant relationship between knowledge and the larva-free rate (ABJ) and there was a significant relationship between the role of the Jumantik Cadre Coordinator, namely Periodic Lartic Monitoring (PJB) on the larva-free rate (ABJ)."