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"This paper discusses the situation and issues concerning the distinctively Japanese school graduates employment system that has underpinned the stable transition of high school graduated from education to work in Japanese society using data from an interview survey conducted by the Japanese Instute for Labour Policy and Training (JILPT) in 2007 and the Japan Education Longitudinal study (JELS), and focuses in particular on vocational counseling for hogh school graduates...."

"Latar belakang: Lupus eritematosus sistemik (LES) merupakan penyakit autoimun sistemik yang 10-20% kasusnya memiliki awitan sejak masa kanak. Kesintasan anak dengan LES di negara maju maupun berkembang jauh meningkat sejak beberapa dekade terakhir. Meskipun kesintasannya meningkat, tidak semua anak dan remaja LES dapat memasuki masa dewasa dengan baik. Layanan transisi remaja merupakan jembatan penghubung antara layanan kesehatan anak dan dewasa yang mulai banyak dikembangkan untuk remaja dengan kebutuhan medis khusus seperti LES.Metode: Studi pre-eksperimental pada remaja LES berusia 15 tahun hingga 17 tahun 6 bulan dilakukan di RSUPNCM dalam kurun waktu antara Desember 2022 hingga Mei 2023. Dalam studi ini seluruh subyek diikutkan dalam modul transisi remaja yang kegiatannya dilakukan secara daring maupun luring. Kegiatan daring meliputi 3 kali pemaparan materi dan diskusi interaktif dengan tema LES, masa remaja, dan layanan kesehatan di klinik dewasa. Kegiatan luring dilakukan melalui bermain peran menyerupai suasana saat melakukan kunjungan mandiri di layanan kesehatan dewasa yang dilakukan pada akhir penelitian. Luaran modul transisi dinilai dengan membandingkan rerata skor TRAQ 6.0 Bahasa Indonesia sebelum dan sesudah mengikuti modul transisi.Hasil: Terdapat 36 remaja LES yang mengikuti modul transisi, namun hanya 32 subyek yang mengikuti ≥75% kegiatan. Rerata skor TRAQ 6.0 Bahasa Indonesia sebelum mengikuti modul adalah 3,4 (0,6). Rerata tersebut meningkat menjadi 3,8 (0,6) setelah mengikuti modul (p=0.001). Tidak ada hubungan antara lama sakit, derajat aktivitas penyakit, dan kunjungan mandiri terhadap skor TRAQ 6.0 Bahasa Indonesia sebelum mengikuti modul transisi. Simpulan: Modul transisi remaja terbukti dapat meningkatkan kesiapan transisi remaja dengan LES berusia 15-17 tahun.

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Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease in which 10-20% of cases have an onset in childhood. The survival of children with SLE in both developed and developing countries has increased greatly in the last few decades. Although survival has increased, not all children and adolescents with SLE can enter adulthood well. Adolescent transition services are a bridge between child and adult health services which have begun to be developed for adolescents with special medical needs such as SLE.

Methods: The pre-experimental study on LES adolescents aged 15 to 17 years 6 months was conducted at Cipto Mangunkusumo General Hospital from December 2022 to May 2023. In this study, all subjects were included in the adolescent transition module, whose activities were carried out both online and offline. Online activities include 3 presentations of material and interactive discussions on the themes of LES, adolescence, and health services in adult clinics. Offline activities are carried out through role playing, resembling the atmosphere during independent visits to adult health services carried out at the end of the study. The main outcome of the transition module was assessed by comparing the average Indonesian TRAQ 6.0 score before and after participating in the transition module.

Results: There were 36 LES adolescents who took part in the transition module, but only 32 subjects took ≥75% of the activities. The average Indonesian TRAQ 6.0 score before taking the module was 3.4 (0.6). The mean increased to 3.8 (0.6) after participating in the module (p=0.001). There is no relationship between disease duration, degree of disease activity, and independent visits to the Indonesian TRAQ 6.0 score before joining the transition module.

Conclusion: The transition module has been proven to increasing transition readiness of adolescents aged 15 to 17 years with SLE."

"This article will discuss the ultranationalist movement in Russia, emerged and flourished in the early until in the middle of 1990s in Russian Federation state. This ullranationalist movement emerged sporadically at the same time with the emerge of other movement groups at the time of democracy transition period. The openness condition had pushed elements of society established political groups and parties. Most of them supported government programs, while the other put a role as opposition groups. The ultranationalist movement, united in Democrat-Liberal Party, was the hard-liner groups, who opposed Russian government policy. However, in the middle of 1990s, this movement was becoming weak. The emerge and weakened of this movement was caused by some factors which will be discussed in the article below."

"Studi ini bertujuan untuk mengetahui pengaruh upah minimum terhadap employment transition khususnya di Pulau Jawa sebagai wilayah Indonesia yang mayoritas kabupaten/kotanya menetapkan upah minimum. Studi sejenis sebelumnya dilakukan di negara maju yang tidak mempertimbangkan adanya sektor informal. Analisis yang dilakukan menggunakan data individu yang bersumber dari Sakernas BPS tahun 2010 dan 2015 yang dilihat sebagai bentuk longitudinal t-1 dan t untuk masing-masing tahun. Analisis empiris yang digunakan adalah multinomial logit dengan pendekatan markov chain. Selain upah minimum riil sebagai variabel independen utama, variabel independen lain yang digunakan adalah umur, jenis kelamin, tingkat pendidikan, dan status perkawinan sebagai karakteristik individu, serta PDRB, share sektor manufaktur dalam PDRB, coverage upah minimum, dan rasio penduduk usia kerja terhadap total penduduk sebagai karakteristik regional. Upah minimum berdampak negatif dan signifikan terhadap transisi dari formal ke informal (F ke I), formal ke tidak bekerja (F ke N), dan tidak bekerja ke tidak bekerja (N ke N). Selain itu, upah minimum juga berdampak positif dan signifikan pada transisi dari formal ke formal (F ke F) dan informal ke informal (I ke I). Sedangkan pada transisi dari tidak bekerja ke informal (N ke I) tidak dipengaruhi oleh upah minimum.

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The objectives of the study is to determine the effect of minimum wages on employment transition, especially in Java as the majority of the Indonesian region set a minimum wage in district/city level. Previous similar studies carried out in developed countries that do not take the informal sectors. The analysis was performed using individual data sourced from Sakernas BPS 2010 and 2015 are seen as a form of longitudinal t-1 and t for each year. Empirical analysis used is multinomial logit with Markov chain approach. In addition to a real minimum wage as an primary independent variable, other independent variables used were age, gender, educational level, and marital status as individual characteristics, as well as the GRDP, the share of the manufacturing sector in the GRDP, coverage of the minimum wage, and the ratio of working age population to total population as regional characteristics. Minimum wage has a significant and negative impact on the transition from the informal to the formal (F to I), formal to not employed (F to N), and not employed to not employed (N to N). In addition, the minimum wage is also positive and significant impact on the transition from formal to formal (F to F) and informal to informal (I to I). While the transition from not employed to informal (N to I) are not affected by the minimum wage."

"Epithelial Mesenchymal Transition (EMT) adalah salah satu mekanisme resistensi Sorafenib pada kanker hepatoseluler. Alfa Mangostin diketahui dapat menurunkan aktifitas jalur TGF-βpada hepatic stellate cells. Penelitian ini dilakukan untuk mengetahui pengaruh Alfa Mangostin pada Epithelial Mesenchymal Transition (EMT), HepG2 yang tahan terhadap Sorafenib melalui jalur TGF-β/SMAD. Sel lestari kanker hati, HepG2 dibagi menjadi enam kelompok perlakuan, yaitu kelompok DMSO 0,01%, Alfa Mangostin20μM, Sorafenib10μM, Sorafenib10μM+Sorafenib10μM, Sorafenib10μM-Alfa Mangostin20μM, dan Sorafenib10μM +Sorafenib10μM - Alfa Mangostin20μMselama 24 jam. Sel dihitung menggunakan trypan blue exclusion method. Kadar TGF-β medium diukur menggunakan ELISA. Ekspresi TGF-β,TGF-βRI, SMAD3, SMAD7, E-cadherin dan Vimentin diukur dengan qRT-PCR. Pemberian Alfa Mangostin pada sel HepG2 yang tahan terhadap Sorafenib dapat menurunkan jumlah sel hidup. Namun terdapat peningkatan ekspresi TGF-β, kadar TGF-β1 aktif, TGF-βRI, SMAD3, dan Vimentin serta penurunan ekspresi SMAD7 dan E-cadherin setelah pemberian Sorafenib dan Alfa Mangostin. Alfa Mangostin menurunkan jumlah sel hidup namun tidak menghambat EMT melalui jalur TGF-β/SMAD pada sel HepG2 yang tahan terhadap Sorafenib. Epithelial Mesenchymal Transition (EMT) is one of resistance mechanism through Sorafenib in hepatocellular carcinoma. Alpha Mangosteen is known to have reduced TGF-β/SMAD pathway in hepatic stellate cells. This research purpose is to explore the effect of Alpha Mangosteen on Epithelial Mesenchymal Transition (EMT) on human hepatoceluller carcinoma HepG2 cells surviving Sorafenib via TGF-β/SMAD pathways. Immortalized HCC cell line, HepG2 cells, were divided into 6 groups: DMSO0,01% group, Alpha Mangosteen 20μMgroup, Sorafenib10μM group, Sorafenib 10μM-Sorafenib10μM group, Sorafenib10μM +  Alpha Mangosteen 20μM group, dan Sorafenib10μM + Sorafenib10μM - Alpha Mangosteen 20μMgroup for 24 h. Cells were harvested and counted by trypan blue exclusion method. TGF-β medium concentration was evaluated by ELISA. Expression of TGF-β,TGF-βRI, SMAD3, SMAD7, E-cadherinand Vimentin measured by qRT-PCR. Alpha Mangosteen administration on HepG2 surviving Sorafenib cells reduced mean live cells. However, the expression of TGF-β, TGF-β1 active concentration, TGF-βR, SMAD3, and Vimentin were elevated. Alpha Mangosteen also decreased SMAD7 dan E-cadherin expression. Alpha Mangosteen reduced live cells but did not have effect on preventing EMT activation through TGF-β/SMAD pathways on HepG2 surviving Sorafenib cells. "

"Penelitian ini mengevaluasi dan mengidentifikasi tingkat ketangkasan proses pengembangan perangkat lunak pada sistem Perizinan Online Kementerian ESDM yang terdampak oleh Undang-Undang Cipta Kerja, di mana terjadi banyak perubahan proses bisnis layanan dan kewajiban integrasi dengan sistem Kementerian Investasi yang belum terdefinisi dengan baik. Evaluasi dilaksanakan dengan menggunakan kerangka kerja transisi dan adopsi agile yang mengolaborasikan kerangka kerja 4-DAT dan SAMI. Pengumpulan data dilakukan melalui wawancara, observasi dan pengisian kuesioner dengan responden yang terdiri dari manajer proyek, pimpinan tim, penilai, pengembang dan pemilik bisnis proses layanan. Hasil evaluasi menunjukkan bahwa proses pengembangan perangkat lunak belum mencapai tingkat ketangkasan kolaboratif level 1 (SAMI) dan tingkat ketangkasan 0.7 skala 1 (4-DAT). Sebagai rekomendasi, dibutuhkan transisi proses pengembangan perangkat lunak menuju agile dengan mengoptimalkan proses pengembangan perangkat lunak pada kondisi bisnis dan regulasi yang dinamis, demi peningkatan standar layanan berdasarkan metodologi SAMI. Rekomendasi proses adopsi menggunakan Kanban dapat mendukung proses manajemen perubahan, peningkatan visibilitas proyek dan efisiensi penyelesaian sistem. Penyusunan rekomendasi kerangka kerja transisi dan adopsi agiledidasarkan kondisi pengembangan aplikasi saat ini dengan memperhatikan pemetaan dengan praktik agile, prinsip-prinsip agile, dan alur proses Kanban. Transisi dan adopsi agile menggunakan framework Kanban pada organisasi diharapkan mampu mengoptimalkan proses pengembangan perangkat lunak pada kondisi bisnis dan regulasi yang dinamis dalam rangka peningkatan standar layanan.

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This study evaluates and identifies the agility level of the software development process in the Online Licensing System of the Ministry of Energy and Mineral Resources (ESDM), which has been impacted by the Job Creation Law. This law led to significant changes in business processes and the need for integration with the well-not-defined systems of the Ministry of Investment. The evaluation was carried out using an agile transition and adoption framework, combining the 4-DAT and SAMI frameworks. Data collection was conducted through interviews, observations, and questionnaires with respondents including project managers, team leaders, evaluators, developers, and business owners of the service process. The results showed that the software development process has not yet reached collaborative agility level 1 (SAMI) and an agility level of 0.7 on a scale of 1 (4-DAT). As a recommendation, a transition of the software development process towards agile is needed, optimizing the software development process in dynamic business and regulatory conditions, to improve service standards based on the SAMI methodology. The recommended adoption process using Kanban can support change management, increase project visibility, and enhance system completion efficiency. The formulation of the agile transition and adoption framework recommendations is based on the current application development conditions, considering mapping with agile practices, agile principles, and Kanban process flows. The transition and adoption of agile using the Kanban framework in the organization are expected to optimize the software development process under dynamic business and regulatory conditions to improve service standards."

"The Japanese system of transition from school to work has attracted much attention abroad and has often been praised for its efficiency. The reality of both its formation in the past and its transformation at present, however, seems not to be reported accurately in other countries. This examination of the processes of the formation and transformation of the Japanese transition system will demonstrate that the apparent efficiency of the system has been the product of several historical factors. Moreover, the drawbacks of this system are becoming increasingly apparent amid the recent, drastic changes in Japanese society. The aim of this paper is to describe the process of formation in the 1960s and the subsequent transformation in the 1990s of the Japanese system of transition from school to work in order to reveal the limits of its supposed efficiency."

"Telah diketahui bahwa perairan Laut Banda sangat dipengaruhi oleh faktor musiman yang mempengaruhi kondisi fitoplankton. Tetapi informasi kondisi fitoplankton, khusus kelompok Cyanobacteria pada Musim Peralihan belum banyak terungkap. Untuk itu dilakukan penelitian pada bulan Oktober 1998 dan November 1999 yang dianggap mewakili Musim Peralihan dengan mengambil contoh fitoplankton dari permukaan sampai kedalaman 200 m untuk mengetahui kelimpahan, komposisi dan distribusi Cyanobacteria.Kelimpahan Trichodesmium erahtraeum berkisar antara 0,02-1,2 x 102 koloni m-3, nilai tertinggi dijumpai di kedalaman 100 m dan terendah di kedalaman 200 m. Kelimpahan Trichodesmium thiebautii berkisar antara 0-8,8 x 102 sel m-3. Distribusi Trichodesmium erythraeum dijumpai pada kedalaman 50 m kelimpahannya relatif tinggi yang dipengaruhi oleh kondisi nitrat perairan (r2 =28,30 %) dan suhu perairan (r2 =17,30 %). Berdasarkan kelimpahan, keanekaragaman, kemerataan dan distribusinya Trichodesmium eryhtraeum dan Trichodesmium thiebautii mendominasi pada musim peralihan.

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Domination of Cyanobacteria at Transition Monsoon around Banda Sea Area. Banda Sea had affected by monsoon factor, this condition also influenced fitoplankton condition, but information about fitoplankton condition especially Cyanobacteria group still not complete yet. Therefore had done the researched about fitoplankton in October 1998 and November 1999, that months is regarded as vice of transition monsoon. Fitoplankton samples were taken from the surface to 200 m depth to known the abundant, composition, and distribution of Cyanobacteria.The results showed that the abundant of Trichodesmium erahtraeum varied between 0.02-1.2 x 102 coloni m-3, the highest vale found in 100 m depth and the lowest in 200 m depth. The abundance of Trichodesmium thiebautii varied between 0-8.8 x 102 cel m-3. Distribution of Trichodesmium erythraeum found until 50 m depth, their abundance high relative, this condition caused by nitrate concentration (r2 =28,30 %) and temperature (r2 =17,30 %). Based on their abundance, diversity, evenness and distribution Trichodesmium eryhtraeum dan Trichodesmium thiebautii dominated in transition monsoon."