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"Background: Diabetes Mellitus is a chronic disease characterised by elevated levels of blood glucose known ashyperglycaemia. Diabetes is due to impaired insulin action in the metabolism of glucose and can result in impairedwound healing. Excessive production of pro-inflammatory cytokines, an increased number of macrophages andneutrophils, and decreased levels of transforming growth factor ? beta 1 (TGF-β1) serum can be characteristic ofimpaired wound healing. This study aims to determine the effects of squid extract on certain wound parameters such aslevels of tumour necrosis factor ? alpha (TNF-α), and TGF-β1 serum and the number of macrophages and neutrophils.Methods: This was a post-test only, randomized controlled group study that was conducted on male Wistar rats.Experimental animals were divided into 6 groups; (1) normal wound with standard diet, (2) diabetic wound withstandard diet, (3) diabetic wound with chitosan supplement, (4) diabetic wound given squid extract orally once a day,(5) diabetic wound given squid extract orally twice a day, and (6) diabetic wound given squid extract orally once everytwo days. Levels of TNF-α and TGF-β1 serum were observed using Enzyme-Linked Immunosorbent Assay.Haematocylin and eosin staining was used to observed macrophage and neutrophil counts. All data was analysedstatistically by one-way analysis of variance. Results: TNF-α serum levels showed a significant decrease (p < 0.05) insubjects that received squid extract orally once every two days. The mean levels of TGF-β1 showed no significantdifferences. The mean number of macrophage cells showed a significant decrease (p < 0.05) in all treatment groups.The mean number of neutrophil cells also showed significant decrease (p < 0.05) in all treatment groups. Conclusions:Squid extract is effective in lowering the TNF-α serum levels and the number of macrophages and neutrophils cells inWistar rats. However, there were insignificant findings on increasing levels of TGF-β1 serum. This data suggests thatsquid extract is most effective during the inflammatory phase of wound healing which takes places about 2-4 days afterwound creation."

"Diabetes Mellitus is a chronic disease characterised by elevated levels of blood glucose known as hyperglycaemia. Diabetes is due to impaired insulin action in the metabolism of glucose and can result in impaired wound healing. Excessive production of pro-inflammatory cytokines, an increased number of macrophages and neutrophils, and decreased levels of transforming growth factor ? beta 1 (TGF-β1) serum can be characteristic of impaired wound healing. This study aims to determine the effects of squid extract on certain wound parameters such as levels of tumour necrosis factor ? alpha (TNF-α), and TGF-β1 serum and the number of macrophages and neutrophils.Methods: This was a post-test only, randomized controlled group study that was conducted on male Wistar rats. Experimental animals were divided into 6 groups; (1) normal wound with standard diet, (2) diabetic wound with standard diet, (3) diabetic wound with chitosan supplement, (4) diabetic wound given squid extract orally once a day, (5) diabetic wound given squid extract orally twice a day, and (6) diabetic wound given squid extract orally once every two days. Levels of TNF-α and TGF-β1 serum were observed using Enzyme-Linked Immunosorbent Assay. Haematocylin and eosin staining was used to observed macrophage and neutrophil counts. All data was analysedstatistically by one-way analysis of variance.Results: TNF-α serum levels showed a significant decrease (p < 0.05) in subjects that received squid extract orally once every two days. The mean levels of TGF-β1 showed no significant differences. The mean number of macrophage cells showed a significant decrease (p < 0.05) in all treatment groups. The mean number of neutrophil cells also showed significant decrease (p < 0.05) in all treatment groups.Conclusions: Squid extract is effective in lowering the TNF-α serum levels and the number of macrophages and neutrophils cells in Wistar rats. However, there were insignificant findings on increasing levels of TGF-β1 serum. This data suggests that squid extract is most effective during the inflammatory phase of wound healing which takes places about 2-4 days after wound creation.Keywords: diabetic wound, squid, TNF"

"Latar BelakangPrevalensi diabetes diprediksi meningkat selama beberapa tahun ke depan di mana luka diabetes itu sendiri dapat menyebabkan kecacatan seumur hidup bahkan kematian. Bonggol nanas (Ananas comosus L.) memiliki senyawa aktif yaitu bromelain yang berperan dalam penyembuhan luka. Penelitian ini bertujuan untuk melihat aktivitas penyembuhan luka dari pemberian ekstrak bonggol nanas.MetodePenelitian ini merupakan studi eksperimental in-vivo dengan melibatkan 54 tikus putih jantan Webster berusia 8-10 minggu dengan berat badan 150-200 gram yang dibagi acak menjadi 18 kelompok: kontrol negatif, kontrol positif, serta tiga kelompok dengan dosis ekstrak bonggol nanas berbeda dengan durasi 1, 2 dan 3 minggu. Sebanyak 45 tikus diinduksi diabetes dengan larutan streptozotocin dalam larutan buffer sitrat sedangkan 9 tikus lainnya dijadikan sebagai kontrol sehat. Semua tikus dicukur, dianastesi dan luka dibuat di bagian dorsal. Tikus kemudian diberikan zat yang sesuai dengan kelompok percobaan. Kelompok kontrol positif akan diberikan metformin, kontrol negatif tidak diberikan apapun, dosis 1 diberikan ekstrak 0,25 g/KgBB, dosis 2 yaitu 0,5 g/KgBB, dan dosis 3 yaitu 1 g/KgBB. Pengukuran luas luka dengan mengukur area pada plastik transparan yang sudah ditandai sesuai lukanya. Data dianalisis menggunakan perangkat lunak SPSS 29.0 dengan p < 0,05 dianggap bermakna.HasilData persentase penyembuhan luka tidak terdistribusi normal. Kelompok metformin menunjukkan persentase tertinggi pada minggu 1 dan 2. Hasil uji Kruskal-Wallis persentase penyembuhan luka menunjukkan bahwa tidak ada perbedaan bermakna antarkelompok (p = 0,959).KesimpulanPemberian ekstrak bonggol nanas (Ananas comosus L.) tidak berpengaruh terhadap penyembuhan luka diabetes pada tikus putih Jantan (Webster).

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Introduction

The prevalence of diabetes is predicted to increase over the next few years, where diabetic wounds themselves can cause lifelong disability and even death. Pineapple (Ananas comosus L.) has an active compound, bromelain, which plays a role in wound healing. This study aims to look at the wound healing activity of pineapple core extract.

Method

This study was an in-vivo experimental study involving 54 male Webster white rats aged 8-10 weeks with a body weight of 150-200 grams randomly divided into 18 groups: negative control, positive control, and three groups with different doses of pineapple stem extract with a duration of 1, 2 and 3 weeks. A total of 45 rats were induced diabetes with streptozotocin solution in citrate buffer solution while the other 9 rats served as healthy controls. All rats were shaved, anesthetized and a wound was made on the dorsal side. The rats were then administered substances corresponding to the experimental groups. The positive control group will be given metformin, the negative control is given nothing, dose 1 is given 0.25 g/KgBB extract, dose 2 is 0.5 g/KgBB, and dose 3 is 1 g/KgBB. Measurement of wound area by measuring the area on transparent plastic that has been marked according to the wound. Data were analyzed using SPSS 29.0 software with p < 0.05 considered significant.

Results

The wound healing percentage data was not normally distributed. The results of the Kruskal-Wallis test on the percentage of wound healing showed that there was no significant difference between groups (p = 0.959).

Conclusion

The administration of pineapple core extract (Ananas comosus L.) did not show a significant relationship to diabetic wound healing in male white rats (Webster)."

"Tujuan : Mengetahui perbaikan keseimbangan fungsional pada pasien polineropati diabetik anggota gerak bawah pasca latihan stabilitas posturalDisain : Pra dan pasta perlakuan dengan kelompok kontrolSubyek : 50 prang dibagi secara acak sederhana menjadi dua kelompok (kelompok perlakuan dan kelompok kontrol)Tempat : Bagian Ilmu Kedokteran Fisik dan Rehabilitasi Rumah Sakit dr. Hasan Sadikin BandungIntervensi : Kelompok kasus diberi Iatihan stabilitas postural. Kelompok kontrol diberi latihan senam kaki diabetik. Kedua kelompok melakukan latihan 3 kali di rumah sakit dengan supervisi peneliti dan 4 hari di rumah dengan supervisi anggota keluarga yang ditunjuk. Kedua latihan diberikan selama 3 minggu.Parameter : Keseimbangan fungsional melalui 4 tolak ukur, yaitu unipedal stance test (UST), tandem stance test (TST), timed get up and go test (TUG) dan jarak functional reach test (T'RT)Hasil : Pada kelompok kasus terdapat perbaikan keseimbangan fungsional UST (p= 0,010), «T (p= 0,009), TUG (p= 0,014) kecuali FRT (p= 0,176), Pada kelompok kontrol terdapat peningkatan keseimbangan fungsional namun tidal( bermakna.Kesimpulan : Latihan stabilitas postural memperbaiki UST, TST dan TUG pada pasien polineuropati diabetik anggota gerak bawah."

"Latar Belakang: Ulkus diabetik merupakan komplikasi diabetes melitus dengan morbiditas dan mortalitas yang tinggi, dengan prevalensi 6,3% populasi dunia dan angka amputasi mencapai 139,97 kasus per 100.000 orang. Pada kasus lanjut, pasien ulkus diabetik dilakukan debridemen atau bahkan amputasi yang sangat mempengaruhi kualitas hidup pasien. Prediksi penyembuhan luka pasca debridemen merupakan suatu penilaian yang sangat penting untuk memberikan pelayanan terbaik bagi pasien. Namun, hingga saat ini, penelitian untuk mengetahui hubungan antara tekanan sistolik, fasisitas dan volume flow pada pasien ulkus diabetik terhadap penyembuhan luka pasca debridemen belum banyak dilakukan.

Tujuan: Mengetahui hubungan antara tekanan sistolik, fasisitas and volume flow pasien ulkus diabetik terhadap penyembuhan luka pasca debridemen.

Metode: Desain penelitian ini adalah potong lintang, dilakukan di RSUPN Cipto Mangunkusumo. Penelitian dilaksanakan pada bulan Agustus 2023 – Oktober 2023.

Hasil: Terdapat 40 subjek penelitian yang memenuhi kriteria inklusi. Profil subjek penelitian  sebagian besar terdiri dari jenis kelamin perempuan dengan rata-rata usia 56,93 tahun. Jumlah pasien yang memiliki riwayat hipertensi adalah 21 orang (52,5%), riwayat dislipidemia adalah 10 orang (25%), dan riwayat merokok adalah 17 orang (42,5%). Analisis bivariat dengan uji Pearson mendapatkan faktor risiko yang berhubungan signifikan terhadap skor DFUAS adalah diabetes melitus (p<0,001), merokok (p<0,001), dan hipertensi (p=0,007). Terdapat hubungan korelasi yang kuat dan signifikan antara nilai ABI yang semakin kecil dengan skor DFUAS yang semakin besar (p<0,001). Selain itu, terdapat juga hubungan korelasi kuat dan signifikan antara fasisitas arteri poplitea bifasik dengan nilai DFUAS yang semakin besar (p<0,001). Sementara itu, tidak terdapat hubungan korelasi yang signifikan antara tekanan sistolik arteri poplitea, fasisitas arteri femoralis komunis, dan volume flow arteri poplitea maupun femoralis komunis terhadap skor DFUAS atau penyembuhan luka.

Kesimpulan: Pemeriksaan ABI dan fasisitas arteri poplitea dengan ultrasonografi dapat menjadi prediksi penyembuhan luka pada pasien ulkus diabetik.

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Diabetic ulcer is a complication of diabetes mellitus with high morbidity and mortality, with a prevalence of 6.3% of the world population and an amputation rate of 139.97 cases per 100,000 people. In advanced cases, diabetic ulcer patients undergo debridement or even amputation which greatly affects the patient's quality of life. Prediction of wound healing after debridement is a very important assessment to provide the best service for patients. However, until now, there has not been much research to determine the relationship between systolic pressure, fascicity and volume flow in diabetic ulcer patients on post-debridement wound healing.

Objective: Knowing the relationship between systolic pressure, fascicity and volume flow of diabetic ulcer patients on wound healing after debridement.

Method: The design of this study was cross-sectional, conducted at Cipto Mangunkusumo Hospital. The study was conducted in August 2023 - October 2023.

Results: There were 40 research subjects who met the inclusion criteria. The profile of the research subjects mostly consisted of female gender with an average age of 56.93 years. The number of patients who had a history of hypertension was 21 people (52.5%), a history of dyslipidemia was 10 people (25%), and a history of smoking was 17 people (42.5%). Bivariate analysis with the Pearson test found that the risk factors significantly associated with DFUAS scores were diabetes mellitus (p<0.001), smoking (p<0.001), and hypertension (p=0.007). There was a strong and significant correlation between a smaller ABI value and a larger DFUAS score (p<0.001). In addition, there was also a strong and significant correlation between biphasic popliteal artery fascicity and greater DFUAS score (p<0.001). Meanwhile, there was no significant correlation between popliteal artery systolic pressure, common femoral artery fascicity, and popliteal or common femoral artery flow volume on DFUAS score or wound healing.

Conclusion: Ankle brachial index examination and popliteal artery fascicity with ultrasonography can be predictive of wound healing in diabetic ulcer patients."

"Aim: to evaluate the role of clinical characteristics, functional markers of vasodilation, inflammatory response, and atherosclerosis in predicting wound healing in diabetic foot ulcer.

Methods: a cohort study (February-October 2010) was conducted from 40 subjects with acute diabetic foot ulcer at clinical ward of Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Each subject underwent at least two variable measurements, i.e. during inflammatory phase and proliferation phase. The studied variables were clinical characteristics, complete peripheral blood count (CBC) and differential count, levels of HbA1c, ureum, creatinine, lipid profile, fasting blood glucose (FBG), marker of endothelial dysfunction (asymmetric dimethylarginine/ADMA, endothelin-1/ET-1, and flow-mediated dilation/FMD of brachial artery), and marker of vascular calcification (osteoprotegerin/OPG).

Results: median of time achieving 50% granulation tissue in our study was 21 days. There were nine factors that contribute in the development of 50% granulation tissue, i.e. family history of diabetes mellitus (DM), previous history of wound, wound area, duration of existing wound, captopril and simvastatin medications, levels of ADMA, ET-1, and OPG. There were three out of the nine factors that significantly correlated with wound healing, i.e. wound area, OPG levels, and simvastatin medications.

Conclusion: in acute diabetic foot ulcers, wound area and OPG levels had positive correlation with wound healing, whereas simvastatin medications had negative correlation with wound healing."

"ABSTRAKUlkus diabetikum merupakan salah satu komplikasi dari diabetes melitus dan termasuk luka kronik. Ulkus diabetikum menyebabkan berbagai gangguan kenyamanan baik fisik, psikologis maupun sosial. Tujuan penelitian ini adalah untuk mengetahui hubungan derajat luka dengan interaksi sosial pada pasien ulkus diabetikum. Desain penelitian menggunakan pendekatan cross-sectional dengan jumlah sampel 69 pasien di Rumat. Analisis data menggunakan uji T-independen menyatakan tidak ada hubungan yang bermakna antara derajat luka dengan interaksi sosial p: 0,448, ?: 0,05 . Hasil penelitian didapatkan faktor yang berhubungan dengan interaksi sosial yaitu bau p:0.009 , status psikologis p:0,010 and stres p: 0,005 . Penelitian ini menunjukkan untuk memperhatikan kenyamanan psikologis pada gangguan kenyamanan fisik dalam peningkatan kenyamanan sosial pasien ulkus diabetikum.

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ABSTRACTDiabetic ulcer as a chronic wound is one of chronic complication of Diabetes Mellitus. Diabetic ulcer causes a variety of discomfort such as physics, psychology also social. The aim of this research was to identify the correlation between wound degree with social interaction to the diabetic ulcer patient. Cross sectional design applied in this study with 69 samples that recruiting in Rumat. Statistic analyze using independent t test showed wound degree has no significant relationship with social interaction p 0,448, 0,05 . This study found the related factor of social interaction are odor p 0.009 , psychology p 0,010 and stress p 0,005 . This study recommended the importance of paying attention to psychological comfort of physical discomfort to increase social comfort diabetic ulcer patient."

"ABSTRAKUlkus diabetikum merupakan komplikasi yang paling banyak terjadi pada pasien diabetes mellitus. Bertahan dengan penyakit dalam jangka waktu seumur hidup tentu menjadi stressor bagi penderita. Berbagai macam strategi koping akan dilakukan untuk mengatasi masalah yang dihadapi demi memperoleh kenyamanan. Penelitian ini bertujuan untuk melihat perbandingan strategi problem focused coping dengan emotional focused coping terhadap tingkat kenyamanan pada pasien diabetisi dengan ulkus diabetikum. Metode menggunakan desain penelitian cross sectional pada 81 pasien di Praktik Keperawatan wilayah Jabodetabek, Indonesia. Instrumen yang digunakan yaitu Brief-Cope dan Discomfort Evaluation of Wound Instrumen. Hasil penelitian menujukan tidak ada perbedaan bermakna penggunaan strategi problem focused coping dengan emotional focused coping terhadap tingkat kenyamanan p = 0,141; p>? . Strategi problem focused coping dan emotional focused coping merupakan satu kesatuan jenis strategi koping yang tidak bisa dipisahkan. Peneliti merekomendasikan bahwa penting untuk melihat koping secara holistik. Peningkatan kemampuan strategi koping sangat penting untuk memperoleh kenyamanan.

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ABSTRACTDiabetic ulcers are the most common complications in patients with diabetes mellitus. Persisting with illness in a lifetime of time is certainly a stressor for the sufferer. Various coping strategies will be done to overcome the problems faced in order to gain comfort. This study aims to see the comparison of problem focused coping strategies with emotional focused coping on comfort levels in diabetic patients with diabetic ulcers. The method used a cross sectional study design in 81 patients at wound care homes in Jabodetabek area, Indonesia. The instruments used are Brief Cope and Discomfort Evaluation of Wound Instruments. The results showed no significant difference in the use of problem focused coping strategy with emotional focused coping on comfort level p 0,141 p . The strategy of problem focused coping and emotional focused coping is an integral type of coping strategy that can not be distinguished. Researchers recommend that it is important to look at coping in a holistic way. Improving the ability of coping strategies is essential for comfort. "

"ABSTRAKNama : Nur AnisahProgram Studi : Magister Fakultas Ilmu KeperawatanJudul : Pengaruh Terapi Kognitif dan Psikoedukasi Keluarga Terhadap Citra Tubuh dan Harga Diri Klien Ulkus DiabetikDampak biologis yang dirasakan oleh klien ulkus diabetik antara lain penurunan stamina, daya tahan tubuh, serta kekuatan fisik akibat perubahan fungsi, stuktur dan bentuk tubuh sehingga klien mengalami keterbatasan gerak sehingga terjadi gangguan citra tubuh. Dampak psikologis pada klien ulkus diabetik terlihat dari sikap klien merasa putus asa, merasa tidak ada harapan dan cita-cita yang dapat dicapai, merasa sudah cacat, klien tidak dapat menerima keadaan bahwa harus menjalani perawatan luka dan gerak menjadi terbatas dan tidak dapat lagi melaksanakan aktivitas apapun sehigga terjadi harga diri rendah Tujuan penelitian adalah untuk mengetahui pengaruh terapi kognitif dan psikoedukasi keluarga terhadap citra tubuh dan harga diri klien ulkus diabetik. Metode penelitian menggunakan desain kuantitatif dengan pendekatan Quasy Experimental Pre-Post with Control Group. Responden sejumlah 62 dan dipilih dengan purposive sampling. Analisi data yang digunakan adalah dependent t-test dan independent t-test. Hasil penelitian menunjukkan bahwa tindakan keperawatan pada tindakan keperawatan ners, terapi kognitif dan psikoedukasi keluarga lebih tinggi signifikan dalam meningkatkan citra tubuh, harga diri, kemampuan berpikir positif dan kemampuan keluarga sehingga berpengaruh terhadap kondisi ulkus menjadi lebih baik daripada yang mendapatkan tindakan keperawatan ners. terapi kognitif dan. Kesimpulan penelitian ini adalah klien ulkus diabetik direkomendasikan untuk mendapatkan tindakan keperawatan ners, terapi kognitif dan psikoedukasi keluarga.Kata kunci : Ulkus Diabetik, Citra Tubuh, Harga Diri, Tindakan Keperawatan Ners, Terapi Kognitif dan Psikoedukasi keluarga

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ABSTRACTABSTRACT Name Nur AnisahProgram Master of Nursing ScienceTittle The effect of cognitive therapy and family psychoeducation on body image and self esteem clients diabetic ulcers Biological impact perceived by clients diabetic ulcers, among others, a decrease in stamina, endurance and physical strength as a result of changes in the function, structure and shape of the body so that the client is experiencing limitation of motion, causing body image disturbance. The psychological impact on the client ulcer diabetic seen from the attitude of the client feels hopeless, feels there is no hope and ideals that can be achieved, was already disabled, the client can not accept the situation that must undergo wound care and movement is limited and can no longer carry out activities whatever happens sehigga low self esteem research objective was to determine the effect of cognitive therapy and family psychoeducation on body image and self esteem clients diabetic ulcers. The research method uses a quantitative approach to design quasy Experimental Pre Post with Control Group. Respondents number 62 and selected by purposive sampling. Analysis of the data used is dependent t test and independent t test. The results showed that the nursing actions on nurses nursing actions, cognitive therapy and family psychoeducation significantly higher in improving body image, self esteem, positive thinking ability and the ability of the family and therefore contributes to ulcer conditions to be better than getting nurses nursing actions. and cognitive therapy. It is concluded that diabetic ulcer clients is recommended to get the nurses nursing actions, cognitive therapy and family psychoeducation.. Keywords Diabetic Ulcers, Body Image, Self Esteem, Nursing Measures nursesEffects of Cognitive Therapy and family psychoeducation"

"Ulkus Diabetikum menyebabkan berbagai gangguan kenyamanan. Penelitian bertujuan untuk mengetahui kualitas tidur dan faktor-faktor yang mempengaruhi pada pasien ulkus diabetikum. Desain penelitian menggunakan cross-sectional dengan sampel 97 pasien ulkus diabetikum. Hasil penelitian menunjukkan terdapat perbedaan yang bermakna antara kualitas tidur subjektif dengan kualitas tidur yang diukur menggunakan PSQI p: 0,001. Faktor yang mempengaruhi tidur yaitu penghasilan p: 0,014, tingkat stress p: 0,001, medikasi p: 0,026, tingkat nyeri p: 0,048, dan diet p: 0,009. Penelitian menunjukkan pentingnya melakukan pengkajian kualitas tidur dengan melihat faktor-faktor yang mempengaruhi untuk mengatasi masalah tidur pasien ulkus diabetikum.

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Diabetic ulcer cause various comfort disorders. This research was to identify sleep quality and factors that influence in patients with diabetic ulcer. This research design used cross sectional study with a sampel of 97 diabetic ulcer patients. The results showed that there was a significant difference between subjective sleep quality and sleep quality measured using PSQI p 0,001. Factors that affect sleep are income p 0,014, stress levels p 0,001, medications p 0,026, pain levels p 0,048, and diet p 0,009. The results of this study indicate that the importance of conducting sleep quality assessment with factors that influence to overcome sleep problems in diabetic patients."