Hasil Pencarian  ::  Simpan CSV :: Kembali

"ABSTRAKEnzim α-glukosidase (EC. 3.2.1.20, α-D-glukosida glukohidrolase) adalah enzim terikat membran yang terdapat pada epitel usus halus dan berperan pada pencernaan karbohidrat makanan yang memecah karbohidrat menjadi glukosa. Enzim ini diperlukan pada pencarian senyawa analog sebagai inhibitor enzim tersebut dalam rangka penemuan obat Diabetes Melitus tipe dua. Pada penelitian ini, sebagai sumber enzim digunakan beras baru, beras lapuk, dan dedak dari tiga varietas, yaitu Sarinah, IR 64, dan IR 46. Beras baru, beras lapuk, dan dedak selanjutnya dibuat menjadi ekstrak kasar enzim tepung beras baru, tepung beras lapuk, dan tepung dedak. Hasil penelitian menunjukan bahwa dari sembilan ekstrak kasar enzim, tepung beras lapuk IR 46 menunjukan aktivitas tertinggi yaitu 90,3 mU/mL. Aktivitas tertinggi ditemukan pada tingkat kejenuhan 20-50% pada fraksinasi dengan ammonim sulfat sebesar 228,2 mU/mg. Enzim hasil dialisis memiliki aktivitas spesifik 238,9 mU/mg dan pH optimum 5,00. Enzim α-Glukosidase dari beras lapuk IR 46 memiliki nilai Km = 5,17 mM dan Vmax =0,55 mM/menit. Hasil uji logam menunjukkan bahwa merupakan aktivator enzim α-glukosidase sedangkan berperan sebagai inhibitornya. Pada uji inhibisi, quersetin dan ekstrak buah mahkota dewa dengan kadar 1% menyebabkan persen inhibisi tertinggi masing-masing sebesar 19,84% dan 28,20%.

---

ABSTRACTThe enzyme α-glucosidase (EC.3.2.1.20, α-D-glukohidrolase) is a membrane bound enzyme found in intestinal ephitelium and plays role in carbohydrate digestion cleavaging carbohydrate into glucose. This enzyme is needed to find analogous compound as inhibitor of this enzyme in the context of drug exploration for Diabetes Mellitus type two. In this study, the sources of the enzyme used are new rice, moldy rice, and rice bran that for each from three varieties of rice: Sarinah, IR 64, and IR 46. Those nine sources of the enzyme was made into crude enzyme of new rice flour, moldy rice flour, and rice bran flour. The result showed that moldy rice flour IR 46 had the highest activity to be 90,3 mU/mL. The highest activity in fractionation with ammonium sulphate was founded in saturation level of 20-50% to be 228,2 mU/mg. In dialysis, the enzyme had the specific activity to be 238,9 mU/mg and pH optimum was 5,00. α-glucosidase from moldy rice IR 46 had Km value = 5,17 mM and Vmax value = 0,55 mM/minute. The result in metal assay showed that Mg2+ and Mn2+ were activator of α-Glucosidase whereas Co2+ and Zn2+ acted as inhibitor. Mahkota Dewa fruit extract and Quersetin caused the highest percent of inhibition in 1% for each 19.84% and 28,20%."

"Upaya pencegahan primer pada pengelolaan kaki diabetik bertujuan untuk mencegah luka kaki secara dini. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan praktik perawatan kaki pada klien diabetes melitus tipe 2 di Kalimantan Selatan. Penelitian ini merupakan deskriptif korelasi dengan desain cross sectional dan jumlah sampel sebanyak 106 orang. Hasil analisis Chi Square menunjukkan adanya hubungan yang bermakna antara pengetahuan dengan praktik perawatan kaki pada klien diabetes melitus tipe 2 (p= 0,04; α= 0,05). Faktor pengetahuan memiliki peluang 2,38 kali untuk melakukan praktik perawatan kaki. Perlu dikembangkan pendidikan kesehatan tentang perawatan kaki dan pemeriksaan kaki.Clients? Knowledge on Type 2 Diabetes Influence Practice of Foot Care. Primary prevention in diabetic foot management of is to prevent foot injuries. This study aimed to determine the correlation between knowledge and practice of foot care in type 2 diabetes patients in South Kalimantan. This study employed a descriptive correlation research with cross sectional design. A number of 106 samples was recruited. The results of chi Square analysis showed a significant correlation between knowledge and practice of foot care in the type 2 diabetes patients (p= 0.04; α= 0.05). Knowledge factor had chance of 2.38 times on performing practice of foot care. This study suggest the importan of development of health education about foot care and foot examination."

"ABSTRACTBackground: diabetes has become a major public health concern with an estimated 180 million cases worldwide. Nutritional adjustment is one of the key aspects in the management of type 2 diabetes mellitus. Previous studies have suggested an association between vegetarian diets and improvements in glycemic control in type 2 diabetes mellitus, however the relationship is not well established. The aim of this report is to perform a critical appraisal to analyze whether plant-based diet reduces the HbA1c level compared to conventional diet. Methods: a comprehensive computer-based literature search was performed on June 20, 2016 using PubMed, Ovid, EBSCO, and the Cochrane Library. All abstracts and titles from the initial search results were screened, reviewed, and appraised using critical appraisal worksheets by Center of Evidence-Based Medicine, University of Oxford. Results: one systematic review and two RCTs met the inclusion criteria and were considered eligible for this case report. In patients with type 2 diabetes mellitus, HbA1c signicantly yielded greater reduction inBackground: diabetes has become a major public health concern with an estimated 180 million cases worldwide. Nutritional adjustment is one of the key aspects in the management of type 2 diabetes mellitus. Previous studies have suggested an association between vegetarian diets and improvements in glycemic control in type 2 diabetes mellitus, however the relationship is not well established. The aim of this report is to perform a critical appraisal to analyze whether plant-based diet reduces the HbA1c level compared to conventional diet. Methods: a comprehensive computer-based literature search was performed on June 20, 2016 using PubMed, Ovid, EBSCO, and the Cochrane Library. All abstracts and titles from the initial search results were screened, reviewed, and appraised using critical appraisal worksheets by Center of Evidence-Based Medicine, University of Oxford. Results: one systematic review and two RCTs met the inclusion criteria and were considered eligible for this case report. In patients with type 2 diabetes mellitus, HbA1c signicantly yielded greater reduction inBackground: diabetes has become a major public health concern with an estimated 180 million cases worldwide. Nutritional adjustment is one of the key aspects in the management of type 2 diabetes mellitus. Previous studies have suggested an association between vegetarian diets and improvements in glycemic control in type 2 diabetes mellitus, however the relationship is not well established. The aim of this report is to perform a critical appraisal to analyze whether plant-based diet reduces the HbA1c level compared to conventional diet. Methods: a comprehensive computer-based literature search was performed on June 20, 2016 using PubMed, Ovid, EBSCO, and the Cochrane Library. All abstracts and titles from the initial search results were screened, reviewed, and appraised using critical appraisal worksheets by Center of Evidence-Based Medicine, University of Oxford. Results: one systematic review and two RCTs met the inclusion criteria and were considered eligible for this case report. In patients with type 2 diabetes mellitus, HbA1c signicantly yielded greater reduction inBackground: diabetes has become a major public health concern with an estimated 180 million cases worldwide. Nutritional adjustment is one of the key aspects in the management of type 2 diabetes mellitus. Previous studies have suggested an association between vegetarian diets and improvements in glycemic control in type 2 diabetes mellitus, however the relationship is not well established. The aim of this report is to perform a critical appraisal to analyze whether plant-based diet reduces the HbA1c level compared to conventional diet. Methods: a comprehensive computer-based literature search was performed on June 20, 2016 using PubMed, Ovid, EBSCO, and the Cochrane Library. All abstracts and titles from the initial search results were screened, reviewed, and appraised using critical appraisal worksheets by Center of Evidence-Based Medicine, University of Oxford. Results: one systematic review and two RCTs met the inclusion criteria and were considered eligible for this case report. In patients with type 2 diabetes mellitus, HbA1c signicantly yielded greater reduction in the plant-based group compared to conventional diet group after 22 weeks of follow up. Similarly, there was a statistically greater reduction in HbA1c level in the plant-based group after 72 weeks. Furthermore, consumption of plant-based diet was associated with a signicant reduction in HbA1c. Conclusion: in patients with type 2 diabetes mellitus, HbA1c reduction was greater in patients with plant-based diet compared to patients with conventional diet. Further research should be conducted with larger sample size and longer follow-up period."

"Diabetes melitus tipe 2 merupakan kasus diabetes yang paling umum terjadi dengan peningkatan prevalensi setiap tahun. Penyakit diabetes dapat menyebabkan biaya perawatan tinggi dan penurunan kualitas hidup. Terapi pengobatan diabetes yang beragam variasi dapat memberikan efektivitas dan biaya yang berbeda. Penelitian ini dilakukan untuk menganalisis efektivitas biaya terhadap kombinasi metformin-pioglitazon dan metformin-glimepirid pada pasien diabetes melitus tipe 2. Penelitian ini menggunakan desain cross-sectional dengan teknik pengumpulan data retrospektif. Data penelitian diambil dari rekam medis dan data biaya pasien rawat jalan diabetes melitus tipe 2 dengan kombinasi metformin-pioglitazon dan metformin-glimepirid di RSUD Pasar Rebo tahun 2020-2022. Parameter untuk melihat efektivitas terapi adalah pencapaian target HbA1c <7,0% dengan minimal 3 bulan. Data biaya pengobatan pasien menggunakan biaya langsung medis dengan perspektif rumah sakit. Nilai efektivitas terapi yang dihasilkan menunjukkan tidak ada perbedaan bermakna antara kelompok metformin-pioglitazon dengan metformin-glimepirid (p > 0,05). Berdasarkan hasil analisis, nilai inkremental efektivitas antara kedua kelompok terapi sebesar 8% dan nilai inkremental total biaya sebesar Rp350.170,00. Berdasarkan penelitian ini, dapat disimpulkan bahwa terapi kombinasi metformin-pioglitazon lebih efektivitas-biaya dibandingkan metformin-glimepirid dengan penambahan biaya sebesar Rp43.771,25 untuk berpindah dari terapi metformin-glimepirid menjadi metformin-pioglitazon pada pasien diabetes melitus tipe 2 di RSUD Pasar Rebo.

---

Diabetes mellitus type 2 is the most common case of diabetes with an increase in prevalence every year. Various diabetes treatment therapies can provide different effectiveness and costs. This study was performed to analyze cost-effectiveness of the combination of metformin-pioglitazone and metformin-glimepiride in patients with type 2 diabetes mellitus. This method was cross-sectional with retrospective data collection techniques. The research data was taken from medical records and cost data for type 2 diabetes with combination of metformin-pioglitazone and metformin-glimepiride at Pasar Rebo Hospital in 2020-2022. The parameter to see effectiveness of therapy is achievement of HbA1c target of <7.0% at least 3 months. Patient treatment cost data using medical direct costs with a hospital perspective. The resulting therapeutic effectiveness value showed no significant difference between the metformin-pioglitazone group and metformin-glimepiride (p > 0.05). Based on the results of the analysis, incremental value of effectiveness between the two therapy groups was 8% and total incremental value of cost was Rp350,170.00. Based on the results of this study, metformin-pioglitazone combination therapy is more cost-effective than metformin-glimepiride with additional cost of Rp43,771.25 by changing metformin-glimepiride therapy to metformin-pioglitazone in type 2 diabetes mellitus patients at RSUD Pasar Rebo."

"Latar Belakang Diabetes melitus tipe 2 merupakan salah satu faktor risiko dari infeksi COVID-19. Studi ini bertujuan untuk meneliti hubungan antara diabetes melitus tipe 2 dengan tingkat keparahan COVID-19 pada pasien RSUI tahun 2020. Metode Penelitian ini dilakukan melalui studi cross-sectional analitik menggunakan rekam medis pasien COVID-19 di RSUI antara Juni hingga September 2020. Uji Chi-square atau Fisher digunakan untuk menguji hubungan antara diabetes melitus tipe 2 dan keparahan COVID-19. Faktor risiko lain juga dianalisis bivariat dan analisis regresi logistik multivariat. Hasil Hasil analisis data bivariat menunjukkan nilai OR = 2.494 yang menunjukkan terdapat kecenderungan asosiasi antara diabetes melitus tipe 2 dengan keparahan COVID-19 pada pasien RSUI tahun 2020, namun tidak bermakna secara statistik (p = 0.071; 95% CI = 0.903 – 6.890). Mayoritas dari 172 pasien COVID-19 di RSUI berjenis kelamin laki-laki (59.3%) dan berusia dibawah 60 tahun (89.4%). Ditemukan 19 pasien memiliki riwayat penyakit diabetes melitus tipe 2 (11.0%) pada keseluruhan pasien COVID-19. Faktor risiko lain yang diteliti, seperti berjenis kelamin laki-laki, lansia, hipertensi, PPOK, penyakit autoimun, keganasan, penyakit ginjal, dan gagal jantung tidak ditemukan memiliki hubungan signifikan dengan keparahan COVID-19 (p > 0.05). Kesimpulan Pada populasi pasien COVID-19 dengan diabetes melitus tipe 2 di RSUI tahun 2020, meskipun terdapat kecenderungan asosiasi dengan keparahan COVID-19, namun tidak bermakna secara statistik. Faktor risiko lain juga tidak ditemukan kemaknaan secara statistik.

---

Introduction Type 2 diabetes mellitus is one of the risk factors for COVID-19 infection. This study aimed to analyze the association between type 2 diabetes mellitus and the severity of COVID-19-infected patients in RSUI in 2020. Method This cross-sectional analytical study uses medical records of COVID-19 patients in RSUI from June to September 2020. The chi-square test and Fisher’s exact test are utilized to test the association between type 2 diabetes mellitus and the severity of COVID-19. A bivariate analysis is conducted to analyze the other risk factors of COVID-19 that may affect the severity of COVID-19, followed by a multivariate logistic regression analysis. Result Data analysis found an OR = 2.494, indicating a tendency to have an association between type 2 diabetes mellitus and COVID-19 severity that is not statistically significant (p = 0.071; 95% CI = 0.903 – 6.890). Most of the 172 COVID-19 patients from RSUI are male-gendered (59.3%) and aged below 60 (89.4%). It is found that 19 patients have a history of type 2 diabetes mellitus (11.0%). Other risk factors analyzed, including male gender, geriatrician, hypertension, COPD, autoimmune disease, malignancy, kidney disease, and heart failure, lack significant association with COVID-19 severity (p > 0.05). Conclusion In this population of COVID-19 patients with type 2 diabetes mellitus in RSUI in 2020, although there is a tendency for an association with the severity of COVID-19, the value is statistically insignificant. Other risk factors studied are also found to lack a statistically significant association."

"Glikosaminoglikan (GAG) adalah komponen utama dari membran basal dan memiliki" "potensi sebagai penanda yang baik serta penentuan adanya disfungsi endotel pada tahap awal penyakit ginjal diabetes dan perkembangan penyakit. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan kadar GAG pada pasien dengan terapi metformin dan kombinasi metformin-glimepirid pada penderita diabetes melitus tipe 2. Penelitian dilakukan dengan desain potong lintang dengan metode consecutive sampling di Puskesmas Kecamatan Pasar Minggu dan Puskesmas Depok Jaya. Sampel darah dan urin subjek penelitian akan dikumpulkan untuk pengukuran HbA1c, estimasi laju filtrasi glomerulus (eLFG), perbandingan albumin-kreatinin urin, dan kadar GAG. Kadar GAG dapat dianalisis menggunakan 1,9-dimetilmetilen biru (GAG-DMMB). Total123 subjek penelitian dibagi menjadi dua kelompok yaitu pengguna terapi metformin (n=57) dan kombinasi metformin-glimepirid (n=66). Nilai koefisien korelasi dari hasil penelitian secara berturut-turut yaitu 0,9972; 0,9240; 0,9980; 0,9983; 0,9997; 0,9997; dan 0,9975. Terdapat perbedaan yang bermakna hanya pada karakteristik dasar usia (p=0,034) dan karakteristik dasar klinis yaitu HbA1c (p=0,037). Tidak terdapat perbedaan yang bermakna (p=1,000) pada hasil pengukuran glikosaminoglikan urin pada kelompok metformin (2,00 (0,17-8,09)) dan kombinasi metfonnin-glimepirid (2,07 (0,24-13,99)). Terdapat faktor lain yang signifikan dapat meningkatkan nilai GAG yaitu durasi menderita DMT2 >5 tahun dan komorbid. Oleh karena itu dapat disimpulkan bahwa tidak ada perbedaan nilai GAG urin pada kelompok metformin dan kombinasi metformin­ glimepirid.

---

Glycosaminoglycans (GAGs) are major components of the basement membrane and have" "potential as good markers and determinations of endothelial dysfunction in the early stages of diabetic kidney disease and disease progression. The purpose of the study was to determine differences in GAG levels in patients treated with metformin and a combination of metformin-glimepiride in patients with type 2 diabetes mellitus. The study was conducted with a cross-sectional design with consecutive sampling method at Pasar Minggu Subdistrict Health Center and Depok Jaya Health Center. Blood and urine samples of research subjects will be collected for measurement of HbA1c, estimated glomerular filtration rate (eGFR), urine albumin-creatinine ratio, and GAG levels. GAG levels can be analyzed using 1,9-dimethylmethylene blue (GAG-DMMB). Total of 123 research subjects were divided into two groups, which are divided into users ofmetformin therapy (n=57) and metformin-glimepiride combinations (n=66). The value of the correlation coefficient from the results of the research in order is 0,9972; 0,9240; 0,9980;" "0,9983; 0,9997; 0,9997; and 0,9972. There was a significant difference only in the basic" "characteristics of age (p=0,034) and basic clinical characteristics, namely HbA1c (p=0,037). There was no significant difference (p=1,000) in the measurement results of urine glycosaminoglycans in the metformin (2.00 (0.17-8.09)) and metformin­ glimepiride combination (2.07 (0.24-13.99)). Patient with other comorbidities and have suffered by Diabetes Mellitus Type 2 >5 years can significantly increase the value of GAG. Therefore, it can be said that there was no difference in urinary GAG values in the metformin and metformin-glimepiride group."

"Diabetes melitus tipe 2 (DMT2) adalah penyakit yang ditandai dengan hiperglikemia dan dikaitkan dengan keadaan inflamasi kronis, Sel punca merupakan terapi sel yang menjanjikan untuk DMT2 namun, efek parakrin dari hasil sekresi sel punca atau sekretom lebih potensial. Sekretom dan Autologous Activated Platelet Rich Plasma (aaPRP) berpotensi sebagai terapi bebas sel dan memiliki kandungan biomolekul yang sama untuk terapi DMT2. Penelitian ini bertujuan untuk mengevaluasi sitokin dan faktor pertumbuhan pada aaPRP dan sekretom sebagai strategi awal pengembangan aaPRP dan sekretom untuk DMT2. Penelitian ini adalah eksperimental in-vitro dengan total 13 pasien (10 DMT2 dan 3 Non DMT2). Analisis total protein dan Luminex terhadap sitokin TNF-α, IL-6, IL-10, growth factor VEGF, dan FGF dilakukan pada plasma, aaPRP, dan sekretom. Sekretom diisolasi dari sel punca jaringan adiposa (ADSC) dengan suplemtasi media kultur PRP Kontrol dan FBS. Hasil penelitian menunjukkan, sitokin dan growth factor dari aaPRP dan sekretom Non DMT2, mayoritas lebih tinggi dibandingkan DMT2. Terdapat perbedaan sitokin dan growth factor antara sekretom dengan media PRP Kontrol dan FBS. Kondisi DMT2 mempengaruhi sitokin dan growth factor pada aaPRP. Sitokin dan growth factor pada sekretom dipengaruhi oleh kondisi DMT2 dan media kultur.

---

Type 2 diabetes mellitus (T2DM) is a disease characterized by hyperglycemia and is associated with a chronic inflammatory state. Stem cells are a promising cell therapy for T2DM however, the paracrine effect of stem cell secretions, or the secretome, has more potential. Secretome and Autologous Activated Platelet Rich Plasma (aaPRP) can be cell-free therapies for T2DM. This study aims to evaluate cytokines and growth factors in aaPRP and the secretome as an initial strategy for developing aaPRP and the secretome for T2DM. This was an in-vitro experimental study with 13 patients (10 T2DM and 3 non-T2DM). Total protein and Luminex assays of the cytokines TNF-α, IL-6, IL-10, growth factor VEGF, and FGF were taken from plasma, aaPRP, and the secretome. The secretome was isolated from adipose tissue stem cells (ADSC) by supplementing control PRP and FBS culture media. The results showed that most cytokines and growth factors from aaPRP and the non-DMT2 secretome were higher than those from DMT2. There are differences in cytokines and growth factors between the secretome and control PRP and FBS media. T2DM conditions affect cytokines and growth factors in aaPRP. Cytokines and growth factors in the secretome are influenced by T2DM conditions and culture mediums."

"Tujuan : Mengetahui perbaikan keseimbangan fungsional pada pasien polineropati diabetik anggota gerak bawah pasca latihan stabilitas posturalDisain : Pra dan pasta perlakuan dengan kelompok kontrolSubyek : 50 prang dibagi secara acak sederhana menjadi dua kelompok (kelompok perlakuan dan kelompok kontrol)Tempat : Bagian Ilmu Kedokteran Fisik dan Rehabilitasi Rumah Sakit dr. Hasan Sadikin BandungIntervensi : Kelompok kasus diberi Iatihan stabilitas postural. Kelompok kontrol diberi latihan senam kaki diabetik. Kedua kelompok melakukan latihan 3 kali di rumah sakit dengan supervisi peneliti dan 4 hari di rumah dengan supervisi anggota keluarga yang ditunjuk. Kedua latihan diberikan selama 3 minggu.Parameter : Keseimbangan fungsional melalui 4 tolak ukur, yaitu unipedal stance test (UST), tandem stance test (TST), timed get up and go test (TUG) dan jarak functional reach test (T'RT)Hasil : Pada kelompok kasus terdapat perbaikan keseimbangan fungsional UST (p= 0,010), «T (p= 0,009), TUG (p= 0,014) kecuali FRT (p= 0,176), Pada kelompok kontrol terdapat peningkatan keseimbangan fungsional namun tidal( bermakna.Kesimpulan : Latihan stabilitas postural memperbaiki UST, TST dan TUG pada pasien polineuropati diabetik anggota gerak bawah."

"Alpha-glucosidase (EC 3.2.1.20) is a carbohydrase that catalyzes the liberation of a-glucose from the nonreducing end of the diet carbohydrate. In diabetic patients, inhibition of these enzymes causes the restraint of glucose absorption and decreases the postprandial hyperglycemia. The purpose of this research is to study the antihyperglycemic activity of mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] leaf extracts by inhibition test to alpha glucosidase enzyme. This research was conducted in three steps: fractionation and extraction samples with methanol, ethyl acetate, n-butanol, and water, followed by phytochemistry screening and alpha-glucosidase inhibition test. The alpha-glucosidase inhibition test was performed by using alpha-glucosidase enzyme and p-nitrophenyl α-D-glucopyranoside as a substrate.The result of phytochemistry screening showed that Mahkota dewa leaves contain class of phenolics, thanins, flavonoids, alkaloids, and carbohydrates. The result of alpha-glucosidase inhibition test showed that ethyl acetate fraction extract had the highest inhibition activity with inhibition percentage at 50 ppm for old leaves which is 55.04% and for young leaves which is 56.92%. At 50 ppm, inhibition activity from the methanol extract and boiled water extract of old leaves is higher than that of young leaves with inhibition percentage of old leaves methanol extract which is 14.25% and 10.97% for young leaves and for old leaves; boiled water extract is 10.32% and 6.85% for young leaves. For n-butanol fraction extract, inhibition activity of young leaf extract (14.26%) is higher than old leaf extract (9.49%)."

"Penelitian ini bertujuan untuk menganalisis risiko kejadian DM Tipe 2 pada pekerja PT.X Tahun 2014. Penelitian ini menggunakan pendekatan kuantitatif dengan desain penelitian cross sectional yang dilakukan untuk mengetahui besaran kontribusi variabel independen (lokasi kerja, masa kerja, perilaku merokok, dislipidemia) terhadap variabel dependen (risiko DM tipe 2, usia, indeks masa tubuh, ukuran lingkar abdomen, aktivitas fisik, konsumsi sayur dan buah, riwayat konsumsi obat anti-hipertensi, riwayat kadar glukosa tinggi dalam darah dan riwayat keluarga dengan DM). Penelitian menggunakan total sampling dengan jumlah sampel sebanyak 373 orang. Pengumpulan data dilakukan melalui telaah dokumen Medical Check Up (MCU). Proses input data menggunakan software EpiData dan Excel dan proses analisis dengan menggunakan SPSS. Hasil penelitian menunjukkan bahwa risiko DM tipe 2 pada pekerja di PT.X dipengaruhi oleh faktor risiko di antaranya faktor individu (usia, Indeks Masa tubuh, ukuran lingkar pinggang, aktivitas fisik, konsumsi sayur dan buah setiap hari, konsumsi obat-obatan anti hipertensi dengan rutin, riwayat pernah memiliki hasil pengukuran glukosa di atas normal, riwayat keluarga dengan DM, Lokasi Kerja dan dislipidemia (p value = 0,00). Dapat disimpulkan bahwa semua pekerja permanen PT. X berisiko menderita DM Tipe 2. Disarankan untuk mengotimalkan program manajemen kesehatan kerja dan promosi kesehatan terkait diabetes melitusdi tempat kerja.

---

The aims of this study is to analyze the risk of diabetes mellitus type 2 incident on workers of PT.X 2014. This study uses a quantitative approach with cross sectional study design which conduted to determine the contribution of independent variables (age, BMI, waist circumference size, physical activity, consumption of vegetables and fruits, anti-drug hypertension consumption, a history of high levels of glucose in the blood and family history with DM, the location of the work, the work?s period, the behavior of smoking, hypertension) to the dependent variable (risk of DM type 2). This study uses the total sampling (373 people). The data was collected using medical check up?s document. Processing the data in this study using SPSS.

This study found that there are risk factors of diabetes mellitus on workers at PT X including individu factor such as age, body mass index, waist circumference, physical activity, daily consumption of fruits and vegetables, history of antihypertensive drug treatment, high blood glucose, family history with DM, location of work and dislipidemia ( p value = 0.00 ). It can be concluded that risk of diabetes mellitus type 2 on workers including low risk. Management advised to optimizing occupational health program and promotion of health at work."