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Hasil Pencarian

Ditemukan 9 dokumen yang sesuai dengan query
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Siti Hajati Hoesin
Jakarta: Damera Press, 2023
344.01 SIT m
Buku Teks  Universitas Indonesia Library
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Arry Yanuar
"ABSTRACT
Cytochrome P450 isoform 2C9 (CYP2C9) is a main enzyme which metabolizes phenytoin [I]. The inhibition of this enzyme will increase plasma level of phenytoin. Cimetidine is known as drug that inhibits this enzyme, resulting an increased plasma level of phenytoin [2]. Recently, the three dimentional molecular basis of interaction between phenytoin and cimetidine toward CYP2C9 has not been described well yet. The present findings may represent an important advance for understanding interaction CYP2C9 with drugs to predict its toxicity an also metabolism based on structural interaction from docking results. A computational methodology, molecular docking can be used to analyze interaction which exist between ligand and macromolecule. AutoDock is one of the most commonly used methodology, shows the efficiency of scoring function ligand that bound to its active site [3]. So that, it can be used to understand about interaction between phenytoin and cimetidine in CYP2C9. Crystal structure of CYP2C9 complexed with flurbiprofen (PDB ID: 1R90) has resolution 2.00 A. This structure, used in this experiment, has the closed conformational structure and complexed with S-warfarin. Three dimensional structure of phenytoin and cimetidine were minimized, charge were added for docking preparation. Binding of substrate phenytoin in CYP2C9 is stabilized by hidrogen bonds, interaction with cationic residue Argl08, hydrophobic interaction particularly with Phel 14. On the other side, binding of cimetidine inhibitor in CYP2C9 is stabilized by hydrogen bonds with some amino acid residues, including Glu300 which has role as anionic residue, also the exist of hydrophobic interaction. Cimetidine being competitive inhibitor of CYP2C9 at the substrate recognition site of phenytoin.
"
2009
MK-Pdf
UI - Makalah dan Kertas Kerja  Universitas Indonesia Library
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Harto Widodo
Karanganyar: B2P2TO-OT Balitbangkes Depkes RI, 2015
615.321 HAR o
Buku Teks SO  Universitas Indonesia Library
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Astari Dwina Pramesti Basuki
"ABSTRAK
Melalui pendekatan fungsi dan estetika antara manusia dengan arsitektur,
desain mengalami proses perkembangannya di bidang pengetahuan arsitektur
terhadap ruang interior. Penelitian berbasis desain pun menjadi peluang sebagai
media yang dapat mempelajari pendekatan tersebut. Sistem yang dapat bekerja
pada suatu interioritas pun menjadi kunci utama penelitian ini. Bagaimana
interioritas dapat menjawab penelitian mengenai metode baru dalam mendesain
yang bergerak pada fungsi dan estetika ruang interior?
Penelitian ini diawali dengan mempelajari seputar fungsi seni kolase
terhadap sistemnya dalam merepresentasikan suatu ruang arsitektur interior.
Kolase dalam kaidahnya memiliki ruang-ruang tersembunyi dibalik lapisan objek
yang menjadi fokus utama teknik representasi ruang tersebut. Teka-teki mengenai
keberadaan ruang tersembunyi ini kemudian dapat menghasilkan seribu satu
kemungkinan cerita yang tersampaikan melalui pengalaman manusia dalam
fungsi. Dengan penelusuran lebih lanjut, kelak seribu satu kemungkinan cerita
tersebut menjadi suatu sistem yang perlu ditelusuri dengan mempertahankan
unsur fungsi dan estetika terhadap interioritas.
Image seribu satu kemungkinan cerita yang terkandung dan
bercengkerama dalam interioritas sebuah ruang dapat menjadi sistem yang disebut
sebagai mesin. Mesin tersebut adalah sistem yang dapat bekerja di antara persepsi
manusia dan pengalamannya akan ruang secara berkelanjutan. Ruang sebuah
pasar di daerah Santa pun dimanfaatkan sebagai tapak pengembangan mesin
tersebut, dengan alasan peluang image tapak yang dimiliki serta ruang yang berpotensi dapat mewadahi seribu satu cerita. Dialog antara sistem seribu satu
cerita mengenai fungsi dan estetika ini dapat disebut sebagai Living Machine yang
kelak dapat menjawab keberadaan dialog tersebut sebagai suatu interioritas.

ABSTRACT
Through the function and aesthetic approach of the relationship between
man and architecture, design has been through the development in the cognition
of architecture towards interior. Design based study became the opportunity as the
new media that can answer the study approach. The system that is able for
working throughout the interiority is the keyword of the study. How can
interiority answer the new method of design study about function and aesthetic of
an interior space?
The study begins by learning the main function of a collage art and its role
in representing an interior architecture space. Collage art in its own rule has got
some unfound space between its layers as the main focus of the space
representation technique. Puzzles of the existence of the unfound space then
collect a thousand and one probability of stories that were represented through the
human responds by each of their experience as the function of the interior space.
Thus by the further research, a thousand and one stories themselves could create
their own system that should be followed with the function and aesthetic of the
interiority.
The image that is brought by one thousand and one probability of stories
that contained and theatrically involved each other inside the interiority is called
as machine. The machine is a system that works between human perception and
its following experience of space sustainably. The existence of a traditional
market in Santa is chosen to be the site for further development of the machine.
The image that is brought by one thousand and one probability of stories
that contained and theatrically involved each other inside the interiority is called
as machine. The machine is a system that works between human perception and
its following experience of space sustainably. The existence of a traditional
market in Santa is chosen to be the site for further development of the machine
By reason of ?image? opportunities and space that potentially can contain the
combination of one thousand and one stories. The dialogue between each system
of one thousand and one stories about function and aesthetic is identified as
?Living Machine? that later can respond to the dialogue?s existence as an
interiority."
2016
S62787
UI - Skripsi Membership  Universitas Indonesia Library
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Rahmania Alaydrus
" ABSTRAK
Manusia merupakan titik penting dalam sebuah pengalaman ruang. Dua aspek
penting dalam ruang publik adalah perasaan nyaman dan tidak nyaman. Kenyamanan
maupun ketidaknyamanan di ruang publik tidak terlepas dari tindak kriminalitas.
Melalui pendekatan tersebut, saya melakukan studi dan penelitian yang bertujuan
untuk mengidentifikasi serangkaian proses dengan menelusuri proses autopoiesis
jejak secara holistic, saat manusia mengalami ketidaknyamanan pada ruang
eksistensialnya. Sehingga, batas tertentu dari sebuah jejak akan menjadi identitas dari
segmen tertentu dalam cerita masa lampaunya. Ketika segmen demi segmen terbaca,
rangkaian cerita akan dapat seutuhnya teridentifikasi menjadi satu keutuhan cerita.
Ketika jejak tersebut dapat hadir dan menjadi sebuah batas, maka disitulah muncul
interioritas.

ABSTRACT
Humans are the most important thing in a space experience. Two important
aspects of public space are the feelings of comfort and discomfort. That comfort or
discomfort kind of feeling in the public space, are obviously inseparable from the acts
of crime. Through such approaches, I undertake this studies and research that aims to
identify the sequence of trails autopoietic processes, holistically, when human come
up against their discomfort, and in their existential space. So, that specific and
particular boundary from the trail will come up as identity. Identity of the past. When
the segments are legible as segment-by-segment, the processes will be holistically
identified as a whole story. When the presence of a trail becomes a boundary, therein
the trail will appear as the interiority."
2016
S63234
UI - Skripsi Membership  Universitas Indonesia Library
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Astidira Apti
"Untuk berpartisipasi dalam memperluas pengetahuan pada pendekatan ekologis di area pengetahuan interior, penelitian berbasis desain dapat menjadi media yang memadai untuk mempelajari pendekatan ekologis secara spasial. Dalam mempertanyakan seberapa jauh kita bisa menantang interioritas, dalam penelitian ini, ekologi dianggap sebagai studi tentang sistem dalam lingkup ruang dan lingkungan.
Penelitian ini dimulai dengan mempelajari sistem filter air pada ekologi buatan kolam koi di mana fokus utamanya adalah pergerakan air dan interaksinya dengan material yang digunakan untuk penyaringan. Sistem ini sendiri dapat dilihat sebagai sebuah mesin, tapi kualitas dalam sistem dimana keterkaitan antara unsur-unsur organik, unsur-unsur anorganik dapat dilihat sebagai pendekatan ekologis pada mesin, di mana sistem dapat dianggap sebagai Living Machine. Menerapkan prinsip-prinsip penyaringan air dan memanfaatkan kualitasnya untuk menghasilkan program pendidikan melalui antarmuka digital digabungkan untuk mempengaruhi manusia melalui interioritas nya.
Tapak yang terintegrasi untuk diinjeksikan sistem adalah kolektif tujuh gudang kayu dikelilingi oleh air mati. Mesin itu sendiri mengintervensi konteks yang berumur yang 400 tahun untuk menghidupkan air mati melalui operasinya yang bergerak di dalam, diantara, dan di luar setiap unit gudang kayu yang lain dan air yang mengelilinginya. Pendekatan ekologis Living Machine filter air di dalam konteks kayu dan air mati menceritakan pesannya mengenai keberadaan air yang berada disekitar kita dan didalam diri kita dan menciptakan konteks yang hidup.

To participate in widening the area of knowlege in interior through an ecological approach, a design based research can be an adequate media to study the approach in a spatial manner. In questioning how far we can challenge interiority, in this research, ecology is perceived as a study of systems in a spatial and enviromental scope.
The research begins with studying water filters system in the artificial ecology of a koi pond where the main focus is water movement and its interraction with materials used for filtering. The system it self can be seen as a machine, but its qualities in the interrelated system between the organic elements, the inorganic elements can be seen as an ecological approach to a machine, in which the system can be perceived as a Living Machine. Applying the principals of filtering water and utilizing its qualities to generate educational programming through digital interface are combined to preoccupy human through its interiority.
The integrated site chosen to inject the system is a collective of seven wooden storage surrounded by dead water. The machine itself intervene the 300 years old existing context to bring the dead water to life through the operation of water moving inside, inbetween, and outside of each wooden storage unit to another and the water that surrounds it. An ecologycal approach of water filter living machine inside a context of wood and dead water narrates its message of waters existence that surrounds us and is within us creates a living pulse of the context.
"
Depok: Fakultas Teknik Universitas Indonesia, 2016
TA-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Deynanti Primalaila
"ABSTRAK
Interioritas yang diinjeksi melalui metode blurring adalah pertanyaan dan penekanan
yang akan dikaji dalam tulisan ini. Penelitian diawali dengan eksplorasi minat photo
transfer yaitu memindahkan tinta foto dari satu media ke media lainnya. Proses transfer
yang membutuhkan overlap media air, gel medium, dan kertas menentukan dasar metode
dalam mengintervensi persepsi manusia. Hasil photo transfer menunjukkan bahwa
komposisi overlap media membuat sebuah foto terlihat blurring. Blurring kemudian
dijadikan dasar sebagai pendekatan riset interioritas. Eksplorasi trigger kinetika
memberikan rules pada living machine dimana komponen antar ruang didalamnya saling
bekerja sama dan saling berinteraksi secara reversible. Stasiun Manggarai berpotensi bagi
aplikasi blurring melalui projection yang merupakan hasil eksplorasi riset. Hasil akhir
tulisan ini dapat memberikan alternatif rutinitas baru bagi pengguna Manggarai. Proyeksi
sebagai komponen utama instalasi sebagai proposisi sistem dalam ruang dapat membuka
diskusi baru mengenai pembentukan interioritas.

ABSTRACT
Interiority that is injected through blurring method is the question and the emphasis that
will be examined in this paper. Examination begins with photo transfer as trigger for
exploration of transferring the ink from one media to the other media. Overlaping media
requirements; water, gel medium, and papers made the transferring as the basic method to
intervene human perception. The results showed that the overlaping composition of the
media makes photo looked blured. The mechanism to make photo blured is being used as
the approaching method of interiority. Kinetics exploration provide rules on living
machine where the components inside could work together and have reversible
interaction in it or with their context. Manggarai Station has the potential for injecting
blurring through projection as the components based on exploration research result. The
final result can provide a new routine alternative for the user of Manggarai Station.
Projection as a main component of installation as system proposition in space could open
new discussion about forming interiority."
2016
TA - pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Helwiah Umniyati
"ABSTRAK
Obesity has become a significant public health problem of the twenty first century. An increasing number of preschool
children are becoming overweight. Although many risk factors have been identified for school-age children, less is
known about this young age group. This study was aimed to determine factors associated with overweight among
preschool children. Study design was a cross sectional survey. Sample in this study was 90 children aged 3?6 years old
in Bina Putik Kindergarten School in Cempaka Putih District (total sampling). The prevalence of overweight and
obesity in this sample were 24.4% and 13.3% respectively. There were significant relationships between overweight
and some variables using chi-square test such as: age of the children, having overweight parents, nutritional knowledge
of the mother, duration of breast feeding, frequency of fast food consumption (p < 0.05). In Cox Regression analysis,
only the age of children and nutritional knowledge of mothers were found as determinant factors influencing childhood
overweight after adjusting other variables. Younger aged children (<5 years) had a greater risk of being overweight than
older children (>5 years old). It could be concluded that mother?s knowledge on nutrition played an important role in
preventing overweight children. Suggested recommendation in order to prevent overweight since childhood was by
increasing mother?s knowledge through optimizing relevant programs in the Puskesmas.
Faktor-faktor yang Berhubungan dengan Kelebihan Berat Badan pada Anak Usia Taman Kanak Kanak.
Obesitas menjadi masalah kesehatan umum yang signifikan dari abad kedua puluh. Nampak terjadi peningkatan jumlah
anak-anak prasekolah yang memilki kelebihan berat badan. Walaupun telah banyak diidentifikasi faktor risiko yang ada
untuk anak-anak usia sekolah, masih sedikit yang diketahui tentang kelompok usia muda ini. Penelitian ini bertujuan
untuk menentukan faktor-faktor yang terkait dengan kelebihan berat badan di kalangan anak-anak prasekolah. Model
penelitian ini adalah melalui survei penampang silang. Sampel dalam studi ini adalah 90 anak berusia 3 sampai 6 tahun
di Taman Kanak Kanak Bina Putik di daerah Cempaka Putih (total sampel). Prevalensi kegemukan dan obesitas dalam
contoh ini masing-masing adalah 24,4% dan 13,3%. Ada hubungan yang signifikan antara kelebihan berat badan dan
beberapa variabel yang menggunakan tes Chi-kuadrat seperti: usia anak-anak, memiliki orangtua yang kelebihan berat
badan, pengetahuan ibu tentang gizi, durasi menyusui, frekuensi konsumsi makanan cepat saji (p < 0,05). Dalam
analisis regresi Cox, hanya usia anak dan pengetahuan gizi ibu ditemukan sebagai faktor-faktor penentu yang
mempengaruhi anak-anak yang kelebihan berat badan setelah menyesuaikan variabel-variabel lainnya. Anak-anak usia
muda (<5 tahun) memiliki risiko yang lebih besar daripada anak-anak lebih tua (>5 tahun). Dapat disimpulkan bahwa
pengetahuan ibu tentang gizi memainkan peranan penting dalam mencegah anak-anak kelebihan berat badan.
Rekomendasi yang disarankan untuk mencegah kelebihan berat badan sejak masa kanak-kanak adalah dengan
meningkatkan pengetahuan ibu melalui optimalisasi program-program yang terkait di Puskesmas."
University of YARSI. Faculty of Medicine, 2014
J-pdf
Artikel Jurnal  Universitas Indonesia Library
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Ni Luh Ayu Megasari
"
ABSTRACT
Background: the global scale-p of antiretroviral therapy (ART) is the primary factor contributing to the decline in deaths from acquired immune deficiency syndrome (AIDS)-related illnesses. However, the emergence of transmitted drug resistance (TDR) compromises the effects of ART in treatment-naive individuals, which may hinder treatment success. The present study aimed to identify the presence of TDR among treatment-naive individuals in Buleleng, Bali, which is currently ranked sixth among Indonesian provinces with the highest cumulative human immunodeficiency virus type 1 (HIV-1) infection cases. Methods: thirty-nine ART-naive individuals in Buleleng Regency General Hospital were enrolled in the present study. Blood samples from participants were subjected to a genotypic analysis. Results: 28 protease (PR) and 30 reverse transcriptase (RT) genes were successfully amplified and sequenced from 37 samples. HIV-1 subtyping revealed CRF01_AE as the dominant circulating recombinant form in the region. No TDR for PR inhibitors was detected; however, TDR for RT inhibitors was identified in five out of 30 samples (16.7%). Conclusion: these results indicate the emergence of TDR among ART-naive individuals in Buleleng, Bali. This issue warrants serious consideration because TDR may hamper treatment success and reduce ART efficacy among newly diagnosed individuals. Continuous surveillance with a larger sample size is necessary to monitor TDR among ART-naive individuals."
Jakarta: University of Indonesia. Faculty of Medicine, 2019
610 UI-IJIM 51:3 (2019)
Artikel Jurnal  Universitas Indonesia Library